| 1 | EDITORIAL |
| 2-10 | Controlled Release of Polypeptides and Other Macromolecules | Ronald A. Siegel and Robert Langer |
| 11-18 | The Potential of Nucleotide Analogs as Inhibitors of Retroviruses and Tumors | Roland K. Robins |
| 19-23 | New Lipophilic Terbutaline Ester Prodrugs with Long Effect Duration | O. A. Torsten Olsson and Leif-Å. Svensson |
| 23-27 | Influence of Bloodflow on the Absorption of Theophylline from the Jejunum of the Rat | Norbert Schurgers and Cornelis J. de Blaey |
| 28-32 | The Hypolipidemic Activity of N-(p-Chlorobenzoyl)-sulfamate in Rodents and its Effect on Lipid Metabolism | I. H. Hall, S. D. Wyrick, P. J. Voorstad and A. Dubey |
| 33-38 | Pharmacokinetics of Anthracyclines in Dogs: Evidence for Structure-Related Body Distribution and Reduction to Their Hydroxy Metabolites | Marijn J. M. Oosterbaan, Rita J. M. Dirks, Tom B. Vree and Eppo van der Kleijn |
| 39 | The Analgesic Activity of Neo-Kyotorphin: A Newly Identified Pentapeptide from Bovine Brain. | Kiyoshi Fukui, Hiro Amano, Yoshiaki Kiso, Kouki Kitagawa and Hiroshi Takagi |
| 40-43 | Continuous Measurements of ATP Secretion in Vivo | J. Bryan Smith, Sandra E. Burke, Allan M. Lefer and Arthur Freilich |
| 43-45 | High Pressure Liquid Chromatographic Analysis of Metoclopramide in Serum | Jordan L. Cohen, Gordon H. Jonathan E. Hisayasu and Stephen B. Strum |
| 46-48 | WIN 44,441: A Stereospecific and Long-Acting Narcotic Antagonist | Paul L. Wood, Carmencita Pilapil, Mira Thakur and Jean W. Richard |
| 49 | Factors Affecting the Determination of Unbound Carbamazepine Concentrations in Plasma | J. J. H. M. Lohman, F. W. H. M. Merkus, G. M. P. J. Costongs, E. P. J. M. H. Hegtermans and P. M. Hooymans |
| 50 | Who Speaks for the Future? | Jere E. Goyan |
| 189-194 | Extraction of Natural Substances with Dense Gases | Egon Stahl and Karl Werner Quirin |
| 194-203 | Pyrazolopyrimidine Metabolism in Parasitic Protozoa | Buddy Ullman |
| 203-209 | Pharmacokinetics and Metabolic Fate of Two Nitroxides Potentially Useful as Contrast Agents for Magnetic Resonance Imaging | William R. Couet, Ulf G. Eriksson, Thomas N. Tozer, L. Dallas Tuck and George E. Wesbey, et al. |
| 209-214 | Radioreceptor Assay of Narcotic Analgesics in Serum | Joachim Grevel, Jeff Thomas, Mark L. Richards and Wolfgang Sadée |
| 215-220 | A Radioimmunoassay for Determination of Glibenclamide and Other Sulfonylureas | Wolfgang Heptner, Mario Badian, Siegfried Baudner, Christa Hellstern and Robert Irmisch, et al. |
| 221-224 | Transmucosal Passage of Liposomally-Entrapped Drugs in Rat Small Intestine | Toshikiro Kimura, Kazutaka Higaki and Hitoshi Sezaki |
| 225-229 | Antipyrine - New Light on an Old Drug | Hartmut Derendorf, Gertrude Drehsen and Peter Rohdewald |
| 229-231 | Prostaglandin E1-induced Catalepsy in the Rat: Role of Putative Neutrotransmitters | Salil K. Bhattacharya, Patchala J. Mohan Rao and Dipankar Bhattacharya |
| 231-233 | Morphine Inhibition of Theophylline Clearance | Mario L. Rocci, Parviz Mojaverian and Consuelo L. Saccar |
| 234-235 | Delayed Ethanol Elimination in Rats after Application of Cefamandole or Cefoperazone | Klaus G. Römer, Klaus J. Freundt, Oscar Torres Alanis and Graciela Garcia de Torres |
| 236 | BOOK REVIEWS |
| 237-244 | Drug Delivery by Program or Sensor Controlled Infusion Devices | Manfred Franetzki |
| 245-249 | Effect of Column Temperature and Eluent Flow Rate on the High Performance Liquid Chromatographic Analysis of Cyclosporin A and D | Kulthoum A. Mereish and Clarence T. Ueda |
| 250-255 | The Hypolipidemic Activity of 3-Iminophthalimidine in Rodents | P. Josée Voorstad, George H. Cocolas and Iris H. Hall |
| 256-259 | Effect of Entrapped Markers on the in situ Jejunal Uptake from Liposomal Systems | D. L. Schwinke, M. G. Ganesan and Norman D. Weiner |
| 259-266 | Relationship of Octanol/Water Partition Coefficient and Molecular Weight to Cellular Permeability and Partitioning in S49 Lymphoma Cells | Victor A. Levin, Doug Dolginow, Herbert D. Landahl, Craig Yorke and Judit Csejtey |
| 267-269 | Hypolipidemic Agents of Phthalimide Derivatives 6. Effects of Aromatic vs. Non-Aromatic Imides | James M. Chapman, Steven D. Wyrick, James H. Maguire, George H. Cocolas and Iris H. Hall |
| 269-271 | In Vitro Antimicrobial Activity of Benzoquinolinediones | Alice M. Clark, Debra L. Huddleston, Cheng Yu Ma and Chuen-Huei Ho |
| 271-274 | Phosphorus GABA Analogues as Potential Prodrugs | Lindley A. Cates and Mohamed S. Rashed |
| 274-276 | In vitro Metabolism of Bumetanide | Giorgio Grosa, Franca Viola, Otto Caputo and Giuseppe Biglino |
| 277-279 | Replacing the Mixed Function Oxidase N-Demethylation by Hydrogen Peroxide and either Hemoglobin or Ferrous Sulfate | Shmuel Zbaida, Dalia Gilhar and Judith Silman-Greenspan |
| 279-282 | Effect of Mangiferin, a Naturally Occurring Glucosylxanthone, on Reproductive Function of Rats | Sukumar Chattopadhyay, Utpala Chattopadhyay, Santyeswar P. Shukla and Shibnath Ghosal |
| 287-288 | Author's Index: Pharmaceutical Research 1984 |
| 289-290 | Subject Index: Pharmaceutical Research 1984 |
| 55-61 | The Molecular Basis of β-Lactamase Catalysis and Inhibition | Anthony L. Fink |
| 61-64 | Drug Release from Suppositories | Cornelis J. de Blaey and Jasper G. Fokkens |
| 65-68 | pH-Solubility Profiles of Organic Bases and Their Hydrochloride Salts | Abu T. M. Serajuddin and Daniel Mufson |
| 69-72 | Pharmacokinetics of Two Prototype Nitroxide Spin Labels for Contrast Enhancement in Magnetic Resonance Imaging | William R. Couet, Ulf G. Eriksson, Robert C. Brasch and Thomas N. Tozer |
| 73-75 | HPLC Analysis of Thimerosal in Ophthalmic Solution. Comparing Electrochemical with Spectrophotometric Detectors | Gary C. Visor, Richard A. Kenley, Jeffrey S. Fleitman, Daniel A. Neu and Irene W. Partridge |
| 75-77 | Studies on the Dissolution of Drugs from Tablets using Perturbed Angular Correlation | Michael Jay, John T. Fell and George A. Digenis |
| 77-80 | The Interaction of Cyanonaphthyridinomycin with DNA | Milton J. Zmijewski and Marcia Mikolajczak |
| 80-83 | Drug Distribution and Biliary Excretion Pattern of a Cyclic Somatostatin Analog: A Comparison of 14C Labeled Drug and a 131I lodinated Drug Analog | Larry J. Caldwell, Alan Parr, Robert M. Beihn, Bushra J. Agha and Arthur R. Mlodozeniec, et al. |
| 83-86 | Effects of 5-Fluorouracil Prodrugs on the Central Nervous System in Mice and Rats | Katsuo Toide, Norio Unemi and Tomio Segawa |
| 87-90 | Differential Inhibitory Effects of Isosorbide Dinitrate and its Mononitrate Metabolites on Platelet Aggregation and Thromboxane Formation | Pierre H. Rolland, José Sampol, Bruno Lacarelle, Dominique Arnoux and François Leca, et al. |
| 90-93 | Evidence for an Acute Antimagnesiuretic Effect of Triamterene Derivatives | Helmut Priewer, Helga Kraft and Ernst Mutschler |
| 94-95 | Verapamil Interacts Stereoselectively with the Muscarinic Receptor | John C. Giacomini, Ray H. Zobrist, Bharati Dave and Kathleen M. Giacomini |
| 96 | Announcements |
| 151-156 | Peptides and Proteins as Drugs | Bobbe L. Ferraiolo and Leslie Z. Benet |
| 156-162 | Sympathomimetic Bronchodilators: Increased Selectivity with Lung-Specific Prodrugs | Leif Å. Svensson |
| 162-165 | Absorption of Etoposide (VP-16-213) from the Small Intestine of the Rat. The Potential Role of Mucus as an Absorption Rate Limiting Barrier | N. Schurgers, Cornelis J. de Blaey and D. J. A. Crommelin |
| 166-170 | Absorption and Bioavailability of Diclofenac after Rectal Administration of Diclofenac-Na Gel Preparation in Rat and Man | Kazuhiro Morimoto, Yoko Iwamoto, Takao Katashima, Toshiyuki Takeeda and Yasuo Nakamoto, et al. |
| 170-175 | Adsorption and Chemical Stability of a Cationic Aggregating Ester – Propantheline Bromide – on Silica Surfaces in Aqueous Dispersions | Rolf Daniels and Herbert Rupprecht |
| 176-177 | The Pharmacokinetics of Amrinone at Three Dose Levels in the Rabbit | Ghassem E. Larijani, Mario L. Rocci, Deborah L. Newman and Hugh Wilson |
| 178-181 | Buprenorphine is an Antagonist at the ϰ Opioid Receptor | Mark L. Richards and Wolfgang Sadée |
| 181-184 | A New Method for the Determination of Partition Coefficients of Air Sensitive Copper(I) Complexes | Hans-Dieter Gaisser, Henk van der Goot and Henk Timmerman |
| 185-187 | Mandibular and Parotid Salivary Levels of Indomethacin Following Intravenous Administration to Rabbits | Jun Watanabe, Tsutomu Setoyama, Kikuo Iwamoto, Yayoi Hayashi and Shoji Ozeki |
| 188-191 | Pharmacokinetics of Pirazolac – a New Anti-Inflammatory Drug – in Human Volunteers II. Dose Linearity of Plasma Levels and Excretion | Ulrich Täuber, Christian Weiss and Heinz Matthes |
| 192-194 | Structure of a Neurotoxin that Induces Parkinsonism Symptoms; l-Methyl-4-phenyl-l,2,3,6-tetra-hydropyridine Hydrochloride | Cheryl L. Klein, Ronald F. Borne and Edwin D. Stevens |
| 195-198 | Prostaglandins and Central Serotonergic Activity in the Rat | Salil K. Bhattacharya |
| 198-202 | Effect of Dextran on the Release of Gonadotropin-Releasing Hormone (GnRH) Injected into Rats: Plasma GnRH and Gonadotropin Response | Nadja Heinrich, Dorothea Lorenz, Hartmut Berger, Klaus Fechner and Hermann Eberhard Schmidt, et al. |
| 202-206 | Cutaneous Absorption of Indomethacin From Two Topical Preparations in Volunteers | Hans Nowack, Udo Marin, Raimund Reger, Herta Böhme and Karl-H. Schriever, et al. |
| 206-211 | Kinetic Analysis of Transdermal Nitroglycerin Delivery | Richard H. Guy and Jonathan Hadgraft |
| 211-217 | Computer Modeling of the Pharmacokinetics of Fluorouracil and Thymine and Their Kinetic Interaction in Normal Dogs | Joseph M. Covey and James A. Straw |
| 217-220 | Inosine Analogs as Anti-Leishmanial Agents | Petrie Rainey, Patricia A. Nolan, Leroy B. Townsend, Roland K. Robins and Jack J. Fox, et al. |
| 221-224 | In Situ Intestinal Absorption of a Poorly Water-Soluble Drug From Mixed Micellar Solutions of Bile Salt and Lipolysis Products in Rats | A.T.M. Serajuddin, M. Rosoff and A.H. Goldberg |
| 225-230 | Thermodynamics of Distribution of Salicylates in Semi-Solid Ointment Bases | Stanley S. Davis, Khalil Al-Khamis and Jonathan Hadgraft |
| 231-233 | Excretion of Metabolites in Bile Following the Administration of Primaquine to Rats | John K. Baker, James D. McChesney and Larry A. Walker |
| 233-238 | The Hypolipidemic Activity of Furoic Acid and Furylacrylic Acid Derivatives in Rodents | Iris H. Hall, Wallace L. Williams Jr, Kathryn A. Rhyne and Margaret Knowles |
| 239-243 | Preparation of Gelatin Nanocapsules and Their Pharmaceutical Characterization | Hans-Jürgen Krause and Peter Rohdewald |
| 243-245 | Effect of Salicylate on the Uptake of Cefmetazole into Brain of Mice | Hiroshi Yoshikawa, Kanji Takada, Yu-ichiro Satoh, Norio Naruse and Shozo Muranishi |
| 246-248 | Use of Lymphoblastoid Namalva Cell Cultures in a Toxicity Test. Application to the Monitoring of Detoxification Procedures for Fluorocarbons to be used as Intravascular Oxygen-Carriers | Maurice Le Blanc, Jean G. Riess, Daniel Poggi and R. Follana |
| 249-250 | Potentiation of Enteral Absorption of Human Interferon Alpha and Selective Transfer into Lymphatics in Rats | Hiroshi Yoshikawa, Kanji Takada, Yu-ichiro Satoh, Norio Naruse and Shozo Muranishi |
| 251-252 | Natural Occurrence of 11-O-Acetylambelline and 11-O-Acetyl-l ,2-β-epoxyambelline in Crinum latifolium: Immuno-regulant Alkaloids | Shibnath Ghosal, Potharaju H. Rao and Kulwant S. Saini |
| 253-261 | Leukotriene Biosynthesis Inhibitors | John R. Cashman |
| 262-266 | Program for Evaluating Drug Dissolution Kinetics in Preformulation | Martin Nicklasson and Anna-Britta Magnusson |
| 266-271 | Synthesis and Pharmacological Characterization of Fluorescent Opioid Receptor Probes | Vera M. Kolb, Ahmet Department of Pharmaceutical Pharmacology Koman and Anders Neil |
| 271-278 | Lymphatic Transport of Liposome-Encapsulated Drugs Following Intraperitoneal Administration – Effect of Lipid Composition | Koichiro Hirano, C. Anthony Hunt, Anne Strubbe and Roderick D. MacGregor |
| 279-284 | Effect of Age on the Disposition and Tissue Clearances of Fluorinated Pyrimidines in Rats | J. Lai-Sim Au |
| 284-293 | In Vitro Drug Absorption Models. I. Brush Border Membrane Vesicles, Isolated Mucosal Cells and Everted Intestinal Rings: Characterization and Salicylate Accumulation | Iwona Osiecka, Patty A. Porter, Ronald T. Borchardt, Joseph A. Fix and Colin R. Gardner |
| 293-298 | In Vitro Drug Absorption Models. II. Salicylate, Cefoxitin, α-Methyldopa and Theophylline Uptake in Cells and Rings: Correlation with In Vivo Bioavailability | Patty A. Porter, Iwona Osiecka, Ronald T. Borchardt, Joseph A. Fix and Linda Frost, et al. |
| 298-301 | Role of Peripheral Adrenergic Responsiveness in the Development of DOCA/NaCl Hypertension in Rats | Eme L Iloeje, Michael J. Katovich, Edward E. Soltis and F. Peter Field |
| 302-306 | Mechanical Activation of Pharmaceutical Systems | Reinhard Hüttenrauch, Sabine Fricke and Petra Zielke |
| 307-309 | Possible Mechanism Regulating Barrier Function of Rat Intestinal Mucosa against Permeation of Cefmetazole, a Hydrophilic Drug | Toshiaki Nishihata, Hideo Takahata and Akira Kamada |
| 309-310 | Change of Phase-Solubility Behavior by Gamma-Cyclodextrin Derivatization | Bernd W. Müller and Ulrich Brauns |
| 311-313 | High-Performance Liquid Chromatographic Analysis of Tocainide in Human Plasma | Ludo Conings and Norbert Verbeke |
| 313-315 | Prostaglandin D2 Induced Potentiation of the Anticonvulsant Actions of Phenobarbitone and Phenytoin in Rats. Role of Serotonin | Salil K. Bhattacharya and Surendra S. Parmar |
| 315-318 | Central Serotonergic Modulation of Carrageenin-induced Pedal Inflammation in Rats | Salil K. Bhattacharya and Neeta Das |
| 319-320 | Announcements |
| 323-324 | Author's Index: Pharmaceutical Research 1985 |
| 325-326 | Subject Index: Pharmaceutical Research 1985 |
| 65-74 | Fundamentals of Powder Compression. II. The Compression of Binary Powder Mixtures | Hans Leuenberger and Bhagwan Dass Rohera |
| 75-80 | Treatment of Filariasis—Diethylcarbamazine and Its Congeners | Satyavan Sharma |
| 81-87 | Characterization of an In Vitro Blood–Brain Barrier Model System for Studying Drug Transport and Metabolism | Kenneth L. Audus and Ronald T. Borchardt |
| 88-92 | An In Vitro Method of Evaluating Tolnaftate Release from Topical Powder | Tacey X. Viegas, Arthur H. Kibbe, Ahmed H. Hikal, Robert W. Cleary and Alan B. Jones |
| 93-101 | The Hypolipidemic Activity of a Series of 2,3-Dihydrophthalazine-l,4-dione Derivatives in Rodents | A. R. K. Murthy, I. H. Hall, J. M. Chapman, K. A. Rhyne and S. D. Wyrick |
| 102-107 | Pharmacodynamics of Basic Triamterene Derivatives | Helmut Priewer, Hildegard Spahn and Ernst Mutschler |
| 108-111 | Bioavailability of Propranolol After Oral, Sublingual, and Intranasal Administration | Guus S. M. J. E. Duchateau, Jan Zuidema and Frans W. H. M. Merkus |
| 112-115 | A Radioimmunoassay Procedure for the Determination of the Antiviral Nucleoside DHPG (9-[(l,3-Dihydroxy-2-propoxy)-methyl]guanine) in Plasma or Serum | Clinton Nerenberg, Sherrie McClung, John Martin, Marian Fass and JoAnn Fargue, et al. |
| 116-117 | Development of Interferon Suppositories. I. Enhanced Rectal Absorption of Human Fibroblast Interferon by Fusogenic Lipid via Lymphotropic Delivery in Rats | Hiroshi Yoshikawa, Kanji Takada, Yu-ichiro Satoh, Norio Naruse and Shozo Muranishi |
| 118-121 | Stabilization of Sulfamerazine Suspensions by Xanthan Gum | Joel L. Zatz and Christine Yarus |
| 123-131 | Comparison of Canine and Human Gastrointestinal Physiology | Jennifer B. Dressman |
| 132-141 | Characterization of the Urinary Metabolites of Primaquine in Rats | John K. Baker, James D. McChesney and Lucia F. Jorge |
| 142-149 | Determination of β-Endorphin and Fragments Thereof in Human Plasma Using High-Performance Liquid Chromatography and a Multiple Radioimmunoassay System | Klaus Wiedemann and Hansjörg Teschemacher |
| 150-155 | Saturable Processes Affecting Renal Clearance of Cefixime in Dogs | Alfred P. Tonelli, Meir Bialer, Zee M. Look, Steven Carson and Avraham Yacobi |
| 156-161 | Correlation Between In Vivo Antipyrine Metabolite Formation and Theophylline Metabolism in Rats | Michael W. E. Teunissen, Irinka O. N. Brorens, H. Joke De Langen, Anne M. Geerlings and Douwe D. Breimer |
| 162-166 | Role of Putative Neurotransmitters in Bradykinin-Induced Catalepsy in the Rat | Salil K. Bhattacharya, Patchala J. R. Mohan Rao, Stanley J. Brumleve and Surendra S. Parmar |
| 167-169 | The Effect of Amiodarone on Theophylline Pharmacokinetics in the Rat | Ghassem E. Larijani, Mario L. Rocci, Parviz Mojaverian, Consuelo L. Saccar and Cindy Hoholick, et al. |
| 170-172 | Fungal Metabolism of 4-Methylprimaquine | Alice M. Clark, James D. McChesney and Charles D. Hufford |
| 173-177 | Pharmacokinetics and Reversible Biotransformation of Sulfinpyrazone and Its Metabolites in Rabbits. I. Single-Dose Study | Wolfgang A. Ritschel |
| 178-183 | Pharmacokinetics and Reversible Biotransformation of Sulfinpyrazone and Its Metabolites in Rabbits. II. Multiple-Dose Study | Be-Sheng Kuo and Wolfgang A. Ritschel |
| 184 | Announcement |
| 185 | Editorial |
| 186 | AAPS and pharmaceutical research | Leslie Z. Benet |
| 187-194 | The interactions of water with cellulose- and starch-derived pharmaceutical excipients | George Zografi and Mark J. Kontny |
| 195-207 | The applications of synthetic oligonucleotides to molecular biology | Ronald W. Ellis |
| 208-213 | The effect of density on the gastric emptying of single- and multiple-unit dosage forms | Stanley S. Davis, Anita F. Stockwell, Margaret J. Taylor, John G. Hardy and David R. Whalley, et al. |
| 214-217 | Microviscosity and drug release from topical gel formulations | Khalil I. Al-Khamis, Stanley S. Davis and Jonathan Hadgraft |
| 218-224 | Conformation and electrostatic potential surfaces of opiates: Relationship to µ- and λ-site binding | Terry P. Lybrand, Peter A. Kollman, Victor C. Yu and Wolfgang Sadée |
| 225-229 | Systemic delivery of timolol after dermal application: Transdermal flux and skin irritation potential in the rat and dog | Robyn Cargill, Karen Engle, Gerald Rork and Larry J. Caldwell |
| 230-234 | Capsules with prolonged action. II. Capsule filling by a gelation process | Peter C. Schmidt and B. Stockebrand |
| 235-239 | Capsules with prolonged action. III. Release of active ingredients from cast films | Peter C. Schmidt and B. Stockebrand |
| 240-243 | Effect of lycoriside, an acylglucosyloxy alkaloid, on mast cells | Shibnath Ghosal, Amirthalingam Shanthy, Mita Mukhopadhyay, Mihir K. Sarkar and Prasun K. Das |
| 244-248 | In Vivo performance of ophthalmic preparations of betamethasone and phenylephrine hydrochloride in the rabbit eye: Effect of polyvinyl alcohol | Mahfouz A. Kassem, Mohamed A. Attia, Fawzia S. Habib and Abdel-Razak A. Mohamed |
| 249-251 | Association news and announcements |
| 253-262 | The Bioavailability of Dermatological and Other Topically Administered Drugs | Richard H. Guy, Anna H. Guy, Howard I. Maibach and Vinod P. Shah |
| 263-270 | A Critical Analysis of the Experimental Evaluation of Nociceptive Reactions in Animals | Krishnaswami Ramabadran and Mylarrao Bansinath |
| 271-277 | New Class of 5-Lipoxygenase Inhibitors: Correlation Between Inhibition of LTB4 Production and Chemiluminescence of Human Polymorphonuclear Granulocytes | Dieter Steinhilber, Karlheinz Schmidt, Kurt Eger and Hermann J. Roth |
| 278-285 | Improved Delivery Through Biological Membranes. XXIV. Synthesis, in Vitro Studies, and in Vivo Characterization of Brain-Specific and Sustained Progestin Delivery Systems | Marcus Eli Brewster, Kerry S. Estes and Nicholas Bodor |
| 286-289 | The Synthesis of Homophthalimide and Related Derivatives and Their Hypolipidemic Activity in Rodents | Akula R. K. Murthy, James M. Chapman, Steven D. Wyrick and Iris H. Hall |
| 290-293 | Selective Toxicity of the Antimalarial Primaquine—Evidence for Both Uncoupling and Inhibitory Effects of a Metabolite on the Energetics of Mitochondria and Its ATP Synthase Complex | John K. Baker, Joanne M. Hullihen and Peter L. Pedersen |
| 294-297 | The Influence of Urea on Percutaneous Absorption | Janet Beastall, Richard H. Guy, Jonathan Hadgraft and Ian Wilding |
| 298-301 | Thermal Decomposition of Thonzonium Bromide | Lester Chafetz, R. Clive Greenough and John Frank |
| 302-306 | In Vitro Cytotoxic Effects of Dibromodulcitol in 9L Rat Brain Tumor Cells | Stefan-M. Pulst, Victor A. Levin and Dennis F. Deen |
| 307-308 | Immunostimulatory Activity of Mangiferin, A Naturally Occurring Xanthone-C-Glucoside | U. Chattopadhyay, L. Chaudhuri and S. Ghosal |
| 309-310 | Association News and Announcements |
| 1-2 | EDITORIAL |
| 3-4 | Targeted Drug Delivery-Some Pharmacokinetic Considerations | Gerhard Levy |
| 5-15 | Fast Atom Bombardment Mass Spectrometry and Its Application to the Analysis of Some Peptides and Proteins | Mark E. Hemling |
| 16-20 | N-(2-Cyanoethyl)tranylcypromine, a Potential Prodrug of Tranylcypromine: Its Disposition and Interaction with Catecholamine Neurotransmitters in Brain | Adil J. Nazarali, Glen B. Baker, Ronald T. Coutts and T. F. James Wong |
| 21-27 | Synthesis and Hypolipidemic Activity of 3-Imino-l-oxoisoindolines in Rodents | Akula R. K. Murthy, Oi T. Wong, David J. Reynolds and Iris H. Hall |
| 28-32 | A Reversed-Phase High-Performance Liquid Chromatography Assay Procedure for Progabide and Its Related Metabolic Derivatives | Nidal F. Farraj, Stanley S. Davis, Graham D. Parr and Howard N. E. Stevens |
| 33-37 | Dose-Dependent Pharmacokinetics of a New Oral Cephalosporin, Cefixime, in the Dog | Meir Bialer, Vijay K. Batra, John A. Morrison, B. Michael Silber and Zee M. Look, et al. |
| 38-41 | High-Performance Liquid Chromatographic Assay for Thyrotropin Releasing Hormone and Benzyl Alcohol in Injectable Formulation | Gowdahalli N. Subba Rao, Jerry W. Sutherland and Gopi N. Menon |
| 42-45 | Stability of Lidocaine in Aqueous Solution: Effect of Temperature, pH, Buffer, and Metal Ions on Amide Hydrolysis | Michael F. Powell |
| 46-49 | Improved Radioreceptor Assay of Opiate Narcotics in Human Serum: Application to Fentanyl and Morphine Metabolism | Viktorya Levi, James C. Scott, Paul F. White and Wolfgang Sadée |
| 50-53 | Subcellular Distribution of Basic Drugs Accumulated in the Isolated Perfused Lung | Hisahiro Yoshida, Katsuhiko Okumura and Ryohei Hori |
| 54-58 | Automated Stability-Indicating High-Performance Liquid Chromatographic Assay for Ethinyl Estradiol and (Levo)norgestrel Tablets | Van D. Reif, W. Mark Eickhoff, John K. Jackman and Nicholas J. DeAngelis |
| 59-61 | Application of Moment Analysis to Nonlinear Drug Disposition Described by the Michaelis–Menten Equation | Andrew T. Chow and William J. Jusko |
| 62-65 | Effects of Plasma Proteins on Degradation Properties of Poly(L-lactide) Microcapsules | Kimiko Makino, Hiroyuki Ohshima and Tamotsu Kondo |
| 66-69 | Dissociation of the Natriuretic and Antikaliuretic Properties of Triamterene Derivatives by Dose–Response Experiments | Helmut Priewer, Erwin Wolf, Helga Kraft, Heinrich Knauf and Ernst Mutschler |
| 70-74 | Drug Release from Tablets Containing Cellulose Acetate Phthalate As an Additive or Enteric-Coating Material | Shan-Yang Lin and Y. Kawashima |
| 75-77 | Report of the Workshop on Controlled-Release Dosage Forms: Issues and Controversies | Jerome P. Skelly, William H. Barr, Leslie Z. Benet, James T. Doluisio and Arthur H. Goldberg, et al. |
| 78 | The Effect of Density on the Gastric Emptying and Intestinal Transit of Solid Dosage Forms: Comments on the Article by Davis et al. | Lydia C. Kaus |
| 79-81 | Association News and Announcements |
| 83-85 | Managing Potential Conflicts of Interest in University-Industrial Partnerships | Michael A. Schwartz |
| 86-91 | Kinetic-Effect Models and Their Applications | Joachim Grevel |
| 92-97 | Use of Vaccinia Virus to Express Biopharmaceutical Products | Dennis E. Hruby and Gary Thomas |
| 98-103 | Kinetics and Mechanism of Captopril Oxidation in Aqueous Solution Under Controlled Oxygen Partial Pressure | Tak-Yee Lee and Robert E. Notari |
| 104-112 | Water Vapor Sorption of Water-Soluble Substances: Studies of Crystalline Solids Below Their Critical Relative Humidities | Mark J. Kontny, George P. Grandolfi and George Zografi |
| 113-119 | Effect of Pyrimidine Nucleosides on Body Temperatures of Man and Rabbit in Relation to Pharmacokinetic Data | Godefridus J. Peters, Cees J. van Groeningen, Emile Laurensse, Ineke Kraal and Albert Leyva, et al. |
| 120-125 | Selection of a Derivative of the Antiviral Agent 9-[(1,3-Dihydroxy-2-propoxy)-methyl]Guanine (DHPG) with Improved Oral Absorption | Eric J. Benjamin, Bruce A. Firestone, Robert Bergstrom, Marian Fass and Ian Massey, et al. |
| 126-129 | Identification of Prescription Drugs in Adulterated Chinese Herbal Medications | Thomas Cairns, Emil G. Siegmund and Bobby R. Rader |
| 130-132 | Prostaglandin Derivative PGBX Improves Neurologic Recovery After Ischemic Spinal Injury | Thomas P. Jacobs, John M. Hallenbeck, Thomas M. Devlin and Giora Z. Feuerstein |
| 133-136 | A High-Performance Liquid Chromatographic Microassay Employing a Liquid–Solid Extraction Technique for Etintidine in Plasma | Shiew-Mei Huang, Elaine Rubin and Thomas B. Marriott |
| 137-141 | The Solid-State Decarboxylation of the Diammonium Salt of Moxalactam | Stephen R. Byrn, Phillipe Perrier, Chung-Tang Lin, Herberto Martinez and Ralph R. Pfeiffer |
| 142-146 | Binding of Basic Drugs to Rat Lung Mitochondria | Ryohei Hori, Katsuhiko Okumura and Hisahiro Yoshida |
| 147-149 | A Naloxone–Steroid Hybrid Azine with Selective and Long-Acting Opioid Antagonism at Delta Receptors In Vitro | Ahmet Koman, Vera M. Kolb and Lars Terenius |
| 150-153 | Influence of Tablet Dissolution on Furosemide Bioavailability: A Bioequivalence Study | Patrick J. McNamara, Thomas S. Foster, George A. Digenis, Rajani B. Patel and William A. Craig, et al. |
| 154-157 | A Novel Method for the Synthesis of Kyotorphin, Tyr-Arg, and 3H-Tyr-Arg, Catalyzed by Tyrosyl-tRNA Synthetase from Bacillus stearothermophilus | Senji Kitabatake, Ryoichi Tsurutani, Hiroshi Nakajima, Kosuke Tomita and Yoshihiro Yoshihara, et al. |
| 158-161 | Phenolic Cyclization of Epinephrine, Metaproterenol, Metaraminol, Phenylephrine, and Terbutaline with Formaldehyde | Lester Chafetz and Ramazan Turdiu |
| 162-165 | A New Parenteral Emulsion for the Administration of Taxol | B. D. Tarr, T. G. Sambandan and S. H. Yalkowsky |
| 166-170 | Synthesis and Pharmacological Activity of N- Alkyl-1,2-Diphenylethanolamines | Humeida A. El-Obeid, Abdul Azim E. Madani, Khalid A. Al-Rashood, Kamal E. H. El Tahir and Abdul Karim Tilmisani, et al. |
| 171-172 | In Vitro and In Vivo Interactions of Furosemide and Sucralfate | Ahmed H. Hikal, Larry A. Walker and Thirucote Ramachandran |
| 173-175 | Association News and Announcements |
| 177-180 | A Critical Appraisal of Drug Stability Testing Methods | Robert B. Taylor and Amin S. H. Shivji |
| 181-188 | Immunoconjugates: Applications in Targeted Drug Delivery for Cancer Therapy | Bhanu P. Ram and Praveen Tyle |
| 189-194 | Radioreceptor Assay for Insulin Formulations | Lars Sjödin and Eila Viitanen |
| 195-199 | An Equation for the Systemic Availability of Drugs Undergoing Simultaneous Enterohepatic Cycling, First-Pass Metabolism, and Intestinal Elimination | Theresa A. Shepard and Richard H. Reuning |
| 200-206 | Efficacy of 5-Vinyl-l-β-D-arabinofuranosyluracil (VaraU) Against Herpes Simplex Virus Type 2 Strains in Cell Cultures and Against Experimental Herpes Encephalitis in Mice: Comparison with Acyclovir and Foscarnet | Jürgen Reefschläger, Peter Wutzler, Klaus-Dieter Thiel and Gottfried Herrmann |
| 207-213 | Synthesis and Properties of Haptens for the Development of Radioimmunoassays for Thioridazine, Mesoridazine, and Sulforidazine | Bhaswat S. Chakraborty, Manik S. Sardessai, Theodore J. Jaworski, Kamal K. Midha and Edward M. Hawes |
| 214-219 | Kinetics and Mechanism of Zinc Ion-Mediated Degradation of Cephalosporins in Tromethamine Solution | Hisao Tomida, Kazuya Kohashi, Yasuto Tsuruta, Setsuo Kiryu and Michael A. Schwartz |
| 220-230 | Cosolvency and Cosolvent Polarity | Joseph T. Rubino and Samuel H. Yalkowsky |
| 231-236 | Cosolvency and Deviations from Log-Linear Solubilization | Joseph T. Rubino and Samuel H. Yalkowsky |
| 237-239 | Identification of Phenolic Antioxidants in Elastomers for Pharmaceutical and Medical Use | Charles B. Airaudo, André Gayte-Sorbier, Roland Creusevau and Régine Dumont |
| 240-243 | Kinetics of Drug Action in Disease States. XXII. Effects of Contraceptive Steroids on the Pharmacodynamics of Ethanol in Rats | Sompon Wanwimolruk and Gerhard Levy |
| 244-247 | Adsorption of Inorganic and Organic Ions to Polycarbophil as a Means of Sustained-Release Dosage Formulation | Norman A. See, James Russell, Kenneth A. Connors and Paul Bass |
| 248-250 | Effects of Hypothermia on Drug Absorption | Salomon Stavchansky and I-lan Tung |
| 251-254 | Effect of Amiodarone and Desethylamiodarone on the Pharmacokinetics of Antipyrine in the Rat | Craig K. Svensson, Li-Ling Liu and Philip W. Knowlton |
| 255-257 | Preformulation Salt Selection. Physical Property Comparisons of the Tris(hydroxymethyl)aminomethane (THAM) Salts of Four Analgesic/Antiinflammatory Agents with the Sodium Salts and the Free Acids | Leo Gu and Robert G. Strickley |
| 258-260 | Analysis of the Antimalarial Sesquiterpene Artemisinin in Artemisia annua by High-Performance Liquid Chromatography (HPLC) with Postcolumn Derivatization and Ultraviolet Detection | Hala N. ElSohly, E. M. Croom and M. A. ElSohly |
| 261-262 | A Reversed-Phase High-Performance Liquid Chromatographic (HPLC) Assay for the Determination of Biotin in Multivitamin–Multimineral Preparations | Sharon L. Crivelli, Peter F. Quirk, Daniel J. Steible and S. P. Assenza |
| 263-264 | Obituary: Dr. Takeru Higuchi (1918-1987) |
| 265-267 | FDA and AAPS Report of the Workshop on Principles and Practices of In Vitro Percutaneous Penetration Studies: Relevance to Bioavailability and Bioequivalence | Jerome P. Skelly, Vinod P. Shah, Howard I. Maibach, Richard H. Guy and Ronald C. Wester, et al. |
| 268-270 | Association News and Announcements |
| 271-277 | The Lipoidal Permeability Barriers of the Skin and Alimentary Tract | William Curatolo |
| 278-284 | Protein Degradation: The Role of Mixed-Function Oxidases | Valeric Daggett |
| 285-292 | Enantiomeric Resolution of Drug Compounds by Liquid Chromatography | H.Thomas Karnes and Mohamadi A. Sarkar |
| 293-300 | Disposition and Tumor Localization of Mitomycin C–Dextran Conjugates in Mice | Yoshinobu Takakura, Akira Takagi, Mitsuru Hashida and Hitoshi Sezaki |
| 301-304 | Validation of Fiber-Optic Doppler Anemometry (FODA) for Characterizing the Droplet Size of Emulsions | Barbara J. Floy, Joe L. White and Stanley L. Hem |
| 305-310 | Coupling of Naltrexone to Biodegradable Poly(α-Amino Acids) | Naoki Negishi, David B. Bennett, Chong-Su Cho, SeoYoung Jeong and Wolfgang A. R. Heeswijk, et al. |
| 311-316 | Computer-Aided Dosage Form Design. I. Methods for Defining a Long-Acting First-Order Delivery System of Maximum Formulating Flexibility | Tak-Yee Lee and Robert E. Notari |
| 317-320 | N-Mannich-Base Prodrugs of 5-Iodo-2′-deoxycytidine as Topical Delivery Enhancers | Suzanne A. M. Koch and Kenneth B. Sloan |
| 321-326 | Synthesis and Biological Activity of Isodithiobiurets, Dithiobiurets, and Dithiazoles | Surendra N. Pandeya, Ashok Kumar, Bhav N. Singh and Dina N. Mishra |
| 327-331 | High-Performance Liquid Chromatographic (HPLC) Assay Using Fluorescence Detection for the Simultaneous Determination of Gallopamil and Norgallopamil in Human Plasma | Angus M. McLean, Elizabeth Babcock-Atkinson, Kathleen Rein, Donald A. Ruggirello and Mario A. Gonzalez, et al. |
| 332-336 | Pharmacokinetics of Gold Sodium Thiomalate in Rabbits | Srikumaran Melethil and Darryle Schoepp |
| 337-341 | Validation of a Flow-Through Diffusion Cell for Use in Transdermal Research | William J. Addicks, Gordon L. Flynn and Norman Weiner |
| 342-347 | Temperature and pH Dependence of Fluocinolone Acetonide Degradation in a Topical Cream Formulation | Richard A. Kenley, MaryannOtt Lee, Lakshmi Sukumar and Michael F. Powell |
| 348-352 | Effects of Formulation and Food on the Absorption of Hydrochlorothiazide and Triamterene or Amiloride from Combination Diuretic Products | Roger L. Williams, Joyce Mordenti, Robert A. Upton, Emil T. Lin and Winnie L. Gee, et al. |
| 353-354 | Microbial Transformation of Tamoxifen | Saleh El-Sharkawy and Yusuf J. Abul-Hajj |
| 355-357 | Binding of Piroxicam to Human Serum Albumin: Effect of Piroxicam on Warfarin and Diazepam Binding | Kenji Matsuyama, Asok C. Sen and John H. Perrin |
| 358 | EDITORIAL |
| 359 | Association News and Announcements |
| 361-363 | Emerging Trends in Biotechnology: A Perspective from the Pharmaceutical Industry | William Szkrybalo |
| 364-374 | Renin Inhibitors | William J. Greenlee |
| 375-378 | Recombinant Tissue Plasminogen Activator: A Brief Review | Elliott B. Grossbard |
| 379-384 | Development of Acute Tolerance to Bumetanide: Bolus Injection Studies | Jack A. Cook and David E. Smith |
| 385-391 | Computer-Aided Dosage Form Design. II. Methods for Defining a Zero-Order Sustained-Release Delivery System of Maximum Formulating Flexibility | Tak-Yee Lee and Robert E. Notari |
| 392-397 | Diketopiperazine Formation, Hydrolysis, and Epimerization of the New Dipeptide Angiotensin-Converting Enzyme Inhibitor RS-10085 | Leo Gu and Robert G. Strickley |
| 398-401 | Estimation of Surface Polarity of Silicas by Absorption Spectroscopy of Glycerin Suspensions of Adsorbed 6-Nitrobenzoindolinopyran | Michael J. Jozwiakowski and Kenneth A. Connors |
| 402-405 | Multiple-Dose Pharmacokinetics of Clozapine in Patients | Miles G. Choc, Robert G. Lehr, Frances Hsuan, Gilbert Honigfeld and Harold T. Smith, et al. |
| 406-408 | Prostaglandin D2 Inhibits Pentylenetetrazole-Induced Convulsions in Rats by a Serotonin-Mediated Mechanism | Salil K. Bhattacharya and Surendra S. Parmar |
| 409-411 | Bioavailability and Pharmacokinetics of a New Sustained-Release Potassium Chloride Tablet | Charles J. Betlach, John D. Arnold, R. Wayne Frost, Philip T. Leese and Mario A. Gonzalez |
| 412-415 | Quantitative Analysis of Hydroxyurea and Urea by Proton Nuclear Magnetic Resonance (NMR) Spectroscopy | Karen B. Main, Thomas Medwick, Leonard C. Bailey and John H. Shinkai |
| 416-419 | Analysis of in Vitro Dissolution of Whole vs. Half Controlled-Release Theophylline Tablets | Vinod P. Shah, Lawrence A. Yamamoto, Donald Schuirman, Jerome Elkins and Jerome P. Skelly |
| 420-424 | Dose-Proportional Absorption of Etretinate After Doses of 25, 50, 75, and 100 mg | Robert J. Wills, Lolita C. Rodriguez, Amy H. Lin, Clara Puccini and Wayne A. Colburn |
| 425-428 | Inhibition of Intestinal Pyrimidine Nucleoside Phosphorylases | M. Guill Wientjes and J. Lai-Sim Au |
| 429-432 | Polymorphism of l,2-Dihydro-6-neopentyl-2-oxonicotinic Acid: Characterization, Interconversion, and Quantitation | Robert S. Chao and Kenneth C. Vail |
| 433-435 | Pharmacokinetics of Pentoxifylline During Concomitant Theophylline Administration to Rats | Mario L. Rocci, David R. Luke and Consuelo L. Saccar |
| 436-437 | The Effect of Vehicle Additives on the Transdermal Delivery of Nitroglycerin | Thorsteinn Loftsson, Nancy Gildersleeve and Nicholas Bodor |
| 438 | Electrode Material in Iontophoresis | Lars Erik Linblad and Lena Ekenvall |
| 439-442 | Bio-organic and Natural Products Chemistry Molecular Biology Workshop | Laurence H. Hurley, John Kozarich and Michael Rogers |
| 443 | EDITORIAL |
| 444 | Association News and Announcements |
| 445-449 | The Influence of Drugs on Nasal Ciliary Movement | Walter A. J. J. Hermens and Frans W. H. M. Merkus |
| 450-456 | Electron-Transfer and Charge-Transfer Clastic Binding Hypotheses for Drug–Receptor Interactions | Vera M. Kolb |
| 457-464 | Mechanisms of Mucoadhesion of Poly(acrylic Acid) Hydrogels | Haesun Park and Joseph R. Robinson |
| 465-471 | The Preparation and Evaluation of Drug-Containing Poly(dl-lactide) Microspheres Formed by the Solvent Evaporation Method | Roland Bodmeier and James W. McGinity |
| 472-479 | Hypolipidemic Activity of o-(N-Phthalimido)acetophenone in Sprague Dawley Rats | Iris H. Hall, David J. Reynolds, Oi T. Wong, C. Brent Oswald and Akula R. K. Murthy |
| 480-485 | Investigation of the Gastrointestinal Transit and In Vivo Drug Release of Isosorbide-5-Nitrate Pellets | Wilfried Fischer, Anna Boertz, Stanley S. Davis, Raj Khosla and Willi Cawello, et al. |
| 486-489 | Correlation of Ibuprofen Bioavailability with Gastrointestinal Transit by Scintigraphic Monitoring of 171Er-Labeled Sustained-Release Tablets | Alan F. Parr, Robert M. Beihn, Robert M. Franz, Gregory J. Szpunar and Michael Jay |
| 490-494 | Tissue Tolerance of Intramuscular Injectables and Plasma Enzyme Activities in Rats | Christian Surber and Heinz Sucker |
| 495-498 | In Vivo Efficacy of Antifungal Oxoaporphine Alkaloids in Experimental Disseminated Candidiasis | Alice M. Clark, E. Sue Watson, M. Khalid Ashfaq and Charles D. Hufford |
| 499-503 | Between-Lot and Within-Lot Comparisons of Bioavailability of Macrocrystalline Nitrofurantoin Capsules | William D. Mason, John D. Conklin and Francis J. Hailey |
| 504-508 | Measurement of the Particle Size of Tablet Excipients with the Aid of Video Recording | Kanneganti P. P. Prasad and Lucy S. C. Wan |
| 509-514 | Effect of Helenalin and Bis(helenalinyl)malonate on Nucleic Acid and Protein Synthesis in Human KB Carcinoma Cells | Iris H. Hall, Anne A. Grippo, Kuo-Hsiung Lee, Stephen G. Chaney and David J. Holbrook |
| 515-518 | Effect of Hydralazine on the Elimination of Antipyrine in the Rat | Craig K. Svensson, Philip W. Knowlton and Joseph A. Ware |
| 519-523 | Percutaneous Absorption and Elimination of the Penetration Enhancer Azone in Humans | Johann W. Wiechers, Ben F. H. Drenth, Jan H. G. Jonkman and Rokus A. de Zeeuw |
| 524-526 | Radiolabeling of Intact Dosage Forms by Neutron Activation: Effects on In Vitro Performance | Alan Parr and Michael Jay |
| 527-530 | Therapeutic Effect of Dexamethasone in T-2 Toxicosis | Esther Shohami, Burt Wisotsky, Oliver Kempski and Giora Feuerstein |
| 531-535 | Kinetics of Potassium Excretion Following Oral Supplements: Evidence of Induced Natriuresis | Ashok Rakhit, Srikumaran Melethil, John D. Arnold and William E. Wagner |
| 536 | Assessment of Variance in Bioavailability Studies: Comments on the Article by McNamara et al. | Carl M. Metzler |
| 537 | Association News and Announcements |
| 538-540 | Reviewers for Pharmaceutical Research (1987) |
| 541-543 | Author Index to Volume 4 (1987) |
| 544-548 | Subject Index to Volume 4 (1987) |
| 1-9 | Monoclonal Antibodies as Magic Bullets | Frances M. Brodsky |
| 10-15 | Liquid Chromatographic Analysis of Di(2-ethylhexyl) Phthalate: Application to Pharmacokinetic Studies in the Mongrel Dog | David B. Haughey, William F. Elmquist, David A. Breutzmann, D. Gary Hemphill and Edward G. Constantini |
| 16-20 | Release of Lonapalene from Two-Phase Emulsion-Type Ointment Systems | John T. H. Ong and Elizabeth Manoukian |
| 21-30 | Porous Biodegradable Microspheres for Controlled Drug Delivery. I. Assessment of Processing Conditions and Solvent Removal Techniques | Toyomi Sato, Motoko Kanke, Hans G. Schroeder and Patrick P. DeLuca |
| 31-35 | Structural Determination of Testosterone Esters in Oil Injectables by Thermospray Mass Spectrometry | Thomas Cairns, Emil G. Siegmund and Thomas S. Savage |
| 36-39 | Comparison of Output Particle Size Distributions from Pressurized Aerosols Formulated as Solutions or Suspensions | Richard N. Dalby and Peter R. Byron |
| 40-43 | Pharmacokinetics of Ibuprofen Enantiomers in Humans Following Oral Administration of Tablets with Different Absorption Rates | Fakhreddin Jamali, Nikhilesh N. Singh, Franco M. Pasutto, Anthony S. Russell and Ronald T. Coutts |
| 44-47 | Prodrugs for Improved Oral β-Estradiol Bioavailability | Munir A. Hussain, Bruce J. Aungst and Eli Shefter |
| 48-52 | The Effect of Food on the Absorption of Controlled-Release Theophylline in Mini-Swine | Gerald K. Shiu, Arlen O. Sager, Raja B. Velagapudi, Vadlamani K. Prasad and Jerome P. Skelly |
| 53-56 | Stereospecific High-Performance Liquid Chromatographic (HPLC) Assay of Fenoprofen Enantiomers in Plasma and Urine | Reza Mehvar and Fakhreddin Jamali |
| 57-60 | An Area Function Method for Estimating the Apparent Absorption Rate Constant | Haiyung Cheng, Alfred E. Staubus and Linyee Shum |
| 61-64 | Effect of Taurolithocholate on In Vivo Sulfation and Glucuronidation of Acetaminophen in Rats | Raymond E. Galinsky and Barbara Chalasinska |
| 65 | Editorial |
| 66 | Association News and Announcements |
| 129-139 | The Role of Tumor Necrosis Factor and Interleukin 1 in the Immunoinflammatory Response | James W. Larrick and Steven L. Kunkel |
| 140-150 | The Role of Protein and Lipid Domains in the Uptake of Solutes by Human Stratum Corneum | Prakash V. Raykar, Man-Cheong Fung and Bradley D. Anderson |
| 151-155 | Bambuterol: Uptake and Metabolism in Guinea Pig Isolated Lungs | Åke Ryrfeldt, Elisabeth Nilsson, Anders Tunek and Leif-Åke Svensson |
| 156-164 | Mean Residence Time Concepts for Pharmacokinetic Systems with Nonlinear Drug Elimination Described by the Michaelis–Menten Equation | Haiyung Cheng and William J. Jusko |
| 165-171 | Assessment and Validation of Animal Models to Evaluate Topical Effects of Substances on Gastrointestinal Mucosa | John W. Fara, Larry D. Anderson, Alfred G. T. Casper and Robert E. Myrback |
| 172-177 | High-Performance Liquid Chromatographic Assay of a Central Nervous System (CNS)-Directed Estradiol Chemical Delivery System and Its Application After Intravenous Administration to Rats | Gotelind Mullersman, Hartmut Derendorf, Marcus E. Brewster, Kerry S. Estes and Nicholas Bodor |
| 178-182 | Relation Between Individual and Ensemble Release Kinetics of Indomethacin from Microspheres | Simon Benita, Dany Babay, Amnon Hoffman and Max Donbrow |
| 183-186 | Phenobarbital Adsorption from Simulated Intestinal Fluid, U.S.P., and Simulated Gastric Fluid, U.S.P., by Two Activated Charcoals | Dale Eric Wurster, Gerald M. Burke, Mary J. Berg, Peter Veng-Pedersen and Dorothy D. Schottelius |
| 187-189 | Measurement of Underivatized Propranolol Enantiomers in Serum Using a Cellulose –Tris(3,5 -Dimethylphenylcarbamate) High-Performance Liquid Chromatographic (HPLC) Chiral Stationary Phase | Robert J. Straka, Richard L. Lalonde and Irving W. Wainer |
| 190-192 | Determination of a Novel Antiarrhythmic Agent ACC-9358 in Human Plasma by High-Performance Liquid Chromatography | Ramanuj Achari and David A. Thomas |
| 193-195 | The Estimation of Solubility in Binary Solvents: Application of the Reduced 3-Suffix Solubility Equation to Ethanol–Water Mixtures | N. Adeyinka Williams and Gordon L. Amidon |
| 196 | Calculations and Application of Mean Residence Times for Drugs Which Demonstrate One-Compartment Distribution and Michaelis-Menten Elimination | Jack A. Cook and Peter R. Gwilt |
| 197-198 | Association News and Announcements |
| 199-200 | Genes and the Pharmaceutical Sciences | Wolfgang Sadée |
| 201-208 | Quantitative Structure–Activity Study on Human Pharmacokinetic Parameters of Benzodiazepines Using the Graph Theoretical Approach | Rodney S. Markin, Wallace J. Murray and Harold Boxenbaum |
| 209-213 | Role of Phosphatidylserine in the Cellular and Subcellular Lung Distribution of Quinidine in Rats | Akio Nishiura, Teruo Murakami, Yutaka Higashi and Noboru Yata |
| 214-219 | Stability of Prostacyclin Analogues: An Unusual Lack of Reactivity in Acid-Catalyzed Alkene Hydration | Adina Magill, Counde O'Yang and Michael F. Powell |
| 220-225 | Capillary Gas Chromatography and Thermionic N-P-Specific Detection of 13-Bis(2-chloroethyl)-l-nitrosourea (BCNU) or l-(2-Chloroethyl)-3-cyclohexyl-l-nitrosourea (CCNU) in Stability and Pharmacokinetic Studies | Adnan El-Yazigi and Cazemiro R. Martin |
| 226-231 | The Stability and Solubility of Progabide and Its Related Metabolic Derivatives | Nidal F. Farraj, Stanley S. Davis, Graham D. Parr and Howard N. E. Stevens |
| 232-235 | A Biotin–Avidin-Based Enzyme Immunoassay for βh-Endorphin | Guenther Hochhaus and Wolfgang Sadée |
| 236-237 | Antimuscarinic Effects of (R)- and (S)-Oxyphencyclimine Hydrochloride | Lise Schjelderup, Michael R. Kozlowski, Albert Weissman and Arne J. Aasen |
| 238-241 | The Effect of Azone on Ocular Levobunolol Absorption: Calculating the Area Under the Curve and Its Standard Error Using Tissue Sampling Compartments | Diane D.-S. Tang-Liu and P. Joshua Burke |
| 242-244 | Antihypertensive Activity of 2[(2-Hydroxyphenyl) amino] -4(3H)-quinazolinone | Munir A. Hussain, Andrew T. Chiu, William A. Price, Pieter B. Timmermans and Eli Shefter |
| 245-246 | Comparing the Biological Activity of Humulin R and Novolin R Using an Intravenous Bioassay | Ghana R. Kowarski, Senshang Lin, Lora M. Michalek and A. Avinoam Kowarski |
| 247-248 | ABSPLOTS: A LOTUS 123 Spreadsheet for Calculating and Plotting Drug Absorption Rates | Robert C. Shumaker, Harold Boxenbaum and Gary A. Thompson |
| 249 | Interpretation of Drug Stability Testing | Lester Chafetz |
| 250 | Approaches to Drug Stability | Robert B. Taylor |
| 251 | Electrode Material in Iontophoresis | Praveen Tyle |
| 252 | Association News and Announcements |
| 253-260 | Free Radicals and Oxygen Toxicity | Douglas D. Buechter |
| 261-265 | The Protein Binding of Phenytoin, Propranolol, Diazepam, and AL01576 (an Aldose Reductase Inhibitor) in Human and Rat Diabetic Serum | Patrick J. McNamara, Robert A. Blouin and Romulus K. Brazzell |
| 266-271 | Epimerization Kinetics of Moxalactam in Frozen Solution | Naofumi Hashimoto, Teruhisa Ichihashi, Etsuko Yamamoto, Koichiro Hirano and Masayoshi Inoue, et al. |
| 272-282 | Dissolution of lonizable Drugs in Buffered and Unbuffered Solutions | Sadettin S. Ozturk, Bernhard O. Palsson and Jennifer B. Dressman |
| 283-287 | Development of a Radioreceptor Assay for the D2-Selective Dopamine Agonist N-0437 | Kees Ensing, Dick A. Bloemhof, Willy G. in't Hout, Jan van der Lende and Rokus A. de Zeeuw |
| 288-296 | Potential Improvement in the Shelf Life of Parenterals Using the Prodrug Approach: Bacampicillin and Talampicillin Hydrolysis Kinetics and Utilization Time | Ngoc-Anh T. Nguyen, Lobna M. Mortada and Robert E. Notari |
| 297-299 | Thiol Reduction of 3′-Azidothymidine to 3′-Aminothymidine: Kinetics and Biomedical Implications | Anthony L. Handlon and Norman J. Oppenheimer |
| 300-304 | Receptor-Mediated Magnetic Carriers: Basis for Targeting | James M. Gallo and Emad Eldin Hassan |
| 305-308 | Site Dependence of Absorption-Promoting Actions of Laureth-9, Na Salicylate, Na2EDTA, and Aprotinin on Rectal, Nasal, and Buccal Insulin Delivery | Bruce J. Aungst and Nancy J. Rogers |
| 309-312 | Enhanced Membrane Permeability to Phenol Red by Medium-Chain Glycerides: Studies on the Membrane Permeability and Microviscosity | Kazutaka Higaki, Muneyoshi Kato, Mitsuru Hashida and Hitoshi Sezaki |
| 313-315 | Mass Balance and Dose Accountability in Percutaneous Absorption Studies: Development of a Nonocclusive Application System | Daniel A. W. Bucks, Howard I. Maibach and Richard H. Guy |
| 316-318 | Stereoselective Binding of Disopyramide to Plasma Proteins | Luisa Valdivieso, Kathleen M. Giacomini, Wendel L. Nelson, Robert Pershe and Terrence F. Blaschke |
| 319-321 | Serum Protein Binding of AL01576, a New Aldose Reductase Inhibitor | Patrick J. McNamara, Robert A. Blouin and R. K. Brazzell |
| 322 | Reply to “Assessment of Variance in Bioavailability Studies: Comments on the Article by McNamara et al.” by Carl M. Metzler. | Jerome P. Skelly, Vinod P. Shah and Donald J. Schuirmann |
| 323-324 | Association News and Announcements |
| 325-334 | Approaches to Radiolabeling of Antibodies for Diagnosis and Therapy of Cancer | Alan R. Fritzberg, Ronald W. Berninger, Stephen W. Hadley and Dennis W. Wester |
| 335-340 | Disposition of Detirelix, A Potent Luteinizing Hormone-Releasing Hormone Antagonist, in Rats and Monkeys | Rebecca L. Chan, William Ho, Austin S. Webb, JoAnn LaFargue and Clinton A. Nerenberg |
| 341-346 | Enhancement of Colonic Drug Absorption by the Paracellular Permeation Route | Mikio Tomita, Masaharu Shiga, Masahiro Hayashi and Shoji Awazu |
| 347-351 | Metabolite Formation Pharmacokinetics: Rate and Extent of Metabolite Formation Determined by Deconvolution | Michael D. Karol and Scott Goodrich |
| 352-358 | Cellular Uptake of a Fluid-Phase Marker by Human Neutrophils from Solutions and Liposomes | Jeffrey F. Scieszka and Moo J. Cho |
| 359-364 | Structure–Activity Relationship Studies of Hemicholinium (HC-3) Congeners | Joseph G. Cannon, Teresa M.-L. Lee, Y.-a. Chang, Alfred M. Nyanda and Bula Bhattacharyya, et al. |
| 365-368 | Liquid Chromatographic Assay and Pharmacokinetics of Quazepam and Its Metabolites Following Sublingual Administration of Quazepam | Samir K. Gupta and Everett H. Ellinwood |
| 369-371 | Carrier-Mediated Transport of Baclofen Across Monolayers of Bovine Brain Endothelial Cells in Primary Culture | Joost B. M. M van Bree, Kenneth L. Audus and Ronald T. Borchardt |
| 372-376 | In Vitro Measurement of Gastrointestinal Tissue Permeability Using a New Diffusion Cell | George M. Grass and Stephanie A. Sweetana |
| 377-382 | Drug Transport from Thin Applications of Topical Dosage Forms: Development of Methodology | William J. Addicks, Gordon L. Flynn, Norman Weiner and Chia-Ming Chiang |
| 383-386 | Assay for Hydralazine as Its Stable p-Nitrobenzaldehyde Hydrazone | Hugh A. Semple, Yun K. Tam, Sarah Tin and Ronald T. Courts |
| 387-390 | Time-Dependent Absorption of Phenprobamate Following Multiple Dosing in Rats | Jim Xin-Sheng Sun, Koral Embil and Ching-San C. Lee |
| 391-395 | Thermodynamics in the Prediction of the Solubilities of Binary Mixtures of the Diastereoisomers and Enantiomers of Ephedrine | Walter F. Schmidt, William Porter and Jens. T. Carstensen |
| 396 | Association News and Announcements |
| 397-400 | Drug Discovery—Today and Tomorrow: The Role of Medicinal Chemistry | Kurt R. Freter |
| 401-407 | Pharmacodynamics of Zoxazolamine and Chlorzoxazone in Rats | Masato Yasuhara and Gerhard Levy |
| 408-412 | Searching for the Endogenous Benzodiazepine Using the Graph Theoretical Approach | Rodney S. Markin and Wallace J. Murray |
| 413-420 | The Effects of Phthalimide and Saccharin Derivatives on Low-Density Lipoprotein (LDL) and High-Density Lipoprotein (HDL) Receptor Activity and Related Enzyme Activities | Iris H. Hall, Oi T. Wong and Steven D. Wyrick |
| 421-425 | Hygroscopicity of Cefazolin Sodium: Application to Evaluate the Crystallinity of Freeze-Dried Products | Takashi Osawa, Madhav S. Kamat and Patrick P. DeLuca |
| 426-429 | Estimation of the Degree of Crystallinity of Cefazolin Sodium by X-Ray and Infrared Methods | Madhav S. Kamat, Takashi Osawa, Robert J. DeAngelis, Yasuto Koyama and Patrick P. DeLuca |
| 430-433 | Receptor Binding Studies of the Flavone, REC 15/2053, and Other Bladder Spasmolytics | GianAlfredo Abbiati, Roberto Ceserani, Dante Nardi, Claudio Pietra and Rodolfo Testa |
| 434-436 | Evidence for the Involvement of a Nitrenium Ion in the Covalent Binding of Nitrofurazone to DNA | Anthony J. Streeter and Betty-ann Hoener |
| 437-439 | Dextromethorphan Pretreatment Induces Antipyrine Clearance in the Rat | Craig K. Svensson and Joseph A. Ware |
| 440-442 | Protein Binding of Cocaine in Human Serum | David J. Edwards and Susan K. Bowles |
| 443-446 | A New System for In Vitro Studies of Iontophoresis | Peretz Glikfeld, Christopher Cullander, Robert S. Hinz and Richard H. Guy |
| 447-452 | Teratogenic and Behavioral Anomalies Induced by Acute Exposure of Mice to Ethanol and Their Possible Relation to Fetal Brain DNA Synthesis | Arthur A. Ciociola and Ronald F. Gautieri |
| 453-456 | Absorption Enhancement of Rectally Infused Cefoxitin Sodium by Medium-Chain Fatty Acids in Conscious Rats: Concentration–Effect Relationship | Ewoud J. van Hoogdalem, Martin A. Hardens, Albertus G. de Boer and Douwe D. Breimer |
| 457-462 | Percutaneous Absorption of Nicardipine and Ketorolac in Rhesus Monkeys | Diana Yu, Lynda M. Sanders, George W. R. Davidson III, Martha J. Marvin and Teck Ling |
| 463 | Association News and Announcements |
| 465-471 | Renal Transport of Drugs: An Overview of Methodology with Application to Cimetidine | Kathleen M. Giacomini, Poe-Hirr Hsyu and Lee G. Gisclon |
| 472-476 | Recombinant Human Interferon Alpha-2a: Delivery to Lymphoid Tissue by Selected Modes of Application | Andreas Supersaxo, Wayne Hein, Harald Gallati and Hans Steffen |
| 477-481 | Percutaneous and Systemic Disposition of Hexamethylene Lauramide and Its Penetration Enhancement Effect on Hydrocortisone in a Rat Sandwich Skin-Flap Model | Diane D-S. Tang-Liu, John Neff, Heraldo Zolezio and Rhonda Sandri |
| 482-487 | Determination of the pH-Dependent Phase Distribution of Prostaglandin El in a Lipid Emulsion by Ultrafiltration | Dirk L. Teagarden, Bradley D. Anderson and William J. Petre |
| 488-494 | Drug/Polymer Matrix Swelling and Dissolution | Ronald S. Harland, Andrea Gazzaniga, M. Edvige Sangalli, Paolo Colombo and Nikolaos A. Peppas |
| 495-500 | Dissolution Rate Studies from a Stationary Disk/Rotating Fluid System | Nahla Khoury, John W. Mauger and Stephen Howard |
| 501-505 | Mineral Metabolism of Aging Female Rats Fed Various Commercially Available Calcium Supplements or Yogurt | Alison R. Behling and Janet L. Greger |
| 506-508 | Turbuhaler: A New Powder Inhaler for Administration of Drugs to the Airways | Kjell Wetterlin |
| 509-513 | Comparative Pharmacokinetics of Methylprednisolone Phosphate and Hemisuccinate in High Doses | Helmut Möllmann, Peter Rohdewald, Jürgen Barth, Carsten Möllmann and Matthi Verho, et al. |
| 514-517 | An Accurate Prediction of the pH Change Due to Degradation: Correction for a “Produced” Secondary Buffering System | Leonard S. Rosenberg, Cheryl K. Hostetler, Dietmar M. Wagenknecht and Diane A. Aunet |
| 518-522 | Dynamics of Bromodeoxyuridine Incorporation into DNA of Squamous Carcinoma Cells During Mid and Late Logarithmic Growth | Amnon Shapira, John G. ***MISSING END TAG*** Ira S. Wagner, Jonathan Phillip L. Maybaum, William D. Ensminger and Thomas E. Carey |
| 523-527 | Formulation of Vaccine Adjuvant Muramyldipeptides (MDP). 1. Characterization of Amorphous and Crystalline Forms of a Muramyldipeptide Analogue | Tai Wah Chan and Allyn Becker |
| 528-532 | Formulation of Vaccine Adjuvant Muramyldipeptides (MDP). 2. The Thermal Reactivity and pH of Maximum Stability of MDP Compounds in Aqueous Solution | Michael F. Powell, Linda C. Foster, Allyn R. Becker and William Lee |
| 533-536 | Controlled Gastric Emptying. 1. Effects of Physical Properties on Gastric Residence Times of Nondisintegrating Geometric Shapes in Beagle Dogs | Robyn Cargill, Larry J. Caldwell, Karen Engle, Joseph A. Fix and Patricia A. Porter, et al. |
| 537-538 | Association News and Announcements |
| 623-627 | Glucocorticoid Receptors in Human Synovial Tissue and Relative Receptor Affinities of Glucocorticoid-21-Esters | Martin Pörtner, Helmut Möllmann and Peter Rohdewald |
| 628-633 | Cimetidine Elimination from the Cerebrospinal Fluid of the Rat | Mathew T. Whittico and Kathleen M. Giacomini |
| 634-638 | Potential Improvement in Shelf Life Using the Prodrug Approach. II. A Systematic Examination of Kinetic Requirements | Ngoc-Anh T. Nguyen and Robert E. Notari |
| 639-644 | Effects of Gender, Posture, and Age on Gastric Residence Time of an Indigestible Solid: Pharmaceutical Considerations | Parviz Mojaverian, Peter H. Vlasses, Paul E. Kellner and Mario L. Rocci |
| 645-650 | Characterization of the Oral Absorption of β-Lactam Antibiotics. I. Cephalosporins: Determination of Intrinsic Membrane Absorption Parameters in the Rat Intestine In Situ | Patrick J. Sinko and Gordon L. Amidon |
| 651-654 | Estimating Human Oral Fraction Dose Absorbed: A Correlation Using Rat Intestinal Membrane Permeability for Passive and Carrier-Mediated Compounds | Gordon L. Amidon, Patrick J. Sinko and David Fleisher |
| 655-659 | Complexation of Nifedipine with Substituted Phenolic Ligands | Kathleen M. Boje, Marion Sak and Ho-Leung Fung |
| 660-663 | The Relationship of pKa and Acute Skin Irritation in Man | Bret Berner, Donald R. Wilson, Richard H. Guy, Gerard C. Mazzenga and Frank H. Clarke, et al. |
| 664-667 | Determination of Spectinomycin Dihydrochloride by Liquid Chromatography with Electrochemical Detection | Lee Elrod, John F. Bauer and Stacy L. Messner |
| 668-672 | Correlation of Unbound Plasma Clearances of Fifteen Extensively Metabolized Drugs Between Humans and Rats | Win L. Chiou and Fung-Hwa Hsu |
| 673-676 | In Vitro Model for Ciclosporin Intestinal Absorption in Lipid Vehicles | Jean-Philippe Reymond and Heinz Sucker |
| 677-679 | In Vivo Model for Ciclosporin Intestinal Absorption in Lipid Vehicles | Jean-Philippe Reymond, Heinz Sucker and Jacky Vonderscher |
| 680-683 | The Measurement of Warfarin Enantiomers in Serum Using Coupled Achiral/Chiral, High-Performance Liquid Chromatography (HPLC) | Ya-Qin Chu and Irving W. Wainer |
| 684-686 | A Precolumn Derivatization High-Performance Liquid Chromatographic (HPLC) Procedure for the Quantitation of Difluoromethylornithine in Plasma | Jacquelyn Smithers |
| 687-688 | Association News and Announcements |
| 689-693 | The Adjuvant Effect of Bacitracin on Nasal Absorption of Gonadorelin and Buserelin in Rats | Susanne C. Raehs, Jürgen Sandow, Klaus Wirth and Hans P. Merkle |
| 694-698 | A Quantitative Method of Evaluating the Diuretic Response to Furosemide in Rats | Ryohei Hori, Katsuhiko Okumura, Ken-ichi Inui, Takashi Shibata and Toshihiro Kikkoji, et al. |
| 699-703 | Urinary Excretion and Diuretic Action of Furosemide in Rats: Increased Response to the Urinary Excretion Rate of Furosemide in Rats with Acute Renal Failure | Toshihiro Kikkoji, Akira Kamiya, Ken-ichi Inui and Ryohei Hori |
| 704-708 | Micellar Solubilization of Timobesone Acetate in Aqueous and Aqueous Propylene Glycol Solutions of Nonionic Surfactants | John T. H. Ong and Elizabeth Manoukian |
| 709-712 | Determination of Amiodarone Hydrochloride in Pharmaceutical Formulations by Derivative UV Spectrophotometry and High-Performance Liquid Chromatography (HPLC) | Anna M. Di Pietra, Vanni Cavrini, Rita Gatti and Maria A. Raggi |
| 713-717 | Amorphous Water-Soluble Cyclodextrin Derivatives: 2-Hydroxyethyl, 3-Hydroxypropyl, 2-Hydroxyisobutyl, and Carboxamidomethyl Derivatives of β-Cyclodextrin | Tetsumi Irie, Kazuhiro Fukunaga, Atsuya Yoshida, Kaneto Uekama and Henry M. Fales, et al. |
| 718-721 | Pharmacokinetics and Bioavailability of Hydromorphone: Effect of Various Routes of Administration | Shyi-Feu Chang, Luana Moore and Yie W. Chien |
| 722-725 | Thermal Behavior of Poly Hydroxy Ethyl Methacrylate (pHEMA) Hydrogels | Wouter E. Roorda, Johanna A. Bouwstra, Mattina A. de Vries and Hans E. Junginger |
| 726-728 | Experimental Confirmation of the Change of Water Structure in the Critical Range of Micelle Formation: A New Method of Critical Micelle Concentration (CMC) Determination | Reinhard Hüttenrauch, Sabine Fricke and Marion Köhler |
| 729-733 | The Reversibility of Absorption Promoter Interaction with Red Blood Cell Membranes Studied with Differential Scanning Calorimetry | Jurij Holinej, Howard Y. Ando and Julian W. Snow |
| 734-737 | Synthesis, Physicochemical Properties, and Cytotoxicity of a Series of 5′-Ester Prodrugs of 5-Iodo-2′-deoxyuridine | Milind M. Narurkar and Ashim K. Mitra |
| 738-740 | Effects of Dithiothreitol and Ascorbate on the Penetration of Diclofenac Across Excised Rat Dorsal Skin | Toshiaki Nishihata, J. Howard Rytting, Koich Takahashi and Kiyoshi Sakai |
| 741-744 | Nonenzymatic and Enzymatic Hydrolysis of 5-Fluoro-2′-deoxyuridine (FUdR) Esters | Takeo Kawaguchi, Shoji Fukushima, Yoshiki Hayashi and Masahiro Nakano |
| 745-747 | Renal Excretion and Metabolism of p-Aminohippurate in the Isolated Perfused Rat Kidney | Ling-Jar Lee and David E. Smith |
| 748 | Association News and Announcements |
| 749-752 | Exogenous Methemoglobin as a Cyanide Antidote in Rats | Garry W. Boswell, Daniel E. Brooks, Alison J. Murray, Angelia A. Doye and David J. Disselhorst, et al. |
| 753-758 | Physicochemical Aspects of Percutaneous Penetration and Its Enhancement | Richard H. Guy and Jonathan Hadgraft |
| 759-764 | In Vitro and In Vivo Studies Evaluating a Liposome System for Drug Solubilization | Deborah M. Lidgate, Philip L. Feigner, Jeffrey S. Fleitman, John Whatley and Roger Cherng-Chi Fu |
| 765-771 | Preformulation Stability Studies of the New Dipeptide Angiotensin-Converting Enzyme Inhibitor RS-10029 | Leo Gu and Robert G. Strickley |
| 772-775 | Limiting Solubilities and lonization Constants of Sparingly Soluble Compounds: Determination from Aqueous Potentiometric Titration Data Only | Adriaan P. IJzerman |
| 776-780 | The Effect of Compactional Pressure on Urease Activity | Ching-Ling Diana Teng and Michael J. Groves |
| 781-785 | An Implantable Pump for Intrarenal Infusion of Immunosuppressants in a Canine Autotransplant Model | Scott A. Gruber, Robert J. Cipolle, Daniel M. Canafax, Gary R. Erdmann and Barbara A. Burke, et al. |
| 786-789 | Enhancement of Colonic Drug Absorption by the Transcellular Permeation Route | Mikio Tomita, Masahiro Hayashi, Toshiharu Horie, Takayuki Ishizawa and Shoji Awazu |
| 790-794 | [Biocytin13]Dynorphin A 1-13 Amide: A Potential Probe for the κ-Opioid Receptor | Guenther Hochhaus, Andreas Patthy, Reinier Schwietert, Daniel V. Santi and Wolfgang Sadée |
| 795-799 | Agonist-Induced Substance P Receptor Down-Regulation in Rat Central Nervous System | Atsuko Inoue, Ryoko Takeda, Takeshi Fukuyasu, Yoshihiro Nakata and Tomio Segawa |
| 800-802 | Physical Stability of a Recombinant Alpha1-Antitrypsin Injection | Cheng-Der Yu, Niek Roosdorp and Shamim Pushpala |
| 803-805 | Phenobarbital Stability in Different Dosage Forms: Alternatives for Elixirs | Nancy J. Dietz, Peter J. Cascella, Joel E. Houglum, Gary S. Chappell and Ronald M. Sieve |
| 806 | Association News and Announcements |
| 807-808 | Reviewers for Pharmaceutical Research (1988) |
| 809-811 | Author Index to Volume 5 (1988) |
| 812-818 | Subject Index to Volume 5 (1988) |
| 1-3 | Benzodiazepines: Are They of Natural Origin? | Elisabeth Unseld and Ulrich Klotz |
| 4-12 | Application of Mean Residence-Time Concepts to Pharmacokinetic Systems with Noninstantaneous Input and Nonlinear Elimination | Haiyung Cheng and William J. Jusko |
| 13-19 | Phenotypic Differences in Dextromethorphan Metabolism | Santosh J. Vetticaden, Bernard E. Cabana, Vadlamani K. Prasad, Edward D. Purich and Jan H. J. Jonkman, et al. |
| 20-27 | Kinetics of Drug Decomposition by Heat Conduction Calorimetry | Lee D. Hansen, Edwin A. Lewis, Delbert J. Eatough, Robert G. Bergstrom and Damans DeGraft-Johnson |
| 28-32 | Isolation of a Novel Morphinan 3-O-Diglucuronide Metabolite from Dog Urine | Ross Dixon, Jane Hsiao, Hon-Bin Hsu, Maciej Smulkowski and Tze-Ming Chan, et al. |
| 33-39 | Transdermal Drug Transport and Metabolism. I. Comparison of In Vitro and In Vivo Results | Donald B. Guzek, Alane H. Kennedy, Stephen C. McNeill, E. Wakshull and Russell O. Potts |
| 40-43 | Enhanced Intestinal Absorption of Cyclosporine in Rats Through the Reduction of Emulsion Droplet Size | Bryan D. Tarr and Samuel H. Yalkowsky |
| 44-48 | Influence of Indomethacin Amphoteric Gel on Gastric Ulcerogenicity and Absorption of Indomethacin in Rats | Gary G. Liversidge, John Dent and W. Mark Eickhoff |
| 49-52 | Hollow Fibers as an Oral Sustained-Release Delivery System | Munir A. Hussain, Robert C. DiLuccio and Eli Shefter |
| 53-57 | Pharmacokinetics of Furegrelate After Oral Administration to Normal Humans | Duane B. Lakings, Janice M. Friis, Cynthia M. Lunan, James T. VanderLugt and J. Scott Mohrland |
| 58-61 | Complex Formation Between Metronidazole and Sodium Urate: Effect on Photodegradation of Metronidazole | Muhammed J. Habib and Ahmed F. Asker |
| 62-65 | Pharmacokinetics of Ketorolac and p-Hydroxyketorolac Following Oral and Intramuscular Administration of Ketorolac Tromethamine | Donald Jung, Edward J. Mroszczak, Anne Wu, Teck L. Ling and Hilli Sevelius, et al. |
| 66-70 | Use of the Peptide Carrier System to Improve the Intestinal Absorption of L-α-Methyldopa: Carrier Kinetics, Intestinal Permeabilities, and In Vitro Hydrolysis of Dipeptidyl Derivatives of L-α-Methyldopa | Ming Hu, Pullachipatti Subramanian, Henry I. Mosberg and Gordon L. Amidon |
| 71-77 | The Madin Darby Canine Kidney (MDCK) Epithelial Cell Monolayer as a Model Cellular Transport Barrier | Moo J. Cho, David P. Thompson, Clay T. Cramer, Thomas J. Vidmar and Jeffrey F. Scieszka |
| 78-84 | Neutrophil-Mediated Transport of Liposomes Across the Madin Darby Canine Kidney Epithelial Cell Monolayer | Moo J. Cho, Jeffrey F. Scieszka, Clay T. Cramer, David P. Thompson and Thomas J. Vidmar |
| 85-90 | lontophoretic Transport of a Homologous Series of Ionized and Nonionized Model Compounds: Influence of Hydrophobicity and Mechanistic Interpretation | Sam Del Terzo, Charanjit R. Behl and Robert A. Nash |
| 91-95 | Rectal Absorption Enhancement of Des-Enkephalin-γ-Endorphin (DEγE) by Medium-Chain Glycerides and EDTA in Conscious Rats | Ewoud J. van Hoogdalem, Cornelia D. Heijligers-Feijen, Albertus G. de Boer, J. Coos Verhoef and Douwe D. Breimer |
| 96-99 | Drug Delivery via Ion Exchange Across a Fiber Membrane | Dennis R. Jenke |
| 100-102 | Reversed-Phase High-Performance Liquid Chromatographic Analysis of Oligoglycines (One to Six Amino Acid Residues) | Ian G. Tucker, Martin E. Dowty, Michel Veillard, Mark A. Longer and Joseph R. Robinson |
| 103-104 | Association News and Announcements |
| 105-118 | Covalent and Noncovalent Protein Binding of Drugs: Implications for Hepatic Clearance, Storage, and Cell-Specific Drug Delivery | Dirk K. F. Meijer and Peter van der Sluijs |
| 119-124 | Transdermal Drug Transport and Metabolism. II. The Role of Competing Kinetic Events | Russell O. Potts, Stephen C. McNeill, Charlene R. Desbonnet and E. Wakshull |
| 125-132 | Procedures to Characterize In Vivo and In Vitro Enantioselective Glucuronidation Properly: Studies with Benoxaprofen Glucuronides | Hildegard Spahn, Seigo Iwakawa, Emil T. Lin and Leslie Z. Benet |
| 133-139 | The Area Function Method for Assessing the Drug Absorption Rate in Linear Systems with Zero-Order Input | Haiyung Cheng and William J. Jusko |
| 140-146 | Statistical Moment Analysis of Hepatobiliary Transport of Phenol Red in the Perfused Rat Liver | Koyo Nishida, Chiaki Tonegawa, Toshiyuki Kakutani, Mitsuru Hashida and Hitoshi Sezaki |
| 147-151 | Solubility Behavior of Narcotic Analgesics in Aqueous Media: Solubilities and Dissociation Constants of Morphine, Fentanyl, and Sufentanil | Samir D. Roy and Gordon L. Flynn |
| 152-155 | Radioreceptor Assay of Metoprolol in Human Plasma: Comparison with an Enantiospecific High-Performance Liquid Chromatographic (HPLC) Procedure | Hildegard Spahn, Anton Wellstein, Gabriele Pflugmann, Ernst Mutschler and Dieter Palm |
| 156-159 | Drug Binding to α1-Acid Glycoprotein Studied by Circular Dichroism | Masaki Otagiri, Ryuji Yamamichi, Toru Marayama, Teruko Imai and Ayaka Suenaga, et al. |
| 160-166 | Cultured Buccal Epithelium: An In Vitro Model Derived from the Hamster Pouch for Studying Drug Transport and Metabolism | M. Reza Tavakoli-Saberi and Kenneth L. Audus |
| 167-170 | An In Vitro Model to Evaluate Muscle Damage Following Intramuscular Injections | Gayle A. Brazeau and Ho-Leung Fung |
| 171-176 | Synthesis of Palmitoyl Derivatives of Insulin and Their Biological Activities | Muneaki Hashimoto, Kanji Takada, Yoshiaki Kiso and Shozo Muranishi |
| 177-181 | The Determination of Microscopic lonization Constants of a Substituted Piperazine Using Estimates from Model Compounds | Nivedita K. Pandit and John M. Sisco |
| 182-185 | Racial Differences in Drug Response: Isoproterenol Effects on Heart Rate in Healthy Males | David R. Rutledge, Lavoisier Cardozo and Joel D. Steinberg |
| 186-189 | The Use of α-Aminoboronic Acid Derivatives to Stabilize Peptide Drugs During Their Intranasal Absorption | Munir A. Hussain, Ashok B. Shenvi, Susan M. Rowe and Eli Shefter |
| 190 | Association News and Announcements |
| 191 | Editorial |
| 192-202 | Receptor-Mediated Transport of Peptide Hormones and Its Importance in the Overall Hormone Disposition in the Body | Yuichi Sugiyama and Manabu Hanano |
| 203-209 | Binding of Sulfonamides to Carbonic Anhydrase: Influence on Distribution Within Blood and on Pharmacokinetics | Alan Boddy, Phillip Edwards and Malcolm Rowland |
| 210-215 | Dehydration Kinetics of Prostaglandin E1 in a Lipid Emulsion | Dirk L. Teagarden, Bradley D. Anderson and William J. Petre |
| 216-224 | Synthesis and Biological Evaluation of Ether-Linked Derivatives of Phosphatidylinositol | Khalid S. Ishaq, Maria Capobianco, Claude Piantadosi, Alessandro Noseda and Larry W. Daniel, et al. |
| 225-229 | Optimized Inhalation Aerosols. I. The Effects of Spherical Baffle Size and Position upon the Output of Several Pressurized Nonaqueous Suspension Formulations | Peter R. Byron, Richard N. Dalby and Anthony J. Hickey |
| 230-234 | The Hypolipidemic Activity of l-N-3-Methylphthalimido-butan-3-semicarbazone in Rodents | Oi T. Wong, Iris H. Hall and James M. Chapman |
| 235-238 | Uptake of Colchicine, a Microtubular System Disrupting Agent, by Isolated Rat Hepatocytes | Konstanty Wierzba, Yuichi Sugiyama, Kazuho Okudaira, Tatsuji Iga and Manabu Hanano |
| 239-243 | Controlled Release of Steroids Through Microporous Membranes with Sodium Dodecyl Sulfate Micelles | Keith A. Johnson, Gerald B. Westermann-Clark and Dinesh O. Shah |
| 244-247 | Structure/Effect Studies of Fatty Acid Isomers as Skin Penetration Enhancers and Skin Irritants | Bruce J. Aungst |
| 248-251 | Nonlinear Distribution of Atenolol Between Plasma and Cerebrospinal Fluid | Francis M. Gengo, Susan C. Pagan, L. Nelson Hopkins, Debby Wagner and David P. Schuster |
| 252-254 | The Antiarrhythmic Activity of N- Alkyl-1,2-diphenylethanolamines | Kamal E. H. El Tahir, Humeida A. Al-Obeid, Khalid A. Al-Rashood, Abdul Azim E. Madani and Abdulrahman M. Ageel |
| 255-257 | The Effect of End-to-Side Portacaval Shunt on Cyclosporine Pharmacokinetics in Rats | Joachim Grevel, Paolo Rigotti, Franco Citterio, Mario Plebani and Barry D. Kahan |
| 258-261 | Mean Residence Time of Drugs Showing Simultaneous First-Order and Michaelis–Menten Elimination Kinetics | Haiyung Cheng and William J. Jusko |
| 262 | Association News and Announcements |
| 265-273 | Idiosyncratic Drug Reactions: Possible Role of Reactive Metabolites Generated by Leukocytes | Jack P. Uetrecht |
| 274-278 | Correlation of Phenylpropanolamine Bioavailability with Gastrointestinal Transit by Scintigraphic Monitoring of 111In-Labeled Hydroxypropylmethylcellulose Matrices | Liam C. Feely and Stanley S. Davis |
| 279-285 | Experimental Animal Models for Studying Antimicrobial Pharmacokinetics in Otitis Media | Daniel M. Canafax, Naobumi Nonomura, Gary R. Erdmann, Chap T. Le and Steven K. Juhn, et al. |
| 286-295 | New Alkyl N,N-Dialkyl-Substituted Amino Acetates as Transdermal Penetration Enhancers | Ooi Wong, James Huntington, Toshiaki Nishihata and J. Howard Rytting |
| 296-301 | Protein Precoating of Polylactide Microspheres Containing a Lipophilic Immunopotentiator for Enhancement of Macrophage Phagocytosis and Activation | Yasuhiko Tabata and Yoshito Ikada |
| 302-307 | Transport Characteristics of Ceftibuten (7432-S), a New Oral Cephem, in Rat Intestinal Brush-Border Membrane Vesicles: Proton-Coupled and Stereoselective Transport of Ceftibuten | Takayoshi Yoshikawa, Noriyuki Muranushi, Mariko Yoshida, Takayoshi Oguma and Koichiro Hirano, et al. |
| 308-312 | Transport Characteristics of Ceftibuten, a New Oral Cephem, in Rat Intestinal Brush-Border Membrane Vesicles: Relationship to Oligopeptide and Amino β-Lactam Transport | Noriyuki Muranushi, Takayoshi Yoshikawa, Mariko Yoshida, Takayoshi Oguma and Koichiro Hirano, et al. |
| 313-317 | Zero-Order Release Formulation of Oxprenolol Hydrochloride with Swelling and Erosion Control | Kanikanti Padmalatha Devi, Kanikanti V. Ranga Rao, Srikrishan Baveja, Marc Fathi and Marc Roth |
| 318-322 | Biologic Activity of 5′-Deoxy-5-fluorouridine by Rectal Administration | Steven L. Bramer, Lena C. Gunnarsson and J. Lai-Sim Au |
| 323-327 | Absorption of 5′-Deoxy-5-fluorouridine from Colon | J. Lai-Sim Au and Lena C. Gunnarsson |
| 328-331 | Intra- and Intersubject Variability: Mixed-Effects Statistical Analysis of Repeated Doses of an Angiotensin Converting Enzyme Inhibitor, CGS 16617 | Gregory M. Kochak, Robert A. Smith, R. Leslie Choi, Vivian John and Vijay Tipnis, et al. |
| 332-337 | Nutrient Influences on Rat Intestinal Phenytoin Uptake | David Fleisher, Neel Sheth, Heidi Griffin, Martin McFadden and Gregory Aspacher |
| 338-341 | Evaluation of Polyvinyl Alcohol Hydrogel as a Sustained-Release Vehicle for Rectal Administration of Indomethacin | Kazuhiro Morimoto, Atsushi Nagayasu, Shinichi Fukanoki, Katsuaki Morisaka and Suong-Hyu Hyon, et al. |
| 342-345 | Tissue Distribution of Cisplatin After Hepatic Arterial Injection of a Cisplatin–Lipiodol Suspension Containing Phosphatidylcholine to Rabbits Carrying VX-2 Hepatic Carcinoma | Mikiro Nakashima, Mihoko Nakano, Yoshikazu Ishii, Kenji Matsuyama and Masataka Ichikawa, et al. |
| 346-351 | In Vitro Release Profiles of Clonidine Transdermal Therapeutic Systems and Scopolamine Transdermal Patches | Vinod P. Shah, Norlin W. Tymes and Jerome P. Skelly |
| 352-353 | Association News and Announcements |
| 355-361 | Drug Delivery by Phonophoresis | Praveen Tyle and Praful Agrawala |
| 362-366 | Interactions Between Aminoglycosides and Phospholipids Using Liposomes: A Possible Mechanism of Nephrotoxicity | Yukihiko Aramaki and Seishi Tsuchiya |
| 367-372 | Efficiency of Drug Targeting: Steady-State Considerations Using a Three-Compartment Model | Alan Boddy, Leon Aarons and Karel Petrak |
| 373-378 | Evaluating the Fracture Toughness of Sucrose Crystals Using Microindentation Techniques | Wendy C. Duncan-Hewitt and George C. Weatherly |
| 379-386 | Multiple-Dose Pharmacokinetics and Pharmacodynamics of Adinazolam in Elderly Subjects | Joseph C. Fleishaker, J. Paul Phillips, Thomas C. Smith and Randall B. Smith |
| 387-393 | Kinetics of the Aspartyl Transpeptidation of Daptomycin, a Novel Lipopeptide Antibiotic | Lee E. Kirsch, R. Michael Molloy, Manual Debono, Patrick Baker and Khadiga Z. Farid |
| 394-398 | Study on the Renal and Cardiovascular Activities of Aminouracil Derivatives | Ali A. Mustafa, Abdulgader A. Alhaider and Abdullah A. Hijazi |
| 399-403 | Correlation of Partitioning of Nitroimidazoles in the n-Octanol/Saline and Liposome Systems with Pharmacokinetic Parameters and Quantitative Structure–Activity Relationships (QSAR) | Gurupadappa V. Betageri and James A. Rogers |
| 404-407 | Kinetics of Drug Action in Disease States. XXXI. Effect of Experimental Hyperthyroidism on the Hypnotic Activity of a Benzodiazepine (Oxazepam) in Rats | Judith S. Walker, Patricia M. Klockowski and Gerhard Levy |
| 408-412 | Preformulation Study of Etoposide: Identification of Physicochemical Characteristics Responsible for the Low and Erratic Oral Bioavailability of Etoposide | Jaymin C. Shah, Jivn R. Chen and Diana Chow |
| 413-417 | A Novel Approach to the Oral Delivery of Micro- or Nanoparticles | Roland Bodmeier, Huagang Chen and Ornlaksana Paeratakul |
| 418-421 | Effect of Drug (Core) Particle Size on the Dissolution of Theophylline from Microspheres Made from Low Molecular Weight Cellulose Acetate Propionate | Atul J. Shukla and James C. Price |
| 422-427 | Synthesis of Gelatin Microspheres Containing Interferon | Yasuhiko Tabata and Yoshito Ikada |
| 428-430 | Analysis of Diltiazem and Desacetyldiltiazem in Plasma Using Modified High-Performance Liquid Chromatography: Improved Sensitivity and Reproducibility | Hong Zhao and Moses S. S. Chow |
| 431-435 | In Vitro Diffusion Cell Design and Validation. I. A Stability-Indicating High-Performance Liquid Chromatographic Assay for Betamethasone 17-Valerate in Purified Isopropyl Myristate Receptor Phase | Eric W. Smith and John M. Haigh |
| 436-437 | Letter to the Editor | Kenneth J. Himmelstein |
| 438-439 | Letter to the Editor | Bernhard Palsson, Sadettin Ozturk and Jennifer B. Dressman |
| 440-441 | Association News and Announcements |
| 443-448 | Facilitated Transport of Basic and Acidic Drugs in Solutions Through Snakeskin by a New Enhancer—Dodecyl N,N-Dimethylamino Acetate | Christine Flecker, Ooi Wong and J. Howard Rytting |
| 449-457 | The Role of Calcium Ions and Bile Salts on the Pancreatic Lipase-Catalyzed Hydrolysis of Triglyceride Emulsions Stabilized with Lecithin | Francisco J. Alvarez and Valentine J. Stella |
| 458-465 | Stability of Phenobarbital N-Glucosides: Identification of Hydrolysis Products and Kinetics of Decomposition | Floyd B. Vest, William H. Soine, Richard B. Westkaemper and Phyllis J. Soine |
| 466-473 | Permeability and Mechanism of Albumin, Cationized Albumin, and Glycosylated Albumin Transcellular Transport Across Monolayers of Cultured Bovine Brain Capillary Endothelial Cells | Kevin R. Smith and Ronald T. Borchardt |
| 474-476 | Synthesis and Receptor Binding Studies of (±)l-Iodo-MK-801 | David J. Yang, Brian J. Ciliax, Marcian E. Van Dort, David L. Gildersleeve and Jean-Luc Pirat, et al. |
| 477-480 | Effect of the Immunomodulator Tilorone on the in Vivo Acetylation of Procainamide in the Rat | Craig K. Svensson and Philip W. Knowlton |
| 481-485 | Pharmacokinetics and Oral Bioavailability of Scopolamine in Normal Subjects | Lakshmi Putcha, Nitza M. Cintrón, James Tsui, James M. Vanderploeg and William G. Kramer |
| 486-491 | Prediction of the Distribution Volumes of Cefazolin and Tobramycin in Obese Children Based on Physiological Pharmacokinetic Concepts | Rie Koshida, Emi Nakashima, Noboru Taniguchi, Akira Tsuji and Leslie Z. Benet, et al. |
| 492-496 | Pharmacokinetics of Platinum in Cancer Patients Treated with Carboplatin in Combination with High-Dose Methotrexate | Adnan El-Yazigi, Magid Amer and Cazemiro R. Martin |
| 497-500 | Differential Molecular Connectivity in Data-Base Fragment Searching | Lemont B. Kier and Lowell H. Hall |
| 501-505 | Short-Chain Alkyl Esters of L-Dopa as Prodrugs for Rectal Absorption | Joseph A. Fix, Jose Alexander, Margot Cortese, Karen Engle and Paula Leppert, et al. |
| 506-509 | Controlled Gastric Emptying. II. In Vitro Erosion and Gastric Residence Times of an Erodible Device in Beagle Dogs | Robyn Cargill, Karen Engle, Colin R. Gardner, Patricia Porter and Randall V. Sparer, et al. |
| 510-516 | Side-Effect Evaluation of a New Diazepam Formulation: Venous Sequela Reduction Following Intravenous (iv) Injection of a Diazepam Emulsion in Rabbits | Menashe Yoram Levy, Lev Langerman, Shoshanna Gottschalk-Sabag and Simon Benita |
| 517-520 | Modification of Gelatin Beadlets for Zero-Order Sustained Release | Charles S. L. Chiao and James C. Price |
| 521-524 | Determination of Reserpine by Circular Dichroism | Kathy A. Swallows and Neil Purdie |
| 525-527 | Summary of Drug Needs in Cystic Fibrosis | Richard C. Boucher and Robert J. Beall |
| 528 | ERRATUM |
| 529 | Association News and Announcements |
| 531-554 | Current Aspects of Practical Two-Dimensional (2D) Nuclear Magnetic Resonance (NMR) Spectroscopy: Applications to Structure Elucidation | Richard W. Kriwacki and T. Phil Pitner |
| 555-563 | Pancreatic Lipase-Catalyzed Hydrolysis of Esters of Hydroxymethyl Phenytoin Dissolved in Various Metabolizable Vehicles, Dispersed in Micellar Systems, and in Aqueous Suspensions | Francisco J. Alvarez and Valentine J. Stella |
| 564-570 | Temperature Dependence of Non-Fickian Water Transport and Swelling in Glassy Gelatin Matrices | Cathy M. Klech and Jill H. Pari |
| 571-577 | Profile of in Vitro Binding Affinities of Neuroleptics at Different Rat Brain Receptors: Cluster Analysis Comparison with Pharmacological and Clinical Profiles | Rodolfo Testa, Gianalfredo Abbiati, Roberto Ceserani, Gianvico Restelli and Alessandro Vanasia, et al. |
| 578-584 | Effect of Polymeric Network Structure on Drug Release from Cross-Linked Poly(Vinyl Alcohol) Micromatrices | Bruno Gander, Robert Gurny, Eric Doelker and Nikolaos A. Peppas |
| 585-591 | Relationship Between Receptor Occupancy at 37°C and the Anticonvulsant Effect of Flunitrazepam in Rats | Marijke Hollander-Jansen, Jasper Dingemanse, Mariska W. E. Langemeijer and Meindert Danhof |
| 592-600 | Effects of a Brain-Enhanced Chemical Delivery System for Estradiol on Body Weight and Food Intake in Intact and Ovariectomized Rats | James W. Simpkins, Wesley R. Anderson, Ralph Dawson and Nicholas Bodor |
| 601-607 | Liposomal Formulation Eliminates Acute Toxicity and Pump Incompatibility of Parenteral Cyclosporine | Scott A. Gruber, Suresh Venkataram, Daniel M. Canafax, Robert J. Cipolle and Larry Bowers, et al. |
| 608-611 | Quantitative Fourier Transform-Infrared/Attenuated Total Reflectance (FT-IR/ATR) Analysis of Trimethoprim and Sulfamethoxazole in a Pharmaceutical Formulation Using Partial Least Squares | Kerry J. Hartauer and J. Keith Guillory |
| 612-618 | In Vitro Dissolution Profile of Water-Insoluble Drug Dosage Forms in the Presence of Surfactants | Vinod P. Shah, John J. Konecny, Richard L. Everett, Brace McCullough and A. Carol Noorizadeh, et al. |
| 619-623 | In Vitro Adsorption of Bile Salts by Colestipol Hydrochloride | Thomas J. Konechnik, Rosemary Kos, Joe L. White, Stanley L. Hem and Marie T. Borin |
| 624-627 | The Application of Bovine Brain Microvessel Endothelial-Cell Monolayers Grown onto Polycarbonate Membranes in Vitro to Estimate the Potential Permeability of Solutes Through the Blood–Brain Barrier | Mandar V. Shah, Kenneth L. Audus and Ronald T. Borchardt |
| 628-632 | Enhanced in Vitro Skin Permeation of Cationic Drugs | Philip G. Green, Jonathan Hadgraft and Geoffrey Ridout |
| 633-636 | The Influence of Liposomal Encapsulation on Sodium Cromoglycate Pharmacokinetics in Man | Kevin M. G. Taylor, Glyn Taylor, Ian W. Kellaway and John Stevens |
| 637-640 | Kmeriol and Other Aromatic Constituents of Kmeria Duperreana | Xiaoping Dong, Ing-On Mondranondra, Chun-tao Che, Harry H. S. Fong and Norman R. Farnsworth |
| 641-646 | Testosterone in a Cyclodextrin-Containing Formulation: Behavioral and Physiological Effects of Episode-like Pulses in Rats | George T. Taylor, Jürgen Weiss and Josef Pitha |
| 647-649 | Association News and Announcements |
| 651-659 | Endothelium-Derived Nitric Oxide: Pharmacology and Relationship to the Actions of Organic Nitrate Esters | Louis J. Ignarro |
| 660-666 | Route of Administration and Sex Differences in the Pharmacokinetics of Aspirin, Administered as Its Lysine Salt | Leon Aarons, Katie Hopkins, Malcolm Rowland, S. Brossel and Jean-François Thiercelin |
| 667-676 | Improved Delivery Through Biological Membranes. XXXVII. Synthesis and Stability of Novel Redox Derivatives of Naproxen and Indomethacin | Michael J. Phelan and Nicholas Bodor |
| 677-682 | A Pharmacokinetic Model of Intravenously Administered Hyaluronan in Sheep | Lena Lebel, J. Robert E. Fraser, Wayne S. Kimpton, Johan Gabrielsson and Bengt Gerdin, et al. |
| 683-689 | Structure–Pharmacokinetic Relationships in a Series of Valpromide Derivatives with Antiepileptic Activity | Abdulla Haj-Yehia and Meir Bialer |
| 690-696 | Saturable Process Involved in Active Efflux of Vincristine as a Mechanism of Multidrug Resistance in P388 Leukemia Cells | Tohru Watanabe, Makoto Inaba and Yuichi Sugiyama |
| 697-701 | The Effect of Ultrasound on the in Vitro Penetration of Ibuprofen Through Human Epidermis | Richard Brucks, Maulik Nanavaty, Donald Jung and Frederick Siegel |
| 702-705 | A Retrospective Analysis of Fenoldopam Renal Excretion in 65 Subjects: Evidence for Possible Intrarenal Formation of Fenoldopam from Its Metabolites | John A. Ziemniak, Venkata K. Boppana, Matthew J. Cyronak and Robert M. Stote |
| 706-708 | A Nuclear Magnetic Resonance (NMR) Method for the Determination of the cis/trans Isomeric Content of Chlorprothixene | Karl-Heinz A. Rosler, Jeremy Wright, Kristine M. Fox, Rolland M. Waters and Patrick S. Callery |
| 709-713 | A Comparison of the Cholinergic Activity of Selected H2-Antagonists and Sulfoxide Metabolites | Joseph W. Kosh, J. Walter Sowell and James M. Chapman |
| 714-718 | Nylon Microcapsules. II. Effect of Selected Variables on Theophylline Release | P. L. Madan and P. Chareonboonsit |
| 719-724 | Gastrointestinal Transit of a Solid Indigestible Capsule as Measured by Radiotelemetry and Dual Gamma Scintigraphy | Parviz Mojaverian, Keith Chan, Anil Desai and Vivian John |
| 725-730 | Evaluation of Drug-Containing Polymer Films Prepared from Aqueous Latexes | Roland Bodmeier and Ornlaksana Paeratakul |
| 731-733 | Noncompartmental Analysis for a One-Compartment Model with Equal Absorption and Elimination Rate Constants | Howard Ko, James F. Caputo and Wade J. Adams |
| 734-736 | Dose-Ranging Pharmacokinetics of Zidovudine (Azidothymidine) in the Rat | Jashvant D. Unadkat, Ji Ping Wang, David Pulham and Robin L. O. Semmes |
| 737-739 | Phosphorus–Nitrogen Compounds. 31. N-Phosphinylamino-1,2,5,6-tetrahydropyridines: Analgesic Activity and Effect on Blood Glucose | Lindley A. Cates, Ven-Shun Li and Sharathchandra S. Hegde |
| 740-741 | A Simple Microwave Technique for the Separation of Epidermis and Dermis in Skin Uptake Studies | Saran Kumar, Charan R. Behl, Sunil B. Patel and A. Waseem Malick |
| 742 | Association News and Announcements |
| 743-747 | Ion Pair Transport Across Membranes | Reinhard Neubert |
| 748-752 | Formulation of Vaccine Adjuvant Muramyldipeptides. 3. Processing Optimization, Characterization, and Bioactivity of an Emulsion Vehicle | Deborah M. Lidgate, Roger C. Fu, Noelene E. Byars, Linda C. Foster and Jeffrey S. Fleitman |
| 753-758 | Transdermal Controlled Delivery of Propranolol from a Multilaminate Adhesive Device | Michael Corbo, Jue-Chen Liu and Yie W. Chien |
| 759-765 | Evidence for Site-Specific Absorption of a Novel ACE Inhibitor | George M. Grass and William T. Morehead |
| 766-771 | Use of an in Vitro Model for the Assessment of Muscle Damage from Intramuscular Injections: in Vitro-in Vivo Correlation and Predictability with Mixed Solvent Systems | Gayle A. Brazeau and Ho-Leung Fung |
| 772-778 | The Kinetics of Timolol in the Rabbit Lens: Implications for Ocular Drug Delivery | Imran Ahmed, Michael L. Francoeur, Avinash G. Thombre and Thomas F. Patton |
| 779-786 | Amino Acids Bracketing the Predicted Transmembrane Domains of Membrane Proteins | Charles Pidgeon, Renee L. Williard and Susan C. Schroeder |
| 787-793 | Chloroquine Blood Levels After Administration of the Liposome-Encapsulated Drug in Relation to Therapy of Murine Malaria | Pierre A. M. Peeters, Karen de Leest, Wijnand M. C. Eling and Daan J. A. Crommelin |
| 794-797 | Effect of Anions on Adsorption of Bile Salts by Colestipol Hydrochloride | Christine V. Bilicki, Joe L. White, Stanley L. Hem and Marie T. Borin |
| 798-803 | Dose-Dependent Enhancement Effects of Azone on Skin Permeability | William J. Lambert, William I. Higuchi, Kristine Knutson and Steven L. Krill |
| 804-808 | Solid-State Interaction of Magnesium Oxide and Ibuprofen to Form a Salt | Tugrul T. Kararli, Thomas E. Needham, Clifford J. Seul and Pat M. Finnegan |
| 809-812 | A Graph-Theoretical Approach to the Prediction of Physical Properties of Alkanes Based on the Distance Matrix | James F. Caputo and Kathleen J. Cook |
| 813-816 | Enhanced Bioavailability of Subcutaneously Injected Insulin Coadministered with Collagen in Rats and Humans | Ryohei Hori, Fusao Komada, Seigo Iwakawa, Yutaka Seino and Katsuhiko Okumura |
| 817-821 | Estimation of Bioavailability on a Single Occasion After Semisimultaneous Drug Administration | Mats O. Karlsson and Ulf Bredberg |
| 822-823 | Association News and Announcements |
| 825-832 | Transdermal Delivery of Narcotic Analgesics: Comparative Permeabilities of Narcotic Analgesics Through Human Cadaver Skin | Samir D. Roy and Gordon L. Flynn |
| 833-839 | Erythrocytes as Barriers for Drug Elimination in the Isolated Rat Liver. I. Doxorubicin | Hye-Jung Lee and Win L. Chiou |
| 840-843 | Erythrocytes as Barriers for Drug Elimination in the Isolated Rat Liver. II. Propranolol | Hye-Jung Lee and Win L. Chiou |
| 844-847 | Polyvinyl Alcohol–Methyl Acrylate Copolymers as a Sustained-Release Oral Delivery System | Robert C. DiLuccio, Munir A. Hussain, David CoffinBeach, George Torosian and Eli Shefter, et al. |
| 848-852 | Drug Absorption Through Mucosal Membranes: Effect of Mucosal Route and Penetrant Hydrophilicity | Diane C. Corbo, Jue-Chen Liu and Yie W. Chien |
| 853-856 | Absorption Enhancement of Intranasally Administered Insulin by Sodium Taurodihydrofusidate (STDHF) in Rabbits and Rats | Marc J. M. Deurloo, Walter A. J. J. Hermens, Stefan G. Romeyn, J. Coos Verhoef and Frans W. H. M. Merkus |
| 857-862 | A Correlation of Permeabilities for Passively Transported Compounds in Monkey and Rabbit Jejunum | George M. Grass and Stephanie A. Sweetana |
| 863-866 | Effect of Uridine Diphosphoglucose on Levels of 5-Phosphoribosyl Pyrophosphate and Uridine Triphosphate in Murine Tissues | Joseph R. Colofiore, Robert C. Sawyer, M. Earl Balis and Daniel S. Martin |
| 867-873 | Synthesis and Biological Evaluation of Ω-(N,N,N-Trialkylammonium)alkyl Esters and Thioesters of Carboxylic Acid Nonsteroidal Antiinflammatory Agents | Michael C. Venuti, John M. Young, Patrick J. Maloney, David Johnson and Kenneth McGreevy |
| 874-876 | Influence of Unbound Fraction and Perfusate Flow Rate on Taurocholate Elimination by Perfused Rat Liver: Applicability of Three Distributed Models | Denis J. Morgan |
| 877-882 | Contribution of Monoamine Oxidase (MAO) to the Binding of Tertiary Basic Drugs in Lung Mitochondria | Hisahiro Yoshida, Akira Kamiya, Katsuhiko Okumura and Ryohei Hori |
| 883-886 | Antiperspirant Activity of H1-Histamine Blockers as Determined by a Modified Rat Foot Pad Assay | Michael D. Helman, Thomas A. Re and Alison B. Lukacsko |
| 887-891 | Prodrugs of 5-Iodo-2′-Deoxyuridine for Enhanced Ocular Transport | Milind M. Narurkar and Ashim K. Mitra |
| 892-894 | Gas Chromatographic/Mass Spectrometric (GC/MS) Analysis of N-Nitrosodiisopropanolamine at the Nanogram-per-Gram Level in a Gel Formulation Containing a Nonsteroidal Antiinflammatory Agent | John C. James, Michael J. Pastel, Katherine A. Ledoux and John M. Baldoni |
| 895-899 | Analytical Method for the Quantification of 2′,3′-Didehydro-3′-Deoxythymidine, a New Anti-Human Immunodeficiency Virus (HIV) Agent, by High-Performance Liquid Chromatography (HPLC) and Ultraviolet (UV) Detection in Rat and Monkey Plasma | Sanjeev Kaul, Kishor A. Dandekar and Kenneth A. Pittman |
| 900 | BOOK REVIEWS |
| 901 | Association News and Announcements |
| 903-918 | Stability of Protein Pharmaceuticals | Mark C. Manning, Kamlesh Patel and Ronald T. Borchardt |
| 919-923 | Macromolecular Prodrugs. XV. Colon-Targeted Delivery—Bioavailability of Naproxen from Orally Administered Dextran–Naproxen Ester Prodrugs Varying in Molecular Size in the Pig | Elin Harboe, Claus Larsen, Marianne Johansen and Henning Peter Olesen |
| 924-932 | Quantitative Whole-Body Autoradiographic Determination of Tacrine Tissue Distribution in Rats Following Intravenous or Oral Dose | William McNally, Michelle Roth, Remedios Young, Howard Bockbrader and Tsun Chang |
| 931-937 | Analysis of Drug Penetration Through the Skin by the Two-Layer Skin Mode | Hirokazu Okamoto, Fumiyoshi Yamashita, Kyoko Saito and Mitsuru Hashida |
| 938-944 | Transdermal Delivery of Levonorgestrel. V. Preparation of Devices and Evaluation in Vitro | David R. Friend, Paul Catz, Jorge Heller and Michael Okagaki |
| 945-948 | Design and in Vitro Evaluation of Dapsone-Loaded Micropellets of Ethyl Cellulose | Suranjana Roy, Sudip K. Das, Manjusree Pal and Bijan K. Gupta |
| 949-953 | Assessment of Skin Barrier Function Using Transepidermal Water Loss: Effect of Age | Kathleen V. Roskos and Richard H. Guy |
| 954-957 | Decreased Transport of p-Aminohippurate in Renal Basolateral Membranes Isolated from Rats with Acute Renal Failure | Ken-ichi Inui, Mikihisa Takano, Hitoshi Maegawa, Miyako Kato and Ryohei Hori |
| 958-960 | Solid Surfactant Solutions of Active Ingredients in Sugar Esters | Lorenz Hahn and Heinz Sucker |
| 961-965 | Near-Infrared Spectroscopic Determination of Residual Moisture in Lyophilized Sucrose Through Intact Glass Vials | Madhav S. Kamat, Robert A. Lodder and Patrick P. DeLuca |
| 966-970 | Buccal Absorption. III. Simultaneous Diffusion and Metabolism of an Aminopeptidase Substrate in the Hamster Cheek Pouch | Kevin W. Garren, Elizabeth M. Topp and A. J. Repta |
| 971-975 | An Unexpected pH Effect on the Stability of Moexipril Lyophilized Powder | Robert G. Strickley, Gary C. Visor, Li-Hwa Lin and Leo Gu |
| 976-981 | Gender Differences in the Pharmacodynamics of Barbiturates in Rats | Amnon Hoffman and Gerhard Levy |
| 982-987 | Microbial Models of Mammalian Metabolism: Stereoselective Metabolism of Warfarin in the Fungus Cunninghamella elegans | Yiu W. J. Wong and Patrick J. Davis |
| 988-990 | Noninvasive Sampling of Biological Fluids by Iontophoresis | Peretz Glikfeld, Robert S. Hinz and Richard H. Guy |
| 991-993 | High-Performance Liquid Chromatographic Determination and Pharmacokinetics of Methyl N-[5[[4-(2-Pyridinyl)-l-piperazinyl]carbonyl]-1H-benzimidazol-2-yl] Carbamate (CDRI Compound 81-470), a New Anthelmintic Agent in Rats | Jyoti Kumar Paliwal, Ram Chandra Gupta and Pyara Krishen Grover |
| 994 | Association News and Announcements |
| 995-999 | Macromolecular Prodrugs. XVI. Colon-Targeted Delivery—Comparison of the Rate of Release of Naproxen from Dextran Ester Prodrugs in Homogenates of Various Segments of the Pig Gastrointestinal (GI) Tract | Claus Larsen, Elin Harboe, Marianne Johansen and Henning Peter Olesen |
| 1000-1010 | Transdermal Dual-Controlled Delivery of Contraceptive Drugs: Formulation Development, in Vitro and in Vivo Evaluations, and Clinical Performance | Yie W. Chien, Te-yen Chien, Robert E. Bagdon, Yih C. Huang and Robert H. Bierman |
| 1011-1016 | Noninvasive Assessment of Lipid Disposition in Treated and Untreated Atherosclerotic Rabbits | Laura E. DeForge, Susan W. Schwendner, Mark R. DeGalan, Daniel S. McConnell and Raymond E. Counsell |
| 1017-1024 | Determination of the Relative Amounts of Anhydrous Carbamazepine (C15H12N2O) and Carbamazepine Dihydrate (C15H12N2O · 2H2O) in a Mixture by Powder X-ray Diffractometry | Raj Suryanarayanan |
| 1025-1031 | Intrahepatic Delivery of Glutathione by Conjugation to Dextran | Yoshiharu Kaneo, Yumie Fujihara, Tetsuro Tanaka, Yoko Kozawa and Hideki Mori, et al. |
| 1032-1038 | Dextrose Adduct Formation in Aqueous Teicoplanin Solutions | William H. Streng and Nicholas W. Brake |
| 1039-1042 | The Beagle Dog as an Animal Model for a Bioavailability Study of Controlled-Release Theophylline Under the Influence of Food | Gerald K. Shiu, Armelle LeMarchand, Arlan O. Sager, Raja B. Velagapudi and Jerome P. Skelly |
| 1043-1047 | Passive and Carrier-Mediated Intestinal Absorption Components of Two Angiotensin Converting Enzyme (ACE) Inhibitor Prodrugs in Rats: Enalapril and Fosinopril | Doron I. Friedman and Gordon L. Amidon |
| 1048-1051 | High Performance Liquid Chromatographic (HPLC) Determination of Centchroman in Human Serum and Application to Single-Dose Pharmacokinetics | Jyoti Kumar Paliwal, Ram Chandra Gupta, Pyara Krishen Grover, Omkar P. Asthana and Jagdishwar Sahai Srivastava, et al. |
| 1052-1055 | Hollow Fibers as an Oral Sustained-Release Delivery System Using Propranolol Hydrochloride | Munir A. Hussain, Robert C. DiLuccio, Eli Shefter and Arthur R. Hurwitz |
| 1056-1059 | Effect of a Change in the Luminal Perfusion Rate on Intestinal Drug Absorption Studied by a Simple Unified Organ Clearance Approach | Win L. Chiou |
| 1060-1066 | Evaluating the Deformation Kinetics of Sucrose Crystals Using Microindentation Techniques | Wendy C. Duncan-Hewitt and George C. Weatherly |
| 1067-1072 | Pharmacokinetics of Sulfasalazine Metabolites in Rats Following Concomitant Oral Administration of Riboflavin | Vinod S. Chungi, Lewis W. Dittert and Leon Shargel |
| 1073 | Association News and Announcements |
| 1074-1076 | Reviewers for Pharmaceutical Research (1989) |
| 1077-1079 | Author Index to Volume 6 (1989) |
| 1080-1088 | Subject Index to Volume 6 (1989) |
| 1-7 | Amplification of Butyrylcholinesterase and Acetylcholinesterase Genes in Normal and Tumor Tissues: Putative Relationship to Organophosphorous Poisoning | Hermona Soreq and Haim Zakut |
| 8-13 | Solute Absorption from the Airways of the Isolated Rat Lung. II. Effect of Surfactants on Absorption of Fluorescein | Ralph W. Niven and Peter R. Byron |
| 14-20 | Pharmacokinetics of Methylergometrine in the Rat: Evidence for Enterohepatic Recirculation by a Linked-Rat Model | Ulf Bredberg and Lennart Paalzow |
| 21-27 | Irreversible Binding of Tolmetin Glucuronic Acid Esters to Albumin in Vitro | Alain Munafo, Antony F. McDonagh, Philip C. Smith and Leslie Z. Benet |
| 28-33 | Conversion of Ouabain-Induced Ventricular Tachycardia in Dogs with Epicardial Lidocaine: Pharmacodynamics and Functional Effects | Amnon Sintov, William A. Scott, Kim P. Gallagher and Robert J. Levy |
| 34-40 | Enhancement of the in Vitro Skin Permeability of Azidothymidine (AZT) via Iontophoresis and Chemical Enhancer | Lorraine Wearley and Yie W. Chien |
| 41-45 | Differential Effects of Anesthetic Regimens on Gentamicin Pharmacokinetics in the Rat: A Comparison with Chronically Catheterized Conscious Animals | Mark Gumbleton, Paul J. Nicholls and Glyn Taylor |
| 46-48 | High-Fat Meals Increase the Clearance of Cyclosporine | Suneel K. Gupta and Leslie Z. Benet |
| 49-53 | Mucoadhesion of Hydroxypropylmethacrylate Nanoparticles to Rat Intestinal Ileal Segments in Vitro | Clara Pimienta, Vincent Lenaerts, Céline Cadieux, Philippe Raymond and Julianna Juhasz, et al. |
| 54-58 | Plasma Concentrations of Remoxipride and the Gastrointestinal Transit of 111ln-Marked Extended-Release Coated Spheres | Christina Graffner, Zoltan Wagner, Maj-Inger Nilsson and Erik Widerlöv |
| 59-63 | Effects of First-Pass Metabolism on Metabolite Mean Residence Time Determination After Oral Administration of Parent Drug | Keith K. H. Chan and Milo Gibaldi |
| 64-68 | Percutaneous Penetration of Acyclovir Through Excised Hairless Mouse and Rat Skin: Effect of Vehicle and Percutaneous Penetration Enhancer | Hirokazu Okamoto, Kenji Muta, Mitsuru Hashida and Hitoshi Sezaki |
| 69-75 | Model of Disposition of Drugs Administered into the Human Nasal Cavity | Igor Gonda and Elizabeth Gipps |
| 76-79 | Effects of Variation in Drug Elimination on Five Methods for Assessing Zero-Order Drug Absorption Rates | Haiyung Cheng and William J. Jusko |
| 80-86 | Intrinsic Dissolution Rates of Tablet Filler-Binders and Their Influence on the Dissolution of Drugs from Tablet Formulations | Arun D. Koparkar, Larry L. Augsburger and Ralph F. Shangraw |
| 87-90 | The Biliary Elimination and Enterohepatic Circulation of Ibuprofen in Rats | Klaus Dietzel, Winfried S. Beck, Hans-Th. Schneider, Gerd Geisslinger and Kay Brune |
| 91-95 | Effect of Aliphatic Side-Chain Substituents on the Antimalarial Activity and on the Metabolism of Primaquine Studied Using Mitochondria and Microsome Preparations | John K. Baker, Robert H. Yarber, N. P. D. Nanayakkara, James D. McChesney and Frederic Homo, et al. |
| 96-102 | The Effects of Urine pH Modification on the Pharmacokinetics and Pharmacodynamics of Phenylpropanolamine | Cheryl L. Zimmerman, Mary Beth O'Connell and Inmaculada Soria |
| 103-107 | Mean Residence Times of Multicompartmental Drugs Undergoing Reversible Metabolism | Haiyung Cheng and William J. Jusko |
| 108-109 | Reimbursement for Drugs Under Third-Party Programs | Francis B. Palumbo |
| 110 | BOOK REVIEWS |
| 111 | Editorial |
| 112 | Association News and Announcements |
| 113-117 | Percolation Theory and Compactibility of Binary Powder Systems | Dieter Blattner, Max Kolb and Hans Leuenberger |
| 118-126 | Transport Mechanisms in Iontophoresis. I. A Theoretical Model for the Effect of Electroosmotic Flow on Flux Enhancement in Transdermal Iontophoresis | Michael J. Pikal |
| 127-133 | Bile Salt–Fatty Acid Mixed Micelles as Nasal Absorption Promoters of Peptides. I. Effects of Ionic Strength, Adjuvant Composition, and Lipid Structure on the Nasal Absorption of [D-Arg2]Kyotorphin | Parkpoom Tengamnuay and Ashim K. Mitra |
| 134-143 | DC Electrical Properties of Frozen, Excised Human Skin | Gerald B. Kasting and Lisa A. Bowman |
| 144-146 | Effects of Absorption Enhancers on Human Nasal Tissue Ciliary Movement in Vitro | Walter A. J. J. Hermens, Piet M. Hooymans, J. Coos Verhoef and Frans W. H. M. Merkus |
| 147-153 | Solid-State Chemistry and Crystal Structure of Cefaclor Dihydrate | Heriberto Martinez, Stephen R. Byrn and Ralph R. Pfeiffer |
| 154-160 | Method Validation Revisited: A Chemometric Approach | Mario J. Cardone, Susan A. Willavize and Mark E. Lacy |
| 161-166 | Bioavailability Improvement of Mycophenolic Acid Through Amino Ester Derivatization | William A. Lee, Leo Gu, Andrew R. Miksztal, Nancy Chu and Kwan Leung, et al. |
| 167-169 | Effect of Molecular Weight on the Lymphatic Absorption of Water-Soluble Compounds Following Subcutaneous Administration | Andreas Supersaxo, Wayne R. Hein and Hans Steffen |
| 170-175 | Mechanism of Ethanol-Enhanced Estradiol Permeation Across Human Skin in Vivo | Lynn K. Pershing, Lyssa D. Lambert and Kristine Knutson |
| 176-179 | Determination of Potential Migrants from Commercial Amber Polyethylene Terephthalate Bottle Wall | Heasook Kim, Seymour G. Gilbert and James B. Johnson |
| 180-183 | Absorption Enhancement of Rectally Infused Insulin by Sodium Tauro-24,25-Dihydrofusidate (STDHF) in Rats | Ewoud J. van Hoogdalem, Corrie D. Heijligers-Feijen, J. Coos Verhoef, Albertus G. de Boer and Douwe D. Breimer |
| 184-187 | Quantitation of the Relative Amounts of Anhydrous Carbamazepine (C15H12N2O) and Carbamazepine Dihydrate (C15H12N2O · 2H2O) in a Mixture by Solid-State Nuclear Magnetic Resonance (NMR) | Raj Suryanarayanan and Timothy S. Wiedmann |
| 188-191 | Disposition of Bismuth in the Rat. I. Red Blood Cell and Plasma Protein Binding | Niranjan Rao and Stuart Feldman |
| 192-198 | Pharmacokinetics of the Aldose Reductase Inhibitor Imirestat Following Topical Ocular Administration | R. Kim Brazzell, C. Bradley Wooldridge, Robert B. Hackett and Bette A. McCue |
| 199-203 | Microbial Metabolism Studies of the Antimalarial Drug Arteether | Ik-Soo Lee, Hala N. ElSohly and Charles D. Hufford |
| 204-207 | Disposition of Antipyrine and Acetaminophen Given Alone and in Combination to Human Subjects | Walid M. Awni, John V. St. Peter, John M. Kovarik and Gary R. Matzke |
| 208 | BOOK REVIEWS |
| 209 | BOOK REVIEWS |
| 210 | ERRATUM |
| 211-212 | Association News and Announcements |
| 213-221 | Transport Mechanisms in Iontophoresis. II. Electroosmotic Flow and Transference Number Measurements for Hairless Mouse Skin | Michael J. Pikal and Saroj Shah |
| 222-229 | Transport Mechanisms in Iontophoresis. III. An Experimental Study of the Contributions of Electroosmotic Flow and Permeability Change in Transport of Low and High Molecular Weight Solutes | Michael J. Pikal and Saroj Shah |
| 230-236 | Percutaneous Absorption of Benzoic Acid Across Human Skin. I. In Vitro Experiments and Mathematical Modeling | Gregory E. Parry, Annette L. Bunge, Geoffrey D. Silcox, Lynn K. Pershing and David W. Pershing |
| 237-241 | Disposition of Bismuth in the Rat. II. Pharmacokinetics and Biliary Excretion | Niranjan Rao and Stuart Feldman |
| 242-246 | Kinetics of Drug Action in Disease States. XXXIX. Effect of Orally Administered Activated Charcoal on the Hypnotic Activity of Phenobarbital and the Neurotoxicity of Theophylline Administered Intravenously to Rats with Renal Failure | Amnon Hoffman and Gerhard Levy |
| 247-250 | The Effect of Compactional Pressure on a Wheat Germ Lipase Preparation | M. Hossein Zarrintan, C. Diana Teng and Michael J. Groves |
| 251-255 | Carboxylic Ester Hydrolase Activity in Hairless and Athymic Nude Mouse Skin | Mridul K. Ghosh and Ashim K. Mitra |
| 256-261 | Effect of Antihepatotoxic Agents Against Microcystin-LR Toxicity in Cultured Rat Hepatocytes | Kay A. Mereish and Rikki Solow |
| 260-263 | Antiendotoxin Activity of Lipid A Analogues: Requirements of the Chemical Structure | Robert L. Danner, Alan L. Van Dervort, Martin E. Doerfler, Peter Stuetz and Joseph E. Parrillo |
| 264-269 | Manufacture and Properties of Erythromycin Beads Containing Neutron-Activated Erbium-171 | Alan F. Parr, George A. Digenis, Erik P. Sandefer, Isaac Ghebre-Sellassie and Uma Iyer, et al. |
| 270-273 | Microbial Biotransformation of Retinoic Acid by Cunninghamella echinulata and Cunninghamella blakesleeana | David A. Hartman, Jack B. Basil, Larry W. Robertson and Robert W. Curley |
| 274-279 | Hydralazine Pharmacokinetics and Interaction with Food: An Evaluation of the Dog as an Animal Model | Hugh A. Semple, Yun K. Tam and Ronald T. Coutts |
| 280-282 | Interactions of 7-[3-(4-[2,3-Dimethylphenyl]piperazinyl)-propoxy]-2(lH)-quinolinone (OPC-4392) with 3H-Spiperone and 3H-SCH 23390 Binding in Rat Striatum: Effects of Lesions | Xiao Zhang, Yoshihiro Nakata, Tetsuro Kikuchi and Tomio Segawa |
| 283-288 | Are Reduction Potentials of Antifungal Agents Relevant to Activity? | Peter Kovacic, Patrick F. Kiser and Benjamin A. Feinberg |
| 289-292 | Applications of Oxygen Polarography to Drug Stability Testing and Formulation Development: Solution-Phase Oxidation of Hydroxymethylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors | Michael J. Kaufman |
| 293-298 | Transport of Desglycinamide-Arginine Vasopressin Across the Blood–Brain Barrier in Rats as Evaluated by the Unit Impulse Response Methodology | Joost B. M. M. van Bree, Susan Tio, Albertus G. de Boer, J. Coos Verhoef and Douwe D. Breimer |
| 299-303 | Mechanism of Acyclovir Uptake in Rat Jejunum | Kem C. Meadows and Jennifer B. Dressman |
| 304-307 | The Effect of Food on Gastrointestinal (GI) Transit of Sustained-Release Ibuprofen Tablets as Evaluated by Gamma Scintigraphy | Marie T. Borin, Subhash Khare, Robert M. Beihn and Michael Jay |
| 308-309 | Mechanism of Absorption of the Dipeptide α-Methyldopa-phe in Intestinal Brush-Border Membrane Vesicles | Akira Tsuji, Ikumi Tamai, Masaru Nakanishi and Gordon L. Amidon |
| 310-312 | Association News and Announcements |
| 313-317 | Sustained-Release Delivery Systems for Treatment of Dental Diseases | Michael Friedman and Doron Steinberg |
| 318-324 | Altered Pharmacokinetics and Dynamics of Apomorphine in the Malnourished Rat: Modeling of the Composed Relationship Between Concentration and Heart-Rate Response | Eva Bredberg and Lennart K. Paalzow |
| 325-331 | Transepithelial Transport of Aliphatic Carboxylic Acids Studied in Madin Darby Canine Kidney (MDCK) Cell Monolayers | Moo J. Cho, Anthony Adson and F. J. Kezdy |
| 332-338 | Modeling the Enhanced Uptake of Zidovudine (AZT) into Cerebrospinal Fluid. 1. Effect of Probenecid | Ronald J. Sawchuk and Mohsen A. Hedaya |
| 339-346 | Disposition Characteristics of Macromolecules in Tumor-Bearing Mice | Yoshinobu Takakura, Takuya Fujita, Mitsuru Hashida and Hitoshi Sezaki |
| 347-351 | Single- vs Multiple-Dose Pharmacokinetics of Clozapine in Psychiatric Patients | Miles G. Choc, Francis Hsuan, Gilbert Honigfeld, William T. Robinson and Larry Ereshefsky, et al. |
| 352-358 | Percutaneous Absorption of Benzoic Acid Across Human Skin. II. Prediction of an in Vivo, Skin-Flap System Using in Vitro Parameters | Geoffrey D. Silcox, Gregory E. Parry, Annette L. Bunge, Lynn K. Pershing and David W. Pershing |
| 359-363 | Formulation and in Vitro-in Vivo Evaluation of Sustained-Release Lithium Carbonate Tablets | Kadriye Çiftçi, Yilmaz Çapan, Orhan Öztürk and A. Atilla Hincal |
| 364-369 | Epimerization Kinetics of Moxalactam in Frozen Urine and Plasma Samples | Naofumi Hashimoto, Teruhisa Ichihashi, Koichiro Hirano and Hideo Yamada |
| 370-375 | Bile Salt–Fatty Acid Mixed Micelles as Nasal Absorption Promoters of Peptides. II. In Vivo Nasal Absorption of Insulin in Rats and Effects of Mixed Micelles on the Morphological Integrity of the Nasal Mucosa | Parkpoom Tengamnuay and Ashim K. Mitra |
| 376-378 | 16α-Hydroxy-(–)-kauranoic Acid: A Selectively Cytotoxic Diterpene from Annona bullata | Yu-hua Hui, Ching-jer Chang, David L. Smith and Jerry L. McLaughlin |
| 379-383 | Drug-Excipient Incompatibility Studies of the Dipeptide Angiotensin-Converting Enzyme Inhibitor, Moexipril Hydrochloride: Dry Powder vs Wet Granulation | Leo Gu, Robert G. Strickley, Li-Hua Chi and Zak T. Chowhan |
| 384-387 | A Comparison of Oral and Rectal Absorption of L-Dopa Esters in Rats and Mice | Joseph A. Fix, Jose Alexander, Margot Cortese, Karen Engle and Paula Leppert, et al. |
| 388-391 | Isothermal and Nonisothermal Kinetics in the Stability Prediction of Vitamin A Preparations | Sumie Yoshioka, Yukio Aso and Yasushi Takeda |
| 392-397 | Intestinal Absorption of Drugs. III. The Influence of Taurocholate on the Disappearance Kinetics of Hydrophilic and Lipophilic Drugs from the Small Intestine of the Rat | Fred G. J. Poelma, Ria Breäs and Josef J. Tukker |
| 398-401 | Contribution of Monoamine Oxidase(MAO) to the Binding of Tertiary Basic Drugs in Isolated Perfused Rat Lung | Hisahiro Yoshida, Katsuhiko Okumura and Ryohei Hori |
| 402-406 | Stereochemical Characterization of the Diastereomers of the Phenobarbital N-β-D-Glucose Conjugate Excreted in Human Urine | William H. Soine, Phyllis J. Soine, Suzanne E. Mongrain and Terry M. England |
| 407-410 | Development of a Sensitive Activity Assay for High-Volume Evaluation of Human Renin Inhibitory Peptides in Rat Serum: Results with U-71,038 | Mary J. Ruwart, Satish K. Sharma, Douglas W. Harris, Duane B. Lakings and Bob D. Rush, et al. |
| 411-417 | Probenecid Inhibits the Metabolic and Renal Clearances of Zidovudine (AZT) in Human Volunteers | Mohsen A. Hedaya, William F. Elmquist and Ronald J. Sawchuk |
| 418-421 | Synthesis, Characterization, and in Vitro Stability of Chitosan-Methotrexate Conjugates | Yeshwant D. Sanzgiri, C. Dewitt Blanton and James M. Gallo |
| 422-424 | Evaluation of Free Tissue Concentrations of Fleroxacin After Oral Administration | Jobst Limberg, Marc LeBel and Hartmut Derendorf |
| 425-429 | On the Use of the Quasi-Equilibrium Assumption for Drug Dissolution | Sadettin S. Ozturk, Jennifer B. Dressman and Bernhard O. Palsson |
| 430 | BOOK REVIEWS |
| 431-432 | Letters to the Editor | Paolo Colombo, Ping I. Lee, Nikolaos A. Peppas and K. Padmalatha Devi |
| 433-434 | Editorial |
| 435-451 | The Use of Cultured Epithelial and Endothelial Cells for Drug Transport and Metabolism Studies | Kenneth L. Audus, Ronnda L. Bartel, Ismael J. Hidalgo and Ronald T. Borchardt |
| 452-460 | Chemical Stability of Pentostatin (NSC-218321), a Cytotoxic and Immunosuppressant Agent | Laman A. Al-Razzak, Annalisa E. Benedetti, Wanda N. Waugh and Valentine J. Stella |
| 461-467 | Nonlinear Binding of Valproic Acid (VPA) and E-Δ2-Valproic Acid to Rat Plasma Proteins | Robin L. O. Semmes and Danny D. Shen |
| 468-475 | The Effects of Permeation Enhancers on the Surface Morphology of the Rat Nasal Mucosa: A Scanning Electron Microscopy Study | Richard D. Ennis, Lucy Borden and William A. Lee |
| 476-483 | Ocular Pharmacokinetics and Pharmacodynamics of Phenylephrine and Phenylephrine Oxazolidine in Rabbit Eyes | Du-Shieng Chien and Ronald D. Schoenwald |
| 484-490 | Effect of Cyclodextrin Derivatives on Indomethacin Stability in Aqueous Solution | Thomas Backensfeld, Bernd W. Müller, Michael Wiese and Joachim K. Seydel |
| 491-495 | A Simple Rheological Method for the in Vitro Assessment of Mucin-Polymer Bioadhesive Bond Strength | Emad Eldin Hassan and James M. Gallo |
| 496-499 | Disposition and Metabolic Profiling of the Penetration Enhancer Azone. I. In Vivo Studies: Urinary Profiles of Hamster, Rat, Monkey, and Man | Johann W. Wiechers, Ben F. H. Drenth, Frank A. W. Adolfsen, Lia Prins and Rokus A. de Zeeuw |
| 500-503 | Nasal Absorption Enhancement of 17β-Estradiol by Dimethyl-β-Cyclodextrin in Rabbits and Rats | Walter A. J. J. Hermens, Marc J. M. Deurloo, Stefan G. Romeyn, J. Coos Verhoef and Frans W. H. M. Merkus |
| 504-507 | Quantification of Three Lidocaine Metabolites and Their Conjugates | Yun K. Tam, June Ke, Ronald T. Coutts, D. George Wyse and Murray R. Gray |
| 508-512 | The Liposome as a Model Membrane in Correlations of Partitioning with α-Adrenoceptor Agonist Activities | Young W. Choi and James A. Rogers |
| 513-517 | Dose-Dependent Pharmacokinetics of Carbamazepine in Rats: Determination of the Formation Clearance of Carbamazepine-10,11-epoxide | Rory P. Remmel, Michael W. Sinz and James C. Cloyd |
| 518-522 | Estimate of Volume/Flow Ratio of Gastrointestinal (GI) Fluids in Humans Using Pharmacokinetic Data | Panayotis Macheras, Christos Reppas and Jennifer B. Dressman |
| 523-529 | Solvent Interaction with Polydimethylsiloxane Membranes and Its Effects on Benzocaine Solubility and Diffusion | Karl M. Gelotte and Richard T. Lostritto |
| 530-536 | High-Performance Liquid Chromatographic (HPLC) and HPLC-Mass Spectrometric (MS) Analysis of the Degradation of the Luteinizing Hormone-Releasing Hormone (LH-RH) Antagonist RS-26306 in Aqueous Solution | Robert G. Strickley, Michael Brandl, Kelvin W. Chan, Kenneth Straub and Leo Gu |
| 537-541 | Drug Binding and Solubility in Milk | Panayotis E. Macheras, Michael A. Koupparis and Sophia G. Antimisiaris |
| 542-546 | Preparation of Asialofetuin-Labeled Liposomes with Encapsulated Human Interferon-γ and Their Uptake by Isolated Rat Hepatocytes | Hiroshi Ishihara, Toshifumi Hara, Yukihiko Aramaki, Seishi Tsuchiya and Kaoru Hosoi |
| 547-552 | The Effect of Sodium Tauro-24,25-Dihydrofusidate on the Nasal Absorption of Human Growth Hormone in Three Animal Models | Patricia A. Baldwin, Corine K. Klingbeil, Carla J. Grimm and John P. Longenecker |
| 553-557 | Adenosine Triphosphate Liposomes: Encapsulation and Distribution Studies | Xu Guo-Xing, Xie Xing-Hui, Liu Fang-Yu, Zang De-Liang and Zheng Dao-Sheng, et al. |
| 558-560 | Oral Bioavailability of Triamcinolone Tablets and a Triamcinolone Diacetate Suspension | Günther Hochhaus, Martin Pörtner, Jürgen Barth, Helmut Möllmann and Peter Rohdewald |
| 561 | A Better Way to Present Posters | Lewis J. Leeson and Gerhard Levy |
| 561-562 | BOOK REVIEWS |
| 562 | BOOK REVIEWS |
| 563 | BOOK REVIEWS |
| 563 | ADDENDUM |
| 564 | Association News and Announcements |
| 565-569 | Pulmonary Delivery of Peptide Drugs: Effect of Particle Size on Bioavailability of Leuprolide Acetate in Healthy Male Volunteers | Akwete Adjei and Julie Garren |
| 570-576 | Simultaneous Modeling of the Pharmacokinetic and Pharmacodynamic Properties of Benzodiazepines. II. Triazolam | Samir K. Gupta, Everett H. Ellinwood, Arlene M. Nikaido and Douglas G. Heatherly |
| 577-586 | Development of a Preformulation Lipophilicity Screen Utilizing a C-18-Derivatized Polystyrene-Divinylbenzene High-Performance Liquid Chromatographic (HPLC) Column | William J. Lambert and Latrelle A. Wright |
| 587-592 | Pharmacokinetics of a Mouse/Human Chimeric Monoclonal Antibody (C-17-1 A) in Metastatic Adenocarcinoma Patients | John M. Trang, Albert F. LoBuglio, Richard H. Wheeler, Elizabeth B. Harvey and Lee Sun, et al. |
| 593-599 | Chemical Pathways of Peptide Degradation. I. Deamidation of Adrenocorticotropic Hormone | Neelima P. Bhatt, Kamlesh Patel and Ronald T. Borchardt |
| 600-605 | Testing of Insulin Hexamer-Stabilizing Ligands Using Theoretical Binding, Microcalorimetry, and Nuclear Magnetic Resonance (NMR) Line Broadening Techniques | Scott E. McGraw, David J. Craik and Siegfried Lindenbaum |
| 606-611 | The Use of Microcalorimetry to Measure Thermodynamic Parameters of the Binding of Ligands to Insulin | Scott E. McGraw and Siegfried Lindenbaum |
| 612-615 | Pharmaceutical Usefulness of Hydroxypropylcyclodextrins: "E Pluribus Unum” Is an Essential Feature | C. Trinadha Rao, Henry M. Fales and Josef Pitha |
| 616-620 | Formulation and Dosage Form Design in Drug-Induced Topical Irritation of the Gastrointestinal Tract | John W. Fara and Robert E. Myrback |
| 621-627 | Oleic Acid: Its Effects on Stratum Corneum in Relation to (Trans)Dermal Drug Delivery | Michael L. Francoeur, Guia M. Golden and Russell O. Potts |
| 628-632 | Constant-Rate Intravenous Infusion Methods for Estimating Steady-State Volumes of Distribution and Mean Residence Times in the Body for Drugs Undergoing Reversible Metabolism | Haiyung Cheng and William J. Jusko |
| 633-637 | Binding of Drugs in Milk: The Role of Casein in Milk Protein Binding | Thomas Stebler and Theodor W. Guentert |
| 638-643 | Metabolic Conversion of Cyoctol During Skin Passage in Humans | Rokus A. de Zeeuw, Renella E. Herder, Johann W. Wiechers and Ben F. H. Drenth |
| 644-647 | Effect of Dextran Sulfate on Renal Accumulation of Gentamicin | Shinji Kikuchi, Yukihiko Aramaki, Homare Nonaka and Seishi Tsuchiya |
| 648-653 | The Effect of Physical Aging on the Dissolution Rate of Anionic Polyelectrolytes | Christopher M. Sinko, Albert F. Yee and Gordon L. Amidon |
| 654-657 | The Relationship Between the Glass Transition Temperature and Water Vapor Absorption by Poly(vinylpyrrolidone) | Cynthia A. Oksanen and George Zografi |
| 658-664 | Application of a Brain-Targeting Chemical Delivery System to 9-Amino-1,2,3,4-Tetrahydroacridine | Emil Pop, Katalin Prókai-Tátrai, James D. Scott, Marcus E. Brewster and Nicholas Bodor |
| 665-669 | Characterization of Epidermal Growth Factor Receptors on Plasma Membranes Isolated from Rat Gastric Mucosa | Ryohei Hori, Hisashi Nomura, Seigo Iwakawa and Katsuhiko Okumura |
| 670-672 | Effects of Amantadine on Dopaminergic Neurons in Discrete Regions of the Rat Brain | Katsuo Toide |
| 673-676 | Comparisons of in Vitro Nitroglycerin (TNG) Flux Across Yucatan Pig, Hairless Mouse, and Human Skins | Mary E. Roberts and Karl R. Mueller |
| 677-680 | Influence of Absorption Rate, Dosing Frequency, and Intrinsic Pharmacokinetic Profile on Steady-State Drug Concentrations | Michael A. Eldon and Wayne A. Colburn |
| 681 | BOOK REVIEWS |
| 682 | Association News and Announcements |
| 683-690 | Crystallographic Consequences of Molecular Dissymmetry | Harry G. Brittain |
| 691-696 | Relationships in the Structure–Tissue Distribution of Basic Drugs in the Rabbit | Koichi Yokogawa, Emi Nakashima, Junko Ishizaki, Hitoshi Maeda and Taizo Nagano, et al. |
| 697-702 | Optimization of the Therapeutic Index by Adjustment of the Rate of Drug Administration or Use of Drug Combinations: Exploratory Studies of Diuretics | Jianguo Zhi and Gerhard Levy |
| 703-711 | Chemical Pathways of Peptide Degradation. II. Kinetics of Deamidation of an Asparaginyl Residue in a Model Hexapeptide | Kamlesh Patel and Ronald T. Borchardt |
| 712-718 | Contributions of Drug Solubilization, Partitioning, Barrier Disruption, and Solvent Permeation to the Enhancement of Skin Permeation of Various Compounds with Fatty Acids and Amines | Bruce J. Aungst, Judy A. Blake and Munir A. Hussain |
| 719-722 | Sulfate Homeostasis. II. Influence of Chronic Aspirin Administration on Inorganic Sulfate in Humans | Marilyn E. Morris and Lisa Jo Benincosa |
| 723-725 | Site- and Stereospecific Ocular Drug Delivery by Sequential Enzymatic Bioactivation | Nicholas Bodor and Laszlo Prokai |
| 726-729 | Optical Purity Determination of threo-Methylphenidate Hydrochloride Using a Chiral Europium Nuclear Magnetic Resonance (NMR) Shift Reagent | George M. Hanna and Cesar A. Lau-Cam |
| 730-735 | Influence of Temperature and Hydrophobic Group-Associated Icebergs on the Activation Energy of Drug Decomposition and Its Implication in Drug Shelf-Life Prediction | Anil K. Kishore and Janardan B. Nagwekar |
| 736-741 | Vidarabine-Loaded Nanoparticles: A Physicochemical Study | Véronique Guise, Jehan-Yves Drouin, Jacqueline Benoit, Jacqueline Mahuteau and Pierre Dumont, et al. |
| 742-745 | The Metabolism of CGP-291: The Use of Microorganisms as Models of Mammalian Metabolism | Tannis M. Jürgens and Alice M. Clark |
| 746-750 | Quantitative Correlations and Reexamination of the Importance of Hydrophobic and Steric Factors in Anticholinergic Drug Receptor Interactions | Samitendu Banerjee and Eric J. Lien |
| 751-755 | Kinetics and Pattern of Degradation of Thyrotropin-Releasing Hormone (TRH) in Human Plasma | Judi Møss and Hans Bundgaard |
| 756-761 | Upper Gastrointestinal (GI) pH in Young, Healthy Men and Women | Jennifer B. Dressman, Rosemary R. Berardi, Lambros C. Dermentzoglou, Tanya L. Russell and Stephen P. Schmaltz, et al. |
| 762-766 | Percutaneous Absorption Enhancement of an Ionic Molecule by Ethanol–Water Systems in Human Skin | Tamie Kurihara-Bergstrom, Kristine Knutson, Linda J. DeNoble and Cynthia Y. Goates |
| 767-771 | Intestinal Transport of Sulfanilic Acid in Rats Immunized with Protein–Sulfanilic Acid Conjugate | A. Yamamoto, T. Kawaratani, K. Kawashima, M. Hashida and H. Sezaki |
| 772-776 | Nasal Absorption Enhancers for Biosynthetic Human Growth Hormone in Rats | Derek T. O'Hagan, Helen Critchley, Nidal F. Farraj, Anthony N. Fisher and Bente R. Johansen, et al. |
| 777-779 | Influence of Food on the Bioavailability of Ro 15-0778 in Humans | Alice A. Holazo, Evelyn E. Pinili, Francis T. De Grazia and Indravadan H. Patel |
| 780 | BOOK REVIEWS |
| 780 | BOOK REVIEWS |
| 780-781 | BOOK REVIEWS |
| 782-785 | Academic Pharmaceutics: The Challenge of Excellence | AAPS Task Force |
| 786 | Comment on “Academic Pharmaceutics: The Challenge of Excellence” | Wayne A. Colburn |
| 787-793 | Chemical Pathways of Peptide Degradation. III. Effect of Primary Sequence on the Pathways of Deamidation of Asparaginyl Residues in Hexapeptides | Kamlesh Patel and Ronald T. Borchardt |
| 794-800 | Stereochemical Characterization of the Diastereomers of the Amobarbital N-Glucosides Excreted in Human Urine | William H. Soine, Phyllis J. Soine, Fred C. Wireko and Donald J. Abraham |
| 801-807 | An Electrotopological-State Index for Atoms in Molecules | Lemont B. Kier and Lowell H. Hall |
| 808-815 | The Molecular Weight Dependence of Nasal Absorption: The Effect of Absorption Enhancers | Maureen D. Donovan, Gordon L. Flynn and Gordon L. Amidon |
| 816-823 | Biochemical and Mechanical Characterization of Enzyme-Digestible Hydrogels | Waleed S. W. Shalaby and Kinam Park |
| 824-834 | Efficiency of Cytoplasmic Delivery by pH-Sensitive Liposomes to Cells in Culture | Chun-Jung Chu, Jan Dijkstra, Ming-Zong Lai, Keelung Hong and Francis C. Szoka |
| 835-841 | Percutaneous Penetration Enhancement in Vivo Measured by Attenuated Total Reflectance Infrared Spectroscopy | Vivien H. W. Mak, Russell O. Potts and Richard H. Guy |
| 842-847 | Transdermal Delivery of Narcotic Analgesics: pH, Anatomical, and Subject Influences on Cutaneous Permeability of Fentanyl and Sufentanil | Samir D. Roy and Gordon L. Flynn |
| 848-851 | A Method for Quantifying Particle Absorption from the Small Intestine of the Mouse | James P. Ebel |
| 852-855 | Enhanced Intestinal Absorption of a Hydrophobic Polymer-Conjugated Protein Drug, Smancs, in an Oily Formulation | Kiichiro Oka, Yoichi Miyamoto, Yasuhiro Matsumura, Shohei Tanaka and Tatsuya Oda, et al. |
| 856-862 | Thermodynamics and Mathematical Modeling of the Partitioning of Chlorpromazine Between n-Octanol and Aqueous Buffer | Shiaw-Wen Cheng, Ravi Shanker and Siegfried Lindenbaum |
| 863-868 | Absorption of Polyethylene Glycols 600 Through 2000: The Molecular Weight Dependence of Gastrointestinal and Nasal Absorption | Maureen D. Donovan, Gordon L. Flynn and Gordon L. Amidon |
| 869-873 | Beta-Cyclodextrin/Steroid Complexation: Effect of Steroid Structure on Association Equilibria | Fang-yu Liu, Dane O. Kildsig and Ashim K. Mitra |
| 874-878 | Performance of Diltiazem Tablet and Multiparticulate Osmotic Formulations in the Dog | Steven C. Sutton, Karen Engle, Rodney A. Deeken, Kathleen E. Plute and Richard D. Shaffer |
| 879-883 | A Redox-Based System that Enhances Delivery of Estradiol to the Brain: Pharmacokinetic Evaluation in the Dog | Klaus Dietzel, Volker Keuth, Kerry S. Estes, Marcus E. Brewster and Roger M. Clemmons, et al. |
| 884 | BOOK REVIEWS |
| 884 | BOOK REVIEWS |
| 885-892 | Prodrugs of Peptides. 6. Bioreversible Derivatives of Thyrotropin-Releasing Hormone (TRH) with Increased Lipophilicity and Resistance to Cleavage by the TRH-Specific Serum Enzyme | Hans Bundgaard and Judi Møss |
| 893-901 | Diffusion in Porous Materials Above the Percolation Threshold | Jayne E. Hastedt and James L. Wright |
| 902-910 | Caco-2 Cell Monolayers as a Model for Drug Transport Across the Intestinal Mucosa | Allen R. Hilgers, Robert A. Conradi and Philip S. Burton |
| 911-918 | Determination of Solute–Polymer Interaction Properties and Their Application to Parenteral Product Container Compatibility Evaluations | Richard A. Kenley and Dennis R. Jenke |
| 919-922 | Synthesis and Calcium Channel Antagonist Activity of 3-Arylmethyl 5-Isopropyl l,4-Dihydro-2,6-dimethyl-4-(pyridyl)-3,5-pyridinedicarboxylates | Murthy R. Akula, Wandikayi C. Matowe, Michael W. Wolowyk and Edward E. Knaus |
| 923-927 | Structure Elucidation and Thermospray High-Performance Liquid Chromatography/Mass Spectroscopy (HPLC/MS) of the Microbial and Mammalian Metabolites of the Antimalarial Arteether | Charles D. Hufford, Ik-Soo Lee, Hala N. ElSohly, Hsien Tao Chi and John K. Baker |
| 928-934 | Influence of Average Molecular Weights of Poly(DL-Lactic Acid-Co-Glycolic Acid) Copolymers 50/50 on Phase Separation and in Vitro Drug Release from Microspheres | Jean-Marc Ruiz, Jean-Pierre Busnel and Jean-Pierre Benoît |
| 935-941 | Physicochemical Factors Associated with Binding and Retention of Compounds in Ocular Melanin of Rats: Correlations Using Data from Whole-Body Autoradiography and Molecular Modeling for Multiple Linear Regression Analyses | Patricia A. Zane, Shirley D. Brindle, Douglas O. Gause, Arlene J. O'Buck and Palayakotai R. Raghavan, et al. |
| 942-947 | Melting Point, Boiling Point, and Symmetry | Robert Abramowitz and Samuel H. Yalkowsky |
| 948-952 | Enhanced Delivery of Zidovudine Through Rat and Human Skin via Ester Prodrugs | Toshinobu Seki, Takeo Kawaguchi and Kazuhiko Juni |
| 953-956 | Comparison of Single-Dose and Steady-State Nadolol Plasma Concentrations | Julie J. Krukemyer, Harisios Boudoulas, Philip F. Binkley and John J. Lima |
| 957-961 | Solubilization of Liposomes by Weak Electrolyte Drugs. I. Propranolol | James A. Rogers, Gurupadappa V. Betageri and Young W. Choi |
| 962-966 | Particle Size and Content Uniformity | Samuel H. Yalkowsky and Sanford Bolton |
| 967-972 | Influence of Solute Degradation on the Accumulation of Solutes Migrating into Solution from Polymeric Parenteral Containers | Lawrence A. Cruz, Mai P. Jenke, Richard A. Kenley, Ming J. Chen and Dennis R. Jenke |
| 973 | BOOK REVIEWS |
| 973 | BOOK REVIEWS |
| 973 | BOOK REVIEWS |
| 974 | ERRATUM |
| 975-982 | In Vitro and in Vivo Testing and Correlation for Oral Controlled/Modified-Release Dosage Forms | Jerome P. Skelly, Gordon L. Amidon, William H. Barr, Leslie Z. Benet and James E. Carter, et al. |
| 983-987 | The Development of USP Dissolution and Drug Release Standards | Jordan L. Cohen, Barbara B. Hubert, Lewis J. Leeson, Christopher T. Rhodes and Joseph R. Robinson, et al. |
| 988-989 | Treating Seriously Ill Patients with Experimental Drugs | Francis B. Palumbo |
| 990-994 | Solute Absorption from the Airways of the Isolated Rat Lung. III. Absorption of Several Peptidase-Resistant, Synthetic Polypeptides: Poly-(2-Hydroxyethyl)-Aspartamides | Ralph W. Niven, Frantisek Rypacek and Peter R. Byron |
| 995-1002 | In Vitro Skin Permeation and Bioassay of Chlorhexidine Phosphanilate, a New Antimicrobial Agent | Jonas C. T. Wang, Robert R. Williams, Lotte Wang and John Loder |
| 1003-1010 | Mean Interconversion Times and Distribution Rate Parameters for Drugs Undergoing Reversible Metabolism | Haiyung Cheng and William J. Jusko |
| 1011-1018 | Growth Hormone (GH) Secretory Dynamics in Animals Administered Estradiol Utilizing a Chemical Delivery System | William J. Millard, Teresa M. Romano, Nicholas Bodor and James W. Simpkins |
| 1019-1025 | Phosphatidylserine as a Determinant for the Tissue Distribution of Weakly Basic Drugs in Rats | Noboru Yata, Toshihiko Toyoda, Teruo Murakami, Akio Nishiura and Yutaka Higashi |
| 1026-1032 | Application of Radiotelemetric Technique in Evaluating Diclofenac Sodium Absorption After Oral Administration of Various Dosage Forms in Healthy Volunteers | Keith K. H. Chan, Parviz Mojaverian, Barbara A. Ziehmer and Vivian A. John |
| 1033-1037 | Evaluation of a Noninvasive Method for Monitoring Percutaneous Absorption of Lidocaine in Vivo | Gregory P. Kushla and Joel L. Zatz |
| 1038-1041 | Analysis of Hepatic Transport of Cefpiramide in Rats with Obstructive Jaundice by Using Isolated Hepatocytes | Tadanao Yamao, Seiya Nakayama, Yuji Kurosaki, Taiji Nakayama and Toshikiro Kimura |
| 1042-1047 | Use of Shed Snake Skin as a Model Membrane for in Vitro Percutaneous Penetration Studies: Comparison with Human Skin | Tomoo Itoh, Jun Xia, Ravi Magavi, Toshiaki Nishihata and J. Howard Rytting |
| 1048-1054 | Topical Drug Delivery from Thin Applications: Theoretical Predictions and Experimental Results | William Addicks, Norman Weiner, Gordon Flynn, Rane Curl and Elizabeth Topp |
| 1055-1060 | Binding of Pyrimethamine to Human Plasma Proteins and Erythrocytes | Anita C. Rudy and Wesley J. Poynor |
| 1061-1067 | Dose and Time-Course Evaluation of a Redox-Based Estradiol-Chemical Delivery System for the Brain. I. Tissue Distribution | Mohamad H. Rahimy, James W. Simpkins and Nicholas Bodor |
| 1068-1070 | A Method for Determination of the Absolute Pulmonary Bioavailability of Inhaled Drugs: Terbutaline | Lars Borgström and Marita Nilsson |
| 1071-1076 | Pharmacokinetic Screening of o-Naphthoquinone 5-Lipoxygenase Inhibitors | Ashok Rakhit, Steve K. Kuwahara, David R. Jones, Victor F. Soliman and Alvin N. Kotake, et al. |
| 1077-1081 | Microdialysis Sampling for Determination of Plasma Protein Binding of Drugs | Ada M. Herrera, Dennis O. Scott and Craig E. Lunte |
| 1082-1085 | Ultraviolet (UV) Absorption and Circular Dichroism (CD) Spectra of Captopril | Harry G. Brittain and Harold Kadin |
| 1086-1091 | The Effects of Formulation Additives on the Degradation of Freeze-Dried Ribonuclease A | Michael W. Townsend, Peter R. Byron and Patrick P. DeLuca |
| 1092-1097 | A Statistical Approach for the Development of an Oral Controlled-Release Matrix Tablet | Alton D. Johnson, Virgil L. Anderson and Garnet E. Peck |
| 1098 | Association News and Announcements |
| 1099-1106 | Transdermal Delivery of Bioactive Peptides: The Effect of n-Decylmethyl Sulfoxide, pH, and Inhibitors on Enkephalin Metabolism and Transport | Hoo-Kyun Choi, Gordon L. Flynn and Gordon L. Amidon |
| 1107-1112 | Dose and Time-Course Evaluation of a Redox-Based Estradiol-Chemical Delivery System for the Brain. II. Pharmacodynamic Responses | Mohamad H. Rahimy, James W. Simpkins and Nicholas Bodor |
| 1113-1118 | A Sensitive and Specific Liquid-Chromatographic Assay for Determination of Ganciclovir in Plasma and Urine and Its Application to Pharmacokinetic Studies in the Rabbit | Mohsen A. Hedaya and Ronald J. Sawchuk |
| 1119-1126 | Characterization of a Hot-Melt Fluid Bed Coating Process for Fine Granules | Michael J. Jozwiakowski, David M. Jones and Robert M. Franz |
| 1127-1133 | Nebulization of Liposomes. I. Effects of Lipid Composition | Ralph W. Niven and Hans Schreier |
| 1134-1140 | Theophylline-Controlled Release Preparations and Fatty Food: An in Vitro Study Using the Rotating Dialysis Cell Method | Silvia K. El-Arini, Gerald K. Shiu and Jerome P. Skelly |
| 1141-1146 | Electrical Analysis of Fresh, Excised Human Skin: A Comparison with Frozen Skin | Gerald B. Kasting and Lisa A. Bowman |
| 1147-1151 | In Vitro Skin Absorption and Metabolism of Benzoic Acid, p-Aminobenzoic Acid, and Benzocaine in the Hairless Guinea Pig | David Nathan, Adel Sakr, J. Leon Lichtin and Robert L. Bronaugh |
| 1152-1156 | Enhancement of the Antiinflammatory Effect of Ethyl 4-Biphenylyl Acetate in Ointment by β-Cyclodextrin Derivatives: Increased Absorption and Localized Activation of the Prodrug in Rats | Hidetoshi Arima, Hirotoshi Adachi, Tetsumi Irie, Kaneto Uekama and Josef Pitha |
| 1157-1162 | Solid and Liquid Heat Capacities of n-Alkyl Para-aminobenzoates Near the Melting Point | Steven H. Neau and Gordon L. Flynn |
| 1163-1166 | Gastrointestinal Transit of Nondisintegrating, Nonerodible Oral Dosage Forms in Pigs | Mohammad Hossain, Wattanaporn Abramowitz, Barbara J. Watrous, Gregory J. Szpunar and James W. Ayres |
| 1167-1171 | Release and Absorption Characteristics of Novel Theophylline Sustained-Release Formulations: In Vitro-in Vivo Correlation | Ziad Hussein and Michael Friedman |
| 1172-1176 | Evaluation of the Pharmacokinetic Interaction Between Diazepam and ACC-9653 (a Phenytoin Prodrug) in Healthy Male Volunteers | Elizabeth K. Hussey, George E. Dukes, John A. Messenheimer, Kim L. R. Brouwer and Karl H. Donn, et al. |
| 1177-1180 | Determination of Temafloxacin, Sarafloxacin, and Difloxacin in Bulk Drug and Dosage Forms by High-Performance Liquid Chromatography | John F. Bauer, Lee Elrod, Jr., Joseph R. Fornnarino, Douglas E. Heathcote and Sue K. Krogh, et al. |
| 1181-1185 | Physical State of Misoprostol in Hydroxypropyl Methylcellulose Films | Tugrul T. Kararli, Thomas E. Needham, Cliff J. Seul, Pat M. Finnegan and Marianne I. Hidvegi, et al. |
| 1186-1189 | Stabilization of Misoprostol with Hydroxypropyl Methylcellulose (HPMC) Against Degradation by Water | Tugrul T. Kararli and Thomas Catalano |
| 1190-1194 | Release of Human Serum Albumin from Poly(lactide-co-glycolide) Microspheres | Maninder S. Hora, Rajsharan K. Rana, Jack H. Nunberg, Thomas R. Tice and Richard M. Gilley, et al. |
| 1195-1197 | A Flat Circular Hole Device for Zero-Order Release of Drugs: Characterization of the Moving Dissolution Boundary | Dinesh S. Mishra and Samuel H. Yalkowsky |
| 1198-1200 | Scintigraphic Evaluation of the Ocular Disposition of 18F-Imirestat in Rabbits | Ganesan Vaidyanathan, Michael Jay, Ranajit K. Bera, Philip R. Mayer and R. K. Brazzell |
| 1201-1204 | Epidermal Differentiation and Permeability in Fetal Pig Skin | Tamie Kurihara-Bergstrom, William R. Good, Carol Signer and Marguerite Woodworth |
| 1205-1207 | Morphine Impurity with Opioid Activity Is Identified as 10α-Hydroxymorphine | Hassan Farsam, Steven Eiger, Jelveh Lameh, Ahmad Rezvani and Bradford W. Gibson, et al. |
| 1208-1209 | Effects of a Diluent on the Retarded–Release Property of Acrylate Methacrylate–Salicylic Acid Coacervates | R. S. Okor and M. A. Yahaya |
| 1210 | BOOK REVIEWS |
| 1210 | BOOK REVIEWS |
| 1211 | BOOK REVIEWS |
| 1212 | Association News and Announcements |
| 1213-1221 | Structure and Function of G Protein Coupled Receptors | Jelveh Lameh, Ric I. Cone, Sadaaki Maeda, Mohan Philip and Maithe Corbani, et al. |
| 1222-1227 | Pharmacokinetics of a Single Intravenous and Oral Dose of Pafenolol—a Beta1Adrenoceptor Antagonist with Atypical Absorption and Disposition Properties—in Man | Carl G. Regårdh, Per Lundborg, Margareth Gabrielsson, Asger Heggelund and Kerstin Kylberg-Hanssen |
| 1228-1233 | Optimized Inhalation Aerosols. II. Inertial Testing Methods for Particle Size Analysis of Pressurized Inhalers | Elaine M. Phillips, Peter R. Byron, Kristen Fults and Anthony J. Hickey |
| 1234-1241 | Analytical Approaches to the Study of Monoclonal Antibody Stability | Wim Jiskoot, E. Coen Beuvery, Ada A. M. de Koning, James N. Herron and Daan J. A. Crommelin |
| 1242-1247 | An Experimental Model for Measuring Middle Ear Antimicrobial Drug Penetration in Otitis Media | Gregg H. Jossart, Gary R. Erdmann, David G. Levitt, Peter Kucera and Chap T. Le, et al. |
| 1248-1252 | The Pharmacokinetics of β-Cyclodextrin and Hydroxypropyl-β-cyclodextrin in the Rat | Henderik W. Frijlink, Jan Visser, Nanco R. Hefting, Roelof Oosting and Dirk K. F. Meijer, et al. |
| 1253-1256 | Stability of Gonadorelin and Triptorelin in Aqueous Solution | Volker J. Helm and Bernd W. Müller |
| 1257-1261 | Column-Switching High-Performance Liquid Chromatographic (HPLC) Determination of Hydrochlorothiazide in Rat, Dog, and Human Plasma | Be-Sheng Kuo, Arun Mandagere, David R. Osborne and Kin-Kai Hwang |
| 1262-1268 | Chiral Amines Derived from 2-Arylpropionic Acids: Novel Reagents for the Liquid Chromatographic (LC) Fluorescence Assay of Optically Active Carboxylic Acid Xenobiotics | Hildegard Spahn and Peter Langguth |
| 1269-1272 | Sesquiterpene Lactones and Other Constituents from a Cytotoxic Extract of Michelia floribunda | Ing-On Mondranondra, Chun-tao Che, Agnes M. Rimando, Srunya Vajrodaya and Harry H. S. Fong, et al. |
| 1273-1277 | Heat Sterilization of Bioindicators in Propylene Glycol and Propylene Glycol–Water Mixtures: Arrhenius Equation, Thermodynamic Data, and Z Values | Brigitte Philipp and Heinz Sucker |
| 1278-1281 | Amorphous-to-Crystalline Transformation of Sucrose | Jens T. Carstensen and Kurt Van Scoik |
| 1282-1288 | Aluminum Compounds Used as Adjuvants in Vaccines | Suhag Shirodkar, Robert L. Hutchinson, Darold L. Perry, Joe L. White and Stanley L. Hem |
| 1289-1293 | Improvement in Wound Healing by Epidermal Growth Factor (EGF) Ointment. I. Effect of Nafamostat, Gabexate, or Gelatin on Stabilization and Efficacy of EGF | Katsuhiko Okumura, Yoshifumi Kiyohara, Fusao Komada, Seigo Iwakawa and Midori Hirai, et al. |
| 1294-1297 | Cytotoxicity of Three Novel Fluoropyrimidines in Cultured L1210 Murine Lymphocytic Leukemia Cells | Annette M. Shipp, Mark H. Holshouser and Paul W. Ferguson |
| 1298-1301 | Cutaneous Pharmacodynamics of Transdermally Delivered Isosorbide Dinitrate | Mitsuhiko Hori, Saburoh Ohtsuka, Masaki Sunami, Richard H. Guy and Howard I. Maibach |
| 1302-1306 | A Method to Predict the Percutaneous Permeability of Various Compounds: Shed Snake Skin as a Model Membrane | Tomoo Itoh, Ravi Magavi, Roger L. Casady, Toshiaki Nishihata and J. Howard Rytting |
| 1307-1312 | Investigations on the Percutaneous Absorption of the Antidepressant Rolipram in Vitro and in Vivo | Jonathan Hadgraft, Stephanie Hill, Michael Hümpel, Linda R. Johnston and Lawrence R. Lever, et al. |
| 1313-1319 | Mechanism of L-α-Methyldopa Transport Through a Monolayer of Polarized Human Intestinal Epithelial Cells (Caco-2) | Ming Hu and Ronald T. Borchardt |
| 1320-1324 | Optimization of Topical Therapy: Partitioning of Drugs into Stratum Corneum | Christian Surber, Klaus-P. Wilhelm, Mitsuhiko Hori, Howard I. Maibach and Richard H. Guy |
| 1325-1328 | Solubility and lonization Behavior of the Antiarrhythmic 4-hydroxy-N-phenyl-3,5-bis(l-pyrrolidinylmethyl)benzamide dihydrochloride (DuP 923) | Michael B. Maurin, George Dowuona-Owoo and George Torosian |
| 1329 | BOOK REVIEWS |
| 1329-1330 | BOOK REVIEWS |
| 1330 | BOOK REVIEWS |
| 1330-1331 | BOOK REVIEWS |
| 1331 | Letters to the Editor | Klaus G. Florey, John W. Fara and Robert E. Myrback |
| 1332-1333 | Reviewers for Pharmaceutical Research (October 1989-October 1990) |
| 1334-1336 | Author Index to Volume 7 (1990) |
| 1337-1345 | Subject Index to Volume 1 (1990) |
| 1346 | Association News and Announcements |
| 1-8 | Development of Delta Opioid Peptides as Nonaddicting Analgesics | Rao S. Rapaka and Frank Porreca |
| 9-16 | The Effect of Parenterally Administered Cyclodextrins on Cholesterol Levels in the Rat | Henderik W. Frijlink, Anko C. Eissens, Nanco R. Hefting, Klaas Poelstra and Coenraad F. Lerk, et al. |
| 17-24 | Terpenes and the Lipid–Protein–Partitioning Theory of Skin Penetration Enhancement | Adrian C. Williams and Brian W. Barry |
| 25-32 | The Role of Metabolites in Bioequivalency Assessment. I. Linear Pharmacokinetics without First-Pass Effect | Mei-Ling Chen and André J. Jackson |
| 33-39 | Quantification of Imipenem’s Primary Metabolite in Plasma by Postcolumn Chemical Rearrangement and UV Detection | Donald G. Musson, Richard Hajdu, William F. Bayne and John D. Rogers |
| 40-42 | Absorption and Disposition of Colloidal Drug Delivery Systems. I. High-Performance Liquid Chromatographic (HPLC) Analysis of a Cyclosporin Emulsion | Susan J. Corvari, R. Gary Hollenbeck, James Leslie, Karen I. Plaisance and David Young |
| 43-46 | Quantitative Structure–Activity Relationships (QSARs) of Pyrimidine Nucleosides as HIV-1 Antiviral Agents | Massoud Mahmoudian |
| 47-54 | Optimization of Spray-Dried and -Congealed Lipid Micropellets and Characterization of Their Surface Morphology by Scanning Electron Microscopy | Türkan Eldem, Peter Speiser and Atilla Hincal |
| 55-59 | In Vitro Release of Hydrocortisone from Topical Preparations and Automated Procedure | Vinod P. Shah, Jerome Elkins, James Hanus, Carol Noorizadeh and Jerome P. Skelly |
| 60-64 | Enhanced Bioavailability of Subcutaneously Injected Insulin by Pretreatment with Ointment Containing Protease Inhibitors | Masaharu Takeyama, Toshihiko Ishida, Noriko Kokubu, Fusao Komada and Seigo Iwakawa, et al. |
| 65-69 | Role of Complements C3 and C5 in the Phagocytosis of Liposomes by Human Neutrophils | Jeffrey F. Scieszka, Linda L. Maggiora, Samuel D. Wright and M. J. Cho |
| 70-75 | A Comparison of Peptidase Activities and Peptide Metabolism in Cultured Mouse Keratinocytes and Neonatal Mouse Epidermis | Praful K. Shah and Ronald T. Borchardt |
| 76-79 | Studies in Phlebitis: Detection and Quantitation Using a Thermographic Camera | Gary H. Ward, Paul E. Nolan, Monica Chawla and Samuel H. Yalkowsky |
| 80-83 | Precipitation of the Renin Inhibitor Ditekiren Upon iv Infusion; in Vitro Studies and Their Relationship to in Vivo Precipitation in the Cynomolgus Monkey | Stephen R. Davio, Margaret M. McShane, Thomas J. Kakuk, Renee M. Zaya and Serena L. Cole |
| 84-87 | Relationship Between Drug Absorption Enhancing Activity and Membrane Perturbing Effects of Acylcarnitines | Edward L. LeCluyse, Leah E. Appel and Steven C. Sutton |
| 88-92 | The Solubility-Modulated Osmotic Pump: In Vitro/in Vivo Release of Diltiazem Hydrochloride | Gregory A. McClelland, Steven C. Sutton, Karen Engle and Gaylen M. Zentner |
| 93-96 | Oral Absorption of Peptides: Influence of pH and Inhibitors on the Intestinal Hydrolysis of Leu-Enkephalin and Analogues | Doron I. Friedman and Gordon L. Amidon |
| 97-100 | Mechanism of Gastric Emptying of a Nondisintegrating Radiotelemetry Capsule in Man | Parviz Mojaverian, James C. Reynolds, Ann Ouyang, Fern Wirth and Paul E. Kellner, et al. |
| 101-105 | Jejunal Absorption, Pharmacological Activity, and Pharmacokinetic Evaluation of Indomethacin-Loaded Poly(d,l-Lactide) and Poly(Isobutyl-Cyanoacrylate) Nanocapsules in Rats | Nazih Ammoury, Hatem Fessi, Jean-Philippe Devissaguet, Marcelle Dubrasquet and Simon Benita |
| 106-111 | Thermal Injury Decreases Hepatic Blood Flow and the Intrinsic Clearance of Indocyanine Green in the Rat | Gary M. Pollack and Kim L. R. Brouwer |
| 112-118 | Dose-Dependent Pharmacokinetics of the Aldose Reductase Inhibitor Imirestat in Man | R. Kim Brazzell, Philip R. Mayer, Richard Dobbs, Patrick J. McNamara and Renli Teng, et al. |
| 119-122 | Structural Confirmation of Ampicillin Polymers Formed in Aqueous Solution | Hatsumi Aki, Nobuyoshi Sawai, Kenji Yamamoto and Magobei Yamamoto |
| 123-126 | Examination of Arrhenius Kinetics for an Antiarrhythmic Compound | Tugrul T. Kararli, Thomas Catalano and Richard M. Bittman |
| 127-130 | The Effects Of Hemodilution, pH, and Protamine on Lidocaine Plasma Protein Binding and Red Blood-Cell Uptake in Vitro | Rory P. Remmel, Alan K. Copa and David M. Angaran |
| 131-133 | Self-Release of Lipase from Compacts Materials | M. Hossein Zarrintan and Michael J. Groves |
| 134-135 | Intranasal Delivery of RS-93522, a Dihydropyridine-Type Calcium-Channel Antagonist | Roger Cherng-Chi Fu, John L. Whatley and Jeffrey S. Fleitman |
| 136-138 | Consensus Report on "Issues in the Evaluation of Bioavailability" | Iain J. McGilveray |
| 139 | Editorial |
| 140 | Reviewers for Pharmaceutical Research (November 1989-November 1990) |
| 141-147 | Mass Receptor Screening for New Drugs | Ronald M. Burch and Donald J. Kyle |
| 148-155 | Solid-State Phase Transitions Initiated by Water Vapor Sorption of Crystalline L-660,711, a Leukotriene D4 Receptor Antagonist | Elizabeth B. Vadas, Pascal Toma and George Zografi |
| 156-161 | Design and Manufacture of a Zero-Order Sustained-Release Pellet Dosage Form Through Nonuniform Drug Distribution in a Diffusional Matrix | Douglas C. Scott and R. Gary Hollenbeck |
| 162-167 | Extent and Variability of the First-Pass Elimination of Adinazolam Mesylate in Healthy Male Volunteers | Joseph C. Fleishaker, H. Friedman and Steven R. Pollock |
| 168-173 | A Method to Study Drug Concentration–Depth Profiles in Tissues: Mitomycin C in Dog Bladder Wall | M. Guillaume Wientjes, James T. Dalton, Robert A. Badalament, Bharat M. Dasani and Joseph R. Drago, et al. |
| 174-177 | Synthesis and in Vitro Receptor Binding Studies of Fluorotamoxifen Analogues | David J. Yang, Sidney Wallace, Wayne Tansey, Kenneth C. Wright and Li-Ren Kuang, et al. |
| 178-184 | Polymorphic Behavior of Sprayed Lipid Micropellets and Its Evaluation by Differential Scanning Calorimetry and Scanning Electron Microscopy | Türkan Eldem, Peter Speiser and Hans Altorfer |
| 185-190 | In Vitro Release Profile of Mitomycin C from Albumin Microspheres: Extrapolation from Macrospheres to Microspheres | Hideshi Natsume, Kenji Sugibayashi and Yasunori Morimoto |
| 191-195 | Water Vapor Adsorption and Desorption Isotherms of Biologically Active Proteins | C. Diana Teng, M. Hossein Zarrintan and Michael J. Groves |
| 196-199 | Opioid-Induced Respiratory Depression and Analgesia May Be Mediated by Different Subreceptors | Enno Freye, Martina Schnitzler and Gustav Schenk |
| 200-203 | High-Affinity [3H]THA (Tetrahydroaminoacridine) Binding Sites in Rat Brain | E. Edward Mena and Manoj C. Desai |
| 204-209 | Influence of Ultrasound on the Percutaneous Absorption of Nicotinate Esters | Heather A. E. Benson, James C. McElnay, Robin Harland and Jonathan Hadgraft |
| 210-216 | A Model of Human Small Intestinal Absorptive Cells. 1. Transport Barrier | J. Nita Cogburn, Matthew G. Donovan and Charles S. Schasteen |
| 217-221 | Nebulization of Liposomes. II. The Effects of Size and Modeling of Solute Release Profiles | Ralph W. Niven, Melissa Speer and Hans Schreier |
| 222-227 | Characterization of the Unstirred Water Layer in Caco-2 Cell Monolayers Using a Novel Diffusion Apparatus | Ismael J. Hidalgo, Kathleen M. Hillgren, George M. Grass and Ronald T. Borchardt |
| 228-231 | Model Selection for the Adsorption of Phenobarbital by Activated Charcoal | Gerald M. Burke, Dale Eric Wurster, Varaporn Buraphacheep, Mary J. Berg and Peter Veng-Pedersen, et al. |
| 232-237 | Computer-Aided Dosage Form Design. III. Feasibility Assessment for an Oral Prolonged-Release Phenytoin Product | Joy R. Irvin and Robert E. Notari |
| 238-241 | Effect of Competing Anions on Binding of Bile Salts by Cholestyramine | Rosemary Kos, Joe L. White, Stanley L. Hem and Marie T. Borin |
| 242-246 | Sulfate Homeostasis. III. Effect of Chronic Naproxen or Sulindac Treatment on Inorganic Sulfate Disposition in Arthritic Patients with Renal Impairment | Marilyn E. Morris, Jack P. Freer and William A. Watson |
| 247-253 | Hybrid Pharmacokinetic Models to Describe Anti-HIV Nucleoside Brain Disposition Following Parent and Prodrug Administration in Mice | James M. Gallo, Joseph T. Etse, Kokila J. Doshi, F. Douglas Boudinot and Chung K. Chu |
| 254-258 | Simple Methods for Estimation of Mean Residence Time and Steady-State Volume of Distribution from Continuous-Infusion Data | William R. Gillespie |
| 259-262 | Stereoselective Transport of Baclofen Across the Blood–Brain Barrier in Rats as Determined by the Unit Impulse Response Methodology | Joost B. M. M. van Bree, Corrie D. Heijligers-Feijen, Albertus G. de Boer, Meindert Danhof and Douwe D. Breimer |
| 263-268 | Pharmacodynamics of Methylprednisolone Phosphate After Single Intravenous Administration to Healthy Volunteers | Hartmut Derendorf, Helmut Möllmann, Michael Krieg, Sabine Tunn and Carsten Möllmann, et al. |
| 269-272 | Simplified Determination of Antipyrine Clearance by Liquid Chromatography of a Microsample of Saliva or Plasma | Adnan El-Yazigi, Dale A. Raines, Hatim Ali, Jens Sieck and Peter Ernst, et al. |
| 273-277 | Protection Against Microcystin-LR-Induced Hepatotoxicity by Silymarin: Biochemistry, Histopathology, and Lethality | Kay A. Mereish, David L. Bunner, Danny R. Ragland and Donald A. Creasia |
| 278-281 | Prediction of Acute Graft Rejection in Renal Transplantation: The Utility of Cyclosporine Blood Concentrations | Joachim Grevel, Kimberly L. Napoli, Maria S. Welsh, Neely E. Atkinson and Barry D. Kahan |
| 282-284 | The Relationship Between Urine and Plasma Concentrations of Carbamazepine: Implications for Therapeutic Drug Monitoring | William F. Elmquist, Lillian E. Riad, Ilo E. Leppik and Ronald J. Sawchuk |
| 285-291 | Protein–Solvent Interactions in Pharmaceutical Formulations | Tsutomu Arakawa, Yoshiko Kita and John F. Carpenter |
| 292-297 | Preformulation Studies Involving Moisture Uptake in Solid Dosage Forms | Dorothy R. Heidemann and Paul J. Jarosz |
| 298-305 | Calculation of the Aqueous Diffusion Layer Resistance for Absorption in a Tube: Application to Intestinal Membrane Permeability Determination | Jim H. Kou, David Fleisher and Gordon L. Amidon |
| 306-312 | Relationship of Apparent Systemic Clearance to Individual Organ Clearances: Effect of Pulmonary Clearance and Site of Drug Administration and Measurement | Reza Mehvar |
| 313-322 | Prodrugs of Peptides. 9. Bioreversible N-α-Hydroxyalkylation of the Peptide Bond to Effect Protection Against Carboxypeptidase or Other Proteolytic Enzymes | Hans Bundgaard and GitteJuel Rasmussen |
| 323-330 | Amine Prodrugs Which Utilize Hydroxy Amide Lactonization. I. A Potential Redox-Sensitive Amide Prodrug | Kent L. Amsberry and Ronald T. Borchardt |
| 331-335 | Bead Coating. I. Change in Release Kinetics (and Mechanism) Due to Coating Levels | Guohua Zhang, Joseph B. Schwartz and Roger L. Schnaare |
| 336-340 | Effect of Moisture Content on Compression Properties of Two Dextrose-Based Directly Compressible Diluents | Atul J. Shukla and James C. Price |
| 341-344 | Production of 5–15 µm Diameter Alginate-Polylysine Microcapsules by an Air-Atomization Technique | K.Keith Kwok, Michael J. Groves and Diane J. Burgess |
| 345-349 | Thermorheologic Properties of Aqueous Solutions and Gels of Tetronic 1508 | Christopher W. Spancake, Dane O. Kildsig and Ashim K. Mitra |
| 350-354 | Evidence that Oleic Acid Exists in a Separate Phase Within Stratum Corneum Lipids | Boonsri Ongpipattanakul, Ronald R. Burnette, Russell O. Potts and Michael L. Francoeur |
| 355-359 | Constant Potassium Chloride Release from Microporous Membrane-Coated Tablets Prepared with Aqueous Colloidal Polymer Dispersions | Roland Bodmeier and Ornlaksana Paeratakul |
| 360-364 | Variation in Gastrointestinal Transit of Pharmaceutical Dosage Forms in Healthy Subjects | Alastair J. Coupe, Stanley S. Davis and Ian R. Wilding |
| 365-369 | Study of the Mechanisms of Flux Enhancement Through Hairless Mouse Skin by Pulsed DC Iontophoresis | Michael J. Pikal and Saroj Shah |
| 370-375 | Sites of First-Pass Bioactivation (Hydrolysis) of Orally Administered Zofenopril Calcium in Dogs | Richard A. Morrison, Dennis E. Burkett, Mark E. Arnold, Celia J. D'Arienzo and Stephen H. Weinstein |
| 376-379 | Sulfate Homeostasis. IV. Probenecid-Induced Alterations of Inorganic Sulfate in Rats | Inger M. Darling and Marilyn E. Morris |
| 380-384 | The Effects of Cyclodextrins on the Disposition of Intravenously Injected Drugs in the Rat | Henderik W. Frijlink, Eric J. F. Franssen, Anko C. Eissens, Roelof Oosting and Coenraad F. Lerk, et al. |
| 385-388 | Pharmacokinetics of Multiple Daily Transdermal Doses of Nicotine in Healthy Smokers | Holly D. Ross, Keith K. H. Chan, Anthony J. Piraino and Vivian A. John |
| 389-392 | In Vivo Microdialysis Sampling for Pharmacokinetic Investigations | Dennis O. Scott, Lori R. Sorenson, Karla L. Steele, DeAnna L. Puckett and Craig E. Lunte |
| 393-399 | Quantitative Analysis of the Active Tablet Ingredient by Powder X-Ray Diffractometry | Raj Suryanarayanan and Craig S. Herman |
| 400-402 | Determination of Degree of Substitution of Formyl Groups in Polyaldehyde Dextran by the Hydroxylamine Hydrochloride Method | Huiru Zhao and Ned D. Heindel |
| 403-408 | Solubilization and in Vitro Spermicidal Assessment of Nonoxynol-9 and Selected Fractions Using Rabbit Spermatozoa | Brian A. Walter, Amale A. Hawi, Panayiotis M. Zavos and George A. Digenis |
| 409-411 | High-Performance Liquid Chromatographic (HPLC) Analysis of Oligomeric Components of the Spermicide Nonoxynol-9 | Brian A. Walter and George A. Digenis |
| 412-414 | The Effect of Pancreatin on the Dissolution Performance of Gelatin-Coated Tablets Exposed to High-Humidity Conditions | Terrence C. Dahl, I-Lan T. Sue and Alicia Yum |
| 415-417 | Kinetics of Drug Action in Disease States. XL. Effect of the Dialyzable Component(s) of Uremic Blood on Theophylline Neurotoxicity in Rats | Amnon Hoffman and Gerhard Levy |
| 418 | BOOK REVIEWS |
| 419 | Letters to the Editor | Henry C. Caldwell and Samuel H. Yalkowsky |
| 420 | Association News and Announcements |
| 421-426 | Validation of Bioanalytical Methods | H. Thomas Karnes, Gerald Shiu and Vinod P. Shah |
| 427-436 | The Effects of Formulation Variables on the Stability of Freeze-Dried Human Growth Hormone | Michael J. Pikal, Karen M. Dellerman, Michael L. Roy and Ralph M. Riggin |
| 437-444 | Hepatic Disposition Characteristics of Electrically Charged Macromolecules in Rat in Vivo and in the Perfused Liver | Koyo Nishida, Kiyoshi Mihara, Toichi Takino, Sachi Nakane and Yoshinobu Takakura, et al. |
| 445-454 | Colon-Specific Delivery of Dexamethasone from a Glucoside Prodrug in the Guinea Pig | Thomas N. Tozer, Jean Rigod, Andrew D. McLeod, Ramon Gungon and M. Kim Hoag, et al. |
| 455-461 | Amine Prodrugs Which Utilize Hydroxy Amide Lactonization. II. A Potential Esterase-Sensitive Amide Prodrug | Kent L. Amsberry, A. Elise Gerstenberger and Ronald T. Borchardt |
| 462-470 | Molecular Structure and Dynamics of cis(Z)- and trans(E)-Flupenthixol and Clopenthixol | Ingebrigt Sylte and Svein G. Dahl |
| 471-474 | Effects of Viscous Hyaluronate–Sodium Solutions on the Nasal Absorption of Vasopressin and An Analogue | Kazuhiro Morimoto, Hiroshi Yamaguchi, Yasushi Iwakura, Katsuaki Morisaka and Yoshihiro Ohashi, et al. |
| 475-479 | In Vitro Evaluation of the Plasma and Blood Compatibility of a Parenteral Formulation for Ditekiren, a Novel Renin Inhibitor Pseudopeptide | John C. Greenfield, Sheryl J. Loux, Virendra K. Sood, Kathryn M. Jenkins and Stephen R. Davio |
| 480-484 | Inactivation Kinetics of Enzyme Pharmaceuticals in Aqueous Solution | Sumie Yoshioka, Ken-ichi Izutsu, Yukio Aso and Yasushi Takeda |
| 485-490 | Stability of Interleukin 1β (IL-1β) in Aqueous Solution: Analytical Methods, Kinetics, Products, and Solution Formulation Implications | Leo C. Gu, Elizabeth A. Erdös, Hi-Shi Chiang, Thomas Calderwood and Kelly Tsai, et al. |
| 491-497 | Effect of Polyethylene Glycol 400 on the Intestinal Permeability of Carbamazepine in the Rabbit | Lillian E. Riad and Ronald J. Sawchuk |
| 498-501 | Effects of Deoxycholate on the Transepithelial Transport of Sucrose and Horseradish Peroxidase in Filter-Grown Madin–Darby Canine Kidney (MDCK) Cells | Yi-Jing Lin and Wei-Chiang Shen |
| 502-504 | Cosolvency of Dimethyl Isosorbide for Steroid Solubility | Hossein Zia, Joseph K. H. Ma, John P. O'Donnell and Louis A. Luzzi |
| 505-507 | Molecular Motion of Drugs in Hydrocolloids Measured by Electron Paramagnetic Resonance | Julijana Kristl, Slavko Pečar, Jelka Šmid-Korbar and Milan Schara |
| 508-511 | Mean Residence Times and Distribution Volumes for Drugs Undergoing Linear Reversible Metabolism and Tissue Distribution and Linear or Nonlinear Elimination from the Central Compartments | Haiyung Cheng and William J. Jusko |
| 512-517 | Suitability of Various Noninfinity Area Under the Plasma Concentration–Time Curve (AUC) Estimates for Use in Bioequivalence Determinations: Relationship to AUC from Zero to Time Infinity (AUCO–INF) | Marilyn N. Martinez and Andre J. Jackson |
| 518-522 | The Preparation and Evaluation of a Tablet Dosage Form of Cyclosporine in Dogs | Hisham Y. Abdallah and Michael Mayersohn |
| 523-526 | High-Performance Liquid Chromatographic (HPLC) Determination of Lobenzarit in Plasma and Its Application to a Bioavailability Study in Beagle Dogs | Francis J. Schwende and Scott W. Turner |
| 527-530 | Synthesis of Poly(Hydroxypropylglutamine-Prazosin Carbamate) and Release Studies | Xiaoling Li, Nathan W. Adams, David B. Bennett, Jan Feijen and Sung Wan Kim |
| 531-537 | “On–Off” Thermocontrol of Solute Transport. I. Temperature Dependence of Swelling of N-Isopropylacrylamide Networks Modified with Hydrophobic Components in Water | You Han Bae, Teruo Okano and Sung Wan Kim |
| 538-540 | In Vitro Binding of Lorazepam and Lorazepam Glucuronide to Cholestyramine, Colestipol, and Activated Charcoal | Robert J. Herman and Archana Chaudhary |
| 541-543 | Determination of the Relative Formation and Elimination Clearance of Two Major Carbamazepine Metabolites in Humans: A Comparison Between Traditional and Pooled Sample Analysis | Lillian E. Riad, Keith K. Chan and Ronald J. Sawchuk |
| 544-546 | Drug Metabolism and Laboratory Anesthetic Protocols in the Rat: Examination of Antipyrine Pharmacokinetics | Mark Gumbleton and Leslie Z. Benet |
| 547-549 | Rapid High-Performance Liquid Chromatographic Analysis and Stability Study of Hydrocortisone 17-Butyrate in Cream Preparations | Sompon Wanwimolruk |
| 550 | Letters to the Editor | P. Macheras, C. Reppas, S. Antimisiaris, T. Stebler and T. W. Guentert |
| 551-556 | Stereoselectivity in Pharmacokinetics: A General Theory | René H. Levy and Alan V. Boddy |
| 557-562 | Comparison of the Methods for Determining Cell-Surface and Intracellular Receptors for Epidermal Growth Factor in the Rat Liver | Shigeo Yanai, Yuichi Sugiyama, Tatsuji Iga, Tohru Fuwa and Manabu Hanano |
| 563-569 | Effect of Receptor Up-Regulation on Insulin Pharmacokinetics in Streptozotocin-Treated Diabetic Rats | Hitoshi Sato, Tetsuya Terasaki, Kiminori Okumura and Akira Tsuji |
| 570-575 | Nonisothermal Stability Assessment of Stable Pharmaceuticals: Testing of a Clindamycin Phosphate Formulation | James E. Kipp and John J. Hlavaty |
| 576-583 | A Novel, Self-Correcting Membrane Coating Technique | Hitesh R. Bhagat, Robert W. Mendes, Edith Mathiowitz and Hridaya N. Bhargava |
| 584-587 | Sustained Pharmacological Activities in Rats Following Single and Repeated Administration of Once-a-Month Injectable Microspheres of Leuprolide Acetate | Hiroaki Okada, Toshiro Heya, Yasuaki Ogawa, Hajime Toguchi and Tsugio Shimamoto |
| 588-592 | Absorption Enhancing Effect of Cyclodextrins on Intranasally Administered Insulin in Rats | Frans W. H. M. Merkus, J. Coos Verhoef, Stefan G. Romeijn and Nicolaas G. M. Schipper |
| 593-599 | Structural Requirements for the Intestinal Mucosal-Cell Peptide Transporter: The Need for N-Terminal α-Amino Group | Pel-Fan Bai, Pullachipatti Subramanian, Henry I. Mosberg and Gordon L. Amidon |
| 600-604 | Use of Modified Ethylcellulose Lattices for Microporous Coating of Osmotic Tablets | Leah E. Appel and Gaylen M. Zentner |
| 605-607 | Bioavailability of Flurbiprofen Following Buccal Administration | Dennis J. Stalker and Steven R. Pollock |
| 608-614 | Dose-Dependent Pharmacokinetics of MK-417, a Potent Carbonic Anhydrase Inhibitor, in Experimental Polycythemic and Anemic Rats | Jiunn H. Lin, I-Wu Chen and Florencia A. deLuna |
| 615-618 | Determination of Sodium and Chloride Ions in Teicoplanin Lyophilized Vials by Nonsuppressed, Single-Column Ion Chromatography | Miguel A. de Soto-Perera |
| 619-623 | High-Performance Liquid Chromatographic Determination of 2′, 3′ -Didehydro-3′ -deoxythymidine (d4T) in Human and Rabbit Plasma and Urine and Its Application to Pharmacokinetic Studies in the Rabbit | Shekman L. Wong and Ronald J. Sawchuk |
| 624-628 | “On–Off“ Thermocontrol of Solute Transport. II. Solute Release from Thermosensitive Hydrogels | You Han Bae, Teruo Okano and Sung Wan Kirn |
| 629-635 | Formulation and in Vitro Evaluation of Pressurized Inhalation Aerosols Containing Isotropic Systems of Lecithin and Water | Richard M. Evans, Stephen J. Farr, N. Anthony Armstrong and Sarah M. Chatham |
| 636-642 | Significance of Partial and Total Cohesion Parameters of Pharmaceutical Solids Determined from Dissolution Calorimetric Measurements | Catherine Rey-Mermet, Paul Ruelle, Hô Nam-Trân, Michel Buchmann and Ulrich W. Kesselring |
| 643-648 | Crystal Growth Kinetics of Theophylline Monohydrate | Naír Rodríguez-Hornedo and Hsiu-Jean Wu |
| 649-652 | Lipophilic Peptides: Synthesis of Lauroyl Thyrotropin-Releasing Hormone and Its Biological Activity | Shozo Muranishi, Atsushi Sakai, Keigo Yamada, Masahiro Murakami and Kanji Takada, et al. |
| 653-655 | Determination of Allopurinol and Oxypurinol in Rat Plasma, Intestinal Wash, and Bile by High-Performance Liquid Chromatography with Electrochemical Detection (HPLC/EC) Following Automated Solid Phase Extraction | Eugene J. Eisenberg, Phil Conzentino, Gary G. Liversidge and Kenneth C. Cundy |
| 656-657 | The Cytotoxicity of p-Chloro-m-xylenol in Primary Culture of Rat Hepatocytes | Julio C. Davila, Angelica Dorantes, Salomon A. Stavchansky and Daniel Acosta |
| 658-660 | Low First-Spray Drug Content in Albuterol Metered-Dose Inhalers | Terry D. Cyr, Susan J. Graham, K. Y. Robert Li and Edward G. Levering |
| 661-662 | Letters to the Editor | Bradley D. Anderson, Richard T. Darrington and Janardan B. Nagwekar |
| 663-675 | Introduction to Fourier Transform Infrared Spectroscopy and Applications in the Pharmaceutical Sciences | Robert J. Markovich and Charles Pidgeon |
| 676-682 | Pharmaceutical Sciences' Manpower Supply and Internal Rate of Return | Abraham G. Hartzema and Eleanor Perfetto |
| 683-689 | Assessment of Drug Disposition in the Perfused Rat Brain by Statistical Moment Analysis | Toshiyasu Sakane, Michiko Nakatsu, Akira Yamamoto, Mitsuru Hashida and Hitoshi Sezaki, et al. |
| 690-697 | In Vitro and in Vivo Investigations of Dihydropyridine-Based Chemical Delivery Systems for Anticonvulsants | Alan V. Boddy, Kanyin Zhang, Francis Lepage, Francis Tombret and J. Greg Slatter, et al. |
| 698-705 | Prediction of Physical Aging in Controlled-Release Coatings: The Application of the Relaxation Coupling Model to Glassy Cellulose Acetate | Christopher M. Sinko, Albert F. Yee and Gordon L. Amidon |
| 706-712 | A Polymer Carrier System for Taste Masking of Macrolide Antibiotics | Mou-ying Fu Lu, Saul Borodkin, Linda Woodward, Ping Li and Curt Diesner, et al. |
| 713-720 | Controlled Delivery Systems for Proteins Based on Poly(Lactic/Glycolic Acid) Microspheres | Smadar Cohen, Toshio Yoshioka, Melissa Lucarelli, Lena H. Hwang and Robert Langer |
| 721-727 | Degradation of Insulin by Trypsin and Alpha-Chymotrypsin | Robert J. Schilling and Ashim K. Mitra |
| 728-733 | Role of Enzymatic Lability in the Corneal and Conjunctival Penetration of Timolol Ester Prodrugs in the Pigmented Rabbit | Du-Shieng Chien, Hitoshi Sasaki, Hans Bundgaard, Anders Buur and Vincent H. L. Lee |
| 734-738 | The Preparation and Acute Antihypertensive Effects of a Nanocapsular Form of Darodipine, a Dihydropyridine Calcium Entry Blocker | Brigitte Hubert, Jeffrey Atkinson, Madeleine Guerret, Maurice Hoffman and Jean Philippe Devissaguet, et al. |
| 739-743 | The Bioavailability and Nonlinear Clearance of (–)-Carbovir in the Rat | Shu-hui Huang, Rory P. Remmel and Cheryl L. Zimmerman |
| 744-749 | Nitroglycerin Absorption from Transdermal Systems: Formulation Effects and Metabolite Concentrations | Roger L. Williams, Kamlesh M. Thakker, Vivian John, Emil T. Lin and Winnie Liang-Gee, et al. |
| 750-753 | Pharmacokinetics and Anticonvulsant Activity of Three Monoesteric Prodrugs of Valproic Acid | Khalil Badir, Abdulla Haj-Yehia, Tom B. Vree, Eppo Kleijn and Meir Bialer |
| 754-757 | Racial Differences in Drug Response: Isoproterenol Effects Before and After Propranolol | David R. Rutledge, Ann Wallace, Joel D. Steinberg, Lavoisier Cardozo and Steven J. Lavine |
| 758-762 | A High-Performance Liquid Chromatographic Assay for the Enantiomers of Bevantolol in Human Plasma | Steven E. Rose and Edward J. Randinitis |
| 763-770 | One-Dimensional and Two-Dimensional 1H- and 13C-Nuclear Magnetic Resonance (NMR) Analysis of Vitamin E Raw Materials or Analytical Reference Standards | John K. Baker and Chris W. Myers |
| 771-775 | Effects of 5′-Ester Modification on the Physicochemical Properties and Plasma Protein Binding of 5-Iodo-2′-deoxyuridine | Mridul K. Ghosh and Ashim K. Mitra |
| 776-781 | Quantitative Structure–Activity Relationship Analysis of Combretastatins: A Class of Novel Antimitotic Agents | Partha Nandy, Samitendu Banerjee, Hua Gao, Mary B. V. Hui and Eric J. Lien |
| 782-786 | Effect of Solution Phase Composition on the Interaction Between Aqueous Model Solutes and Polymeric Container Materials | Dennis R. Jenke |
| 787-791 | Pharmacokinetics of Once-a-Month Injectable Microspheres of Leuprolide Acetate | Hiroaki Okada, Yayoi Inoue, Toshiro Heya, Hayao Ueno and Yasuaki Ogawa, et al. |
| 792-795 | Use of 2-Hydroxypropyl-β-cyclodextrin as a Solubilizing and Stabilizing Excipient for Protein Drugs | Marcus E. Brewster, Maninder S. Hora, James W. Simpkins and Nicholas Bodor |
| 796-800 | Influence of Antibiotics on the Recovery and Kinetics of Saccharomyces boulardii in Rats | Alan V. Boddy, Gary W. Elmer, Lynne V. McFarland and René H. Levy |
| 801-803 | Studies in Phlebitis. II. Early Detection of Amiodarone-Induced Phlebitis in a Rabbit Model | Gary H. Ward, Paul E. Nolan, Milissa White and Samuel H. Yalkowsky |
| 804-805 | Pharmaceutical Marketing in the European Community: The 1992 Changes | Michael Dickson |
| 806 | Association News and Announcements |
| 807-814 | The Nasal Mucociliary Clearance: Relevance to Nasal Drug Delivery | Nicolaas G. M. Schipper, J. Coos Verhoef and Frans W. H. M. Merkus |
| 815-820 | In Vivo Transport of a Dynorphin-like Analgesic Peptide, E-2078, Through the Blood–Brain Barrier: An Application of Brain Microdialysis | Tetsuya Terasaki, Yoshiharu Deguchi, Hitoshi Sato, Ken-ichi Hirai and Akira Tsuji |
| 821-825 | Gas Chromatographic–Mass Spectrometric (GC-MS) Determination of MDL 72,222 and Four Metabolites in Monkey Plasma | Haiyung Cheng and Jonathan A. Ragner |
| 826-831 | Triplet-Sensitized Photooxygenation of Therapeutic Retinoids | Keith A. Humphries and Robert W. Curley |
| 832-839 | Structure–Metabolism Relationships in the Hydrolysis of Nicotinate Esters by Rat Liver and Brain Subcellular Fractions | Anne Durrer, Bernard Walther, Antonio Racciatti, Gilles Boss and Bernard Testa |
| 840-850 | A New Predictive Equation for the Solubility of Drugs Based on the Thermodynamics of Mobile Disorder | Paul Ruelle, Catherine Rey-Mermet, Michel Buchmann, Hô Nam-Tran and Ulrich W. Kesselring, et al. |
| 851-858 | The Importance of Surface Charge in the Optimization of Antigen–Adjuvant Interactions | Patricia M. Callahan, Andrew L. Shorter and Stanley L. Hem |
| 859-864 | Effects of Palytoxin on Guinea Pig Tracheal Strips | Casey P. Robinson and David R. Franz |
| 865-872 | Quantitative Evaluation of Ethanol Effects on Diffusion and Metabolism of β-Estradiol in Hairless Mouse Skin | Puchun Liu, William I. Higuchi, Wei-qi Song, Tamie Kurihara-Bergstrom and William R. Good |
| 873-876 | Enhancement of 3-Hydroxy-3-methylglutaryl–Coenzyme A (HMG–CoA) Reductase Inhibitor Efficacy Through Administration of a Controlled-Porosity Osmotic Pump Dosage Form | Gregory A. McClelland, R. John Stubbs, Joseph A. Fix, Stefano A. Pogany and Gaylen M. Zentner |
| 877-882 | Variable Glyceryl Dinitrate Formation Following Infusions of Glyceryl Trinitrate at Different Vascular Sites in the Rat | Emi Nakashima, David T.-W. Lau and Leslie Z. Benet |
| 883-887 | Steady-State Pharmacokinetics and Pharmacodynamics of Benazeprilat in Spontaneously Hypertensive Rats (SHR) and Wistar–Kyoto (WKY) Rats | Sheryl LeRoy and Bret Berner |
| 888-892 | Binding Study of the Fluorescence Probe l-Anilino-8-naphthalenesulfonate to Human Plasma and Human and Bovine Serum Albumin Using Potentiometric Titration | Georgia N. Valsami, Panayotis E. Macheras and Michael A. Koupparis |
| 893-898 | The Relationship of Diastereomer Hydrolysis Kinetics to Shelf-Life Predictions for Cefuroxime Axetil | Ngoc-Anh T. Nguyen |
| 899-902 | A Simple and Rapid Method for the Quantification of Eudragit RS100 and RL100 Poly(methacrylates) in Sustained-Release Dosage Forms | Colin D. Melia, Bashir R. Hansraj, Karrar A. Khan and Ian R. Wilding |
| 903-907 | Electroanalytical Characteristics of the Cardiotonics, Enoximone and Piroximone | Carl L. Housmyer and Roy L. Lewis |
| 908-912 | X-Ray Structure and Crystal Lattice Interactions of the Taxol Side-Chain Methyl Ester | John R. Peterson, Hoang D. Do and Robin D. Rogers |
| 913-918 | An Electrically Modulated Drug Delivery Device: I | Antony D'Emanuele and John N. Staniforth |
| 919-924 | Tablet Formulation Study of Spray-Dried Sodium Diclofenac Enteric-Coated Microcapsules | Shan-Yang Lin and Yuh-Horng Kao |
| 925-929 | Insulin Aggregation in Aqueous Media and Its Effect on Alpha-Chymotrypsin-Mediated Proteolytic Degradation | Fang-yu Liu, Dane O. Kildsig and Ashim K. Mitra |
| 930-932 | Pharmacodynamics and Biophasic Drug Levels of Methionine Enkephalin | Randall J. Erb, Lih-Min Her, Anna Abdallah and Ashim K. Mitra |
| 933-937 | Dodecyl N,N-Dimethylamino Acetate and Azone Enhance Drug Penetration Across Human, Snake, and Rabbit Skin | Jouni Hirvonen, J. Howard Rytting, Petteri Paronen and Arto Urtti |
| 938-944 | Cotransport of Estradiol and Ethanol Through Human Skin in Vitro: Understanding the Permeant/Enhancer Flux Relationship | Puchun Liu, Tamie Kurihara-Bergstrom and William R. Good |
| 945-950 | Rectal Mucosa Damage in Rabbits After Subchronical Application of Suppository Bases | Christian De Muynck, Claude Cuvelier, Danny Van Steenkiste, Luc Bonnarens and Jean Paul Remon |
| 951-957 | Structural Effects on the Binding of Amine Drugs with the Diphenylmethyl Functionality to Cyclodextrins. I. A Microcalorimetric Study | Wei-Qin Tong, John L. Lach, Ting-Fong Chin and J. Keith Guillory |
| 958-961 | Controlled Delivery of Diphtheria Toxoid Using Biodegradable Poly(D,L-Lactide) Microcapsules | Manmohan Singh, Amarjit Singh and Gursharan Prasad Talwar |
| 962 | BOOK REVIEWS |
| 962 | BOOK REVIEWS |
| 963-973 | Physical Characterization of Pharmaceutical Solids | Harry G. Brittain, Susan J. Bogdanowich, David E. Bugay, Joseph DeVincentis and Geoffrey Lewen, et al. |
| 974-978 | Spectrophotometric Prediction of the Dissolution Rate of Carbamazepine Tablets | Peter N. Zannikos, Wen-I Li, James K. Drennen and Robert A. Lodder |
| 979-988 | Predicting Fraction Dose Absorbed in Humans Using a Macroscopic Mass Balance Approach | Patrick J. Sinko, Glen D. Leesman and Gordon L. Amidon |
| 989-991 | Determination of Clarithromycin as a Contaminant on Surfaces by High-Performance Liquid Chromatography Using Electrochemical Detection | Terry D. Rotsch, Meredith Spanton, Phyllis Cugier and Andrew C. Plasz |
| 992-996 | Simultaneous High-Performance Liquid Chromatographic Analysis of Cefprozil Diastereomers in a Pharmacokinetic Study | Wen Chyi Shyu, Umesh A. Shukla, Vinod R. Shah, Eugene A. Papp and Rashmi H. Barbhaiya |
| 997-1001 | Column-Switching High-Performance Liquid Chromatography for On-Line Simultaneous Determination and Resolution of Enantiomers of Verapamil and Its Metabolites in Plasma | Yoshiya Oda, Naoki Asakawa, Takashi Kajima, Yutaka Yoshida and Tadashi Sato |
| 1002-1005 | Synthesis of the Enantiomers of Reduced Haloperidol | Juan C. Jaen, Bradley W. Caprathe, Stephen Priebe and Lawrence D. Wise |
| 1006-1012 | Quantitative Structure–Activity Relationship (QSAR) Analysis of the Cytotoxicities Of Aminohydroxyguanidine Derivatives and Their Antiviral Activities in Vitro | Pou-Hsiung Wang, Mary B. V. Hui, Partha Nandy, Samitendu Banerjee and Hua Gao, et al. |
| 1013-1020 | The Solution Conformations of Lidocaine Analogues | Paul D. McMaster, Valerie J. Noris, Charles E. Stankard, Eugene W. Byrnes and Peter R. Guzzo |
| 1021-1026 | The Cryopreservation of Liposomes. 1. A Differential Scanning Calorimetry Study of the Thermal Behavior of a Liposome Dispersion Containing Mannitol During Freezing/Thawing | Herre Talsma, Mies J. van Steenbergen, Paul J. M. Salemink and Daan J. A. Crommelin |
| 1027-1031 | Biodegradable Nanospheres Containing Phthalocyanines and Naphthalocyanines for Targeted Photodynamic Tumor Therapy | Akbiri Labib, Vincent Lenaerts, Francois Chouinard, Jean-Christophe Leroux and René Ouellet, et al. |
| 1032-1038 | The Pharmacokinetics and Metabolism of Human Relaxins in Rhesus Monkeys | Bobbe L. Ferraiolo, John Winslow, Gary Laramee, Abbie Celniker and Paul Johnston |
| 1039-1043 | Evaluation of Mucoadhesive Polymers in Ocular Drug Delivery. I. Viscous Solutions | Nigel M. Davies, Stephen J. Fair, Jonathan Hadgraft and Ian W. Kellaway |
| 1044-1049 | Solubilization and Stabilization of a Benzylpenicillin Chemical Delivery System by 2-Hydroxypropyl-β-cyclodextrin | Emil Pop, Thorsteinn Loftsson and Nicholas Bodor |
| 1050-1055 | Absorptive Clearance of Carbamazepine and Selected Metabolites in Rabbit Intestine | Lillian E. Riad and Ronald J. Sawchuk |
| 1056-1058 | Bioavailability of Erythromycin Acistrate from Hard Gelatin Capsules Containing Sodium Bicarbonate | Martti Marvola, Sirkka Nykänen and Marja Nokelainen |
| 1059-1063 | Pharmacokinetic Study of an Iridoid Glucoside: Aucubin | Nan-Joo Suh, Chang-Koo Shim, Min Hwa Lee, Shin Keun Kim and Il-Moo Chang |
| 1064-1065 | Does Hydration Affect Intercellular Lipid Organization in the Stratum Corneum? | Vivien H. W. Mak, Russell O. Potts and Richard H. Guy |
| 1066-1068 | Physicochemical Stability of Nitrofurantoin Anhydrate and Monohydrate Under Various Temperature and Humidity Conditions | Makoto Otsuka, Reiko Teraoka and Yoshihisa Matsuda |
| 1069-1070 | Disposition of Sulfamethazine and N-Acetylsulfamethazine in the Rat | Craig K. Svensson, Hani Zaher and Mark Tomilo |
| 1071-1075 | In Vivo Percutaneous Penetration/Absorption, Washington, D.C., May 1989 | Vinod P. Shah, Gordon L. Flynn, Richard H. Guy, Howard I. Maibach and Hans Schaefer, et al. |
| 1076-1077 | Letters to the Editor | H. Egermann, Sanford Bolton and Samuel Yalkowsky |
| 1078 | ERRATUM |
| 1079-1086 | Liposomes and Nanoparticles in the Treatment of Intracellular Bacterial Infections | Patrick Couvreur, Elias Fattal and Antoine Andremont |
| 1087-1093 | Water-Soluble, Solution-Stable, and Biolabile N-Substituted (Aminomethyl)benzoate Ester Prodrugs of Acyclovir | Hans Bundgaard, Ejvind Jensen and Erik Falch |
| 1094-1102 | Valerian-Derived Sedative Agents. I. On the Structure and Spectral Assignment of the Constituents of Valmane Using the Selective INEPT Nuclear Magnetic Resonance Technique | Lee-Juian Lin, Geoffrey A. Cordell and Manuel F. Balandrin |
| 1103-1112 | Stability of the Thrombolytic Protein Fibrolase: Effect of Temperature and pH on Activity and Conformation | Denise Pretzer, Brenda S. Schulteis, Christopher D. Smith, David G. Vander Velde and James W. Mitchell, et al. |
| 1113-1120 | lontophoretic Delivery of Amino Acids and Amino Acid Derivatives Across the Skin in Vitro | Philip G. Green, Robert S. Hinz, Christopher Cullander, Grace Yamane and Richard H. Guy |
| 1121-1127 | lontophoretic Delivery of a Series of Tripeptides Across the Skin in Vitro | Philip G. Green, Robert S. Hinz, Aeri Kim, Francis C. Szoka and Richard H. Guy |
| 1128-1136 | Nuclear Magnetic Resonance (NMR) Spectroscopic Investigation of Interaction Energies of Ephedrine Stereoisomers in Noncrystalline Solids and Its Correlation with Thermodynamic Data | Walter F. Schmidt and Irwin L. Honigberg |
| 1137-1143 | The Effect of Plasticizers on Compatibility, Mechanical Properties, and Adhesion Strength of Drug-Free Eudragit E Films | Shan-Yang Lin, Chau-Jen Lee and Yih-Yih Lin |
| 1144-1150 | Self-Association of Nicotinamide in Aqueous Solution: Mass Transport, Freezing-Point Depression, and Partition Coefficient Studies | William N. Charman, Christine S. C. Lai, Barrie C. Finnin and Barry L. Reed |
| 1151-1154 | Cyclodextrin Sulfates: Characterization as Polydisperse and Amorphous Mixtures | Josef Pitha, Larry M. Mallis, Diane J. Lamb, Tetsumi Irie and Kaneto Uekama |
| 1155-1158 | Catalysis of Carbaryl Hydrolysis in Micellar Solutions of Cetyltrimethylammonium Bromide | Jatin M. Patel and Dale Eric Wurster |
| 1159-1165 | Solid-State Properties of Tobramycin | Alekha K. Dash and Raj Suryanarayanan |
| 1166-1174 | Formulation Influence on Conjunctival Penetration of Four Beta Blockers in the Pigmented Rabbit: A Comparison with Corneal Penetration | Paul Ashton, Samir K. Podder and Vincent H. L. Lee |
| 1175-1179 | Effects of Proteolytic Enzyme Inhibitors on the Nasal Absorption of Vasopressin and an Analogue | Kazuhiro Morimoto, Hiroshi Yamaguchi, Yasushi Iwakura, Makoto Miyazaki and Emi Nakatani, et al. |
| 1180-1185 | A Redox-Based Chemical Delivery System that Enhances Estradiol Distribution to the Brain: Disposition Studies in the Rat | Kerry S. Estes, Volker Keuth, Klaus Dietzel, Marcus E. Brewster and Nicholas S. Bodor, et al. |
| 1186-1190 | Stereoselective Systemic Disposition of Ibuprofen Enantiomers in the Dog | Hae-Young Ahn, Gordon L. Amidon and David E. Smith |
| 1191-1194 | Operational Evaluation of Three Commercial Configurations of Atropine/HI-6 Wet/Dry Autoinjectors | Janis W. Schlager, Theodore W. Dolzine, James R. Stewart, Gerald L. Wannarka and Ming L. Shih |
| 1195-1198 | Stereospeciflc High-Performance Liquid Chromatographic Assay of Sotalol in Plasma | Robert A. Carr, Robert T. Foster and Nadeem H. Bhanji |
| 1199-1202 | Permselective Characteristics of Rabbit Buccal Mucosa | Rajesh B. Gandhi and Joseph R. Robinson |
| 1203-1205 | Solubility of Mefenamic Acid Under Simulated Fed- and Fasted-State Conditions | Christopher N. TenHoor, Vassiliki Bakatselou and Jennifer Dressman |
| 1206-1209 | Determination of Drug Solubility in Aerosol Propellants | Richard N. Dalby, Elaine M. Phillips and Peter R. Byron |
| 1210-1213 | Determination of Release Limits: A General Methodology | Paul V. Allen, Gary R. Dukes and Mark E. Gerger |
| 1214 | Editorial |
| 1215-1222 | Photoreactivity of LY277359 Maleate, a 5-Hydroxytryptamine3 (5-HT3) Receptor Antagonist, in Solution | Gerold L. Mosher and Julianne McBee |
| 1223-1230 | Low Molecular Weight Proteins as Carriers for Renal Drug Targeting: Naproxen–Lysozyme | Eric J. F. Franssen, Ronald G. M. van Amsterdam, Jan Visser, Frits Moolenaar and Dick de Zeeuw, et al. |
| 1231-1237 | Percutaneous Penetration Kinetics of Nitroglycerin and Its Dinitrate Metabolites Across Hairless Mouse Skin in Vitro | Toshihiro Kikkoji, Mark Gumbleton, Naruhito Higo, Richard H. Guy and Leslie Z. Benet |
| 1238-1242 | Prodrugs of Peptides. 11. Chemical and Enzymatic Hydrolysis Kinetics of N-Acyloxymethyl Derivatives of a Peptide-like Bond | Hans Bundgaard and Gitte Juel Rasmussen |
| 1243-1247 | Antimicrobial Diterpenes of Croton sonderianus. II. ent-Beyer-15-en-18-oic Acid | James D. McChesney, Alice M. Clark and Edilberto R. Silveira |
| 1248-1252 | Application of Neural Computing in Pharmaceutical Product Development | Ajaz S. Hussain, Xuanqiang Yu and Robert D. Johnson |
| 1253-1257 | Hepatic Disposition Characteristics of 111In-Labeled Lactosaminated Bovine Serum Albumin in Rats | Koyo Nishida, Yukiko Eguchi, Toichi Takino, Yoshinobu Takakura and Mitsuru Hashida, et al. |
| 1258-1263 | Parenteral Peptide Formulations: Chemical and Physical Properties of Native Luteinizing Hormone-Releasing Hormone (LHRH) and Hydrophobic Analogues in Aqueous Solution | Michael F. Powell, Lynda M. Sanders, Alan Rogerson and Vicki Si |
| 1264-1269 | Solution Stability of the Monoclonal Antibody–Vinca Alkaloid Conjugate, KS1/4-DAVLB | Alice Riggin, Dean Clodfelter, Ann Maloney, Eugene Rickard and Eddie Massey |
| 1270-1273 | Assessment of Antiinflammatory Agents Using 125I-Labeled Human Serum Albumin to Quantify Footpad Edema Volume in the Rat | Douglas J. Ormrod and Thomas E. Miller |
| 1274-1280 | Differences in Transport Rate of Oxytocin and Vasopressin Analogues Across Proximal and Distal Isolated Segments of the Small Intestine of the Rat | Stefan Lundin, Niclas Pantzar, Anja Broeders, Mats Ohlin and Björn R. Weström |
| 1281-1285 | Correlation of the Gastric Emptying of Nondisintegrating Tablets with Gastrointestinal Motility | Alastair J. Coupe, Stanley S. Davis, David F. Evans and Ian R. Wilding |
| 1286-1291 | Mixed Micelles as a Proliposomal, Lymphotropic Drug Carrier | Andreas Supersaxo, Wayne R. Hein and Hans Steffen |
| 1292-1296 | In Vitro Evaluation of Sustained Drug Release from Biodegradable Elastomer | Ryoichi Wada, Suong-Hyu Hyon, Takayuhi Nakamura and Yoshito Ikada |
| 1297-1301 | Regional Variation in Oral Mucosal Drug Absorption: Permeability and Degree of Keratinization in Hamster Oral Cavity | Yuji Kurosaki, Toshihito Takatori, Hidekatsu Nishimura, Taiji Nakayama and Toshikiro Kimura |
| 1302-1306 | Intrinsic Lymphatic Partition Rate of Mepitiostane, Epitiostanol, and Oleic Acid Absorbed from Rat Intestine | Teruhisa Ichihashi, Haruki Kinoshita, Yasushi Takagishi and Hideo Yamada |
| 1307-1312 | Structural Effects on the Binding of Amine Drugs with the Diphenylmethyl Functionality to Cyclodextrins. II. A Molecular Modeling Study | Wei-Qin Tong, John L. Lach, Ting-Fong Chin and J. Keith Guillory |
| 1313-1317 | Formulation, Bioavailability, and Pharmacokinetics of Sustained-Release Potassium Chloride Tablets | Sevda Şenel, Yilmaz Çapan, Turgay Dalkara, Neriman İnanç and A. Atillâ Hincal |
| 1318-1322 | Evaluation of “True” Creatinine Clearance in Rats Reveals Extensive Renal Secretion | Inger M. Darling and Marilyn E. Morris |
| 1323-1328 | Fourier Transform-Raman Spectroscopy for the Qualitative and Quantitative Characterization of Sulfasalazine-Containing Polymeric Microspheres | Peter J. Watts, Andrew Tudor, Stephen J. Church, Patrick J. Hendra and Paul Turner, et al. |
| 1329-1334 | Chemical Stabilization of a Vasoactive S-Nitrosothiol with Cyclodextrins Without Loss of Pharmacologic Activity | John Anthony Bauer and Ho-Leung Fung |
| 1335-1340 | Dual-Isotope Imaging of Neutron-Activated Erbium-171 and Samarium-153 and the in Vivo Evaluation of a Dual-Labeled Bilayer Tablet by Gamma Scintigraphy | George A. Digenis, Erik P. Sandefer, Robert M. Beihn and Alan F. Parr |
| 1341-1342 | Studies in Phlebitis. III. Evaluation of Diazepam and Phenytoin | Milissa White and Samuel H. Yalkowsky |
| 1343 | Interspecies Differences in the Nasal Absorption of Insulin | F. W. H. M. Merkus, J. C. Verhoef, S. G. Romeijn and N. G. M. Schipper |
| 1344 | Association News and Announcements |
| 1345-1350 | Delivering Peptides to the Central Nervous System: Dilemmas and Strategies | William A. Banks, Abba J. Kastin and Carlos M. Barrera |
| 1351-1359 | Interspecies Scaling of Clearance and Volume of Distribution Data for Five Therapeutic Proteins | Joyce Mordenti, Sharon A. Chen, Jerome A. Moore, Bobbe L. Ferraiolo and James D. Green |
| 1360-1364 | Effect of Freezing on Aggregation of Human Growth Hormone | Brigitte M. Eckhardt, James Q. Oeswein and Thomas A. Bewley |
| 1365-1371 | Role of Paracellular Pathway in Nonelectrolyte Permeation Across Rat Colon Epithelium Enhanced by Sodium Caprate and Sodium Caprylate | Toyohiro Sawada, Takahiro Ogawa, Mikio Tomita, Masahiro Hayashi and Shoji Awazu |
| 1372-1376 | Synthesis and the Biological Evaluation of the Structural Units of Drummondin C | Hiranthi Jayasuriya, John K. Baker, Alice M. Clark and James D. McChesney |
| 1377-1383 | Development and Evaluation of Sustained-Release Ibuprofen-Wax Microspheres. I. Effect of Formulation Variables on Physical Characteristics | Christianah M. Adeyeye and James C. Price |
| 1384-1388 | 113Cd Nuclear Magnetic Resonance (NMR) Study of the Inhibitory Effect of Methylvinylether/Maleic Acid (PVM/MA) Copolymer on the Alkaline Phosphatase of Escherichia coli | John Afflitto, Karen Ann Smith, Manoj Patel, Anthony Esposito and Elke Jensen, et al. |
| 1389-1395 | Improved Delivery Through Biological Membranes. LVI. Pharmacological Evaluation of Alprenoxime—A New Potential Antiglaucoma Agent | Nicholas Bodor and Alaaeldin Elkoussi |
| 1396-1400 | Effect of Drug Loading and Molecular Weight of Cellulose Acetate Propionate on the Release Characteristics of Theophylline Microspheres | Atul J. Shukla and James C. Price |
| 1401-1407 | Mixture Experimental Design in the Development of a Mucoadhesive Gel Formulation | James S. Chu, Gordon L. Amidon, Norman D. Weiner and Arthur H. Goldberg |
| 1408-1412 | Viscometric Study of Polyacrylic Acid Systems as Mucoadhesive Sustained-Release Gels | James S. Chu, Ramachandran Chandrasekharan, Gordon L. Amidon, Norman D. Weiner and Arthur H. Goldberg |
| 1413-1417 | 14C-Isomazole Disposition in Man After Oral Administration | James R. Woodworth, Allyn F. DeLong, A.F. Fasola and Samuel Oldham |
| 1418-1423 | Chemical and Enzymatic Degradation of Ganciclovir Prodrugs: Enhanced Stability of the Diadamantoate Prodrug Under Acid Conditions | Michael F. Powell, Adina Magill, Nancy Chu, Kyle Hama and Cheng I. Mau, et al. |
| 1424-1429 | Interaction of Metronidazole with Antibiotics Containing the 2-Aminothiazole Moiety | Ajit B. Thakur, Mohamed Abdelnasser, Abu T. M. Serajuddin and Deodatt A. Wadke |
| 1430-1433 | Liquid Chromatographic Analysis of the Enantiomeric Impurities in Various (+)-Pseudoephedrine Samples | Sarma P. Duddu, Reza Mehvar and David J. W. Grant |
| 1434-1440 | A Sensitive Method for Quantitation of Rifabutin and Its Desacetyl Metabolite in Human Biological Fluids by High-Performance Liquid Chromatography (HPLC) | Richard C. Lewis, Naomi Z. Hatfield and Prem K. Narang |
| 1441-1443 | Evidence for Glucuronide Conjugation of p-Nitrophenol in the Caco-2 Cell Model | Susan Bjorge, Katherine L. Hamelehle, Reynold Homan, Steven E. Rose and Daniel A. Turluck, et al. |
| 1444-1447 | Racemization of Ibutilide in Solution: A Factor to Consider When Choosing to Develop the Racemate or a Single Enantiomer | William J. Lambert and Paula G. Timmer |
| 1448-1451 | Sensitive High-Performance Liquid Chromatographic (HPLC) Determination of Diphenhydramine in Plasma Using Fluorescence Detection | Christine L. Webb and Michael A. Eldon |
| 1452 | Association News and Announcements |
| 1453-1460 | The Influence of Peptide Structure on Transport Across Caco-2 Cells | Robert A. Conradi, Allen R. Hilgers, Norman F. H. Ho and Philip S. Burton |
| 1461-1469 | Solubilization and Wetting Effects of Bile Salts on the Dissolution of Steroids | Vassiliki Bakatselou, Richard C. Oppenheim and Jennifer B. Dressman |
| 1470-1476 | The Pharmacokinetics of Antipyrine and Three of Its Metabolites in the Rabbit: Intravenous Administration of Pure Metabolites | John V. St. Peter, Yusuf Abul-Hajj and Walid M. Awni |
| 1477-1481 | Desolvation Energy: A Major Determinant of Absorption, But Not Clearance, of Peptides in Rats | Michael S. Karls, Bob D. Rush, Karen F. Wilkinson, Thomas J. Vidmar and Philip S. Burton, et al. |
| 1482-1488 | In Vitro and in Vivo Evaluation of Whole and Half Tablets of Sustained-Release Adinazolam Mesylate | John W. Skoug, Marie T. Borin, Joseph C. Fleishaker and Anne M. Cooper |
| 1489-1494 | Experimental Determinations of Diffusion Coefficients in Dilute Aqueous Solution Using the Method of Hydrodynamic Stability | Marylee Z. Southard, Lloyd J. Dias, Kenneth J. Himmelstein and Valentino J. Stella |
| 1495-1499 | Effect of 2-Hydroxypropyl-β-cyclodextrin on the Ocular Absorption of Dexamethasone and Dexamethasone Acetate | Arunya Usayapant, Adel H. Karara and Milind M. Narurkar |
| 1500-1504 | Influence of Physical Aging on Mechanical Properties of Polymer Free Films: The Prediction of Long-Term Aging Effects on the Water Permeability and Dissolution Rate of Polymer Film-Coated Tablets | Jian-Hwa Guo, Richard E. Robertson and Gordon L. Amidon |
| 1505-1510 | Simultaneous Modeling of the Pharmacokinetics and Methemoglobin Pharmacodynamics of an 8-Aminoquinoline Candidate Antimalarial (WR 238605) | Ralf P. Brueckner and Lawrence Fleckenstein |
| 1511-1515 | Pharmacokinetics of Zopolrestat, a Carboxylic Acid Aldose Reductase Inhibitor, in Normal and Diabetic Rats | Philip B. Inskeep, Anne E. Reed and Robert A. Ronfeld |
| 1516-1519 | The Effect of Raising Gastric pH with Ranitidine on the Absorption and Elimination of Theophylline from a Sustained-Release Theophylline Tablet | Charles J. Betlach, Arthur B. Straughn, Marvin C. Meyer, Meir Bialer and V. I. Vashi, et al. |
| 1520-1524 | Stereoselective Disposition of Ibuprofen Enantiomers in the Isolated Perfused Rat Kidney | Hae-Young Ahn, Fakhreddin Jamali, Steven R. Cox, Dangnoi Kittayanond and David E. Smith |
| 1525-1527 | Determination of Cefsulodin, Cefmenoxime, and Cefadroxil as Residues on Surfaces | Ronald J. Gorski, Andrew C. Plasz, Lee Elrod, John Yoder and Landy B. White |
| 1528-1532 | The Stereospecific Determination of Fluoxetine and Norfluoxetine Enantiomers in Human Plasma by High-Pressure Liquid Chromatography (HPLC) with Fluorescence Detection | Albert L. Peyton, Russell Carpenter and Kathleen Rutkowski |
| 1533-1538 | Prodrugs of Peptides. 13. Stabilization of Peptide Amides Against α-Chymotrypsin by the Prodrug Approach | Anne H. Kahns and Hans Bundgaard |
| 1539-1542 | Improved Corneal Pilocarpine Permeability with O,O′-(l,4-Xylylene) Bispilocarpic Acid Ester Double Prodrugs | Pekka Suhonen, Tomi Järvinen, Päivi Rytkönen, Pekka Peura and Arto Urtti |
| 1543-1544 | Reviewers for Pharmaceutical Research (October 1990-October 1991) |
| 1545-1548 | Author Index to Volume 8 (1991) |
| 1549-1557 | Subject Index to Volume 8 (1991) |
| 1558 | Association News and Announcements |
| 1-9 | Drug Metabolism in the Nasal Mucosa | Mohamadi A. Sarkar |
| 10-16 | Composite Poly(vinyl alcohol) Beads for Controlled Drug Delivery | Cherng-Ju Kim and Ping I. Lee |
| 17-25 | Estimation of Permanence Time, Exit Time, Dilution Factor, and Steady-State Volume of Distribution | Joyce Mordenti and Aldo Rescigno |
| 26-32 | The Influence of Polymer Glass Transition Temperature and Molecular Weight on Drug Release from Tablets Containing Poly(DL-lactic Acid) | Marcelo O. Omelczuk and James W. McGinity |
| 33-36 | Lyophilized Formulations of Recombinant Tumor Necrosis Factor | Maninder S. Hora, Rajsharan K. Rana and Flint W. Smith |
| 37-39 | Controlled Protein Release from Polyethyleneimine-Coated Poly(L-lactic Acid)/Pluronic Blend Matrices | Tae Gwan Park, Smadar Cohen and Robert Langer |
| 40-44 | Localization of Epidermal Growth Factor (EGF) Binding Sites on Antiluminal Plasma Membrane of Rat Kidney: Autoradiographic Study Using Nonfiltering Perfused Rat Kidney | Dong Chool Kim, Yuichi Sugiyama, Yasushi Kanai, Norio Ohnuma and Manabu Hanano |
| 45-51 | Feasibility of Measuring the Bioavailability of Topical Betamethasone Dipropionate in Commercial Formulations Using Drug Content in Skin and a Skin Blanching Bioassay | Lynn K. Pershing, Barbara S. Silver, Gerald G. Krueger, Vinod P. Shah and Jerome P. Skelley |
| 52-57 | Tolerability and Absorption Enhancement of Intranasally Administered Octreotide by Sodium Taurodihydrofusidate in Healthy Subjects | Thomas Kissel, Juergen Drewe, Siegfried Bantle, Andreas Rummelt and Christoph Beglinger |
| 58-69 | Dissolution of lonizable Drugs into Unbuffered Solution: A Comprehensive Model for Mass Transport and Reaction in the Rotating Disk Geometry | Marylee Z. Southard, Don W. Green, Valentino J. Stella and Kenneth J. Himmelstein |
| 70-75 | A Surface Energy Analysis of Mucoadhesion: Contact Angle Measurements on Polycarbophil and Pig Intestinal Mucosa in Physiologically Relevant Fluids | Claus-Michael Lehr, Joke A. Bouwstra, Harry E. Boddé and Hans E. Junginger |
| 76-81 | Buffer Effects on Swelling Kinetics in Polybasic Gels | Ronald A. Siegel, Ingegerd Johannes, C. Anthony Hunt and Bruce A. Firestone |
| 82-86 | Influence of Formulation, Receptor Fluid, and Occlusion, on in Vitro Drug Release from Topical Dosage Forms, Using an Automated Flow-Through Diffusion Cell | Alain Rolland, Gilles Demichelis, Jean-Claude Jamoulle and Braham Shroot |
| 87-93 | Self-Emulsifying Drug Delivery Systems: Formulation and Biopharmaceutic Evaluation of an Investigational Lipophilic Compound | Susan A. Charman, William N. Charman, Mark C. Rogge, Terry D. Wilson and Frank J. Dutko, et al. |
| 94-100 | Complexation Studies of Cyclodextrins with Tricyclic Antidepressants Using Ion-Selective Electrodes | Georgia N. Valsami, Michael A. Koupparis and Panayotis E. Macheras |
| 101-108 | A Sensitive and Specific Procedure for Quantitation of ADR-529 in Biological Fluids by High-Performance Liquid Chromatography (HPLC) with Column Switching and Amperometric Detection | Richard C. Lewis, Barbara A. Phillips, John R. Baldwin, David T. Rossi and Prem K. Narang |
| 109-114 | Evaluation of the Physical Stability of Freeze-Dried Sucrose-Containing Formulations by Differential Scanning Calorimetry | Marcel P. W. M. te Booy, Rien A. de Ruiter and André L. J. de Meere |
| 115-118 | Analysis of Hydroxyurea in Capsules and Aqueous Solution and Stability Study with Capillary Gas Chromatography and Thermionic (N–P) Specific Detection | Adnan El-Yazigi and Sameer Al-Rawithi |
| 119-125 | Validation of a Column-Switching High-Performance Liquid Chromatographic (HPLC) Method for Determination of ML-1035 and Its Five Metabolites in Plasma | Be-Sheng Kuo, James C. Poole and Kin-Kai Hwang |
| 126-130 | Surface Characterization of Activated Charcoal by X-Ray Photoelectron Spectroscopy (XPS): Correlation with Phenobarbital Adsorption Data | Gerald M. Burke, Dale Eric Wurster, Mary J. Berg, Peter Veng-Pedersen and Dorothy D. Schottelius |
| 131-137 | Kinetics of Degradation of Levothyroxine in Aqueous Solution and in Solid State | Chong Min Won |
| 138-142 | Kinetic Study of the Transformation from Tetrahydrate to Monohydrate of a New Antiallergic, Sodium 5-(4-oxo-phenoxy-4H-quinolizine-3-carboxamide)-tetrazolate | Satoshi Kitamura, Toshiji Tada, Yoshihiko Okamoto and Tsutomu Yasuda |
| 143-148 | Bisacylphosphonates Inhibit Hydroxyapatite Formation and Dissolution in Vitro and Dystrophic Calcification in Vivo | Gershon Golomb, Ada Schlossman, Hanan Saadeh, Matilda Levi and Joel M. Van Gelder, et al. |
| 149-154 | Poly(L-lactic Acid) Microspheres Containing Neutron-Activatable Holmium-165: A Study of the Physical Characteristics of Microspheres Before and After Irradiation in a Nuclear Reactor | Russell J. Mumper and Michael Jay |
| 155-158 | Potential Use of Microdialysis in Pharmacokinetics: A Protein Binding Study | Marianne Ekblom, Margareta Hammarlund-Udenaes, Thomas Lundqvist and Per Sjöberg |
| 159-160 | Iceberg Formation and the Resulting Effects on Rates of Hydrolysis of Aspirin | Richard J. Prankerd |
| 160 | Editorial |
| 161-168 | Pharmacokinetic Analysis of Drug Absorption from Muscle Based on a Physiological Diffusion Model: Effect of Molecular Size on Absorption | Eiji Nara, Masaaki Masegi, Tetsuya Hatono and Mitsuru Hashida |
| 169-177 | An Experimental Design Strategy for Quantitating Complex Pharmacokinetic Models: Enterohepatic Circulation with Time-Varying Gallbladder Emptying as an Example | Yow-MingChen Wang and Richard H. Reuning |
| 178-181 | Potentiation of Cytotoxicity of Mitoxantrone Toward CHO-K1 Cells in Vitro by Dipyridamole | Pankaj B. Desai and Rajagopalan Sridhar |
| 182-186 | A Novel Approach for the Determination of the Pain-Producing Potential of Intravenously Injected Substances in the Conscious Rat | John M. Marcek, William J. Seaman and Royal J. Weaver |
| 187-190 | Cutaneous Metabolism of Nitroglycerin in Vitro. I. Homogenized Versus Intact Skin | Naruhito Higo, Robert S. Hinz, David T. W. Lau, Leslie Z. Benet and Richard H. Guy |
| 191-194 | Enhanced Bioavailability of Cefoxitin Using Palmitoyl L-Carnitine. I. Enhancer Activity in Different Intestinal Regions | Steven C. Sutton, Edward L. LeCluyse, Leilani Cammack and Joseph A. Fix |
| 195-199 | Hydrophobic Anionic Gel Beads for Swelling-Controlled Drug Delivery | Cherng-Ju Kim and Ping I. Lee |
| 200-205 | Biodegradable Pseudolatexes: The Chemical Stability of Poly(D,L-Lactide) and Poly (ε-Caprolactone) Nanoparticles in Aqueous Media | Mark D. Coffin and James W. McGinity |
| 206-210 | Development of Extended-Release Solid Dispersions of Nonsteroidal Antiinflammatory Drugs with Aqueous Polymeric Dispersions: Optimization of Drug Release via a Curve-Fitting Technique | Chris Ho and GeorgeChiaw-Chi Hwang |
| 211-214 | Determination of Lidocaine Concentrations in Skin After Transdermal Iontophoresis: Effects of Vasoactive Drugs | J.Edmond Riviere, Nancy A. Monteiro-Riviere and Alfred O. Inman |
| 215-219 | An Electrically Modulated Drug Delivery Device. II. Effect of Ionic Strength, Drug Concentration, and Temperature | Antony D'Emanuele and John N. Staniforth |
| 220-223 | Factors Affecting the Release Rate of Terbutaline from Liposome Formulations After Intratracheal Instillation in the Guinea Pig | Robert M. Fielding and Robert M. Abra |
| 224-227 | Pharmacokinetic Evaluation of Drug Interactions with Anti-Human Immunotrophic Virus (HIV) Drugs. III. 2′,3′-Dideoxycytidine (ddC) and Zidovudine in Monkeys | Mingxin Qian, Anne R. Swagler, Mehul Mehta, C. T. Vishwanathan and James M. Gallo |
| 228-235 | Competitive Inhibition of Zidovudine Clearance by Probenecid During Continuous Coadministration | Shekman L. Wong, Mohsen A. Hedaya and Ronald J. Sawchuk |
| 236-243 | Effect of Chronic Hypertension on the Blood–Brain Barrier Permeability of Libenzapril | Jian-ping Tang, Ashok Rakhit, Frank L. Douglas and Srikumaran Melethil |
| 244-249 | Bioavailability of Leuprolide Acetate Following Nasal and Inhalation Delivery to Rats and Healthy Humans | Akwete Adjei, Dean Sundberg, James Miller and Alexander Chun |
| 250-254 | Pharmaceutical Properties of Loracarbef: The Remarkable Solution Stability of an Oral 1-Carba-l-dethiacephalosporin Antibiotic | Carol E. Pasini and Joseph M. Indelicato |
| 255-259 | Development and Evaluation of a Novel Dissolution Apparatus for Medicated Chewing Gum Products | James N. Rider, Ed L. Brunson, Walter G. Chambliss, Robert W. Cleary and Ahmed H. Hikal, et al. |
| 260-265 | Prolonged Systemic Delivery of Peptide Drugs by Long-Circulating Liposomes: Illustration with Vasopressin in the Brattleboro Rat | Martin C. Woodle, Gert Storm, Mary S. Newman, Jill J. Jekot and Lila R. Collins, et al. |
| 266-270 | The Influence of Sucrose, Dextran, and Hydroxypropyl-β-cyclodextrin as Lyoprotectants for a Freeze-Dried Mouse IgG2a Monoclonal Antibody (MN12) | Maaike E. Ressing, Wim Jiskoot, Herre Talsma, Cor W. van Ingen and E.Coen Beuvery, et al. |
| 271-275 | Renal Tubular Handling of p-Aminohippurate and Epidermal Growth Factor (EGF) in Filtering and Nonfiltering Perfused Rat Kidneys | Dong-Chool Kim, Yuichi Sugiyama, Yasufumi Sawada and Manabu Hanano |
| 276-278 | Colonic Drug Delivery: Enhanced Release of Indomethacin from Cross-Linked Chondroitin Matrix in Rat Cecal Content | Abraham Rubinstein, David Nakar and Amnon Sintov |
| 279-280 | European Reviewers for Pharmaceutical Research (November 1990-November 1991) |
| 281 | Association News and Announcements |
| 283-290 | Hydrogels: Swelling, Drug Loading, and Release | Sung Wan Kim, You Han Bae and Teruo Okano |
| 291-297 | Pharmacokinetic/Dynamic Correlation of Pulmonary and Cardiac Effects of Fenoterol in Asthmatic Patients After Different Routes of Administration | Günther Hochhaus, Ernst-Wilhelm Schmidt, Karl L. Rominger and Helmut Möllmann |
| 298-302 | The Bilayer Floating Capsule: A Stomach-Directed Drug Delivery System for Misoprostol | Marianne Oth, Michel Franz, Jacques Timmermans and Andre Möes |
| 303-306 | Cutaneous Metabolism of Nitroglycerin in Vitro. II. Effects of Skin Condition and Penetration Enhancement | Naruhito Higo, Robert S. Hinz, David T. W. Lau, Leslie Z. Benet and Richard H. Guy |
| 307-311 | Rotating-Disk Dissolution Kinetics of Nitrofurantoin Anhydrate and Monohydrate at Various Temperatures | Makoto Otsuka, Reiko Teraoka and Yoshihisa Matsuda |
| 312-315 | An Electrically Modulated Drug Delivery Device. III. Factors Affecting Drug Stability During Electrophoresis | Antony D'Emanuele and John N. Staniforth |
| 316-319 | Simultaneous in Vitro Measurement of Intestinal Tissue Permeability and Transepithelial Electrical Resistance (TEER) Using Sweetana–Grass Diffusion Cells | Steven C. Sutton, Alexander E. Forbes, Robyn Cargill, Jerome H. Hochman and Edward L. LeCluyse |
| 320-325 | Intestinal Absorption of Peptides and Peptide Analogues: Implications of Fasting Pancreatic Serine Protease Levels and pH on the Extent of Oral Absorption in Dogs and Humans | Patrick J. Sinko |
| 326-331 | Mechanism and Site Dependency of Intestinal Mucosal Transport and Metabolism of Thymidine Analogues | Gee-Bae Park and Ashim K. Mitra |
| 332-338 | Analysis of Zidovudine Distribution to Specific Regions in Rabbit Brain Using Microdialysis | Shekman L. Wong, Yanfeng Wang and Ronald J. Sawchuk |
| 339-344 | Uptake and Stereoselective Binding of the Enantiomers of MK-927, a Potent Carbonic Anhydrase Inhibitor, by Human Erythrocytes in Vitro | Jiunn H. Lin, Tsu-Han Lin and Haiyung Cheng |
| 345-349 | Population Characteristics of Biological Systems Influenced by Multicomponent Random and Uniform Variation | Gregory M. Kochak |
| 350-356 | Use of a Pharmacokinetic Model Incorporating Discontinuous Gastrointestinal Absorption to Examine the Occurrence of Double Peaks in Oral Concentration–Time Profiles | A. Benjamin Suttle, Gary M. Pollack and Kirn L. R. Brouwer |
| 357-364 | Bacterial Monitoring in Vials Using a Spectrophotometric Assimilation Method | Leonard J. Galante, Michael A. Brinkley and Robert A. Lodder |
| 365-371 | The Structure of Celiprolol | Narendra Kumar, Christianna Strohbeck and Herman L. Ammon |
| 372-377 | New Water-Soluble Pilocarpine Derivatives with Enhanced and Sustained Muscarinic Activity | Pascal Druzgala, David Winwood, Malgorzata Drewniak-Deyrup, Scott Smith and Nicholas Bodor, et al. |
| 378-384 | The Anomalous Hydrolytic Behavior of 1-Phenylvinyl Phosphate | Albert S. Kearney and Valentino J. Stella |
| 385-389 | Evaluation of the Poisson Distribution for Estimating the Quality of Drug/Diluent Random Powder Mixtures. I. High Particle Size of the Drug Constituent | Herbert Egermann, Peter Frank and Anna Krumphuber |
| 390-397 | Optimized Formulation of Magnetic Chitosan Microspheres Containing the Anticancer Agent, Oxantrazole | Emad Eldin Hassan, Roy C. Parish and James M. Gallo |
| 398-405 | Mechanisms to Control Drug Release from Pellets Coated with a Silicone Elastomer Aqueous Dispersion | Terrence C. Dahl and I-Ian T. Sue |
| 406-409 | Effect of Surfactant Phase in Perfluorocarbon Emulsification Efficiency | Jean M. Pasternacki-Surian, Roger L. Schnaare and Edwin T. Sugita |
| 410-413 | A Novel Method for Determination of Sterility of Microcapsules and Measurement of Viability of Encapsulated Organisms | K. Keith Kwok and Diane J. Burgess |
| 414-418 | Application of Curdlan to Controlled Drug Delivery. I. The Preparation and Evaluation of Theophylline-Containing Curdlan Tablets | Motoko Kanke, Keiko Koda, Yoko Koda and Hirokazu Katayama |
| 419-424 | The Disposition of a Human Relaxin (hRlx-2) in Pregnant and Nonpregnant Rats | Paul A. Cossum, Kevin A. Dwyer, Michael Roth, Sharon A. Chen and Barbara Moffat, et al. |
| 425-434 | Sustained Delivery of Interleukin-2 from a Poloxamer 407 Gel Matrix Following Intraperitoneal Injection in Mice | Thomas P. Johnston, Monika A. Punjabi and Christopher J. Froelich |
| 435-439 | The Influence of Peptide Structure on Transport Across Caco-2 Cells. II. Peptide Bond Modification Which Results in Improved Permeability | Robert A. Conradi, Alien R. Hilgers, Norman F. H. Ho and Philip S. Burton |
| 440 | Association News and Announcements |
| 441-449 | Polyalkylcyanoacrylate Nanoparticles as Polymeric Carriers for Antisense Oligonucleotides | Christine Chavany, Trung Le Doan, Patrick Couvreur, Francis Puisieux and Claude Hélèna |
| 450-456 | Correlation of in Vitro Release Rate and in Vivo Absorption Characteristics of Four Chlorpheniramine Maleate Extended-Release Formulations | Parviz Mojaverian, Elaine Radwanski, Chin-Chung Lin, Phillip Cho and Winston A. Vadino, et al. |
| 457-463 | Pharmacokinetic and Pharmacodynamic Comparison of Immediate-Release and Sustained-Release Adinazolam Mesylate Tablets After Single- and Multiple-Dose Administration | Joseph C. Fleishaker and C. Eugene Wright |
| 464-468 | The Pharmacokinetics of Trilostane and Ketotrilostane in an Interconverting System in the Rat | J. Paul McGee and P. Nicholas Shaw |
| 469-473 | Saturable Tissue Binding and Imirestat Pharmacokinetics in Rats | Jenny Y. Chien, Christopher R. Banfield, Romulus K. Brazzell, Philip R. Mayer and John T. Slattery |
| 474-479 | Significance of Binding to Na,K-ATPase in the Tissue Distribution of Ouabain in Guinea Pigs | Hideyoshi Harashima, Michio Mamiya, Masayo Yamazaki, Yuichi Sugiyama and Yasufumi Sawada, et al. |
| 480-484 | The in Situ Acetylation of an Immobilized Human Serum Albumin Chiral Stationary Phase for High-Performance Liquid Chromatography in the Examination of Drug–Protein Binding Phenomena | Terence A. G. Noctor and Irving W. Wainer |
| 485-491 | An Air-Gap Enzyme Electrode: Development and Applications | Ravi M. Shanker, Nashed E. Nashed and Siegfried Lindenbaum |
| 492-496 | Stereoselective Enzymatic Hydrolysis of Various Ester Prodrugs of Ibuprofen and Flurbiprofen in Human Plasma | Niels Mørk and Hans Bundgaard |
| 497-503 | The in Vitro Enzymic Labilities of Chemically Distinct Phosphomonoester Prodrugs | Albert S. Kearney and Valentine J. Stella |
| 504-514 | Amino Acid Side-Chain Contributions to Free Energy of Transfer of Tripeptides from Water to Octanol | Aeri Kim and Francis C. Szoka Jr |
| 515-520 | Nebulization of Liposomes. III. The Effects of Operating Conditions and Local Environment | Ralph W. Niven, Teresa M. Carvajal and Hans Schreier |
| 521-528 | Infrared Imaging of Pharmaceutical Materials Undergoing Compaction | Simon R. Bechard and G. R. B. Down |
| 529-534 | Absorptive-Mediated Endocytosis of an Adrenocorticotropic Hormone (ACTH) Analogue, Ebiratide, into the Blood–Brain Barrier: Studies with Monolayers of Primary Cultured Bovine Brain Capillary Endothelial Cells | Tetsuya Terasaki, Susumu Takakuwa, Akira Saheki, Shuzo Moritani and Takesada Shimura, et al. |
| 535-540 | Aminopeptidase Activity in the Jejunal and Heal Peyer's Patches of the Albino Rabbit | Eiji Hayakawa and Vincent H. L. Lee |
| 541-546 | Phagocytosis of Nanoparticles by Human Immunodeficiency Virus (HlV)-Infected Macrophages: A Possibility for Antiviral Drug Targeting | Volker Schäfer, Hagen von Briesen, Reinhard Andreesen, Anne-Marie Steffan and Cathy Royer, et al. |
| 547-553 | Bioadhesion by Means of Specific Binding of Tomato Lectin | Claus-Michael Lehr, Joke A. Bouwstra, Wouter Kok, Arthur B. J. Noach and Albertus G. de Boer, et al. |
| 554-558 | Influence of Supersaturation on the Pharmacodynamic Effect of Bupranolol After Dermal Administration Using Microemulsions as Vehicle | Jens Kemken, Albrecht Ziegler and Bernd W. Müller |
| 559-564 | Sonophoresis. I. The Use of High-Frequency Ultrasound to Enhance Transdermal Drug Delivery | D. Bommannan, Hirohisa Okuyama, Paul Stauffer and Richard H. Guy |
| 565-569 | Characteristics of Association of Oleoyl Derivatives of 5-Fluorodeoxyuridine and Methotrexate with Low-Density Lipoproteins (LDL) | P. Chris de Smidt and Theo J. C. van Berkel |
| 570-574 | Physicochemical Properties of the Novel Heteropolyanion Antiviral Hexapotassium-α-vanado-11-tungstoborate (DuP 925) | Michael B. Maurin, Rodney D. Vickery, W. M. Bryant, III and Munir A. Hussain |
| 575-577 | 1H-Nuclear Magnetic Resonance (NMR) Studies on the Inclusion Complex of Prostaglandin El (PGE1 with α-Cyclodextrin | Bert Steffan, Wilfried Fischer, Günther Cordes, Ilona Habon and Robert Müller |
| 578-581 | A Flexible Automated Dissolution Testing System for Use with Either USP Apparatus 1 or USP Apparatus 2 | Jeanette D. Dunkle, Daniel J. Gleason and Gerard C. Hokanson |
| 582-584 | Determination of Dissociation Constants of Selected Cyclodextrin–Benzaldehyde Inclusion Complexes Using Pulse Polarography1 | Hee-Sook Choi, Ching-jer Chang and Adelbert M. Knevel |
| 585 | BOOK REVIEWS |
| 585-586 | BOOK REVIEWS |
| 586-587 | BOOK REVIEWS |
| 586-587 | BOOK REVIEWS |
| 588-592 | Analytical Methods Validation: Bioavailability, Bioequivalence and Pharmacokinetic Studies | Vinod P. Shah, Kamal K. Midha, Shrikant Dighe, Iain J. McGilveray and Jerome P. Skelly, et al. |
| 593-594 | Association News and Announcements |
| 595-600 | Stability Studies of Gabapentin in Aqueous Solutions | Elena Zour, Shahid A. Lodhi, Russell U. Nesbitt, Steven B. Silbering and Pravin R. Chaturvedi |
| 601-606 | Analytical Method Comparison Based upon Statistical Power Calculations | David J. Mazzo and Margaret Connolly |
| 607-612 | Effect of Water Mobility on Drug Hydrolysis Rates in Gelatin Gels | Sumie Yoshioka, Yukio Aso and Tadao Terao |
| 613-616 | Initial Studies on the N-Glucosylation of Phenobarbital by Mouse Liver Microsomes Using a Radiochemical High-Performance Liquid Chromatographic (HPLC) Method | William H. Soine, Hosai Safi and Richard B. Westkaemper |
| 617-622 | Kinetics and Mechanism of Isomerization of Cyclosporin A | Reza Oliyai and Valentino J. Stella |
| 623-625 | Microbial Production of a Crisnatol Metabolite | Charles D. Hufford, Saleh H. El-Sharkawy, Tannis M. Jurgens and Julie R. Mikell |
| 626-628 | A Phosphinic Acid Dipeptide Analogue to Stabilize Peptide Drugs During Their Intranasal Absorption | Munir A. Hussain, Marguerita S. L. Lim, Krishnaswamy S. Raghavan, Nancy J. Rogers and Rommel Hidalgo, et al. |
| 629-635 | Adsorption of Fluorescein Dyes on Albumin Microspheres | Kamel Egbaria and Michael Friedman |
| 636-642 | Prediction and Assessment of Flammability Hazards Associated with Metered-Dose Inhalers Containing Flammable Propellants | Richard N. Dalby |
| 643-647 | Analytical Control Procedures of Immunoreactivity for IgG and Fab Fragments Specific to Haptens | Nathalie J. Cano, Alain E. Sabouraud, Michel Urtizberea, Jean Carcagne and Michel Grandgeorge, et al. |
| 648-653 | Differences in the Enhancing Effects of Sodium Caprate on Colonic and Jejimal Drug Absorption | Mikio Tomita, Toyohiro Sawada, Takahiro Ogawa, Hiroyuki Ouchi and Masahiro Hayashi, et al. |
| 654-657 | Gastrointestinal Transit and Systemic Absorption of Captopril from a Pulsed-Release Formulation | Ian R. Wilding, Stanley S. Davis, Massoud Bakhshaee, Howard N. E. Stevens and Robert A. Sparrow, et al. |
| 658-662 | Heat-Induced Drug Release Rate and Maximal Targeting Index of Thermosensitive Liposome in Tumor-Bearing Mice | Katsumi Iga, Yasuaki Ogawa and Hajime Toguchi |
| 663-669 | Predicting Skin Permeability | Russell O. Potts and Richard H. Guy |
| 670-676 | Equilibrium and Kinetic Factors Influencing Bile Sequestrant Efficacy | Paul E. Luner and Gordon L. Amidon |
| 677-682 | Pharmacokinetic and Metabolic Disposition of p-Chloro-m-xylenol (PCMX) in Dogs | Angelica Dorantes and Salomon Stavchansky |
| 683-686 | Effect of an Acute Dose of Alcohol on the Pharmacokinetics of Oral Nifedipine in Humans | Saeed Qureshi, Sylvie Laganière, Gilles Caillé, Denys Gossard and Yves Lacasse, et al. |
| 687-689 | Esterase Activity Toward the Diastereomers of Cefuroxime Axetil in the Rat and Dog | Gerold L. Mosher, Julianne McBee and David B. Shaw |
| 690-693 | Molecular Complexation: β-Cyclodextrin and Benzaldehyde Inclusion Complex | Hee-Sook Choi, Adelbert M. Knevel and Ching-jer Chang |
| 694-696 | Pharmacokinetics of Droperidol in Healthy Volunteers Following Intravenous Infusion and Rectal Administration from an Osmotic Drug Delivery Module | Suneel K. Gupta, Mary Southam and Stephen Hwang |
| 697-699 | Enhanced Bioavailability of 6-Mercaptopurine After Rectal Administration in Rats | Yasuhisa Kato, Takeji Matsushita, Tomomasa Yokoyama and Kiminori Mohri |
| 700 | BOOK REVIEWS |
| 700-701 | BOOK REVIEWS |
| 702 | Association News and Announcements |
| 703-714 | Anti-AIDS Drug Development: Challenges and Strategies | Prem Mohan |
| 715-726 | Chemical Stability of Insulin. 1. Hydrolytic Degradation During Storage of Pharmaceutical Preparations | Jens Brange, Liselotte Langkj\sgmaelig;r, Svend Havelund and Aage Vølund |
| 727-734 | Chemical Stability of Insulin. 2. Formation of Higher Molecular Weight Transformation Products During Storage of Pharmaceutical Preparations | Jens Brange, Svend Havelund and Philip Hougaard |
| 735-738 | Derivatives of 4-(2-N,N-Di-n-propylaminoethyl)-5-hydroxyindole: Synthesis and Pharmacological Effects | Joseph G. Cannon, Ioannis Roufos, Sheng Xing Ma and John Paul Long |
| 739-742 | Structural Modification Study of Anthracyclinones: Synthesis and Biological Activity of Several Derivatives of η-Pyrromycinone | Dun-Fu Liu, Hui Xiong and Chia-Chung Cheng |
| 743-749 | Improved Delivery Through Biological Membranes. XLV. Synthesis, Physical-Chemical Evaluation, and Brain Uptake Studies of 2-Chloroethyl Nitrosourea Delivery Systems | Krishnaswamy Raghavan, Thorsteinn Loftsson, Marcus E. Brewster and Nicholas Bodor |
| 750-752 | Parenteral Formulation of the Kappa Agonist Analgesic, DuP 747, via Micellar Solubilization | Munir A. Hussain, Lei-Shu Wu, Christopher Koval and Arthur R. Hurwitz |
| 753-758 | Acceleration of Heat Transfer in Vial Freeze-Drying of Pharmaceuticals. II. A Fluid Cushion Device | Samuel H. Yalkowsky and Suresh D. Patel |
| 759-763 | Microencapsulation of Solid Dispersions: Release of Griseofulvin from Griseofulvin:Phospholipid Coprecipitates in Microspheres | Gopi K. Vudathala and James A. Rogers |
| 764-768 | The Pharmacokinetics of Pulmonary-Delivered Insulin: A Comparison of Intratracheal and Aerosol Administration to the Rabbit | Paul Colthorpe, Stephen J. Farr, Glyn Taylor, lan J. Smith and David Wyatt |
| 769-775 | Conjunctival Penetration of Insulin and Peptide Drugs in the Albino Rabbit | Eiji Hayakawa, Du-Shieng Chien, Kazuhiro Inagaki, Akira Yamamoto and Wei Wang, et al. |
| 776-781 | Immobilization of Active Urokinase on Albumin Microspheres: Use of a Chemical Dehydrant and Process Monitoring | Kumaril Bhargava and Howard Y. Ando |
| 782-787 | Macrophage Activation by Polymeric Nanoparticles of Polyalkylcyanoacrylates: Activity Against Intracellular Leishmania donovani Associated with Hydrogen Peroxide Production | Rogério Gaspar, Veronique Préat, Fred R. Opperdoes and Michel Roland |
| 788-791 | The Mobile Order Theory Versus UNIFAC and Regular Solution Theory-Derived Models for Predicting the Solubility of Solid Substances | Paul Ruelle, Michel Buchmann, Hô Nam-Tran and Ulrich W. Kesselring |
| 792-799 | Cholesterol (Thermodynamic) Activity Determinations in Bile Salt–Lecithin–Cholesterol Systems and Cholesterol-Rich Liquid Crystalline Mesophase Formation | Uday K. Jain, William I. Higuchi, Chen L. Liu, Paul H. Lee and Norman A. Mazer |
| 800-807 | Plasma Concentration Clamping in the Rat Using a Computer-Controlled Infusion Pump | Lars L. Gustafsson, William F. Ebling, Eileen Osaki, Sandy Harapat and Donald R. Stanski, et al. |
| 808-811 | Stability of the New Anticancer Platinum Analogue 1,2-Diaminomethyl-Cyclobutane-Platinum(II)-Lactate (Lobaplatin; D19466) in Intravenous Solutions | Henk-Jan Guchelaar, Donald R. A. Uges, Paul Aulenbacher, Elisabeth G. E. de Vries and Nanno H. Mulder |
| 812-816 | Simultaneous Microdetermination of Rifampin, Deacetylrifampin, Isoniazid, and Acetylisoniazid in Plasma by Liquid Chromatography with Dual Electrochemical and Spectrophotometric Detection | Adnan El-Yazigi and Dale A. Raines |
| 817-821 | Comparison of Azone and Hexamethylene Lauramide in Toxicologic Effects and Penetration Enhancement of Cimetidine in Rabbit Eyes | I. Maged Ismail, Chi-Chu Chen, Joseph B. Richman, Jon S. Andersen and Diane D.-S. Tang-Liu |
| 822-825 | Pharmacokinetics of Oral 2′,3′-Dideoxyinosine in Rats | M. Guillaume Wientjes and Jessie L.-S. Au |
| 826-833 | Opportunities for Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development | Carl C. Peck, William H. Barr, Leslie Z. Benet, Jerry Collins and Robert E. Desjardins, et al. |
| 834 | Association News and Announcements |
| 835-844 | Biosensor Development | Jeffrey N. Roe |
| 845-849 | Reversal of Signs of Induced Cotton Effects of Dicumarol-α1-Acid Glycoprotein Systems by Phenothiazine Neuroleptics Through Ternary Complexation | Toshimi Miyoshi, Ryuji Yamamichi, Toru Maruyama and Masaki Otagiri |
| 850-855 | The Enantiomers of the Valproic Acid Analogue 2-n-Propyl-4-pentynoic Acid (4-yn-VPA): Asymmetric Synthesis and Highly Stereoselective Teratogenicity in Mice | Ralf-Siegbert Hauck and Heinz Nau |
| 856-859 | Microscopic Characterization of Particle Size and Shape: An Inexpensive and Versatile Method | Michael E. Houghton and Gregory E. Amidon |
| 860-863 | Sterile Filtration of a Parenteral Emulsion | Deborah M. Lidgate, Thomas Trattner, Richard M. Shultz and Richard Maskiewicz |
| 864-869 | Dissociation of Insulin Oligomers by Bile Salt Micelles and Its Effect on α-Chymotrypsin-Mediated Proteolytic Degradation | Yuping Li, Zezhi Shao and Ashim K. Mitra |
| 870-877 | Effect of Zinc Binding on the Structure and Stability of Fibrolase, a Fibrinolytic Protein from Snake Venom | Denise Pretzer, Brenda Schulteis, David G. Vander Velde, Christopher D. Smith and James W. Mitchell, et al. |
| 878-883 | Vaginal Absorption of Insulin in the Rat: Effect of Penetration Enhancers on Insulin Uptake and Mucosal Histology | Julie L. Richardson, Lisbeth Illum and Norman W. Thomas |
| 884-887 | The Influence of Different Strains and Age on in Vitro Rat Skin Permeability to Water and Mannitol | Ian P. Dick and Robert C. Scott |
| 888-893 | Oral Delivery of a Renin Inhibitor Compound Using Emulsion Formulations | Tugrul T. Kararli, Thomas E. Needham, Marty Griffin, Grant Schoenhard and Leonard J. Ferro, et al. |
| 894-900 | Intestinal Water and Solute Absorption Studies: Comparison of in Situ Perfusion with Chronic Isolated Loops in Rats | Hsiao-Hwa Lu, James D. Thomas, Josef J. Tukker and David Fleisher |
| 901-907 | Absorption of Flurbiprofen in the Fed and Fasted States | Jennifer B. Dressman, Rosemary R. Berardi, Grace H. Elta, Thomas M. Gray and Patricia A. Montgomery, et al. |
| 908-914 | Effect of Chronic Administration of Phenobarbital on the Hepatobiliary Transport of Phenol Red: Assessment by Statistical Moment Analysis | Toshiyuki Kakutani, Kaori Endo, Eiji Nara, Shigenobu Nakazora and Mitsuru Hashida |
| 915-919 | Multiple Oral Administration of a Ketoprofen–Dextran Ester Prodrug in Pigs: Assessment of Gastrointestinal Unavailability by Deconvolution | Frank Larsen, Bodil Hamborg Jensen, Henning Peter Olesen and Claus Larsen |
| 920-924 | An in Vitro Pharmacodynamic Model to Simulate Antibiotic Behavior of Acute Otitis Media with Effusion | Kyle Vance-Bryan, Tom A. Larson, Mark W. Garrison, John P. Toscano and Daniel M. Canafax, et al. |
| 925-928 | Bioequivalence | Aldo Rescigno |
| 929-932 | Method for the Determination of Diphenhydramine in Rabbit Whole Blood by High-Performance Liquid Chromatography (HPLC) with Ultraviolet (UV) Detection in Conjunction with Gas Chromatography (GC) with Mass Selective Detection (MSD) | Karen M. Walters-Thompson and William D. Mason |
| 933-938 | Investigation of the Degradation Mechanism of 5-Aminosalicylic Acid in Aqueous Solution | Rita K. Palsmeier, Donna M. Radzik and Craig E. Lunte |
| 939-944 | Solid-State Stability Testing of Drugs by Isothermal Calorimetry | Michael J. Koenigbauer, Stephen H. Brooks, Gregory Rullo and Richard A. Couch |
| 945-951 | Application of Electrospray Mass Spectrometry (ES-MS) for the Analysis of Monoclonal Antibody Fc Subunits | Wim Jiskoot, Gerrit van de Werken, José M. Coco Martin, Brian N. Green and E. Coen Beuvery, et al. |
| 952-954 | Transdermal Delivery of Insulin to Alloxan-Diabetic Rabbits by Ultrasound Exposure | Katsuro Tachibana |
| 955-957 | Electric Current-Sensitive Drug Delivery Systems Using Sodium Alginate/Polyacrylic Acid Composites | Soon Hong Yuk, Sun Hang Cho and Hai Bang Lee |
| 958-959 | Ideal Solubility of a Solid Solute: Effect of Heat Capacity Assumptions | Dinesh S. Mishra and Samuel H. Yalkowsky |
| 960-962 | Physical Properties of Fast-Release Nonreverting Hydrochlorothiazide Solid Dispersions | Mahasen M. Meshali and Khairy E. Gabr |
| 963-965 | Etorphine Is an Opiate Analgesic Physicochemically Suited to Transdermal Delivery | Lynn M. Jolicoeur, M. Reza Nassiri, Charles Shipman Jr, Hoo-Kyun Choi and Gordon L. Flynn |
| 966 | BOOK REVIEWS |
| 966-967 | BOOK REVIEWS |
| 968 | Association News and Announcements |
| 969-978 | Structural Specificity of Mucosal-Cell Transport and Metabolism of Peptide Drugs: Implication for Oral Peptide Drug Delivery | Jane P. F. Bai and Gordon L. Amidon |
| 979-989 | Novel Animal Model for Evaluating Topical Efficacy of Antiviral Agents: Flux Versus Efficacy Correlations in the Acyclovir Treatment of Cutaneous Herpes Simplex Virus Type 1 (HSV-1) Infections in Hairless Mice | Paul H. Lee, Muh-Hwan Su, Earl R. Kern and William I. Higuchi |
| 990-992 | Protein–Peptide Interactions as Probed by Tryptophan Fluorescence: Serum Albumins and Enkephalin Metabolites | Sunil Jain, C. Vijaya Kumar and Devendra S. Kalonia |
| 993-1002 | An Implantable Dosage Form for the Treatment of Bone Infections | Alekha K. Dash and Raj Suryanarayanan |
| 1003-1009 | Pharmacodynamics of Insulin Following Intravenous and Enteral Administrations of Porcine-Zinc Insulin to Rats | Robert J. Schilling and Ashim K. Mitra |
| 1010-1017 | Antisense c-myc Oligodeoxyribonucleotide Cellular Uptake | Susanna Wu-Pong, Tania L. Weiss and C. Anthony Hunt |
| 1018-1023 | Measurement of Serum [3H]Tetracycline Kinetics and Indices of Kidney Function Facilitate Study of the Activity and Toxic Effects of Bisphosphonates in Bone Resorption | Gershon Golomb, Yael Eitan and Amnon Hoffman |
| 1024-1028 | Enhancement of Nasal Delivery of a Renin Inhibitor in the Rat Using Emulsion Formulations | Tugrul T. Kararli, Thomas E. Needham, Grant Schoenhard, David A. Baron and R. Eric Schmidt, et al. |
| 1029-1034 | The Transport Barrier of Epithelia: A Comparative Study on Membrane Permeability and Charge Selectivity in the Rabbit | Yongyut Rojanasakul, Li-Ying Wang, Meenakshi Bhat, Douglas D. Glover and Carl J. Malanga, et al. |
| 1035-1042 | Quantitative Evaluation of Aqueous Isopropanol Enhancement of Skin Flux of Terbutaline (Sulfate). I. Ion Associations and Species Equilibria in the Formulation | Puchun Liu, Tamie Kurihara-Bergstrom, Frank H. Clarke, Nina Gonnella and William R. Good |
| 1043-1047 | Sonophoresis. II. Examination of the Mechanism(s) of Ultrasound-Enhanced Transdermal Drug Delivery | D. Bommannan, Gopinathan K. Menon, Hirohisa Okuyama, Peter M. Elias and Richard H. Guy |
| 1048-1052 | Brain Parenchymal Metabolism of 5-Iodo-2′-Deoxyuridine and 5′-Ester Prodrugs | Mridul K. Ghosh and Ashim K. Mitra |
| 1053-1057 | Disposition, Bioavailability, and Serum Protein Binding of Pentachlorophenol in the B6C3F1 Mouse | Bruno G. Reigner, Jean F. Rigod and Thomas N. Tozer |
| 1058-1063 | Pharmacokinetic Analysis of the Structural Requirements for Forming “Stable” Analogues of Valpromide | Abdulla Haj-Yehia, Salim Hadad and Meir Bialer |
| 1064-1069 | Pilocarpine Disposition and Salivary Flow Responses Following Intravenous Administration to Dogs | Margaret L. Weaver, Jason M. Tanzer and Paul A. Kramer |
| 1070-1075 | Nonlinear Disposition of Intravenous 2′,3′-Dideoxyinosine in Rats | M. Guillaume Wientjes, Elora Mukherji and Jessie L-S. Au |
| 1076-1082 | Is ICRF-187 [(+)-1,2-Bis(3,5-dioxopiperazinyl-1-yl)propane] Unusually Reactive for an Imide? | Jay M. Sisco and Valentino J. Stella |
| 1083-1091 | Formation of the Racemic Compound of Ephedrine Base from a Physical Mixture of Its Enantiomers in the Solid, Liquid, Solution, or Vapor State | Sarma P. Duddu and David J. W. Grant |
| 1092-1095 | Aqueous Stability and Solubility of CI-988, a Novel “Dipeptoid” Cholecystokinin-B Receptor Antagonist | Albert S. Kearney, Surendra C. Mehta and Galen W. Radebaugh |
| 1096-1098 | Corticosteroid Pharmacodynamic Modeling: Osteocalcin Suppression by Prednisolone | Jeffrey A. Wald and William J. Jusko |
| 1099-1102 | Inhibition of Hepatic and Cutaneous Biotransformation of Resorufin Ethers Following Intraperitoneal Administration of 1-Aminobenzotriazole | Neil F. Oldfield, Mildred Mortillo, William A. Garland and Bruce A. Mico |
| 1103-1106 | Peptides Are Better Absorbed from the Lung than the Gut in the Rat | Jennifer L. Hoover, Bob D. Rush, Karen F. Wilkinson, Jeff S. Day and Philip S. Burton, et al. |
| 1107-1112 | Principles and Criteria in the Development and Optimization of Topical Therapeutic Products | Vinod P. Shah, Charan R. Behl, Gordon L. Flynn, William I. Higuchi and Hans Schaefer |
| 1113-1122 | Transport of Thyrotropin Releasing Hormone in Rabbit Buccal Mucosa in Vitro | Martin E. Dowty, Kim E. Knuth, Brian K. Irons and Joseph R. Robinson |
| 1123-1127 | Assessment of the Twin Impinger for Size Measurement of Metered-Dose Inhaler Sprays | Nicholas C. Miller, Virgil A. Marple, Robert K. Schultz and Wai Sing Poon |
| 1128-1131 | Calcium Alginate Beads as Core Carriers of 5-Aminosalicylic Acid | Shun Y. Lin and James W. Ayres |
| 1132-1136 | Indomethacin-Loaded Microspheres: Design and Preparation by a Multiple-Emulsification Technique and Their in Vitro Evaluation | Suranjana Roy, Manjusree Pal and Bijan K. Gupta |
| 1137-1144 | Evaluation of Mucoadhesive Polymers in Ocular Drug Delivery. II. Polymer-Coated Vesicles | Nigel M. Davies, Stephen J. Farr, Jonathan Hadgraft and Ian W. Kellaway |
| 1145-1151 | Percutaneous Absorption and Metabolism of Lonapalene in Psoriatic Skin | Paul A. Lehman, Raymond V. Tomlinson, Jerry I. Johnson, John E. Olerud and William A. Akers, et al. |
| 1152-1156 | Correlation Between the Inhibitory Effects of Basic Drugs on the Uptake of Cardiac Glycosides and Taurocholate by Isolated Rat Hepatocytes | Kazuho Okudaira, Masayo Yamazaki, Yasufumi Sawada, Yuichi Sugiyama and Tatsuji Iga, et al. |
| 1157-1163 | Cyclodextrins as Nasal Absorption Promoters of Insulin: Mechanistic Evaluations | Zezhi Shao, Ramesh Krishnamoorthy and Ashim K. Mitra |
| 1164-1167 | In Vivo Percutaneous Absorption of Hydrocortisone: Multiple-Application Dosing in Man | Joseph L. Melendres, Daniel A. W. Bucks, Etienne Camel, Ronald C. Wester and Howard I. Maibach |
| 1168-1172 | Effects of Transdermal Penetration Enhancers on the Permeability of Shed Snakeskin | Tomoo Itoh, Lori Wasinger, T. Marjukka Turunen and J. Howard Rytting |
| 1173-1176 | Enhanced Delivery of 5-Iodo-2′-Deoxyuridine to the Brain Parenchyma | Mridul K. Ghosh and Ashim K. Mitra |
| 1177-1183 | Direct Suppression of Phagocytosis by Amphipathic Polymeric Surfactants | Nancy Watrous-Peltier, Joanne Uhl, Vivian Steel, Lynne Brophy and Elaine Merisko-Liversidge |
| 1184-1189 | Nasal Membrane and Intracellular Protein and Enzyme Release by Bile Salts and Bile Salt-Fatty Acid Mixed Micelles: Correlation with Facilitated Drug Transport | Zezhi Shao and Ashim K. Mitra |
| 1190-1194 | Influence of Gastrointestinal Site of Drug Delivery on the Absorption Characteristics of Ranitidine | Melissa F. Williams, George E. Dukes, William Heizer, Yieng-Hau Han and David J. Hermann, et al. |
| 1195-1198 | Molecular Weight-Dependent Lymphatic Transfer of Exogenous Macromolecules from Large Intestine of Renal Insufficiency Rats | Hiroshi Yoshikawa, Kanji Takada and Shozo Muranishi |
| 1199-1202 | Quantitative Analysis of Mercaptoundecahydrododecaborate by Fourier Transform Infrared Spectroscopy | D. Robert Lu and Corey Munro |
| 1203-1208 | Solid-State Stability Studies of 13-cis-Retinoic Acid and All-trans-Retinoic Acid Using Microcalorimetry and HPLC Analysis | Xinyi Tan, Noel Meltzer and Siegfried Lindenbaum |
| 1209-1214 | An Unexpected Hydrolysis pH-Rate Profile, at pH Values Less than 7, of the Labile Imide, ICRF-187: (+)-1,2-Bis-(3,5 -dioxopiperazin-1-yl)propane | Jay M. Sisco and Valentino J. Stella |
| 1215-1218 | A New Application Chamber for Skin Penetration Studies in Vivo with Liquid Preparations | Claudia S. Leopold and Bernhard C. Lippold |
| 1219-1223 | Analysis of Pilocarpine and Its Degradation Products by Micellar Electrokinetic Capillary Chromatography | William N. Charman, Andrew J. Humberstone and Susan A. Charman |
| 1224-1226 | Survey of Chlorinated Hydrocarbons and Other Organic Volatile Impurities in Captopril Raw Materials and Tablets | Terry D. Cyr, Robert C. Lawrence and Edward G. Lovering |
| 1227-1230 | Determination of a Novel Calcium Channel Antagonist, Mepirodipine, in Plasma by Radioreceptor Assay Using (+)-[3H]PN 200-110 | Shizuo Yamada, Youmei Matsuoka, Naoko Suzuki, Noriaki Sugimoto and Yoshihisa Kato, et al. |
| 1231 | BOOK REVIEWS |
| 1231-1232 | BOOK REVIEWS |
| 1233-1234 | Letters to the Editor | Wolfgang Klement, Detlef Kindgen-Milles, John M. Marcek, William J. Seaman and Royal J. Weaver |
| 1234 | Obituary for Razia Zaman and Shahanara Zaman Saroya | L. Bernstam, I. Bernstein, K. Brabec, M. Brabec and R. Brown, et al. |
| 1235-1242 | Delivery of Plasmid DNA into Mammalian Cell Lines Using pH-Sensitive Liposomes: Comparison with Cationic Liposomes | Jean-Yves Legendre and Francis C. Szoka Jr |
| 1243-1251 | Regional Jejunal Perfusion, a New in Vivo Approach to Study Oral Drug Absorption in Man | Hans Lennernäs, Örjan Ahrenstedt, Roger Hällgren, Lars Knutson and Märta Ryde, et al. |
| 1252-1255 | Suppression of Inflammation by Cyclosporin A Is Mediated via a T Lymphocyte-Independent Process | Thomas E. Miller, Glenne Findon and Douglas J. Ormrod |
| 1256-1261 | Microdialysis Sampling for the Investigation of Dermal Drug Transport | Joseph M. Ault, Craig E. Lunte, Noel M. Meltzer and Christopher M. Riley |
| 1262-1267 | Acyclovir Permeation Enhancement Across Intestinal and Nasal Mucosae by Bile Salt-Acylcarnitine Mixed Micelles | Gee-Bae Park, Zezhi Shao and Ashim K. Mitra |
| 1268-1274 | Effect of Loading on Swelling-Controlled Drug Release from Hydrophobic Polyelectrolyte Gel Beads | Cherng-Ju Kim and Ping I. Lee |
| 1275-1278 | Metabolism, Distribution, and Transdermal Permeation of a Soft Corticosteroid, Loteprednol Etabonate | Nicholas Bodor, Thorsteinn Loftsson and Whei-mei Wu |
| 1279-1283 | Molecular Weight Changes in Polymer Erosion | Antony D’Emanuele, Jennifer Hill, Janet A. Tamada, Abraham J. Domb and Robert Langer |
| 1284-1289 | Dose Proportionality of Transdermal Nitroglycerin | R. C. Jewell, C. R. Banfield, D. A. Ruggirello, Y. W. Huang and P. K. Noonan, et al. |
| 1290-1294 | Metabolism of Testosterone During in Vitro Transport Across CACO-2 Cell Monolayers: Evidence for β-Hydroxysteroid Dehydrogenase Activity in Differentiated CACO-2 Cells | Anders Buur and Niels Mørk |
| 1295-1298 | High-Dose Methotrexate Does Not Affect the Pharmacodynamics of Phenobarbital Hypnotic Action but Decreases the Central Nervous System (CNS) Sensitivity to Pentylenetetrazol-Induced Maximal Seizures in Rats | Amnon Hoffman and Jose Alfon |
| 1299-1305 | Studies on the Excretion of Diazepam and Nordazepam into Milk for the Prediction of Milk-to-Plasma Drug Concentration Ratios | Thomas Stebler and Theodor W. Guentert |
| 1306-1313 | General Treatment of the Enterohepatic Recirculation of Drugs and Its Influence on the Area Under the Plasma Level Curves, Bioavailability, and Clearance | José-Esteban Peris-Ribera, Francisca Torres-Molina, M. Carmen Garcia-Carbonell, Juan Carlos Aristorena and Luis Granero |
| 1314-1320 | Kinetics and Mechanism of Degradation of a Cyclic Hexapeptide (Somatostatin Analogue) in Aqueous Solution | Ramesh Krishnamoorthy and Ashim K. Mitra |
| 1321-1323 | A Quantitative Structure-Activity Relationship (QSAR) Study of Alkylpyrazine Odor Modalities | Anna Tsantili-Kakoulidou and Lemont B. Kier |
| 1324-1329 | The Effects of N(4-Methylphenyl)diphenimide on Lipid Metabolism of Sprague Dawley Rats | Iris H. Hall, O. T. Wong, Rupendra Simlot and David J. Reynolds |
| 1330-1335 | Microparticles of Polyvinyl Alcohol for Nasal Delivery. I. Generation by Spray-Drying and Spray-Desolvation | Teck-Yeo Ting, Igor Gonda and Elizabeth M. Gipps |
| 1336-1340 | Participation of Macrogolstearate 400 Lamellar Phases in Hydrophilic Creams and Vesicles | Valentina Paspaleeva-Kühn and Eberhard Nürnberg |
| 1341-1346 | Benzoyl Peroxide Solubility and Stability in Hydric Solvents | Eric M. Chellquist and William G. Gorman |
| 1347-1350 | Predicting the Effect of Nonionic Surfactants on Dispersed Droplet Radii in Submicron Oil-in-Water Emulsions | Shawn Silvestri, Nandita Ganguly and Esmail Tabibi |
| 1351-1358 | Powdered Solution Technology: Principles and Mechanism | Spiros S. Spireas, Charles I. Jarowski and Bhagwan D. Rohera |
| 1359-1361 | In Vitro Oral Mucosal Absorption of Liposomal Triamcinolone Acetonide | Stefan J. Sveinsson and Michael Mezei |
| 1362-1364 | Nasal Absorption of Leucine Enkephalin in Rats and the Effects of Aminopeptidase Inhibition, as Determined from the Percentage of the Dose Unabsorbed | Munir A. Hussain and Bruce J. Aungst |
| 1365-1369 | High-Performance Liquid Chromatography Determination of Acitretin in Plasma and Its Application to a Pharmacokinetic Study in Human Subjects | Christian Surber, Jean-Philippe Laugier, Jean-Marie Geiger, Hot Bun and Alain Durand, et al. |
| 1370-1373 | Inhibition of myo-Inositol 1-Phosphatase by cis-l,2,3-Cyclohexanetriol 1-Phosphate, a Molecular Simplification of the Natural Substrate | Marc W. Harrold, Anong Sriburi, Paul Caimano, Hansheng Qi and David Seybert, et al. |
| 1374 | Association News and Announcements |
| 1375-1379 | Monoclonal Antibodies in Hapten Immunoassays | Olivier N. Chappey, Pierre Sandouk and Jean-Michel G. Scherrmann |
| 1380-1385 | An Alternative Approach for Assessment of Rate of Absorption in Bioequivalence Studies | Mei-Ling Chen |
| 1386-1393 | Identification of Sites of Degradation in a Therapeutic Monoclonal Antibody by Peptide Mapping | Daniel J. Kroon, Alysia Baldwin-Ferro and Praful Lalan |
| 1394-1401 | Localization of Binding Sites for Epidermal Growth Factor (EGF) in Rat Kidney: Evidence for the Existence of Low Affinity EGF Binding Sites on the Brush Border Membrane | Dong Chool Kim, Manabu Hanano, Yasushi Kanai, Norio Ohnuma and Yuichi Sugiyama |
| 1402-1409 | Skin Alteration and Convective Solvent Flow Effects During Iontophoresis II. Monovalent Anion and Cation Transport Across Human Skin | Sandra M. Sims, William I. Higuchi and V. Srinivasan |
| 1410-1414 | Noninvasive in Vivo Percutaneous Absorption Measurements Using X-Ray Fluorescence | J. David Robertson, Elizabeth Ferguson, Michael Jay and Dennis J. Stalker |
| 1415-1421 | Lamellar Structures Formed by Stratum Corneum Lipids in Vitro: A Deuterium Nuclear Magnetic Resonance (NMR) Study | William Abraham and Donald T. Downing |
| 1422-1427 | Local Enhanced Topical Delivery (LETD) of Drugs: Does It Truly Exist? | Stephen C. McNeill, Russell O. Potts and Michael L. Francoeur |
| 1428-1435 | Physicochemical Properties of Salts of p-Aminosalicylic Acid. I. Correlation of Crystal Structure and Hydrate Stability | Robert T. Forbes, Peter York, Victor Fawcett and Leonard Shields |
| 1436-1441 | In Vivo Evaluation of Enteric-Coated Naproxen Tablets Using Gamma Scintigraphy | Ian R. Wilding, John G. Hardy, R. Andrew Sparrow, Stanley S. Davis and Paul B. Daly, et al. |
| 1442-1450 | Distribution and Elimination of the Glycosidase Inhibitors 1-Deoxymannojirimycin and N-Methyl-1-Deoxynojirimycin in the Rat in Vivo | Esther D. Faber, Roelof Oosting, Jacques J. Neefjes, Hidde L. Ploegh and Dirk K. F. Meijer |
| 1451-1455 | Pharmacokinetic Disposition of Multiple-Dose Transdermal Nicotine in Healthy Adult Smokers | Gregory M. Kochak, Jim X. Sun, R. Leslie Choi and Anthony J. Piraino |
| 1456-1459 | Age and the Pharmacokinetic-Pharmacodynamic Relationship of Phenobarbital in Rats: “Pseudo”-Longitudinal vs Cross-Sectional Study Design | Annemiek M. Stijnen, Meindert Danhof and Cornelius F. A. Bezooijen |
| 1460-1464 | Glutathione S-Transferase-Mediated Metabolism of Glyceryl Trinitrate in Subcellular Fractions of Bovine Coronary Arteries | David T.-W. Lau, Elaine K. Chan and Leslie Z. Benet |
| 1465-1473 | Kinetics and Mechanism of Degradation of Zileuton, a Potent 5-Lipoxygenase Inhibitor | Francisco J. Alvarez and Russell T. Slade |
| 1474-1479 | Synthesis of 2-(3-Substituted-1,2,4-oxadiazol-5-yl)-8-methyl-8-azabicyclo[3.2.1]octanes and 2α-(3-Substituted-1,2,4-oxadiazol-5-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-enes as Potential Muscarinic Agonists | David J. Triggle, Yong Wha Kwon, Philip Abraham, M. Abdur Rahman and F. Ivy Carroll |
| 1480-1486 | Relative Lipophilicities and Structural-Pharmacological Considerations of Various Angiotensin-Converting Enzyme (ACE) Inhibitors | Sunanda A. Ranadive, Andrew X. Chen and Abu T. M. Serajuddin |
| 1487-1492 | The Development of a Microwave Fluid-Bed Processor. I. Construction and Qualification of a Prototype Laboratory Unit | Michael K. Doelling, David M. Jones, Richard A. Smith and Robert A. Nash |
| 1493-1501 | The Development of a Microwave Fluid-Bed Processor. II. Drying Performance and Physical Characteristics of Typical Pharmaceutical Granulations | Michael K. Doelling and Robert A. Nash |
| 1502-1506 | In Vivo Evaluation of Biodegradable Progesterone Microspheres in Mares | Pramod K. Gupta, Rahul C. Mehta, Robert H. Douglas and Patrick P. Luca |
| 1507-1509 | Sustained Propranolol Delivery and Increased Oral Bioavailability in Dogs Given a Propranolol Laurate Salt | Brace J. Aungst and Munir A. Hussain |
| 1510-1514 | Relationship Between Polymer Viscosity and Drug Release from a Matrix System | Lucy Wan Sai Cheong, Paul Wan Sia Heng and Lee Fun Wong |
| 1515-1517 | Effect of Isoflurane Anesthesia on Antipyrine Pharmacokinetics in the Rat | Francis L. S. Tse, David F. Nickerson and Renee Aim |
| 1518-1520 | Employing lonization Behaviors to Resolve a Trace-Level Impurity: Determination of l,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedi-carboxylic Acid Di-2-[methyl-(phenylmethyl)amino]ethyl Ester in Nicardipine Drug Substance | Michael B. Maurin, Rodney D. Vickery, Philip Ma, Joseph Manalo and Munir A. Hussain |
| 1521-1523 | Degradation of Synthetic Salmon Calcitonin in Aqueous Solution | Kang Choon Lee, Yoon Joong Lee, Hyun Myo Song, Chang Ju Chun and Patrick P. Luca |
| 1524 | Association News and Announcements |
| 1525-1533 | Instrumentation of a High-Shear Mixer: Evaluation and Comparison of a New Capacitive Sensor, a Watt Meter, and a Strain-Gage Torque Sensor for Wet Granulation Monitoring | Vincent Corvari, William C. Fry, William L. Seibert and Larry Augsburger |
| 1534-1539 | Lymphatic Targeting of Polymeric Nanoparticles After Intraperitoneal Administration in Rats | Philippe Maincent, Pierre Thouvenot, Claude Amicabile, Maurice Hoffman and Jörg Kreuter, et al. |
| 1540-1545 | Hydrogels for Site-Specific Drug Delivery to the Colon: In Vitro and in Vivo Degradation | Helle Brøndsted and Jindřich Kopeček |
| 1546-1549 | The Influence of Liquid Crystalline Phases on Drug Percutaneous Absorption. I. Development of a Vehicle | James Swarbrick and James R. Siverly |
| 1550-1555 | The Influence of Liquid Crystalline Phases on Drug Percutaneous Absorption. II. Permeation Studies Through Excised Human Skin | James Swarbrick and James R. Siverly |
| 1556-1562 | Mixed Micelles as Proliposomes for the Solubilization of Teniposide | Hayat Alkan-Onyuksel and Kyonghee Son |
| 1563-1567 | Mucoadhesion of Copolymers and Mixtures Containing Polyacrylic Acid | Florence Thermes, Jeffrey Grove, Annouk Rozier, Bernard Plazonnet and Alain Constancis, et al. |
| 1568-1574 | Determination of Association Constants in Cyclodextrin/Drug Complexation Using the Scatchard Plot: Application to β-Cyclodextrin-Anilinonaphthalenesulfonates | Evangelos E. Sideris, Georgia N. Valsami, Michael A. Koupparis and Panayotis E. Macheras |
| 1575-1579 | Percutaneous Absorption Enhancement of Leuprolide | Mou-ying Fu Lu, Dennis Lee and G. Subba Rao |
| 1580-1586 | Permeability Characteristics of Various Intestinal Regions of Rabbit, Dog, and Monkey | Nancy Jezyk, Werner Rubas and George M. Grass |
| 1587-1591 | Influence of Permanent Cannulation of the Jugular Vein on Pharmacokinetics of Amoxycillin and Antipyrine in the Rat | Francisca Torres-Molina, Juan-Carlos Aristorena, Carmen Garcia-Carbonell, Luis Granero and Jesús Chesa-Jiménez, et al. |
| 1592-1598 | Validation of Different Microdialysis Methods for the Determination of Unbound Steady-State Concentrations of Theophylline in Blood and Brain Tissue | Per Sjöberg, Ing-Marie Olofsson and Thomas Lundqvist |
| 1599-1606 | Decreased Systemic Clearance of Diltiazem with Increased Hepatic Metabolism in Rats with Uranyl Nitrate-Induced Acute Renal Failure | Yong-Hee Lee, Min-Hwa Lee and Chang-Koo Shim |
| 1607-1611 | Kinetic Modeling of Ouabain Tissue Distribution Based on Slow and Saturable Binding to Na,K-ATPase | Hideyoshi Harashima, Michio Mamiya, Masayo Yamazaki, Yasufumi Sawada and Tatsuji Iga, et al. |
| 1612-1616 | The Bioinequivalence of Carbamazepine Tablets with a History of Clinical Failures | Marvin C. Meyer, Arthur B. Straughn, Eric J. Jarvi, George C. Wood and Francis R. Pelsor, et al. |
| 1617-1621 | Factors Determining the Intrinsic Lymphatic Partition Rate of Epitiostanol and Mepitiostane | Teruhisa Ichihashi, Yasushi Takagishi and Hideo Yamada |
| 1622-1628 | The Effect of Valproate on the Metabolism of Phenobarbital in the Rat | Gail D. Anderson and René H. Levy |
| 1629-1633 | Influence of Age and Gender on the Plasma Profiles of 3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-CoA) Reductase Inhibitory Activity Following Multiple Doses of Lovastatin and Simvastatin | Haiyung Cheng, J. Douglas Rogers, Anna E. Sweany, Michael R. Dobrinska and Evan A. Stein, et al. |
| 1634-1639 | Use of Analytically Defined Estimates of Aerosol Respirable Fraction to Predict Lung Deposition Patterns | Ted B. Martonen, Ira Katz, Kristen Fults and Anthony J. Hickey |
| 1640-1643 | A High-Performance Liquid Chromatographic Method for the Quantitative Enantioselective Analysis of Mefloquine Stereoisomers | Yihong Qiu, Satoshi Kitamura and J. Keith Guillory |
| 1644-1647 | Mapping the Ligand Binding Pocket of the Human Muscarinic Cholinergic Receptor Hml: Contribution of Tyrosine-82 | Volkmar Drübbisch, Jelveh Lameh, Mohan Philip, Yogesh K. Sharma and Wolfgang Sadée |
| 1648-1653 | Effects of Diethyl Phthalate and Other Plasticizers on Laurate Hydroxylation in Rat Liver Microsomes | Richard T. Okita and Janice Rice Okita |
| 1654-1658 | Drug Delivery via Ion Exchange Across a Micromembrane | Dennis R. Jenke, Christopher D. Baron and Carol L. Mayers |
| 1659-1663 | Viscoelastic Properties of Polyacrylic Acid Gels in Mixed Solvents | James S. Chu, Danny M. Yu, Gordon L. Amidon, Norman D. Weiner and Arthur H. Goldberg |
| 1664-1667 | Formulation and Optimization of a Modified Microporous Cellulose Acetate Latex Coating for Osmotic Pumps | Leah E. Appel, James H. Clair and Gaylen M. Zentner |
| 1668-1670 | Chemoprevention of Chemically Induced Skin Tumor Development by Diallyl Sulfide and Diallyl Disulfide | Chandradhar Dwivedi, Stacie Rohlfs, Donnita Jarvis and Ferzaan N. Engineer |
| 1671-1672 | Cyclodextrin/Weak-Electrolyte Complexation: Interpretation and Estimation of Association Constants from Phase Solubility Diagrams | Fang-yu Liu, Dane O. Kildsig and Ashim K. Mitra |
| 1673-1676 | Chemical Stability of Ethyl Icosapentate Against Autoxidation. I. Effect of Temperature on Oxidation Kinetics | Reiko Teraoka, Makoto Otsuka and Yoshihisa Matsuda |
| 1677 | BOOK REVIEWS |
| 1677 | BOOK REVIEWS |
| 1678-1681 | Author Index to Volume 9 (1992) |
| 1682-1686 | Subject Index to Volume 9 (1992) |
| 1-7 | Behavior of Hygroscopic Pharmaceutical Aerosols and the Influence of Hydrophobic Additives | Anthony J. Hickey and Ted B. Martonen |
| 8-13 | Mean Residence Time of Oral Drugs Undergoing First-Pass and Linear Reversible Metabolism | Haiyung Cheng and William J. Jusko |
| 14-21 | Enantioselective Pharmacokinetics of dl-threo-Methylphenidate in Humans | Nuggehally R. Srinivas, John W. Hubbard, Elarien D. Korchinski and Kamal K. Midha |
| 22-27 | Pharmacokinetics of Stereomeric 1,4:3,6-Dianhydrohexitol Mononitrates in Rats | Tsang-Bin Tzeng and Ho-Leung Fung |
| 28-34 | Steady-State Bioavailability and Day-to-Day Variability of a Multiple-Unit (CR/ZOK) and a Single-Unit (OROS) Delivery System of Metoprolol After Once-Daily Dosing | Anders Sandberg, Bertil Abrahamsson, Agneta Svenheden, Bertil Olofsson and Robert Bergstrand |
| 35-43 | Time-Dependent Disposition of β-Naphthoflavone in the Rat | Adedayo Adedoyin, Leon Aarons and J. Brian Houston |
| 44-48 | Distribution of Tacrine Across the Blood–Brain Barrier in Awake, Freely Moving Rats Using in Vivo Microdialysis Sampling | Martin Telting-Diaz and Craig E. Lunte |
| 49-55 | Prinomide Tromethamine Pharmacokinetics: Mutually Dependent Saturable and Competitive Protein Binding Between Prinomide and Its Own Metabolite | Gregory M. Kochak, Sudhakar Pai, Robert Iannucci, Frank Honc and Deborah Kachmar, et al. |
| 56-60 | Column-Switching High-Performance Liquid Chromatographic Determination of a 2-Pyridinone-Based Human Immunodeficiency Virus Type 1 (HlV-l)-Specific Reverse Transcriptase Inhibitor in Human Plasma | Eric J. Woolf and Bogdan K. Matuszewski |
| 61-67 | Changes in Material Properties Accompanying the National Formulary (NF) Identity Test for Microcrystalline Cellulose | Harry G. Brittain, Geoffrey Lewen, Ann W. Newman, Kenneth Fiorelli and Susan Bogdanowich |
| 68-74 | Prodrugs of Peptides. 18. Synthesis and Evaluation of Various Esters of Desmopressin (dDAVP) | Anne H. Kahns, Anders Buur and Hans Bundgaard |
| 75-79 | The 3′-Keto–Diol Equilibrium of Trospectomycin Sulfate Bulk Drug and Freeze-Dried Formulation: Solid-State Carbon-13 Cross-Polarization Magic Angle Spinning (CP/MAS) and High-Resolution Carbon-13 Nuclear Magnetic Resonance (NMR) Spectroscopy Studies | Michael D. Likar, Richard J. Taylor, Paul E. Fagerness, Yukio Hiyama and Russell H. Robins |
| 80-87 | Design of New Formulations for Topical Ocular Administration: Polymeric Nanocapsules Containing Metipranolol | Cándida Losa, Laurent Marchal-Heussler, Francisco Orallo, José L. Vila Jato and Maria J. Alonso |
| 88-94 | Compression Characteristics of Granulated Materials. VII. The Effect of Intragranular Binder Distribution on the Compactibility of Some Lactose Granulations | Martin Wikberg and Göran Alderborn |
| 95-102 | Chemical Pathways of Peptide Degradation. IV. Pathways, Kinetics, and Mechanism of Degradation of an Aspartyl Residue in a Model Hexapeptide | Cecilia Oliyai and Ronald T. Borchardt |
| 103-108 | Stability of β-Galactosidase, a Model Protein Drug, Is Related to Water Mobility as Measured by 17O Nuclear Magnetic Resonance (NMR) | Sumie Yoshioka, Yukio Aso, Ken-ichi Izutsu and Tadao Terao |
| 109-112 | Controlled Delivery of Pilocarpine. 1. In Vitro Characterization of Gelfoam® Matrices | Sreekant R. Nadkarni and Samuel H. Yalkowsky |
| 113-118 | Comparison of the Permeability Characteristics of a Human Colonic Epithelial (Caco-2) Cell Line to Colon of Rabbit, Monkey, and Dog Intestine and Human Drug Absorption | Werner Rubas, Nancy Jezyk and George M. Grass |
| 119-125 | Sustained Bronchodilation with Isoproterenol Poly(Glycolide-co-Lactide) Microspheres | Yih-Loong Lai, Rahul C. Mehta, Arthur A. Thacker, Sun-Dong Yoo and Patrick J. McNamara, et al. |
| 126-129 | Human Transbuccal Absorption of Diclofenac Sodium from a Prototype Hydrogel Delivery Device | James Cassidy, Bret Berner, Keith Chan, Vivian John and Stephen Toon, et al. |
| 130-135 | Regional Gastrointestinal Absorption of the Beta-Blocker Pafenolol in the Rat and Intestinal Transit Rate Determined by Movement of 14C-Polyethylene Glycol (PEG) 4000 | Hans Lennernäs and Carl-Gunnar Regårdh |
| 136-140 | Relationship Among Physicochemical Properties, Skin Permeability, and Topical Activity of the Racemic Compound and Pure Enantiomers of a New Antifungal | Lorraine Wearley, Barry Antonacci, Anthony Cacciapuoti, Seb Assenza and Imtiaz Chaudry, et al. |
| 141-146 | Acacia-Gelatin Microencapsulated Liposomes: Preparation, Stability, and Release of Acetylsalicylic Acid | Cunji Dong and James A. Rogers |
| 147-151 | Comparison of the Leakage of Carboxyfluorescein from Symmetric-and Asymmetric-Acyl Chain Phosphatidylcholine Vesicles | Timothy S. Wiedmann, Amir Salmon and Walter R. Perkins |
| 152-155 | Effect of Humidity and Occlusion on the Percutaneous Absorption of Parathion in Vitro | Shao-Kaung Chang and Jim E. Riviere |
| 156-159 | Kinetics of Aspirin Hydrolysis and Stabilization in the Presence of 2-Hydroxypropyl-β-Cyclodextrin | Somesh Choudhury and Ashim K. Mitra |
| 160-161 | Reviewers for Pharmaceutical Research (October 1, 1991-October 19, 1992) |
| 162 | European Reviewers for Pharmaceutical Research (October 1991-October 1992) |
| 162 | Japanese Reviewers for Pharmaceutical Research (May 1992-September 1992) |
| 163 | Association News and Announcements |
| 164 | HANS BUNDGAARD IN MEMORIAM | Henning G. Kristensen and Douwe D. Breimer |
| 165-170 | Introduction to Backpropagation Neural Network Computation | Randall J. Erb |
| 171-186 | Applications of Capillary Electrophoresis in Pharmaceutical Analysis | Shelley R. Rabel and John F. Stobaugh |
| 187-196 | Upper Gastrointestinal pH in Seventy-Nine Healthy, Elderly, North American Men and Women | Tanya L. Russell, Rosemary R. Berardi, Jeffrey L. Barnett, Lambros C. Dermentzoglou and Kathleen M. Jarvenpaa, et al. |
| 197-203 | Solid-State Nuclear Magnetic Resonance (NMR) Spectra of Pharmaceutical Dosage Forms | Patricia J. Saindon, Nina S. Cauchon, Paul A. Sutton, C.-j. Chang and Garnet E. Peck, et al. |
| 204-207 | A Fluorescence Quenching Method for Estimating Chelating Groups in Chelate-Conjugated Macromolecules | Wanlong Ma, Karl J. Hwang and Vincent H. L. Lee |
| 208-213 | Preparation of Heptakis(2,6-di-O-ethyl)-β-cyclodextrin and Its Nuclear Magnetic Resonance Spectroscopic Characterization | Fumitoshi Hirayama, Masahiko Kurihara, Yasuhide Horiuchi, Tadanobu Utsuki and Kaneto Uekama, et al. |
| 214-219 | Antitumor Agents. 125. New 4β-Benzoylamino Derivatives of 4′-O-Demethyl-4-desoxypodophyllotoxin and 4β-Benzoyl Derivatives of 4′-O-Demethylpodophyllotoxin as Potent Inhibitors of Human DNA Topoisomerase II | Xiao-Ming Zhou, Zhe-Qing Wang, Hong-Xing Chen, Yung-Chi Cheng and Kuo-Hsiung Lee |
| 220-222 | The Effect of Phenol on the Electrolyte Flocculation of Certain Polymeric Dispersions to Thixotropic Gels | Roland S. Okor |
| 223-227 | The Pharmacokinetics and Absorption of Recombinant Human Relaxin in Nonpregnant Rabbits and Rhesus Monkeys After Intravenous and Intravaginal Administration | Sharon A. Chen, Baron Reed, Tue Nguyen, Natalie Gaylord and Gene B. Fuller, et al. |
| 228-232 | Pulmonary Delivery of Free and Liposomal Insulin | Fang-yu Liu, Zezhi Shao, Dane O. Kildsig and Ashim K. Mitra |
| 233-238 | An in Vitro/in Vivo Correlation for the Disintegration and Onset of Drug Release from Enteric-Coated Pellets | James P. Ebel, Michael Jay and Robert M. Beihn |
| 239-242 | Correlation Between the Disintegration Time and the Bioavailability of Vitamin C Tablets | Hemmige N. Bhagavan and Brigitte I. Wolkoff |
| 243-251 | Differential Effects of Anionic, Cationic, Nonionic, and Physiologic Surfactants on the Dissociation, α-Chymotryptic Degradation, and Enteral Absorption of Insulin Hexamers | Zezhi Shao, Yuping Li, Ramesh Krishnamoorthy, Todd Chermak and Ashim K. Mitra |
| 252-257 | Use of the Gamma-Ray Perturbed Angular Correlation (PAC) Technique for Monitoring Liposomal Phospholipid Bilayer Integrity | Wanlong Ma, Karl J. Hwang and Vincent H. L. Lee |
| 258-263 | In Vitro Evaluation of Calcium Pectinate: A Potential Colon-Specific Drug Delivery Carrier | Abraham Rubinstein, Raphael Radai, Miriam Ezra, Seema Pathak and J. Stefan Rokem |
| 264-270 | Estimating the Fraction Dose Absorbed from Suspensions of Poorly Soluble Compounds in Humans: A Mathematical Model | Doo-Man Oh, Rane L. Curl and Gordon L. Amidon |
| 271-275 | Mass Balance Approaches for Estimating the Intestinal Absorption and Metabolism of Peptides and Analogues: Theoretical Development and Applications | Patrick J. Sinko, Glen D. Leesman and Gordon L. Amidon |
| 276-281 | A Saturable Transport Mechanism in the Intestinal Absorption of Gabapentin Is the Underlying Cause of the Lack of Proportionality Between Increasing Dose and Drug Levels in Plasma | Barbra H. Stewart, Alan R. Kugler, Paul R. Thompson and Howard N. Bockbrader |
| 282-288 | Biotin Uptake and Transport Across Bovine Brain Microvessel Endothelial Cell Monolayers | Fenglin Shi, Carole Bailey, A. Waseem Malick and Kenneth L. Audus |
| 289-293 | Influence of Dose Range on Degree of Nonlinearity Detected in Dose-Proportionality Studies for Drugs with Saturable Elimination: Single-Dose and Steady-State Studies | Theresa A. Shepard, Nicholas Lordi and Philip E. Sparrow |
| 294-299 | Selective Effect of Adjuvant Arthritis on the Disposition of Propranolol Enantiomers in Rats Detected Using a Stereospecific HPLC Assay | Micheline Piquette-Miller and Fakhreddin Jamali |
| 300-304 | Effect of Plasma Protein Binding on Kinetics of Capillary Uptake and Efflux | Denis J. Morgan and Jiu Li Huang |
| 305-308 | A Spectrophotometric Modification of the Winkler Method for Measurement of Dissolved Oxygen | Francis J. Nowaczyk Jr, Roger L. Schnaare, Clyde M. Ofner III and Rodney J. Wigent |
| 309-312 | Physical Chemical Properties of Alpha Styryl Carbinol Antifungal Agents | Michael B. Maurin, William J. Addicks, Susan M. Rowe and Robert Hogan |
| 313-316 | Scaleup of Immediate Release Oral Solid Dosage Forms | J. P. Skelly, G. A. Van Buskirk, D. R. Savello, G. L. Amidon and H. M. Arbit, et al. |
| 317-327 | Solid-State Nuclear Magnetic Resonance Spectroscopy: Theory and Pharmaceutical Applications | David E. Bugay |
| 328-334 | Solid-State Diode Laser-Induced Fluorescence Detection in High-Performance Liquid Chromatography | Sadayappan V. Rahavendran and H. Thomas Karnes |
| 335-342 | In Vivo Microdialysis Sampling in the Bile, Blood, and Liver of Rats to Study the Disposition of Phenol | Dennis O. Scott and Craig E. Lunte |
| 343-350 | Antitumor Agents 126. Novel 4β-Substituted Anilino Derivatives of 3′,4′ -O, O-Didemethylpodophyllotoxin as Potent Inhibitors of Human DNA Topoisomerase II | Zhe-Qing Wang, Ya-Ching Shen, Hong-Xing Chen, Jang-Yang Chang and Xin Guo, et al. |
| 351-355 | Low-Substituted Hydroxypropylcellulose as a Sustained-Drug Release Matrix Base or Disintegrant Depending on Its Particle Size and Loading in Formulation | Yoshiaki Kawashima, Hirofumi Takeuchi, Tomoaki Hino, Toshiyuki Niwa and Tzu-Lang Lin, et al. |
| 356-361 | Drug Release Mechanism from a Microcrystalline Cellulose Pellet System | Robert E. O'Connor and Joseph B. Schwartz |
| 362-368 | The Preparation and Characterization of Poly(lactide-co-glycolide) Microparticles. II. The Entrapment of a Model Protein Using a (Water-in-Oil)-in-Water Emulsion Solvent Evaporation Technique | Hayley Jeffery, Stanley S. Davis and Derek T. O'Hagan |
| 369-380 | Tissue Response to Bioerodible, Subcutaneous Drug Implants: A Possible Determinant of Drug Absorption Kinetics | F. D. Anderson, D. F. Archer, S. M. Harman, R. J. Leonard and W. H. Wilborn |
| 381-385 | Electrochemical Characterization of Human Skin by Impedance Spectroscopy: The Effect of Penetration Enhancers | Kyösti Kontturi, Lasse Murtomäki, Jouni Hirvonen, Petteri Paronen and Arto Urtti |
| 386-390 | Poly(ε-Caprolactone) Nanocapsules in Carteolol Ophthalmic Delivery | Laurent Marchal-Heussler, Daniel Sirbat, Maurice Hoffman and Philippe Maincent |
| 391-399 | Polyanhydride Mierospheres that Display Near-Constant Release of Water-Soluble Model Drug Compounds | Yasuhiko Tabata and Robert Langer |
| 400-404 | Peptide Carrier-Mediated Transport in Intestinal Brush Border Membrane Vesicles of Rats and Rabbits: Cephradine Uptake and Inhibition | Hiroaki Yuasa, Gordon L. Amidon and David Fleisher |
| 405-410 | An Investigation into the Mechanical and Transport Properties of Aqueous Latex Films: A New Hypothesis for the Film-Forming Mechanism of Aqueous Dispersion System | Jian-Hwa Guo, Richard E. Robertson and Gordon L. Amidon |
| 411-417 | Viscoelasticity of Anionic Polymers and Their Mucociliary Transport on the Frog Palate | Shun Y. Lin, Gordon L. Amidon, Norman D. Weiner and Arthur H. Goldberg |
| 418-422 | Disposition of Azole Antifungal Agents. I. Nonlinearities in Ketoconazole Clearance and Binding in Rat Liver | Diane Matthew, Beverley Brennan, Katayoun Zomorodi and J. Brian Houston |
| 423-426 | Interaction of Nucleoside Analogues with the Sodium–Nucleoside Transport System in Brush Border Membrane Vesicles from Human Kidney | Claire M. Brett, Carla B. Washington, Ronda J. Ott, Marcelo M. Gutierrez and Kathleen M. Giacomini |
| 427-433 | Pharmacokinetics of a Novel Antiarrhythmic Drug, Actisomide | Chyung S. Cook, Leonard F. Rozek, James Stolzenbach, Steve Anderson and Grant L. Schoenhard, et al. |
| 434-440 | Comparison of the Hepatic Uptake Clearances of Fifteen Drugs with a Wide Range of Membrane Permeabilities in Isolated Rat Hepatocytes and Perfused Rat Livers | Seiji Miyauchi, Yasufumi Sawada, Tatsuji Iga, Manabu Hanano and Yuichi Sugiyama |
| 441-444 | Rapid Determination of Methadone in Plasma, Cerebrospinal Fluid, and Urine by Gas Chromatography and Its Application to Routine Drug Monitoring | Norbert Schmidt, Reinhard Sittl, Kay Brune and Gerd Geisslinger |
| 445-448 | Stabilization of Oxygen-Sensitive Formulations via a Secondary Oxygen Scavenger | Carol L. Mayers and Dennis R. Jenke |
| 449-453 | Three Approaches to the Analysis of Trace Formaldehyde in Bulk and Dosage Form Pharmaceuticals | Gerald J. Manius, Lan-Fun Li Wen and David Palling |
| 454-456 | Axial Ratio Measurements for Early Detection of Crystal Growth in Suspension-Type Metered Dose Inhalers | Elaine M. Phillips, Peter R. Byron and Richard N. Dalby |
| 457-460 | Loading of Bovine Serum Albumin into Hydrogels by an Electrophoretic Process and Its Potential Application to Protein Drugs | Waleed S. W. Shalaby, Anna A. Abdallah, Haesun Park and Kinam Park |
| 461-465 | Molecular Cloning of Two cDNAs Encoding the Mouse Bilirubin/Phenol Family of UDP-Glucuronosyltransferases (mUGTBr/p) | Ah-Ng Tony Kong, Meihui Ma, Deling Tao and Linding Yang |
| 466-469 | Feasibility of Developing a Neural Network for Prediction of Human Pharmacokinetic Parameters from Animal Data | Ajaz S. Hussain, Robert D. Johnson, Nimish N. Vachharajani and Wolfgang A. Ritschel |
| 470-472 | Formation of a Chromophoric Complex Between Alendronate and Copper(II) Ions | Dražen Ostović, Christine Stelmach and Becky Hulshizer |
| 473 | BOOK REVIEWS |
| 473 | BOOK REVIEWS |
| 474 | BOOK REVIEWS |
| 475-486 | Strategies for Indirect Computer-Aided Drug Design | Gilda H. Loew, Hugo O. Villar and Ibon Alkorta |
| 487-496 | Controlled Delivery Systems for Proteins Using Polyanhydride Microspheres | Yasuhiko Tabata, Sunitha Gutta and Robert Langer |
| 497-506 | A New Method for Estimating Dermal Absorption from Chemical Exposure. 1. General Approach | Robert L. Cleek and Annette L. Bunge |
| 507-514 | Immunotargeting of Liposomes Containing Lipophilic Antitumor Prodrugs | Atsuhide Mori, Stephen J. Kennel and Leaf Huang |
| 515-520 | Synthesis and Testing of New Antileukemic Schiff Bases of N-Hydroxy-N′ - Aminoguanidine Against CCRF-CEM/0 Human Leukemia Cells in Vitro and Synergism Studies with Cytarabine (Ara-C) | Phanesh B. Koneru, Eric J. Lien and Vassilios I. Avramis |
| 521-524 | Taxol and Related Taxanes. I. Taxanes of Taxus brevifolia Bark | Koppaka V. Rao |
| 525-534 | Aqueous Ethylcellulose Dispersion of Ethylcellulose. I. Evaluation of Coating Process Variables | Nilesh H. Parikh, Stuart C. Porter and Bhagwan D. Rohera |
| 535-541 | A Method for the Early Evaluation of the Effects of Storage and Additives on the Stability of Parenteral Fat Emulsions | Jianmin Li, Karin D. Caldwell and Bradley D. Anderson |
| 542-548 | The Influence of Thermal Treatment on the Physical-Mechanical and Dissolution Properties of Tablets Containing Poly(DL-Lactic Acid) | Marcelo O. Omelczuk and James W. McGinity |
| 549-552 | Uptake of Phosphatidylserine Liposomes by Rat Peyer's Patches Following Intraluminal Administration | Hitoshi Tomizawa, Yukihiko Aramaki, Yoshimine Fujii, Toshifumi Kara and Norio Suzuki, et al. |
| 553-561 | In Vitro Nasal Transport Across Ovine Mucosa: Effects of Ammonium Glycyrrhizinate on Electrical Properties and Permeability of Growth Hormone Releasing Peptide, Mannitol, and Lucifer Yellow | Patricia M. Reardon, Caroline H. Gochoco, Kenneth L. Audus, Glynn Wilson and Philip L. Smith |
| 562-566 | Development of Activity Assays for High-Volume Evaluation of Human Immunodeficiency Virus (HIV) Protease Inhibitors in Rat Serum: Results with Ditekiren | Karen F. Wilkinson, Bob D. Rush, Satish K. Sharma, David B. Evans and Mary J. Ruwart, et al. |
| 567-572 | Pharmacokinetics of Recombinant Human Interferon-βser in Healthy Volunteers and Its Effect on Serum Neopterin | Janie Chiang, Carol A. Gloff, Carl N. Yoshizawa and Gary J. Williams |
| 573-576 | Decreased Cellular Toxicity of Neomycin in a Clonal Cell Line Isolated from LLC-PK1 | Ryohei Hori, Masahiro Okuda, Yoshiko Ohishi, Masato Yasuhara and Ken-ichi Inui, et al. |
| 577-582 | Physicochemical Stability of Phenobarbital Polymorphs at Various Levels of Humidity and Temperature | Makoto Otsuka, Mika Onoe and Yoshihisa Matsuda |
| 583-587 | An in Vitro Study of Diamorphine Permeation Through Premature Human Neonatal Skin | David A. Barrett, Nicholas Rutter and Stanley S. Davis |
| 588-592 | In Vivo/in Vitro Correlation of Experimental Sustained-Release Theophylline Formulations | Kah-Hay Yuen, Arvind A. Desmukh and John M. Newton |
| 593-597 | Comparison of the Pharmacokinetics and Pharmacodynamics of the Aldose Reductase Inhibitors, AL03152 (RS), AL03802 (R), and AL03803 (S) | Young Han Park, Philip R. Mayer, Ronnie Barker, Mark DuPriest and Brenda W. Griffin, et al. |
| 598-602 | Pharmacokinetic Monitoring in Subcutaneous Tissue Using in Vivo Capillary Ultrafiltration Probes | Michael C. Linhares and Peter T. Kissinger |
| 603-605 | Clinical Pharmacokinetics and Relative Bioavailability of Oral Procaterol | Michael A. Eldon, Michele M. Battle, Michael J. Coon, Gerald D. Nordblom and Allen J. Sedman, et al. |
| 606-610 | Distinction Between the Depletion of Opsonins and the Saturation of Uptake in the Dose-Dependent Hepatic Uptake of Liposomes | Hideyoshi Harashima, Kazuya Sakata and Hiroshi Kiwada |
| 611-615 | Formycin B Elimination from the Cerebrospinal Fluid of the Rat | Xiaochun Wu, Andrew C. Hui and Kathleen M. Giacomini |
| 616-620 | The Determination of Diffusion Coefficients in Semisolids by Fourier Transform Infrared (FT-IR) Spectroscopy | Dale Eric Wurster, Varaporn Buraphacheep and Jatin M. Patel |
| 621-626 | Optimization of Conditions for Preparing 2- to 5-Micron-Range Gelatin Microparticles by Using Chilled Dehydration Agents | Levent Öner and Michael J. Groves |
| 627-630 | Molecular Cloning of the Alcohol/Hydroxysteroid Form (mSTa1) of Sulfotransferase from Mouse Liver | Ah-Ng Tony Kong, Deling Tao, Meihui Ma and Linding Yang |
| 631-634 | Micellar Solubilization of Clofazimine Analogues in Aqueous Solutions of Ionic and Nonionic Surfactants | Khairi M. S. Fahelelbom, Richard F. Timoney and Owen I. Corrigan |
| 635 | BOOK REVIEWS |
| 635-637 | Letters to the Editor | Russell O. Potts, Richard H. Guy, Philip S. Burton, Norman F. H. Ho and Robert A. Conradi, et al. |
| 638 | Association News and Announcements |
| 639-648 | Hydrolysis of Carbonates, Thiocarbonates, Carbamates, and Carboxylic Esters of α-Naphthol, β-Naphthol, and p-Nitrophenol by Human, Rat, and Mouse Liver Carboxylesterases | Tien L. Huang, András Székács, Tamon Uematsu, Eiichi Kuwano and Andrew Parkinson, et al. |
| 649-659 | Formulation Design of Acidic Fibroblast Growth Factor | P. K. Tsai, David B. Volkin, Jonathan M. Dabora, Karen C. Thompson and Mark W. Bruner, et al. |
| 660-661 | Enkephalin Antisense Peptides: Design, Synthesis, and Biological Activity | Pravin K. Misra, Wahajul Haq, Seturam B. Katti, Krishna B. Mathur and Ram Raghubir, et al. |
| 662-666 | Decomposition of Arteether in Simulated Stomach Acid Yielding Compounds Retaining Antimalarial Activity | John K. Baker, James D. McChesney and Hsien Tao Chi |
| 667-673 | Thyrotropin-Releasing Hormone (TRH) Uptake in Intestinal Brush-Border Membrane Vesicles: Comparison with Proton-Coupled Dipeptide and Na+-Coupled Glucose Transport | David T. Thwaites, Nicholas L. Simmons and Barry H. Hirst |
| 674-681 | Passive Transepithelial Absorption of Thyrotropin-Releasing Hormone (TRH) via a Paracellular Route in Cultured Intestinal and Renal Epithelial Cell Lines | David T. Thwaites, Barry H. Hirst and Nicholas L. Simmons |
| 682-686 | Nasal Insulin Delivery with Dimethyl-β-Cyclodextrin as an Absorption Enhancer in Rabbits: Powder More Effective than Liquid Formulations | Nicolaas G. M. Schipper, Stefan G. Romeijn, J. Coos Verhoef and Frans W. H. M. Merkus |
| 687-691 | Aggregates Formed During Storage of β-Galactosidase in Solution and in the Freeze-Dried State | Sumie Yoshioka, Yukio Aso, Ken-ichi Izutsu and Tadao Terao |
| 692-696 | Development of a Sensitive Radioimmunoassay for Fab Fragments: Application to Fab Pharmacokinetics in Humans | Corinne Vo Thanh-Barthet, Michel Urtizberea, Alain E. Sabouraud, Nathalie J. Cano and Jean-Michel G. Scherrmann |
| 697-702 | Hydrogel-Based lontotherapeutic Delivery Devices for Transdermal Delivery of Peptide/Protein Drugs | Ajay K. Banga and Yie W. Chien |
| 703-708 | Prolongation of the Circulation Time of Doxorubicin Encapsulated in Liposomes Containing a Polyethylene Glycol-Derivatized Phospholipid: Pharmacokinetic Studies in Rodents and Dogs | Alberto A. Gabizon, Yechezkel Barenholz and Meir Bialer |
| 709-714 | Absorption, Gastrointestinal Transit, and Tablet Erosion of Felodipine Extended-Release (ER) Tablets | Bertil Abrahamsson, Magne Alpsten, Morgan Hugosson, Ulf E. Jonsson and Mats Sundgren, et al. |
| 715-721 | Targeted Delivery of a Heme Oxygenase Inhibitor with a Lyophilized Liposomal Tin Mesoporphyrin Formulation | John B. Cannon, Carrie Martin, George S. Drummond and Attallah Kappas |
| 722-726 | The Effect of Meal Composition on the Gastrocolonic Response: Implications for Drug Delivery to the Colon | Jennifer M. C. Price, Stanley S. Davis, Robert A. Sparrow and Ian R. Wilding |
| 727-731 | Dose-Dependent Intestinal Absorption and Significant Intestinal Excretion (Exsorption) of the β-Blocker Pafenolol in the Rat | Hans Lennernäs and Carl-Gunnar Regårdh |
| 732-736 | The Development of a Predictive Method for the Estimation of Flux Through Polydimethylsiloxane Membranes. III. Application to a Series of Substituted Pyridines | Meng-wei Hu and Lloyd E. Matheson |
| 737-742 | Effects of Solute Characteristics and Concentration on a Lyotropic Liquid Crystal: Solute-Induced Phase Change | Hussein G. Ibrahim, El-Sayed Sallam, Mahmoud Takieddin and Mayssoun Habboub |
| 743-749 | Drug Absorption Limited by P-Glycoprotein-Mediated Secretory Drug Transport in Human Intestinal Epithelial Caco-2 Cell Layers | Janice Hunter, Barry H. Hirst and Nicholas L. Simmons |
| 750-756 | Influence of Poly(DL-Lactide) Nanocapsules on the Biliary Clearance and Enterohepatic Circulation of Indomethacin in the Rabbit | Fawaz Fawaz, François Bonini, Michel Guyot, Anne-Marie Lagueny and Hatem Fessi, et al. |
| 757-762 | Pharmacokinetic Analysis of an Oral Sustained-Release Diltiazem Preparation Using Multifraction Absorption Models | Kazuo Murata and Kazuo Noda |
| 763-770 | Absorption of 2′, 3′-Dideoxyinosine from Lower Gastrointestinal Tract in Rats and Kinetic Evidence of Different Absorption Rates in Colon and Rectum | Steven L. Bramer, M. Guillaume Wientjes and Jessie L.-S. Au |
| 771-773 | Simplified Synthesis of Mono(4-aminophenyl)-3′ -Thymidilic Acid Ester Used as Thymidine Kinase Specific Ligand for Affinity Chromatography | Kurt Eger, Eberhard Klünder, Rainer A. Beck and Ulrich Schloz |
| 774-776 | The Influence of Free Fatty Acid Formation on the pH of Phospholipid-Stabilized Triglyceride Emulsions | Clifford J. Herman and Michael J. Groves |
| 777-782 | Theoretical Considerations for the Design and Development of a Drug: Influence of Pharmacokinetics and Dosage Regimen on Receptor Interactions | Joyce Mordenti and Aldo Rescigno |
| 783-790 | Interferon-γ in Starch Microparticles: Nitric Oxide-Generating Activity in Vitro and Antileishmanial Effect in Mice | Lena Degling, Peter Stjärnkvist and Ingvar Sjöholm |
| 791-799 | Molecular Mobility in Mixtures of Absorbed Water and Solid Poly(vinylpyrrolidone) | Cynthia A. Oksanen and George Zografi |
| 800-809 | Mechanism and Kinetics of Metal Ion-Mediated Degradation of Fosinopril Sodium | Ajit B. Thakur, Kenneth Morris, John A. Grosso, Kenneth Himes and John K. Thottathil, et al. |
| 810-815 | Tensile Properties of Free Films Cast from Aqueous Ethylcellulose Dispersions | Nilesh H. Parikh, Stuart C. Porter and Bhagwan D. Rohera |
| 816-822 | Calibration of a Compaction Simulator for the Measurement of Tablet Thickness During Compression | Lovelace E. Holman and Keith Marshall |
| 823-827 | Disposition Characteristics of Protein Drugs in the Perfused Rat Kidney | Kiyoshi Mihara, Takami Hojo, Makoto Fujikawa, Yoshinobu Takakura and Hitoshi Sezaki, et al. |
| 828-833 | A New Route of Drug Administration: Intrauterine Delivery of Insulin and Calcitonin | Gershon Golomb, Avi Avramoff and Amnon Hoffman |
| 834-838 | The Pharmacokinetics of Recombinant Human Relaxin in Nonpregnant Women After Intravenous, Intravaginal, and Intracervical Administration | Sharon A. Chen, Andrew J. Perlman, Noreen Spanski, C. Matthew Peterson and Steven W. Sanders, et al. |
| 839-842 | The Development of a Predictive Method for the Estimation of Flux Through Polydimethylsiloxane Membranes. IV. Application to a Series of Substituted Quinolines | Lloyd E. Matheson and Meng-wei Hu |
| 843-852 | A Drug Absorption Model Based on the Mucus Layer Producing Human Intestinal Goblet Cell Line HT29-H | Agneta Wikman, Johan Karlsson, Ingemar Carlstedt and Per Artursson |
| 853-856 | In Vitro/in Vivo Correlation of the Bioadhesive Properties of a Buccal Bioadhesive Miconazole Slow-Release Tablet | Stefan Bouckaert, Remain A. Lefebvre and Jean-Paul Remon |
| 857-864 | Sodium Caprate Elicits Dilatations in Human Intestinal Tight Junctions and Enhances Drug Absorption by the Paracellular Route | Eva Karin Anderberg, Tuulikki Lindmark and Per Artursson |
| 865-870 | Comparison of the Mechanism of Dissolution of Hydrocortisone in Simple and Mixed Micelle Systems | Lori J. Naylor, Vassiliki Bakatselou and Jennifer B. Dressman |
| 871-878 | Deposition Patterns of Aerosolized Drugs Within Human Lungs: Effects of Ventilatory Parameters | Ted B. Martonen and Ira M. Katz |
| 879-883 | Evidence for an Interaction Between the β-Blocker Pafenolol and Bile Salts in the Intestinal Lumen of the Rat Leading to Dose-Dependent Oral Absorption and Double Peaks in the Plasma Concentration–Time Profile | Hans Lennernäs and Carl-Gunnar Regårdh |
| 884-888 | Influence of Anesthetic Regimens on Intestinal Absorption in Rats | Hiroaki Yuasa, Kenji Matsuda and Jun Watanabe |
| 889-894 | Interpretation and Utilization of Effect and Concentration Data Collected in an in Vivo Pharmacokinetic and in Vitro Pharmacodynamic Study | Suneel K. Gupta, Stephen S. Hwang, Leslie Z. Benet and Mark Gumbleton |
| 895-899 | Analysis of Micelle Formation of an Adriamycin-Conjugated Poly(Ethylene Glycol)–Poly(Aspartic Acid) Block Copolymer by Gel Permeation Chromatography | Masayuki Yokoyama, Takumichi Sugiyama, Teruo Okano, Yasuhisa Sakurai and Mayumi Naito, et al. |
| 900-904 | A Spectroscopic Investigation of Losartan Polymorphs | Krishnaswamy Raghavan, Anil Dwivedi, G. Creston Campbell Jr, Eric Johnston and Dorothy Levorse, et al. |
| 905-912 | Structure of 3-Acetyl-5-fluorouracil (5-FU): Implication for Its Rearrangements During Hydrolysis and upon Heating | Howard D. Beall, Richard J. Prankerd, Louis J. Todaro and Kenneth B. Sloan |
| 913-917 | The Liposome Partitioning System for Correlating Biological Activities of Imidazolidine Derivatives | James A. Rogers and Young W. Choi |
| 918-923 | A Structured–Activity Relationship Study of Batracylin Analogues | Yilin Luo, Yun-Feng Ren, Ting-Chao Chou, Allan Y. Chen and Chiang Yu, et al. |
| 924-926 | Intranasal Delivery of the Bisphosphonate Alendronate in the Rat and Dog | Steven C. Sutton, Karen Engle and Joseph A. Fix |
| 927-929 | Modification of the Dialysis Membrane Method for Drug Release from Suppositories | Masaru Yamazaki, Soichi Itoh, Naomi Sasaki, Kazuhisa Tanabe and Mitsuru Uchiyama |
| 930-931 | Can We Assign an Upper Limit to Skin Permeability? | Gerald B. Kasting and Peter J. Robinson |
| 932 | ERRATUM |
| 933-944 | Degradation Pathways for Recombinant Human Macrophage Colony-Stimulating Factor in Aqueous Solution | Jay A. Schrier, Richard A. Kenley, Rick Williams, Robert J. Corcoran and Yangkil Kim, et al. |
| 945-953 | Determinants of Release Rate of Tetanus Vaccine from Polyester Microspheres | Maria J. Alonso, Smadar Cohen, Tae G. Park, Rajesh K. Gupta and George R. Siber, et al. |
| 954-962 | Techniques for Assessing the Effects of Pharmaceutical Excipients on the Aggregation of Porcine Growth Hormone | Susan A. Charman, Kaye L. Mason and William N. Charman |
| 963-969 | Low Molecular Weight Proteins as Carriers for Renal Drug Targeting: Naproxen Coupled to Lysozyme via the Spacer L-Lactic Acid | Eric J. F. Franssen, Frits Moolenaar, Dick de Zeeuw and Dirk K. F. Meijer |
| 970-974 | Biodistribution of Micelle-Forming Polymer–Drug Conjugates | Glen S. Kwon, Masayuki Yokoyama, Teruo Okano, Yasuhisa Sakurai and Kazunori Kataoka |
| 975-979 | Identification of an Escherichia coli Protein Impurity in Preparations of a Recombinant Pharmaceutical | Donald O. O'Keefe, Peter DePhillips and Mark L. Will |
| 980-985 | Swelling and Dissolution Kinetics During Peptide Release from Erodible Anionic Gel Beads | Ping I. Lee |
| 986-990 | Effect of Receiver Fluid pH on in Vitro Skin Flux of Weakly lonizable Drugs | Jim H. Kou, Samir D. Roy, Jie Du and Jean Fujiki |
| 991-997 | Regulation of Tight Junction Permeability by Calcium Mediators and Cell Cytoskeleton in Rabbit Tracheal Epithelium | Meenakshi Bhat, David Toledo-Velasquez, LiYing Wang, Carl J. Malanga and Joseph K. H. Ma, et al. |
| 998-1004 | Characterization of Antacid Compounds Containing Both Aluminum and Magnesium. I. Crystalline Powders | Cheryl L. Peterson, Darold L. Perry, Hamid Masood, Huahua Lin and Joe L. White, et al. |
| 1005-1007 | Characterization of Antacid Compounds Containing Both Aluminum and Magnesium. II. Codried Powders | Cheryl L. Peterson, Darold L. Perry, Hamid Masood, Joe L. White and Stanley L. Hem, et al. |
| 1008-1014 | Growth and Morphology of L-Alanine Crystals: Influence of Additive Adsorption | David Lechuga-Ballesteros and Nair Rodriguez-Hornedo |
| 1015-1019 | ε-Aminocaproic Acid Esters as Transdermal Penetration Enhancing Agents | Pavel Doležal, Alexandr Hrabálek and Vladimir Semecký |
| 1020-1026 | In Vivo Validation of the Release Rate and Palatability of Remoxipride-Modified Release Suspension | Rolf Sjöqvist, Christina Graffner, Inger Ekman, Wendy Sinclair and Jonathan P. Woods |
| 1027-1030 | Effect of Sodium Acid Pyrophosphate on Ranitidine Bioavailability and Gastrointestinal Transit Time | Kevin M. Koch, Alan F. Parr, Julie J. Tomlinson, Erik P. Sandefer and George A. Digenis, et al. |
| 1031-1036 | The Impact of Lag Time on the Estimation of Pharmacokinetic Parameters. I. One-Compartment Open Model | Nadhamuni G. Nerella, Lawrence H. Block and Patrick K. Noonan |
| 1037-1045 | The Effect of Gastric pH on the Absorption of Controlled-Release Theophylline Dosage Forms in Humans | Marvin C. Meyer, Arthur B. Straughn, Eric J. Jarvi, George C. Wood and Vijaykumar I. Vashi, et al. |
| 1046-1051 | Increased Sensitivity to the Anticonvulsant Effect of Valproate in Aging BN/BiRij Rats | Annemiek M. Stijnen, Suzanne Hovinga, Mariska W. E. Langemeijer, Arendien Hoogerkamp and Cornells F. A. van Bezooijen, et al. |
| 1052-1058 | Application of the Periodic Bond Chain (PBC) Theory and Attachment Energy Consideration to Derive the Crystal Morphology of Hexamethylmelamine | Piet Hartman and Hak-Kim Chan |
| 1059-1065 | Albumin Microspheres as a Drug Delivery System: Relation Among Turbidity Ratio, Degree of Cross-linking, and Drug Release | Orapin P. Rubino, Richard Kowalsky and James Swarbrick |
| 1066-1070 | Zero-Order Drug Release from Hydrocolloid Matrices | Jörn E. Möckel and Bernhard C. Lippold |
| 1071-1075 | Solid-State Emulsions: The Effects of Process and Storage Conditions | Merrick L. Shively and Scott Myers |
| 1076-1082 | Solubilization and Stabilization of an Anti-HIV Thiocarbamate, NSC 629243, for Parenteral Delivery, Using Extemporaneous Emulsions | Robert G. Strickley and Bradley D. Anderson |
| 1083-1086 | Intranasal Absorption of a Kappa Agonist Analgesic | Munir A. Hussain, William K. Schmidt and John D. Buehler |
| 1087-1089 | Controlled Gastric Emptying. III. Gastric Residence Time of a Nondisintegrating Geometric Shape in Human Volunteers | Joseph A. Fix, Robyn Cargill and Karen Engle |
| 1090-1092 | Transient Steady-State Analysis: Application in the Determination of the Relative Formation and Elimination Clearances of Two Major Carbamazepine Metabolites in Humans | Lillian E. Riad, Keith K. H. Chan and Ronald J. Sawchuk |
| 1093-1095 | Physiological Parameters in Laboratory Animals and Humans | Brian Davies and Tim Morris |
| 1096 | Editorial |
| 1097-1105 | Tertiary Amines Related to Brompheniramine: Preferred Conformations for N-Oxygenation by the Hog Liver Flavin-Containing Monooxygenase | John R. Cashman, Joy R. Celestial, Andrew Leach, Julie Newdoll and Sang Bum Park |
| 1106-1114 | Proteolysis of Human Growth Hormone by Rat Thyroid Gland in Vitro: Application of Electrospray Mass Spectrometry and N-Terminal Sequencing to Elucidate a Metabolic Pathway | Victor J. Wroblewski, Raymond E. Kaiser and Gerald W. Becker |
| 1115-1122 | Gelatin-Acacia Microcapsules for Trapping Micro Oil Droplets Containing Lipophilic Drugs and Ready Disintegration in the Gastrointestinal Tract | Hiroaki Jizomoto, Eri Kanaoka, Katsuji Sugita and Koichiro Hirano |
| 1123-1129 | Selective Paracellular Permeability in Two Models of Intestinal Absorption: Cultured Monolayers of Human Intestinal Epithelial Cells and Rat Intestinal Segments | Per Artursson, Anna-Lena Ungell and Jan-Erik Löfroth |
| 1130-1135 | Liposome-Mediated Delivery of Gallium to Macrophage-Like Cells in Vitro: Demonstration of a Transferrin-Independent Route for Intracellular Delivery of Metal Ions | Jukka Mönkkönen, Carolyn S. Brown, Tormaine T. Thompson and Timothy D. Heath |
| 1136-1143 | Solubilization of Thiazolobenzimidazole Using a Combination of pH Adjustment and Complexation with 2-Hydroxypropyl-β-Cyclodextrin | Abdi Y. Tinwalla, Barbara L. Hoesterey, Tian-xiang Xiang, Kap Lim and Bradley D. Anderson |
| 1144-1152 | Programmable Drug Delivery from an Erodible Association Polymer System | Xin Xu and Ping I. Lee |
| 1153-1156 | Characterization of Oil-in-Water Emulsions Prepared from Solid-State Emulsions: Effect of Matrix and Oil Phase | Merrick L. Shively |
| 1157-1164 | Biopharmaceutics of Didanosine in Humans and in a Model for Acid-Labile Drugs, the Pentagastrin-Pretreated Dog | Catherine A. Knupp, Wen Chyi Shyu, Elizabeth A. Morgenthien, James S. Lee and Rashmi H. Barbhaiya |
| 1165-1168 | Pharmacokinetics of Diltiazem and Its Metabolites in Dogs After Oral Administration of a Multiparticulate Sustained-Release Preparation | Kazuo Murata, Hiroshi Yamahara and Kazuo Noda |
| 1169-1173 | Stereoselective Interactions of Organic Cations with the Organic Cation Transporter in OK Cells | Ronda J. Ott and Kathleen M. Giacomini |
| 1174-1180 | Demethylation Kinetics of Aspartame and L-Phenylalanine Methyl Ester in Aqueous Solution | Raymond D. Skwierczynski and Kenneth A. Connors |
| 1181-1186 | Phenytoin–Lipid Conjugates: Chemical, Plasma Esterase-Mediated, and Pancreatic Lipase-Mediated Hydrolysis in Vitro | Gerhard K. E. Scriba |
| 1187-1190 | Substituted Xanthones as Selective and Reversible Monoamine Oxidase A (MAO-A) Inhibitors | Ulrike Thull, Silvia Kneubühler, Bernard Testa, M. Fernanda M. Borges and Madalena M. M. Pinto |
| 1191-1199 | Synthesis and Evaluation of Morpholinoalkyl Ester Prodrugs of Indomethacin and Naproxen | Vijay K. Tammara, Milind M. Narurkar, A. Michael Crider and Mansoor A. Khan |
| 1200-1205 | Conformational Analysis of the Opioid Phenylmorphan and Its 9α-Methyl Analogue in Solution Using High-Resolution Nuclear Magnetic Resonance Spectroscopy | Christine M. DiMeglio, Mark Froimowitz and Alexandros Makriyannis |
| 1206-1211 | The Hypolipidemic Effects of l-Acetyl-4-phenyl-l,2,4-triazolidine-3,5-dione in Rodents | Iris H. Hall, Rupenra Simlot, Patricia Day, O. T. Wong and Hamby ElSourady, et al. |
| 1212-1218 | Evaluation of Moisture Sorption by Tablet Cores Containing Superdisintegrants During the Aqueous Film Coating Process | Nazaneen Pourkavoos and Garnet E. Peck |
| 1219-1227 | Dissolution, Stability, and Morphological Properties of Conventional and Multiphase Poly(DL-Lactic-Co-Glycolic Acid) Microspheres Containing Water-Soluble Compounds | Motokazu Iwata and James W. McGinity |
| 1228-1231 | Stability of Liposomes in Vitro and Their Uptake by Rat Peyer's Patches Following Oral Administration | Yukihiko Aramaki, Hitoshi Tomizawa, Toshifumi Hara, Kiyoto Yachi and Hiroshi Kikuchi, et al. |
| 1232-1237 | Decreased Protein-Stabilizing Effects of Cryoprotectants Due to Crystallization | Ken-ichi Izutsu, Sumie Yoshioka and Tadao Terao |
| 1238-1242 | Transforming Growth Factor-α (TGF-α) in a Semisolid Dosage Form: Preservative and Vehicle Selection | Elizabeth L, Tan, Hemanshu S. Shah, Kirk J. Leister, Linda M. Kozick and Pamela Pasciak, et al. |
| 1243-1247 | Oral Immunization of Rats with Proteinoid Microspheres Encapsulating Influenza Virus Antigens | Noemi Santiago, Sam Milstein, Theresa Rivera, Elisa Garcia and Tabassum Zaidi, et al. |
| 1248-1251 | The Use of Statistical Indices to Gauge the Mixing Efficiency of a Conical Screening Mill | Richard P. Poska, Thomas R. Hill and Jan W. van Schaik |
| 1252 | Association News and Announcements |
| 1253-1261 | Synthesis and Pharmacokinetics of a New Liver-Specific Carrier, Glycosylated Carboxymethyl-Dextran, and Its Application to Drug Targeting | Makiya Nishikawa, Akiko Kamijo, Takuya Fujita, Yoshinobu Takakura and Hitoshi Sezaki, et al. |
| 1262-1267 | The Use of Solution Theories for Predicting Water Vapor Absorption by Amorphous Pharmaceutical Solids: A Test of the Flory–Huggins and Vrentas Models | Bruno C. Hancock and George Zografi |
| 1268-1273 | Peptide Stability in Drug Development. II. Effect of Single Amino Acid Substitution and Glycosylation on Peptide Reactivity in Human Serum | Michael F. Powell, Tracy Stewart, Laszlo Otvos, Laszlo Urge and Federico C. A. Gaeta, et al. |
| 1274-1279 | Preparation, Characterization, and Pharmaceutical Application of Linear Dextrins. I. Preparation and Characterization of Amylodextrin, Metastable Amylodextrins, and Metastable Amylose | Gerrit H. P. Te Wierik, Anko C. Eissens, Arie C. Besemer and Coenraad F. Lerk |
| 1280-1284 | Preparation, Characterization, and Pharmaceutical Application of Linear Dextrins. II. Complexation and Dispersion of Drugs with Amylodextrin by Freeze-Drying and Kneading | Gerrit H. P. Te Wierik, Anko C. Eissens, Arie C. Besemer and Coenraad F. Lerk |
| 1285-1290 | Evaluation of the Physicochemical Properties and Dissolution Characteristics of Mesalamine: Relevance to Controlled Intestinal Drug Delivery | Donna L. French and John W. Mauger |
| 1291-1294 | In Vivo Skin Penetration of Acitretin in Volunteers Using Three Sampling Techniques | Christian Surber, Klaus-P. Wilhelm, David Bermann and Howard I. Maibach |
| 1295-1300 | The Dissolution and Bioavailability of Etodolac from Capsules Exposed to Conditions of High Relative Humidity and Temperatures | Mike Dey, Robin Enever, Mike Kraml, David G. Prue and Doug Smith, et al. |
| 1301-1307 | Lack of Effect of Ammonium Glycyrrhizinate on the Morphology of Ovine Nasal Mucosa in Vitro | Patricia M. Reardon, Doris A. Wall, Timothy K. Hart, Philip L. Smith and Caroline H. Gochoco |
| 1308-1314 | Dissolution Modeling: Factors Affecting the Dissolution Rates of Polydisperse Powders | Allan T. K. Lu, Mary E. Frisella and Kevin C. Johnson |
| 1315-1320 | Convective Solvent Flow Across the Skin During Iontophoresis | Aeri Kim, Philip G. Green, Girish Rao and Richard H. Guy |
| 1321-1325 | A Floating Controlled-Release Drug Delivery System: In Vitro-in Vivo Evaluation | Subhash Desai and Sanford Bolton |
| 1326-1331 | Topical Penetration of Piroxicam Is Dependent on the Distribution of the Local Cutaneous Vasculature | Nancy A. Monteiro-Riviere, Alfred O. Inman, Jim E. Riviere, Stephen C. McNeill and Michael L. Francoeur |
| 1332-1337 | Rates of Systemic Degradation and Reticuloendothelial System (RES) Uptake of Thermosensitive Liposome Encapsulating Cisplatin in Rats | Katsumi Iga, Yasuaki Ogawa and Hajime Toguchi |
| 1338-1340 | Effect of Age on Distribution of Zidovudine (Azidothymidine) into the Cerebrospinal Fluid of Macaca nemestrina | Arturo Lopez-Anaya, Jashvant D. Unadkat, Dianne F. Calkins and Arnold L. Smith |
| 1341-1345 | Effect of Apparent Elimination Half-Life on Nitroglycerin-Induced Hemodynamic Rebound in Experimental Heart Failure | JohnAnthony Bauer and Ho-Leung Fung |
| 1346-1349 | Correlation Between the Plasma Concentration of Mepirodipine and Its Occupancy of Ca2+ Antagonist Receptors in Rats | Shizuo Yamada, Youmei Matsuoka and Ryohei Kimura |
| 1350-1355 | Phosphoryloxymethyl Carbamates and Carbonates—Novel Water-Soluble Prodrugs for Amines and Hindered Alcohols | Muhammad Safadi, Reza Oliyai and Valentino J. Stella |
| 1356-1362 | The Effect of Dihydronicotinate N-Substitution on the Brain-Targeting Efficacy of a Zidovudine Chemical Delivery System | Marcus E. Brewster, Emil Pop, Andrew J. Braunstein, Andreea C. Pop and Pascal Druzgala, et al. |
| 1363-1371 | The Effect of Swelling Characteristics of Superdisintegrants on the Aqueous Coating Solution Penetration into the Tablet Matrix During the Film Coating Process | Nazaneen Pourkavoos and Garnet E. Peck |
| 1372-1377 | Absorption of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) from Rat Nasal Mucosa | Minoru Machida, Keiko Sano, Masayuki Arakawa, Masahiro Hayashi and Shoji Awazu |
| 1378-1380 | The Influence of Blood Sampling Site in Nasal Drug Delivery Studies in Rats | Hing Char, Saran Kumar, Giuseppe Ciccone, David Piemontese and A.Waseem Malick, et al. |
| 1381-1384 | Single-Puff Particle-Size Analysis of Albuterol Metered-Dose Inhalers (MDIs) by High-Pressure Liquid Chromatography with Electrochemical Detection (HPLC-EC) | Moheb M. Nasr |
| 1385-1388 | Preparation of Small Gelatin and Albumin Microparticles by a Carbon Dioxide Atomization Process | Levent Öner and Michael J. Groves |
| 1389-1391 | Solid-State Emulsions: The Effects of Maltodextrin on Microcrystalline Aging | Scott L. Myers and Merrick L. Shively |
| 1392 | Association News and Announcements |
| 1393-1401 | Biotechnology and Bone Graft Substitutes | Richard A. Kenley, Kalvin Yim, Joan Abrams, Eyal Ron and Tom Turek, et al. |
| 1402-1410 | Enhancement of Tissue Delivery and Receptor Occupancy of Methylprednisolone in Rats by a Liposomal Formulation | Elena V. Mishina, Robert M. Straubinger, Nancy A. Pyszczynski and William J. Jusko |
| 1411-1419 | Microdialysis Calibration Using Retrodialysis and Zero-Net Flux: Application to a Study of the Distribution of Zidovudine to Rabbit Cerebrospinal Fluid and Thalamus | Yanfeng Wang, Shekman L. Wong and Ronald J. Sawchuk |
| 1420-1426 | Precision, Accuracy, and Data Acceptance Criteria in Biopharmaceutical Analysis | H. Thomas Karnes and Clark March |
| 1427-1433 | Inhibition of the Friend Retrovirus by Antisense Oligonucleotides Encapsulated in Liposomes: Mechanism of Action | C. Ropert, C. Malvy and P. Couvreur |
| 1434-1441 | Modulation of Human Ovarian Tumor Cell Sensitivity to N-(Phosphonacetyl)-L-Aspartate (PALA) by Liposome Drug Carriers | Amarnath Sharma, Ninfa L. Straubinger and Robert M. Straubinger |
| 1442-1445 | Pharmacokinetics, Mass Balance, and Induction Potential of a Novel GABA Uptake Inhibitor, CI-966 HC1, in Laboratory Animals | Louis L. Radulovic, Howard N. Bockbrader and Tsun Chang |
| 1446-1450 | Oral Absorption of FK506 in Rats | Akira Kagayama, Sachiyo Tanimoto, Jiro Fujisaki, Atunori Kaibara and Kaname Ohara, et al. |
| 1451-1457 | Plasma Pharmacokinetics of the Lactone and Carboxylate Forms of 20(S)-Camptothecin in Anesthetized Rats | Dennis O. Scott, Dilbir S. Bindra and Valentine J. Stella |
| 1458-1460 | The Effect of Aluminum Hydroxide Dissolution on the Bleeding of Aluminum Lake Dyes | Archana Desai, Garnet E. Peck, Janet E. Lovell, Joe L. White and Stanley L. Hem |
| 1461-1465 | The Interconversion Kinetics, Equilibrium, and Solubilities of the Lactone and Hydroxyacid Forms of the HMG-CoA Reductase Inhibitor, CI-981 | Albert S. Kearney, Lee F. Crawford, Surendra C. Mehta and Galen W. Radebaugh |
| 1466-1470 | Synthesis and Stability of Isotopically Labeled p-Chloro-m-Xylenol (PCMX) | John C. Reepmeyer, Walter L. Zielinski, Julian E. A. Leakey and Ying Si |
| 1471-1477 | Validation of a Peptide Map for Recombinant Porcine Growth Hormone and Application to Stability Assessment | Susan A. Charman, Louise E. McCrossin and William N. Charman |
| 1478-1483 | Stabilization of Lyophilized Porcine Pancreatic Elastase | Byeong S. Chang, Cynthia S. Randall and Yong S. Lee |
| 1484-1487 | The Effect of Salts on the Stability of β-Galactosidase in Aqueous Solution, as Related to the Water Mobility | Sumie Yoshioka, Yukio Aso, Ken-ichi Izutsu and Tadao Terao |
| 1488-1492 | Development of New Lipophilic Derivatives of Tetragastrin: Physicochemical Characteristics and Intestinal Absorption of Acyl-tetragastrin Derivatives in Rats | Takehiro Tenma, Etsuo Yodoya, Shigeru Tashima, Takuya Fujita and Masahiro Murakami, et al. |
| 1493-1499 | Histocultures of Patient Head and Neck Tumors for Pharmacodynamics Studies | Jessie L.-S. Ail, M. Guillaume Wientjes, Thomas J. Rosol, Antoinette Koolemans-Beynen and Eric A. Goebel, et al. |
| 1500-1506 | Validation of Reflectance Infrared Spectroscopy as a Quantitative Method to Measure Percutaneous Absorption In Vivo | Naruhito Higo, Aarti Naik, D. Bommi Bommannan, Russell O. Potts and Richard H. Guy |
| 1507-1515 | Physicochemical Characterization of High- and Low-Melting Phenylephrine Oxazolidines | Yihong Qiu, Ronald D. Schoenwald and J. Keith Guillory |
| 1516-1520 | Enhanced Bioavailability of Cefoxitin Using Palmitoylcarnitine. II. Use of Directly Compressed Tablet Formulations in the Rat and Dog | Steven C. Sutton, Edward L. LeCluyse, Karen Engle, James D. Pipkin and Joseph A. Fix |
| 1521-1526 | Flow-Through System Effects on in Vitro Analysis of Transdermal Systems | Joseph Sclafani, James Nightingale, Puchun Liu and Tamie Kurihara-Bergstrom |
| 1527-1532 | Sustained Local Anesthetic Release from Bioerodible Polymer Matrices: A Potential Method for Prolonged Regional Anesthesia | David B. Masters, Charles B. Berde, Sanjoy Dutta, Tom Turek and Robert Langer |
| 1533-1543 | Salt and Mesophase Formation in Aqueous Suspensions of Lauric Acid | Scott W. Smith and Bradley D. Anderson |
| 1544-1547 | Preparation and Characterization of Thermal- and pH-Sensitive Nanospheres | Xiao Yu Wu and Ping I. Lee |
| 1548-1551 | Intrapulmonary Delivery of Renin Inhibitory Peptides Results in Sustained Release Because of Saturable Transport | Ann M. Sheehy, Jennifer L. Hoover, Bob D. Rush, Karen F. Wilkinson and Thomas J. Vidmar, et al. |
| 1552 | Association News and Announcements |
| 1553-1562 | In Vitro Evaluation of Dexamethasone-β-D-Glucuronide for Colon-Specific Drug Delivery | Barbara Haeberlin, Werner Rubas, Harold W. Nolen III and David R. Friend |
| 1563-1571 | The Kinetics of Relaxin Oxidation by Hydrogen Peroxide | Tue H. Nguyen, John Burnier and Wei Meng |
| 1572-1579 | Chemical Pathways of Peptide Degradation. V. Ascorbic Acid Promotes Rather than Inhibits the Oxidation of Methionine to Methionine Sulfoxide in Small Model Peptides | Shihong Li, Christian Schöneich, George S. Wilson and Ronald T. Borchardt |
| 1580-1586 | Origin of the Isoelectric Heterogeneity of Monoclonal Immunoglobulin h1B4 | P. K. Tsai, Mark W. Bruner, Joseph I. Irwin, Charlotte C. Yu Ip and Cynthia N. Oliver, et al. |
| 1587-1590 | Determination of Acrolein in Urine by Liquid Chromatography and Fluorescence Detection of Its Quinoline Derivative | Sameer Al-Rawithi, Adnan El-Yazigi and Paul J. Nicholls |
| 1591-1596 | Sterilization of Liposomes by Heat Treatment | Nicolaas J. Zuidam, Stephen S. L. Lee and Daan J. A. Crommelin |
| 1597-1603 | Evaluation of Preflo® Modified Starches as New Direct Compression Excipients. I. Tabletting Characteristics | Pradeepkumar P. Sanghvi, Charles C. Collins and Atul J. Shukla |
| 1604-1610 | Pulmonary Absorption of Recombinant Methionyl Human Granulocyte Colony Stimulating Factor (r-huG-CSF) After Intratracheal Instillation to the Hamster | Ralph W. Niven, Fred D. Lott and Judith M. Cribbs |
| 1611-1614 | Pharmacokinetic Analysis and Cellular Distribution of the Anti-HIV Compound Succinylated Human Serum Albumin (Suc-HSA) in Vivo and in the Isolated Perfused Rat Liver | Robert W. Jansen, Peter Olinga, Geert Harms and Dirk K. F. Meijer |
| 1615-1619 | Recovery and Elimination of the Biotherapeutic Agent, Saccharomyces boulardii, in Healthy Human Volunteers | Susan M. Klein, Gary W. Elmer, Lynne V. McFarland, Christina M. Surawicz and René H. Levy |
| 1620-1626 | Utilization of a Human Intestinal Epithelial Cell Culture System (Caco-2) for Evaluating Cytoprotective Agents | Albert S. Tang, Prashant J. Chikhale, Praful K. Shah and Ronald T. Borchardt |
| 1627-1631 | Formulation, in Vitro Dissolution, and Ocular Bioavailability of High- and Low-Melting Phenylephrine Oxazolidines | Yihong Qiu, J. Keith Guillory and Ronald D. Schoenwald |
| 1632-1637 | Synthesis and Enhancing Effect of Dodecyl 2-(N,N-Dimethylamino)propionate on the Transepidermal Delivery of Indomethacin, Clonidine, and Hydrocortisone | Servet Büyüktimkin, Nadir Büyüktimkin and J. Howard Rytting |
| 1638-1641 | Chemical and α-Chymotrypsin-Mediated Proteolytic Degradation of Insulin in Bile Salt-Unsaturated Fatty Acid Mixed Micellar Systems | Yuping Li, Zezhi Shao and Ashim K. Mitra |
| 1642-1647 | A Critical Comparison of Some Raman Spectroscopic Techniques for Studies of Human Stratum Corneum | Adrian C. Williams, Brian W. Barry, Howell G. M. Edwards and Dennis W. Farwell |
| 1648-1653 | Stereoselective Dissolution of Propranolol Hydrochloride from Hydroxypropyl Methylcellulose Matrices | Sarma P. Duddu, Majid Vakilynejad, Fakhreddin Jamali and David J. W. Grant |
| 1654-1661 | Diffusion of lonizable Solutes Across Planar Lipid Bilayer Membranes: Boundary-Layer pH Gradients and the Effect of Buffers | Tian-xiang Xiang and Bradley D. Anderson |
| 1662-1667 | Transport and Hydrolysis of Enkephalins in Cultured Alveolar Epithelial Monolayers | LiYing Wang, David Toledo-Velasquez, Diane Schwegler-Berry, Joseph K. H. Ma and Yongyut Rojanasakul |
| 1668-1674 | Dipeptide Transport Across Rat Alveolar Epithelial Cell Monolayers | Kazuhiro Morimoto, Hiroshi Yamahara, Vincent H. L. Lee and Kwang-Jin Kim |
| 1675-1682 | Absorption and Disposition of a New Antiarrhythmic Agent Bidisomide in Man | Chyung S. Cook, Gregory B. Ames, Margaret E. Smith, Kenneth G. Kowalski and Aziz Karim |
| 1683-1687 | Evaluation of Sustained/Controlled-Release Dosage Forms of 3-Hydroxy-3-methylglutaryl–Coenzyme A (HMG-CoA) Reductase Inhibitors in Dogs and Humans | Haiyung Cheng, Steven C. Sutton, James D. Pipkin, Gaylen M. Zentner and J. Douglas Rogers, et al. |
| 1688-1692 | Application of Dual Radiotelemetric Technique in Studying Drug–Drug Interaction Between Diclofenac Sodium and Ranitidine HCl in Volunteers | Catherine Alioth, Robert A. Blum, David T. D'Andrea, Gregory M. Kochak and Lichen Teng, et al. |
| 1693-1695 | Prediction of Drug Release from Hydroxypropyl Methylcellulose (HPMC) Matrices: Effect of Polymer Concentration | Navnit Shah, Guohua Zhang, Vahe Apelian, Fuwen Zeng and Martin H. Infeld, et al. |
| 1696 | Oligonucleotides Get a Face-Lift | Sarah Noonberg |
| 1697 | BOOK REVIEWS |
| 1697-1698 | BOOK REVIEWS |
| 1699-1709 | Transport of Ionic Species in Skin: Contribution of Pores to the Overall Skin Conductance | Erik R. Scott, Ana I. Laplaza, Henry S. White and J. Bradley Phipps |
| 1710-1714 | A Correlation Between the Permeability Characteristics of a Series of Peptides Using an in Vitro Cell Culture Model (Caco-2) and Those Using an in Situ Perfused Rat Ileum Model of the Intestinal Mucosa | Dong-Chool Kirn, Philip S. Burton and Ronald T. Borchardt |
| 1715-1721 | Interleukin-2-Containing Liposomes: Interaction of Interleukin-2 with Liposomal Bilayers and Preliminary Studies on Application in Cancer Vaccines | Joep J. Bergers, Willem Den Otter, Hub F. J. Dullens, Catherina T. M. Kerkvliet and Daan J. A. Crommelin |
| 1722-1725 | Mechanism of Intestinal Absorption of Ranitidine and Ondansetron: Transport Across Caco-2 Cell Monolayers | Liang-Shang Gan, Poe-Hirr Hsyu, J. Frederick Pritchard and Dhiren Thakker |
| 1726-1731 | Phonophoresis of Methyl Nicotinate: A Preliminary Study to Elucidate the Mechanism of Action | James C. McElnay, Heather A. E. Benson, Robin Harland and Jonathan Hadgraft |
| 1732-1737 | In Vitro Extended-Release Properties of Drug-Loaded Poly(DL-Lactic Acid) Nanoparticles Produced by a Salting-Out Procedure | Eric Allémann, Jean-Christophe Leroux, Robert Gurny and Eric Doelker |
| 1738-1744 | Site-Specific Drug Delivery to Pilosebaceous Structures Using Polymeric Microspheres | Alain Rolland, Nathalie Wagner, Alain Chatelus, Braham Shroot and Hans Schaefer |
| 1745-1750 | Disparity of in Vitro and in Vivo Oleic Acid-Enhanced β-Estradiol Percutaneous Absorption Across Human Skin | Lynn K. Pershing, Greg E. Parry and Lyssa D. Lambert |
| 1751-1755 | Reverse Iontophoresis: Development of a Noninvasive Approach for Glucose Monitoring | Girish Rao, Peretz Glikfeld and Richard H. Guy |
| 1756-1759 | Influence of Skin Irritants on Percutaneous Absorption | Avinash Nangia, Etienne Camel, Bret Berner and Howard Maibach |
| 1760-1764 | Dose Proportionality and Population Characteristics of Oral Fadrozole Hydrochloride, an Aromatase Inhibitor, in Postmenopausal Women | Gregory M. Kochak, R. Leslie Choi and Elizabeth A. Entwistle |
| 1765-1771 | Assessment of Valproic Acid Serum–Cerebrospinal Fluid Transport by Microdialysis | Pamela L. Golden, Kenneth R. Brouwer and Gary M. Pollack |
| 1772-1776 | The Qualitative and Quantitative Analysis of Chlorpropamide Polymorphic Mixtures by Near-Infrared Fourier Transform Raman Spectroscopy | Andrew M. Tudor, Steven J. Church, Patrick J. Hendra, Martyn C. Davies and Colin D. Melia |
| 1777-1784 | Identification and Isolation of Chlorhexidine Digluconate Impurities | Larry K. Revelle, William H. Doub, Roger T. Wilson, Monica H. Harris and Aaron M. Rutter |
| 1785-1789 | Kinetic Analysis of Molecular Interconversion of Immunosuppressant FK506 by High-Performance Liquid Chromatography | Takashi Nishikawa, Hideyo Hasumi, Satomi Suzuki, Hiroaki Kubo and Hideki Ohtani |
| 1790-1792 | In Vitro/in Vivo Models for Peptide Oral Absorption: Comparison of Caco-2 Cell Permeability with Rat Intestinal Absorption of Renin Inhibitory Peptides | Robert A. Conradi, Karen F. Wilkinson, Bob D. Rush, Allen R. Hilgers and Mary J. Ruwart, et al. |
| 1793-1795 | Thermal Analysis and Solution Calorimetry Studies on Losartan Polymorphs | Lei-Shu Wu, Christine Gerard and Munir A. Hussain |
| 1796-1799 | Binding and Transport of Some Bioadhesive Plant Lectins Across Caco-2 Cell Monolayers | Claus-Michael Lehr and Vincent H. L. Lee |
| 1800-1805 | Scaleup of Oral Extended-Release Dosage Forms | J. P. Skelly, G. A. Van Buskirk, H. M. Arbit, G. L. Amidon and L. Augsburger, et al. |
| 1806-1811 | Bio-International '92, Conference on Bioavailability, Bioequivalence and Pharmacokinetic Studies | Henning H. Blume and Kamal K. Midha |
| 1812 | BOOK REVIEWS |
| 1812-1813 | BOOK REVIEWS |
| 1814 | Association News and Announcements |
| 1815-1818 | Author Index to Volume 10 (1993) |
| 1819-1822 | Subject Index to Volume 10 (1993) |
| 1 | Editorial |
| 2-11 | Immunopotentiation and Delivery Systems for Antigens for Single-Step Immunization: Recent Trends and Progress | M. Zahirul I. Khan, Joan P. Opdebeeck and Ian G. Tucker |
| 12-20 | Feasibility Study on Spray-Drying Protein Pharmaceuticals: Recombinant Human Growth Hormone and Tissue-Type Plasminogen Activator | Marco Mumenthaler, Chung C. Hsu and Rodney Pearlman |
| 21-29 | Moisture-Induced Aggregation of Lyophilized Insulin | Henry R. Costantino, Robert Langer and Alexander M. Klibanov |
| 30-37 | Transcellular Transport of Benzole Acid Across Caco-2 Cells by a pH-Dependent and Carrier-Mediated Transport Mechanism | Akira Tsuji, Hitomi Takanaga, Ikumi Tamai and Tetsuya Terasaki |
| 38-46 | Intracellular Visualization of Ampicillin-Loaded Nanoparticles in Peritoneal Macrophages Infected in Vitro with Salmonella typhimurium | Huguette Pinto-Alphandary, Olivier Balland, Michel Laurent, Antoine Andremont and Francis Puisieux, et al. |
| 47-53 | Conformational Analysis, Molecular Modeling, and Quantitative Structure–Activity Relationship Studies of Agents for the Inhibition of Astrocytic Chloride Transport | Chris L. Waller, Steven D. Wyrick, W. Evans Kemp, Hee Moon Park and Forrest T. Smith |
| 54-59 | Measurement of Glass Transition Temperatures of Freeze-Concentrated Solutes by Differential Scanning Calorimetry | Lih-Min Her and Steven L. Nail |
| 60-64 | Clearance Mechanisms of Atrial and Brain Natriuretic Peptides in Rats | Yukiya Hashimoto, Kazuwa Nakao, Norio Hama, Hiroo Imura and Sachiyo Mori, et al. |
| 65-71 | Acidic Fibroblast Growth Factor: Evaluation of Topical Formulations in a Diabetic Mouse Wound Healing Model | Bozena Matuszewska, Martina Keogan, Dennis M. Fisher, Keith A. Soper and Chao-Min Hoe, et al. |
| 72-76 | Acid-Catalyzed Peptide Bond Hydrolysis of Recombinant Human Interleukin 11 | Richard A. Kenley and Nicholas W. Warne |
| 77-82 | Primary Culture of Rat Gastric Epithelial Cells as an in Vitro Model to Evaluate Antiulcer Agents | Hongjian Zheng, Praful K. Shah and Kenneth L. Audus |
| 83-89 | Diffusion Rates and Transport Pathways of Fluorescein Isothiocyanate (FITC)-Labeled Model Compounds Through Buccal Epithelium | A. Janet Hoogstraate, Christopher Cullander, J. Fred Nagelkerke, Sevda Senel and J. Coos Verhoef, et al. |
| 90-95 | Effect of Cyclodextrins on Protein Binding of Drugs: The Diflunisal/Hydroxypropyl-β-Cyclodextrin Model Case | Evangelos E. Sideris, Michael A. Koupparis and Panayotis E. Macheras |
| 96-103 | Analysis of the Combined Effect of 1-Menthol and Ethanol as Skin Permeation Enhancers Based on a Two-Layer Skin Model | Daisuke Kobayashi, Takayasu Matsuzawa, Kenji Sugibayashi, Yasunori Morimoto and Masayuki Kimura |
| 104-107 | Interaction Between Drugs and Pressure-Sensitive Adhesives in Transdermal Therapeutic Systems | Takemasa Kokubo, Kenji Sugibayashi and Yasunori Morimoto |
| 108-110 | Preparation, Characterization, and Pharmaceutical Application of Linear Dextrins. III. Drug Release from Fatty Suppository Bases Containing Amylodextrin | Gerrit H. P. Te Wierik, Anko C. Eissens and Coenraad F. Lerk |
| 111-116 | An Organic Acid-Induced Sigmoidal Release System for Oral Controlled-Release Preparations | Shinji Narisawa, Minako Nagata, Chieko Danyoshi, Hiroyuki Yoshino and Kazuo Murata, et al. |
| 117-121 | Bioavailability of Flumequine After Semisimultaneous Administration to Veal Calves | Bert A. Meijer, Kristel G. F. Ceyssens, Wytze Th. de Jong and Ben I. J. A. C. de Grève |
| 122-127 | Biodistribution of Mixed Fluorocarbon–Hydrocarbon Dowel Molecules Used as Stabilizers of Fluorocarbon Emulsions: A Quantitative Study by Fluorine Nuclear Magnetic Resonance (NMR) | Leila Zarif, Michéle Postel, Bernard Septe, Leo Trevino and Jean G. Riess, et al. |
| 128-135 | Validation of a Variable Direction Hysteresis Minimization Pharmacodynamic Approach: Cardiovascular Effects of Alfentanil | Nishit B. Modi and Peter Veng-Pedersen |
| 136-143 | pH-Related Changes in the Absorption of Dipyridamole in the Elderly | Tanya L. Russell, Rosemary R. Berardi, Jeffrey L. Barnett, Tami L. O’Sullivan and John G. Wagner, et al. |
| 144-150 | Disposition of Glycosidase Inhibitors in the Isolated Perfused Rat Liver: Hepatobiliary and Subcellular Concentration Gradients of 1-Deoxymannojirimycin and N-Methyl-1-Deoxynojirimycin | Esther D. Faber, Johannes H. Proost, Roelof Oosting and Dirk K. F. Meijer |
| 151-155 | Influence of a Fat-Rich Meal on the Pharmacokinetics of a New Oral Formulation of Cyclosporine in a Crossover Comparison with the Market Formulation | Edgar A. Mueller, John M. Kovarik, Johannes B. van Bree, Joachim Grevel and Peter W. Lücker, et al. |
| 156-159 | Comparison of the Pharmacokinetics of an Ondansetron Solution (8 mg) When Administered Intravenously, Orally, to the Colon, and to the Rectum | Poe-Hirr Hsyu, J. Frederick Pritchard, Haig P. Bozigian, Thomas L. Lloyd and Rita H. Griffin, et al. |
| 160-164 | Pharmacokinetic Analysis of in Vivo Metabolism of Amino Acid or Dipeptide Conjugates of Salicylic Acid in Rabbit Intestinal Microorganisms | Koyo Nishida, Mitsuhiko Kido, Hitoshi Sasaki and Junzo Nakamura |
| 165-170 | Epimerization and Hydrolysis of Dalvastatin, a New Hydroxymethylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitor | Chong Min Won |
| 171-180 | Psychometric Evaluation of Measures of Organizational Commitment and Intention to Quit Among Pharmaceutical Scientists | Sheldon Xiaodong Kong, Albert I. Wertheimer, Joaquima Serradell and William F. McGhan |
| 181-183 | Interaction of Zidovudine (Azidothymidine) with Isoprinosine and Probenecid in Macaca fascicularis | Sayed M. H. Al-Habet, Connie Nosbisch, Tracy Williamson, Che-Chung Tsai and Jashvant D. Unadkat |
| 184 | LEIDEN/AMSTERDAM CENTER FOR DRUG RESEARCH |
| 185-191 | In Vivo and in Vitro Analysis of Skin Penetration Enhancement Based on a Two-Layer Diffusion Model with Polar and Nonpolar Routes in the Stratum Corneum | Fumiyoshi Yamashita, Hiroto Bando, Yasuo Koyama, Shuji Kitagawa and Yoshinobu Takakura, et al. |
| 192-200 | Evaluation of Retinoids as Therapeutic Agents in Dermatology | Anita H. Lewin, Mary E. Bos, F. Christopher Zusi, Xina Nair and Gary Whiting, et al. |
| 201-205 | Solubility Predictions for Solid Nitriles and Tertiary Amides Based on the Mobile Order Theory | Paul Ruelle and Ulrich W. Kesselring |
| 206-212 | A Mixed Micellar Formulation Suitable for the Parenteral Administration of Taxol | Hayat Alkan-Onyuksel, Suganthi Ramakrishnan, Hee-Byung Chai and John M. Pezzuto |
| 213-220 | Pharmacokinetics and Tissue Distribution of Recombinant Human Transforming Growth Factor Beta1 After Topical and Intravenous Administration in Male Rats | Thomas F. Zioncheck, Sharon A. Chen, Louise Richardson, Marina Mora-Worms and Catherine Lucas, et al. |
| 221-225 | Solute Absorption from the Airways of the Isolated Rat Lung. IV. Mechanisms of Absorption of Fluorophore-Labeled Poly-α,β-[N(2-Hydroxyethyl)-DL-Aspartamide] | Peter R. Byron, Zhuang Sun, Hirokazu Katayama and Frantisek Rypacek |
| 226-230 | Colonic Absorption of Insulin-like Growth Factor I in Vitro | Elizabeth Quadros, Nancy M. Landzert, Sheryl LeRoy, Francis Gasparini and Gregory Worosila |
| 231-236 | Formulation and in Vitro–in Vivo Evaluation of Buccoadhesive Morphine Sulfate Tablets | Şule Anlar, Yilmaz Çapan, Olgun Güven, Ahmet Göğüş and Turgay Dalkara, et al. |
| 237-242 | The Physicochemical Properties, Plasma Enzymatic Hydrolysis, and Nasal Absorption of Acyclovir and Its 2′-Ester Prodrugs | Zezhi Shao, Gee-Bae Park, Ramesh Krishnamoorthy and Ashim K. Mitra |
| 243-250 | Bile Salt–Fatty Acid Mixed Micelles as Nasal Absorption Promoters. III. Effects on Nasal Transport and Enzymatic Degradation of Acyclovir Prodrugs | Zezhi Shao and Ashim K. Mitra |
| 251-256 | Identification of the Pathway of lontophoretic Drug Delivery: Light and Ultrastructural Studies Using Mercuric Chloride in Pigs | Nancy A. Monteiro-Riviere, Alfred O. Inman and Jim E. Riviere |
| 257-266 | Comparative Molecular Field Analysis Combined with Physicochemical Parameters for Prediction of Polydimethylsiloxane Membrane Flux in Isopropanol | Rong Liu and Lloyd E. Matheson |
| 267-271 | Intestinal Absorption of (–)-Carbovir in the Rat | Inmaculada Soria and Cheryl L. Zimmerman |
| 272-277 | The Controlled Release of Prednisolone Using Alginate Gel | Shinya Sugawara, Teruko Imai and Masaki Otagiri |
| 278-282 | Effect of Formulation Additives upon the Intranasal Bioavailability of a Peptide Drug: Tetracosactide (ACTH1−24) | Patrick Wüthrich, Myriam Martenet and Pierre Buri |
| 283-287 | Determination of Transport Rates for Arginine and Acetaminophen in Rabbit Intestinal Tissues in Vitro | Peter W. Swaan, Gary J. Marks, Frederick M. Ryan and Philip L. Smith |
| 288-294 | Effect of Some Penetration Enhancers on Epithelial Membrane Lipid Domains: Evidence from Fluorescence Spectroscopy Studies | T. Marjukka Turunen, Arto Urtti, Petteri Paronen, Kenneth L. Audus and J. Howard Rytting |
| 295-300 | Effect of the H2-Receptor Antagonist Cimetidine, on the Pharmacokinetics and Pharmacodynamics of the H1-Receptor Antagonists Hydroxyzine and Cetirizine in Rabbits | Xueyu Chen, F. Estelle R. Simons and Keith J. Simons |
| 301-304 | Improved Dose Linearity of Cyclosporine Pharmacokinetics from a Microemulsion Formulation | Edgar A. Mueller, John M. Kovarik, Johannes B. van Bree, Wolfgang Tetzloff and Joachim Grevel, et al. |
| 305-311 | In Vivo and in Vitro Blood–Brain Barrier Transport of 3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors | Akira Saheki, Tetsuya Terasaki, Ikumi Tamai and Akira Tsuji |
| 312-317 | Efflux of Zidovudine and 2′,3′-Dideoxyinosine Out of the Cerebrospinal Fluid When Administered Alone and in Combination to Macaca nemestrina | Tove Tuntland, Rashid J. Ravasco, Sayed Al-Habet and Jashvant D. Unadkat |
| 318-323 | Phenobarbital Removal Characteristics of Three Brands of Activated Charcoals: A System Analysis Approach | Nishit B. Modi, Peter Veng-Pedersen, Dale Eric Wurster, Mary J. Berg and Dorothy D. Schottelius |
| 324-330 | In Vitro and in Vivo Transport of Zidovudine (AZT) Across the Blood–Brain Barrier and the Effect of Transport Inhibitors | Rosalinde Masereeuw, Ulrich Jaehde, Mariska W. E. Langemeijer, Albertus G. de Boer and Douwe D. Breimer |
| 331-336 | Fluorometric Study of the Molecular States of 2,5-Diphenyloxazole in Ground Mixtures with γ-Cyclodextrin | Keiji Yamamoto, Toshio Oguchi, Etsuo Yonemochi, Yoshisuke Matsumura and Yoshinobu Nakai |
| 337-340 | Entrapment of Proteins in Poly(L-Lactide) Microspheres Using Reversed Micelle Solvent Evaporation | Yoshiki Hayashi, Sumie Yoshioka, Yukio Aso, Alain Li Wan Po and Tadao Terao |
| 341-344 | Lack of Pharmacokinetic Interaction Between Cimetidine and Tirilazad Mesylate | Joseph C. Fleishaker, Laura K. Hulst and Gary R. Peters |
| 345-348 | Degradation of the Antiarthritic Prodrug, 3-Carboxy-5-methyl-N-[4-(trifluoromethoxy)phenyl]-4-isoxazolecarboxamide, in Aqueous Solution | Michael Brandl and James A. Kennedy |
| 349-350 | Further Commentary: Physiological Parameters in Laboratory Animals and Humans | Robert B. Sothern and Scott A. Gruber |
| 351-352 | Controlled Drug Release of Highly Water-Soluble Pentoxifylline from Time-Limit Disintegration-Type Wax Matrix Tablets | Makoto Otsuka and Yoshihisa Matsuda |
| 355-360 | Physicomechanical Characterization of the Extrusion-Spheronization Process. I. Instrumentation of the Extruder | Rajen D. Shah, Mohan Kabadi, David G. Pope and Larry L. Augsburger |
| 361-364 | Transport of Low and High Molecular Peptides Across Rabbit Peyer's Patches | Shingo Haseto, Hiroyuki Ouchi, Tomonori Isoda, Takashi Mizuma and Masahiro Hayashi, et al. |
| 365-371 | An Enzyme-Linked Immunosorbent Assay (ELISA) for Quantitation of Adducts of Granulocyte–Macrophage Colony Stimulating Factor (GM-CSF) and Human Serum Albumin (HSA) in Stressed Solution Mixtures | Ramasamy Kumarasamy, James Bausch, Diane Kopcha, Suman Patel and Eugene McGonigle |
| 372-376 | Plasma Factor Triggering Alternative Complement Pathway Activation by Liposomes | Kouichi Funato, Chikamasa Yamashita, Junko Kamada, Sachiko Tominaga and Hiroshi Kiwada |
| 377-383 | Comparative Analysis of Percutaneous Absorption Enhancement by d-Limonene and Oleic Acid Based on a Skin Diffusion Model | Yasuo Koyama, Hiroto Bando, Fumiyoshi Yamashita, Yoshinobu Takakura and Hitoshi Sezaki, et al. |
| 384-387 | Controlled Release of Paracetamol from Amylodextrin Tablets: In Vitro and in Vivo Results | Jacoba van der Veen, Anko C. Eissens and Coenraad F. Lerk |
| 388-392 | Pharmacokinetic Analysis of the Absorption Enhancing Action of Decanoic Acid and Its Derivatives in Rats | Koji Takahashi, Teruo Murakami, Atsuko Kamata, Ryoko Yumoto and Yutaka Higashi, et al. |
| 393-397 | Diffusion and Metabolism of Prednisolone Farnesylate in Viable Skin of the Hairless Mouse | Kakuji Tojo, Kayoko Yamada and Tomohiro Hikima |
| 398-401 | Solubility Enhancement of Nucleosides and Structurally Related Compounds by Complex Formation | Andrew X. Chen, S. William Zito and Robert A. Nash |
| 402-406 | Enhanced Hepatic Uptake of Liposomes Through Complement Activation Depending on the Size of Liposomes | Hideyoshi Harashima, Kazuya Sakata, Kouichi Funato and Hiroshi Kiwada |
| 407-411 | Stereospecific Distribution of Methylphenidate Enantiomers in Rat Brain: Specific Binding to Dopamine Reuptake Sites | Takao Aoyama, Hajime Kotaki, Yasufumi Sawada and Tatsuji Iga |
| 412-419 | Hydrogen Bonding Potential as a Determinant of the in Vitro and in Situ Blood–Brain Barrier Permeability of Peptides | Elsbeth G. Chikhale, Ka-Yun Ng, Philip S. Burton and Ronald T. Borchardt |
| 420-425 | Accumulation Kinetics of Propranolol in the Rat: Comparison of Michaelis– Menten-Mediated Clearance and Clearance Changes Consistent with the “Altered Enzyme Hypothesis” | Cornelia Weber, Klaus Stoeckel and David Lalka |
| 426-431 | Pharmacokinetics and Pharmacodynamics of L-703,014, a Potent Fibrinogen Receptor Antagonist, After Intravenous and Oral Administration in the Dog | Jeffrey S. Barrett, Robert J. Gould, Joan D. Ellis, Marie M. Holahan and Maria T. Stranieri, et al. |
| 432-437 | Site-Differential Gastrointestinal Absorption of Benazepril Hydrochloride in Healthy Volunteers | Keith K. H. Chan, Akshay Buch, Robert D. Glazer, Vivian A. John and William H. Barr |
| 438-441 | Dose-Dependent Pharmacokinetics of L-693,612, a Carbonic Anhydrase Inhibitor, Following Oral Administration in Rats | Bradley K. Wong, Patrick J. Bruhin and Jiunn H. Lin |
| 442-448 | Quantification and Visualization of the Transport of Octreotide, a Somatostatin Analogue, Across Monolayers of Cerebrovascular Endothelial Cells | Ulrich Jaehde, Rosalinde Masereeuw, Albertus G. De Boer, Gert Fricker and J. Fred Nagelkerke, et al. |
| 449-454 | Analytical Chiral Separation of the Stereoisomers of a Novel Carbonic Anhydrase Inhibitor and Its Deethylated Metabolite, and the Assignment of Absolute Configuration of the Human Metabolite and Chiral Degradation Products | Bogdan K. Matuszewski, Marvin L. Constanzer and Mary Kiganda |
| 455-457 | Novel Stabilizing Method for Antisense Oligodeoxynucleotides | Toshihiko Sueishi, Toshinobu Seki, Kazuhiko Juni, Tetsuya Hasegawa and Mineo Saneyoshi, et al. |
| 458-465 | 1H-NMR and 13C-NMR Spectral Assignments of Spiramycins I and III | Kumar Ramu, Sachin Shringarpure, Steven Cooperwood, John M. Beale and John S. Williamson |
| 466-469 | Rapid Synthesis of 3-[18F]Fluoro-l-(2′-Nitro-1′-Imidazolyl)-2-Propanol ([18F]Fluoromisonidazole) | Abdallah Cherif, David J. Yang, Wayne Tansey, E. Edmund Kim and Sidney Wallace |
| 470 | Pharmaceutical Research Reviewers for the Editorial Office, Japan (October 1992-September 1993) |
| 471-477 | The Relationship Between the Glass Transition Temperature and the Water Content of Amorphous Pharmaceutical Solids | Bruno C. Hancock and George Zografi |
| 478-484 | Preparation of Agglomerated Crystals for Direct Tabletting and Microencapsulation by the Spherical Crystallization Technique with a Continuous System | Toshiyuki Niwa, Hirofumi Takeuchi, Tomoaki Hino, Akira Itoh and Yoshiaki Kawashima, et al. |
| 485-490 | Chromatographic Methods for Quantitative Analysis of Native, Denatured, and Aggregated Basic Fibroblast Growth Factor in Solution Formulations | Victoria Sluzky, Zahra Shahrokh, Pamela Stratton, Gert Eberlein and Y. John Wang |
| 491-498 | Characterization of Aerosols of Human Recombinant Deoxyribonuclease I (rhDNase) Generated by Jet Nebulizers | David Cipolla, Igor Gonda and Steven J. Shire |
| 499-502 | Controlled Release of Theophylline Monohydrate from Amylodextrin Tablets: In Vitro Observations | Jacoba Van der Veen, Gerrit H. P. Te Wierik, Liesbeth Van der Wal, Anko C. Eissens and Coenraad F. Lerk |
| 503-507 | Entrapping Efficiency and Drug Release Profile of an Oil-in-Water (o/w) Emulsion Formulation Using a Polydimethylsiloxane-Coated Glass Bead Assay | Toshiya Minagawa, Yoshiro Kohno, Toshio Suwa and Akira Tsuji |
| 508-512 | A Quantitative Concept of the Mechanism of Intestinal Lymphatic Transfer of Lipophilic Molecules | Teruhisa Ichihashi, Toru Nagasaki, Yasushi Takagishi and Hideo Yamada |
| 513-517 | Alveolar Permeability Enhancement by Oleic Acid and Related Fatty Acids: Evidence for a Calcium-Dependent Mechanism | Li Ying Wang, Joseph K. H. Ma, Wei Fang Pan, David Toledo-Velasquez and Carl J. Malanga, et al. |
| 518-521 | Activation of Fc Receptor-Mediated Phagocytosis by Mouse Peritoneal Macrophages Following the Intraperitoneal Administration of Liposomes | Yukihiko Aramaki, Makoto Murai and Seishi Tsuchiya |
| 522-527 | The Effect of Temperature and pH on the Solubility of Quinolone Compounds: Estimation of Heat of Fusion | Xuanqiang Yu, Gail L. Zipp and G. W. Ray Davidson III |
| 528-535 | Oral Absorption of Peptides: The Effect of Absorption Site and Enzyme Inhibition on the Systemic Availability of Metkephamid | Peter Langguth, Hans P. Merkle and Gordon L. Amidon |
| 536-540 | Pharmacodynamics of Phenobarbital Anesthesia and Pentylenetetrazol-Induced Maximal Seizures in a Rat Model of Neoplastic Spinal Cord Compression | Amnon Hoffman, Jose Alfon, Tzony Siegal and Tali Siegal |
| 541-544 | Effects of Acute and Chronic Inflammation on the Pharmacokinetics of Prednisolone in Rats | Varun Garg, Yuen Yi Hon and William J. Jusko |
| 545-548 | Simulation for the Analysis of Distorted Pharmacodynamic Data | Yukiya Hashimoto, Junko Ozaki, Toshiko Koue, Atsuko Odani and Masato Yasuhara, et al. |
| 549-555 | Pharmacokinetics of Levodopa and Carbidopa in Rats Following Different Routes of Administration | Eva Bredberg, Hans Lennernäs and Lennart Paalzow |
| 556-560 | An Assessment of the 4-6-20 Rule for Acceptance of Analytical Runs in Bioavailability, Bioequivalence, and Pharmacokinetic Studies | Robert O. Kringle |
| 561-565 | The Use of Fourier Transform Infrared (FT-IR) Spectroscopy to Determine the Diffusion Coefficients of Alcohols in Polydimethylsiloxane | Varaporn Buraphacheep, Dale Eric Wurster and Dale E. Wurster |
| 566-570 | A Simple and Rapid Fluorometric Determination Method of α1-Acid Glycoprotein in Serum Using Quinaldine Red | Hitoshi Imamura, Toru Maruyama, Hiroaki Okabe, Hidekata Shimada and Masaki Otagiri |
| 571-574 | Synthesis and Evaluation of Amino Analogues of Valproic Acid | K. R. Scott, Sandra Adesioye, Patricia B. Ayuk, Ivan O. Edafiogho and Dolly John, et al. |
| 575-579 | Development and Evaluation of Sustained-Release Ibuprofen–Wax Microspheres. II. In Vitro Dissolution Studies | Christianah M. Adeyeye and James C. Price |
| 580-584 | Dosing Reproducibility from Experimental Albuterol Suspension Metered-Dose Inhalers | Peter R. Byron |
| 585-588 | Adsorption of Beta-Blockers onto Polyisobutylcyanoacrylate Nanoparticles Measured by Depletion and Dielectric Methods | Emmanuelle Benoit, Odile Prot, Philippe Maincent and Jacques Bessière |
| 589-591 | A Novel Assay to Determine the Hemolytic Activity of Drugs Incorporated in Colloidal Carrier Systems | Thomas K. Bock and Bernd W. Müller |
| 592-594 | Variability in Gastric pH and Delayed Gastric Emptying in Yucatan Miniature Pigs | Rebecca L. Oberle and Helena Das |
| 595-599 | Mathematical Analysis and Optimization of a Flow-Through Diffusion Cell System | Hoo-Kyun Choi and James T. Angello |
| 600-603 | Videomicroscopy Techniques for Agglomeration Studies | Lorraine E. Pena, Barbara L. Lee and James F. Stearns |
| 604-607 | Effects of Sampling Chamber Volume and Geometry on Aerodynamic Size Distributions of Metered-Dose Inhalation Aerosols Measured with the Andersen Cascade Impactor | Michiel Van Oort, Rebecca O. Gollmar and Robert J. Bohinski |
| 608 | ROCKEFELLER SCIENCE FOR DEVELOPMENT PRIZE CURRENT RESEARCH INTO THERAPIES FOR ALZHEIMER'S DISEASE LEIDEN/AMSTERDAM CENTER FOR DRUG RESEARCH FOURTH SYMPOSIUM OF THE PHARMACEUTICAL COMPACTION RESEARCH LABORATORY & INFORMATION CENTER |
| 609-615 | Cellular Toxicity of Aminoglycoside Antibiotics in G418-Sensitive and -Resistant LLC-PK1 Cells | Mikihisa Takano, Masahiro Okuda, Masato Yasuhara and Ryohei Hori |
| 616-623 | Hardness Anisotropy of Acetaminophen Crystals | Wendy C. Duncan-Hewitt, David L. Mount and Alfred Yu |
| 624-632 | The Stabilization of a Human IgM Monoclonal Antibody with Poly(vinylpyrrolidone) | Wayne R. Gombotz, Susan C. Pankey, Duke Phan, Randy Drager and Karen Donaldson, et al. |
| 633-641 | Differential Disposition of Soluble and Liposome-Formulated Human Recombinant Interleukin-7: Effects on Blood Lymphocyte Population in Guinea Pigs | Tot Bui, Connie Faltynek and Rodney J. Y. Ho |
| 642-647 | Improved Intestinal Absorption of an Enteric-Coated Sodium Ursodeoxycholate Formulation | Aldo Roda, Enrico Roda, Egidio March, Patrizia Simoni and Carolina Cerrè, et al. |
| 648-653 | The Contribution of Intestinal Secretion to the Dose-Dependent Absorption of Celiprolol | Shiu-Ming Kuo, Brian R. Whitby, Per Artursson and John A. Ziemniak |
| 654-658 | An Application of the Hydrodynamic Pore Theory to Percutaneous Absorption of Drugs | Tomomi Hatanaka, Eiichiro Manabe, Kenji Sugibayashi and Yasunori Morimoto |
| 659-664 | Estradiol Permeation from Nonionic Surfactant Vesicles Through Human Stratum Corneum in Vitro | Hans E. J. Hofland, Ronald van der Geest, Harry E. Bodde, Hans E. Junginger and Joke A. Bouwstra |
| 665-673 | Transcellular Permeability of Chlorpromazine Demonstrating the Roles of Protein Binding and Membrane Partitioning | Geri A. Sawada, Norman F. H. Ho, Larry R. Williams, Craig L. Barsuhn and Thomas J. Raub |
| 674-679 | Mucoadhesion of Latexes. I. Analytical Methods and Kinetic Studies | Carlo Durrer, Juan Manuel Irache, Francis Puisieux, Dominique Duchêne and Gilles Ponchel |
| 680-683 | Mucoadhesion of Latexes. II. Adsorption Isotherms and Desorption Studies | Carlo Durrer, Juan Manuel Irache, Francis Puisieux, Dominique Duchêne and Gilles Ponchel |
| 684-686 | Application of in Vivo Microdialysis to Transdermal Absorption of Methotrexate in Rats | Kenji Matsuyama, Mikiro Nakashima, Yukiko Nakaboh, Masataka Ichikawa and Tadanori Yano, et al. |
| 687-697 | Studies on the Effects of Applied Voltage and Duration on Human Epidermal Membrane Alteration/Recovery and the Resultant Effects upon Iontophoresis | Hirohiko Inada, Abdel-Halim Ghanem and William I. Higuchi |
| 698-703 | Pharmacokinetics and Metabolism of Diclofenac Sodium in Yucatan Miniature Pigs | Rebecca L. Oberle, Helena Das, Shekman L. Wong, Keith K. H. Chan and Ronald J. Sawchuk |
| 704-708 | The Effect of Immunosuppression by Total-Body Irradiation on the Pharmacodynamics of Centrally Active Drugs in Rats | Amnon Hoffman, Jose Alfon, Gustav Habib, Evelyne Pinto and Raphael Gorodetsky |
| 709-714 | NM-Win: A Personal Computer-Based Microsoft® Windows™ Front-End to NONMEM IV | Jonathan P. Vielhaber and Jeffrey S. Barrett |
| 715-722 | Bioequivalence: Performance of Several Measures of Extent of Absorption | Frédéric Y. Bois, Thomas N. Tozer, Walter W. Hauck, Mei-Ling Chen and Rabindra Patnaik, et al. |
| 723-727 | Fourier Transform Infrared (FTIR) Spectrometry for the Assay of Polyhedral Boron Compounds in Plasma and Pharmaceutical Formulations | Yohanes Setiawan, Tor Rise and Douglas E. Moore |
| 728-732 | On-Line Moisture Detection for a Microwave Vacuum Dryer | Jackie G. White |
| 733-737 | A Novel Nuclear Magnetic Resonance (NMR) Imaging Method for Measuring the Water Front Penetration Rate in Hydrophilic Polymer Matrix Capsule Plugs and Its Role in Drug Release | Muhammad Ashraf, Virginia L. luorno, David Coffin-Beach, C. Anderson Evans and Larry L. Augsburger |
| 738-746 | Transport of Human Recombinant Brain-Derived Neurotrophic Factor (BDNF) Through the Rat Blood−Brain Barrier in Vivo Using Vector-Mediated Peptide Drug Delivery | William M. Pardridge, Young-Sook Kang and Jody L. Buciak |
| 747-750 | The Bioavailability of Intranasal Salmon Calcitonin in Healthy Volunteers with and Without a Permeation Enhancer | William A. Lee, Richard D. Ennis, John P. Longenecker and Per Bengtsson |
| 751-758 | Chemical Pathways of Peptide Degradation. VI. Effect of the Primary Sequence on the Pathways of Degradation of Aspartyl Residues in Model Hexapeptides | Cecilia Oliyai and Ronald T. Borchardt |
| 759-763 | A Sensitive, High-Volume, Colorimetric Assay for Protein Phosphatases | Diana K. Fisher and Terry J. Higgins |
| 764-771 | Chemical and Physical Stability of Chimeric L6, a Mouse−Human Monoclonal Antibody | Mehdi Paborji, Nancy L. Pochopin, William P. Coppola and Joseph B. Bogardus |
| 772-773 | Effect of Hepatic Cirrhosis on the Pharmacodynamics and Pharmacokinetics of Mivacurium in Humans | Gerhard Levy |
| 774-775 | Determination of Solute–Polymer Interaction Properties via Two-Stage Extraction | Dennis R. Jenke |
| 776 | ROCKEFELLER SCIENCE FOR DEVELOPMENT PRIZECURRENT RESEARCH INTO THERAPIES FOR ALZHEIMER'S DISEASEINDUSTRIAL RHEOLOGY: PRINCIPLES AND PRACTICE |
| 777-783 | Pharmaceutical Applications of Microcalorimetry | Michael J. Koenigbauer |
| 784-793 | The Role of Intramolecular Nucleophilic Catalysis and the Effects of Self-Association on the Deamidation of Human Insulin at Low pH | Richard T. Darrington and Bradley D. Anderson |
| 794-799 | Mucus Gel Thickness and Turnover in the Gastrointestinal Tract of the Rat: Response to Cholinergic Stimulus and Implication for Mucoadhesion | Abraham Rubinstein and Boaz Tirosh |
| 800-808 | Predictions of in Vivo Plasma Concentrations from in Vitro Release Kinetics: Application to Doxepin Parenteral (I.M.) Suspensions in Lipophilic Vehicles in Dogs | Christina Gido, Peter Langguth and Ernst Mutschler |
| 809-815 | Percutaneous Absorption of 2′,3′-Dideoxyinosine in Rats | Elora Mukherji, Nancy J. Millenbaugh and Jessie L.-S. Au |
| 816-823 | Pharmacodynamic Models of Nitroglycerin-Induced Hemodynamic Tolerance in Experimental Heart Failure | John Anthony Bauer and Ho-Leung Fung |
| 824-830 | Pharmacokinetics and Bioinversion of Ibuprofen Enantiomers in Humans | Haiyung Cheng, J. Douglas Rogers, Joan L. Demetriades, Sherry D. Holland and James R. Seibold, et al. |
| 831-834 | The Cutoff Time Point of the Partial Area Method for Assessment of Rate of Absorption in Bioequivalence Studies | Panos Macheras, Mira Symillides and Christos Reppas |
| 835-838 | Microdialysis: An Alternative for in Vitro and in Vivo Protein Binding Studies | Anne Le Quellec, Sylvie Dupin, Ala Eldin Tufenkji, Patrick Genissel and Georges Houin |
| 839-843 | Oral Bioavailability of the Antiretroviral Agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) from Three Formulations of the Prodrug Bis(pivaloyloxymethyl)-PMEA in Fasted Male Cynomolgus Monkeys | Kenneth C. Cundy, James A. Fishback, Jeng-Pyng Shaw, Min L. Lee and Kenneth F. Soike, et al. |
| 844-847 | HPLC Assay for FK 506 and Two Metabolites in Isolated Rat Hepatocytes and Rat Liver Microsomes | Beatrice Y. T. Perotti, Thomayant Prueksaritanont and Leslie Z. Benet |
| 848-854 | Inhibition of Rat Splenocyte Proliferation with Methylprednisolone: In Vivo Effect of Liposomal Formulation | Elena V. Mishina and William J. Jusko |
| 855-859 | Comparison of Two Otitis Media Models for the Study of Middle Ear Antimicrobial Pharmacokinetics | Daniel M. Canafax, Henry Russlie, Michael J. Lovdahl, Gary R. Erdmann and Chap T. Le, et al. |
| 860-864 | Effect of Streptococcus pneumoniae and Influenza A Virus on Middle Ear Antimicrobial Pharmacokinetics in Experimental Otitis Media | Gregg H. Jossart, Daniel M. Canafax, Gary R. Erdmann, Michael J. Lovdahl and Henry Q. Russlie, et al. |
| 865-868 | Chemical Interactions Between Drugs Containing Reactive Amines with Hydrolyzable Insoluble Biopolymers in Aqueous Solutions | Abraham J. Domb, Ludmila Turovsky and Raphael Nudelman |
| 869-874 | Poly(Alkylcyanoacrylate) Nanocapsules: Physicochemical Characterization and Mechanism of Formation | François Chouinard, Stéphane Buczkowski and Vincent Lenaerts |
| 875-881 | Structural Rheology of a Model Ointment | Lorraine E. Pena, Barbara L. Lee and James F. Stearns |
| 882-888 | Mechanical Properties of Dry and Wet Cellulosic and Acrylic Films Prepared from Aqueous Colloidal Polymer Dispersions Used in the Coating of Solid Dosage Forms | Roland Bodmeier and Ornlaksana Paeratakul |
| 889-896 | Novel Taxol Formulations: Preparation and Characterization of Taxol-Containing Liposomes | Amarnath Sharma and Robert M. Straubinger |
| 897-900 | Distribution of Brush-Border Membrane Peptidases Along the Rat Intestine | Jane P. F. Bai |
| 901-908 | Chemical Pathways of Peptide Degradation. VII. Solid State Chemical Instability of an Aspartyl Residue in a Model Hexapeptide | Cecilia Oliyai, Jitendra P. Patel, Linda Carr and Ronald T. Borchardt |
| 909-913 | Improvement of the Pulmonary Absorption of (Asu1,7)-Eel Calcitonin by Various Protease Inhibitors in Rats | Takahiro Morita, Akira Yamamoto, Yoshinobu Takakura, Mitsuru Hashida and Hitoshi Sezaki |
| 914-916 | Geometric Approach for Zero-Order Release of Drugs Dispersed in an Inert Matrix | Mohsen A. Bayomi |
| 917-920 | Interaction Between Ciprofloxacin and Metal Cations: Its Influence on Physicochemical Characteristics and Antibacterial Activity | Ronald C. Li, David E. Nix and Jerome J. Schentag |
| 921-924 | Inhibition of Human CYP3A Catalyzed 1′-Hydroxy Midazolam Formation by Ketoconazole, Nifedipine, Erythromycin, Cimetidine, and Nizatidine | Steven A. Wrighton and Barbara J. Ring |
| 925-928 | A Regulatory and Industrial Perspective of the Use of Carbon-14 and Tritium Isotopes in Human ADME Studies | Jeremy G. Dain, Jerry M. Collins and William T. Robinson |
| 929-935 | Characterization of Convective Solvent Flow During Iontophoresis | M. Begoña Delgado-Charro and Richard H. Guy |
| 936-944 | Major Degradation Products of Basic Fibroblast Growth Factor: Detection of Succinimide and Iso-aspartate in Place of Aspartate15 | Zahra Shahrokh, Gert Eberlein, Doug Buckley, Mallik V. Paranandi and Dana W. Aswad, et al. |
| 945-950 | Interspecies Scaling of Cimetidine–Theophylline Pharmacokinetic Interaction: Interspecies Scaling in Pharmacokinetic Interactions | Alicia R. Gascón, Begoña Calvo, Rosa María Hernández, Alfonso Domínguez-Gil and José-Luis Pedraz |
| 951-960 | Disposition of Azole Antifungal Agents. II. Hepatic Binding and Clearance of Dichlorophenyl-Bis-triazolylpropanol (DTP) in the Rat | Helen L. Bomont, Michael H. Tarbit, Michael J. Humphrey and J. Brian Houston |
| 961-965 | Disposition of Azole Antifimgal Agents. III. Binding of Fluconazole and Other Azoles in Rat Liver | Christopher M. Ervine and J. Brian Houston |
| 966-974 | Bioequivalence: Performance of Several Measures of Rate of Absorption | Frédéric Y. Bois, Thomas N. Tozer, Walter W. Hauck, Mei-Ling Chen and Rabindra Patnaik, et al. |
| 975-978 | Carrier-Mediated Transport of H1-Antagonist at the Blood–Brain Barrier: Mepyramine Uptake into Bovine Brain Capillary Endothelial Cells in Primary Monolayer Cultures | Masahiro Yamazaki, Tetsuya Terasaki, Kuniaki Yoshioka, Osamu Nagata and Hideo Kato, et al. |
| 979-983 | A Drug Dissolution Monitor Employing Multiple Fiber Optic Probes and a UV/Visible Diode Array Spectrophotometer | Chi-Shi Chen and Chris W. Brown |
| 984-989 | Drug Binding by Reservoirs in Elastomeric Infusion Devices | Dennis R. Jenke |
| 990-994 | Microbial and Mammalian Metabolism Studies of the Semisynthetic Antimalarial, Anhydrodihydroartemisinin | Sherief I. Khalifa, John K. Baker, Robin D. Rogers, Farouk S. El-Feraly and Charles D. Hufford |
| 995-999 | Physical Stability and Protein Stability of Freeze-Dried Cakes During Storage at Elevated Temperatures | Ken-ichi Izutsu, Sumie Yoshioka and Shigeo Kojima |
| 1000-1003 | Transdermal lontophoretic Delivery of Luteinizing Hormone Releasing Hormone (LHRH): Effect of Repeated Administration | Mark C. Heit, Nancy A. Monteiro-Riviere, Friederike L. Jayes and Jim E. Riviere |
| 1004-1008 | Thermal Stability of Low Molecular Weight Urokinase During Heat Treatment. II. Effect of Polymeric Additives | Michael Vrkljan, Thomas M. Foster, Michael E. Powers, Jack Henkin and William R. Porter, et al. |
| 1009-1015 | Dose and Load Studies for Subcutaneous and Oral Delivery of Poly(lactide-co-glycolide) Microspheres Containing Ovalbumin | Takahiro Uchida, Stephen Martin, Todd P. Foster, Richard C. Wardley and Susan Grimm |
| 1016-1022 | Polystyrene-Poly (Ethylene Glycol) (PS-PEG2000) Particles as Model Systems for Site Specific Drug Delivery. 2. The Effect of PEG Surface Density on the in Vitro Cell Interaction and in VivoBiodistribution | Susan E. Dunn, Anne Brindley, Stanley S. Davis, Martyn C. Davies and Lisbeth Illum |
| 1023-1029 | Measurement of Glass Transition Temperatures in Freeze Concentrated Solutions of Non-Electrolytes by Electrical Thermal Analysis | Lih-Min Her, Raymond P. Jefferis, Larry A. Gatlin, Bryan Braxton and Steven L. Nail |
| 1030-1034 | Accelerated Degradation of Poly(ε-caprolactone) by Organic Amines | Wen-Jen Lin, Douglas R. Flanagan and Robert J. Linhardt |
| 1035-1041 | Estimation of Skin Target Site Acyclovir Concentrations Following Controlled (Trans)dermal Drug Delivery in Topical and Systemic Treatment of Cutaneous HSV-1 Infections in Hairless Mice | George Imanidis, Wei-qi Song, Paul H. Lee, Muh-Hwan Su and Earl R. Kern, et al. |
| 1042-1047 | Effects of Surfactants on Amiodarone Intestinal Absorption. I. Sodium Laurylsulfate | Rafael V. Martín-Algarra, Rosa M. Pascual-Costa, Matilde Merino and Vicente G. Casabó |
| 1048-1055 | Pulmonary Delivery of Detirelix by Intratracheal Instillation and Aerosol Inhalation in the Briefly Anesthetized Dog | David B. Bennett, Elizabeth Tyson, Clinton A. Nerenberg, Sylvia Mah and Jennifer S. de Groot, et al. |
| 1056-1059 | Pharmacokinetics of Detirelix Following Intratracheal Instillation and Aerosol Inhalation in the Unanesthetized Awake Sheep | Hans Schreier, Kenneth J. McNicol, David B. Bennett, Zvi Teitelbaum and Hartmut Derendorf |
| 1060-1064 | Degradation of O6-Benzylguanine in Aqueous Polyethylene Glycol 400 (PEG 400) Solutions: Concerns with Formaldehyde in PEG 400 | Dilbir S. Bindra, Todd D. Williams and Valentino J. Stella |
| 1065-1067 | The Requirement for a Retinoic Acid Lactone of 11-cis, 13-cis-Stereochemistry for Topical Dermatologic Activity | Anita H. Lewin, R. Richard Goehring, F. Christopher Zusi, Gerald J. Gendimenico and Xina Nair, et al. |
| 1068 | BOOK REVIEWS |
| 1068 | INDUSTRIAL RHEOLOGY: PRINCIPLES AND PRACTICE |
| 1069-1076 | Use of Stable Isotopes for Evaluation of Drug Delivery Systems: Comparison of Ibuprofen Release in Vivo and in Vitro from Two Biphasic Release Formulations Utilizing Different Rate-Controlling Polymers | Don L. Theis, Leo J. Lucisano and Gordon W. Halstead |
| 1077-1081 | Chemical Stability of Ethyl Icosapentate Against Autoxidation. II. Effect of Photoirradiation on Oxidation Kinetics | Reiko Teraoka, Makoto Otsuka and Yoshihisa Matsuda |
| 1082-1087 | Synthesis and in Vitro Study of a Diglyceride Prodrug of a Peptide | Florence Delie, Patrick Couvreur, Dino Nisato, Jean-Baptiste Michel and Francis Puisieux, et al. |
| 1088-1092 | Conformation of Amiodarone · HC1: A Solution and Solid State 13C-NMR Study | Renée C. Rao, Frédéric Lefebvre, Gérard Commenges, Catherine Castet and Lygie Miguel, et al. |
| 1093-1097 | Evaluation of Solubilizers in the Drug Release Testing of Hydrophilic Matrix Extended-Release Tablets of Felodipine | Bertil Abrahamsson, Dick Johansson, Arne Torstensson and Karin Wingstrand |
| 1098-1100 | An Improved Microscope Stage for Direct Observation of Freezing and Freeze Drying | Steven L. Nail, Lih-Min Her, Christopher P. B. Proffitt and Lisa L. Nail |
| 1101-1109 | Pulmonary Delivery of Powders and Solutions Containing Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) to the Rabbit | Ralph W. Niven, Fred D. Lott, Anna Y. Ip and Judith M. Cribbs |
| 1110-1114 | Novel Delivery of Antioxidant Enzyme Catalase to Alveolar Macrophages by Fc Receptor-Mediated Endocytosis | Jeannine Harrison, Xianglin Shi, LiYing Wang, Joseph K. H. Ma and Yongyut Rojanasakul |
| 1115-1120 | Stability of Acyl Derivatives of Insulin in the Small Intestine: Relative Importance of Insulin Association Characteristics in Aqueous Solution | Hiroyuki Asada, Takayuki Douen, Yoshiko Mizokoshi, Takuya Fujita and Masahiro Murakami, et al. |
| 1121-1126 | Receptor-Mediated Peptide Delivery in Pulmonary Epithelial Monolayers | Deepa Deshpande, David Toledo-Velasquez, Li Ying Wang, Carl J. Malanga and Joseph K. H. Ma, et al. |
| 1127-1131 | Comparison of Cell Proliferation and Toxicity Assays Using Two Cationic Liposomes | Katriina Lappalainen, Ilpo Jääskeläinen, Kari Syrjänen, Arto Urtti and Stina Syrjänen |
| 1132-1142 | Intestinal Permeability Enhancement: Efficacy, Acute Local Toxicity, and Reversibility | E. Scott Swenson, William B. Milisen and William Curatolo |
| 1143-1147 | Preparation of Three-Month Depot Injectable Microspheres of Leuprorelin Acetate Using Biodegradable Polymers | Hiroaki Okada, Yayoi Doken, Yasuaki Ogawa and Hajime Toguchi |
| 1148-1154 | Effect of Medium-Chain Glycerides on Physiological Properties of Rabbit Intestinal Epithelium in Vitro | Ping-Yang Yeh, Philip L. Smith and Harma Ellens |
| 1155-1159 | Characterization of Esterase and Alcohol Dehydrogenase Activity in Skin. Metabolism of Retinyl Palmitate to Retinol (Vitamin A) During Percutaneous Absorption | James Boehnlein, Adel Sakr, J. Leon Lichtin and Robert L. Bronaugh |
| 1160-1165 | Uptake of Nanoparticles by Rat Glomerular Mesangial Cells in Vivo and in Vitro | Luc Manil, Jean-Claude Davin, Charles Duchenne, Christine Kubiak and Jacqueline Foidart, et al. |
| 1166-1173 | Non-Isothermal and Isothermal Crystallization of Sucrose from the Amorphous State | Azita Saleki-Gerhardt and George Zografi |
| 1174-1179 | Cyclodextrins as Mucosal Absorption Promoters of Insulin. II. Effects of β-Cyclodextrin Derivatives on α-Chymotryptic Degradation and Enteral Absorption of Insulin in Rats | Zezhi Shao, Yuping Li, Todd Chermak and Ashim K. Mitra |
| 1180-1185 | Enhanced Delivery and Antitumor Activity of Doxorubicin Using Long-Circulating Thermosensitive Liposomes Containing Amphipathic Polyethylene Glycol in Combination with Local Hyperthermia | Sakae Unezaki, Kazuo Maruyama, Noriyuki Takahashi, Masataka Koyama and Tsutomu Yuda, et al. |
| 1186-1189 | Chitosan as a Novel Nasal Delivery System for Peptide Drugs | Lisbeth Illum, Nidal F. Farraj and Stanley S. Davis |
| 1190-1198 | A Modified Product Inhibition Model Describes the Nonlinear Pharmacokinetics of Nicorandil in Rats | Elizabeth L. Bachert, Zhuang-wu Li, Lin Zhao, Suk Jae Chung and Ho-Leung Fung |
| 1199-1203 | Sustained Suppression of the Pituitary-Gonadal Axis by Leuprorelin Three-Month Depot Microspheres in Rats and Dogs | Hiroaki Okada, Yayoi Doken, Yasuaki Ogawa and Hajime Toguchi |
| 1204-1206 | Phenobarbital Disposition in Adult and Neonatal Rabbits | Sun Dong Yoo, David E. Burgio and Patrick J. McNamara |
| 1207-1210 | Study of the Interaction Between β-Cyclodextrin and Chlorhexidine | Hong Qi, Toshiaki Nishihata and J. Howard Rytting |
| 1211-1215 | Synthesis of Novel Aminopropylguanidine Derivatives with Potential Antihypertensive Activity | Unsal Calis, John R. Finch, Edward E. Soltis and George A. Digenis |
| 1216-1220 | Workshop III Report: Scaleup of Liquid and Semisolid Disperse Systems | G. A. Van Buskirk, V. P. Shah, D. Adair, H. M. Arbit and S. V. Dighe, et al. |
| 1221 | Normal Volunteers Should Not Be Used for Bioavailability or Bioequivalence Studies of Clozapine | Rolf Pokorny, Marion J. Finkel and William T. Robinson |
| 1222 | 2ND EUROPEAN CONGRESS OF PHARMACEUTICAL SCIENCES EIGHTH ANNUAL PHARMACOKINETICS COURSE FOR PHARMACEUTICAL SCIENTISTS ONE-WEEK WORKSHOP ON ADVANCED METHODS IN PHARMACOKINETICS |
| 1222 | ERRATUM |
| 1223-1232 | Investigation of the Distribution of EAB 515 to Cortical ECF and CSF in Freely Moving Rats Utilizing Microdialysis | Bimal K. Malhotra, Michel Lemaire and Ronald J. Sawchuk |
| 1233-1238 | Effect of Moisture Sorption on Tabletting Characteristics of Spray Dried (15% Amorphous) Lactose | Tesfai Sebhatu, Ainin A. Elamin and Claes Ahlneck |
| 1239-1243 | Study on Pulmonary Delivery of Salmon Calcitonin in Rats: Effects of Protease Inhibitors and Absorption Enhancers | Shinzo Kobayashi, Shuji Kondo and Kazuhiko Juni |
| 1244-1249 | Effect of Epidermal Growth Factor on Cu, Zn-Superoxide Dismutase Expression in Cultured Fibroblasts from Rat Skin | Kohshi Nishiguchi, Yoshifumi Kiyohara, Fusao Komada, Seigo Iwakawa and Katsuhiko Okumura |
| 1250-1256 | Transepithelial Transport of Tyramine Across Filter-Grown MDCK Cells via a Poly(D-lysine) Carrier | Mitchell E. Taub, Jiansheng Wan and Wei-Chiang Shen |
| 1257-1264 | Brain Delivery of Biotin Bound to a Conjugate of Neutral Avidin and Cationized Human Albumin | Young-Sook Kang and William M. Pardridge |
| 1265-1269 | Effect of Ultrafilterable Platinum Concentration on Cisplatin and Carboplatin Cytotoxicity in Human Tumor and Bone Marrow Cells in Vitro | Henk-Jan Guchelaar, Elisabeth G. E. de Vries, Coby Meijer, Mariet T. Esselink and Edo Vellenga, et al. |
| 1270-1277 | Preparation and Characterization of Novel Poly(methylidene Malonate 2.1.2.)-Made Nanoparticles | François Lescure, Christine Seguin, Pascal Breton, Philippe Bourrinet and Didier Roy, et al. |
| 1278-1282 | Controlled Ocular Timolol Delivery: Systemic Absorption and Intraocular Pressure Effects in Humans | Arto Urtti, Harr Rouhiainen, Timo Kaila and Veyo Saano |
| 1283-1287 | Effects of Cholesterol and Cholesteryl Oleate on Lipolysis and Liver Uptake of Triglyceride/Phosphatidylcholine Emulsions in Rats | Tetsurou Handa, Yuko Eguchi and Koichiro Miyajima |
| 1288-1295 | A Convective-Diffusion Model for Dissolution of Two Non-interacting Drug Mixtures from Co-compressed Slabs Under Laminar Hydrodynamic Conditions | Seshadri Neervannan, Lloyd S. Dias, Marylee Z. Southard and Valentine J. Stella |
| 1296-1300 | Iontophoresis of a Model Peptide Across Human Skin in Vitro: Effects of Iontophoresis Protocol, pH, and Ionic Strength on Peptide Flux and Skin Impedance | W. H. M. Craane-van Hinsberg, L. Bax, N. H. M. Flinterman, J. Verhoef and H. E. Junginger, et al. |
| 1301-1305 | Solid-State Emulsions: Evaluation by 1H and 13C Solid-State Nuclear Magnetic Resonance | Merrick L. Shively and Steven F. Dec |
| 1306-1314 | Hindered Diffusion of Polar Molecules Through and Effective Pore Radii Estimates of Intact and Ethanol Treated Human Epidermal Membrane | Kendall D. Peck, Abdel-Halim Ghanem and William I. Higuchi |
| 1315-1319 | Liquid Scintillation Spectrometry of 5-Fluorouracil in Cervical Tissue Following in Vitro Surface Application of a Bioadhesive Cervical Patch | A. David Woolfson, Dermot F. McCafferty, Paul A. McCarron and John H. Price |
| 1320-1324 | Pulmonary Deposition and Clinical Response of99mTc-Labelled Salbutamol Delivered from a Novel Multiple Dose Powder Inhaler | Mika Vidgren, Jukka Arppe, Petra Vidgren, Liisa Hyvärinen and Pauli Vainio, et al. |
| 1325-1329 | The Determination of Interfacial Transfer Constants Using Side-by-Side Diffusion Cells | Gerold L. Mosher |
| 1330-1336 | Comparison of Single and Multiple Dose Pharmacokinetics Using Clinical Bioequivalence Data and Monte Carlo Simulations | Ahmed A. El-Tahtawy, André J. Jackson and Thomas M. Ludden |
| 1337-1345 | Distribution Kinetics of Salicylic Acid in the Isolated Perfused Rat Liver Assessed Using Moment Analysis and the Two-Compartment Axial Dispersion Model | Ziad Hussein, Andrew J. McLachlan and Malcolm Rowland |
| 1346-1351 | Modeling of the Saturable Time-Constrained Amoxicillin Absorption in Humans | Vladimir K. Piotrovskij, Gilles Paintaud, Gunnar Alván and Tomáš Trnovec |
| 1352-1354 | Peptide Liquid Crystals: Inverse Correlation of Kinetic Formation and Thermodynamic Stability in Aqueous Solution | Michael F. Powell, Jeffrey Fleitman, Lynda M. Sanders and Victoria C. Si |
| 1355-1357 | Impedance Spectroscopy in Human Skin. A Refined Model | Kyösti Kontturi and Lasse Murtomäki |
| 1358-1361 | Effect of Chitosan on the Permeability of Monolayers of Intestinal Epithelial Cells (Caco-2) | Per Artursson, Tuulikki Lindmark, Stanley S. Davis and Lisbeth Illum |
| 1362-1365 | Characterization of the Crystallinity of Drugs: B02669, a Case Study | Karen C. Thompson, Jerome P. Draper, Michael J. Kaufman and Gerald S. Brenner |
| 1366-1369 | Leucine Enkephalin Effects on Brain Microvessel Endothelial Cell Monolayer Permeability | Suzanne E. Thompson and Kenneth L. Audus |
| 1370-1378 | Adsorption of Oligonucleotides onto Polyisohexylcyanoacrylate Nanoparticles Protects Them Against Nucleases and Increases Their Cellular Uptake | Christine Chavany, Tula Saison-Behmoaras, Trung Le Doan, Francis Puisieux and Patrick Couvreur, et al. |
| 1379-1384 | Probing the Mechanisms of Drug Release from Hydroxypropylmethyl Cellulose Matrices | Anh Thu Pham and Ping I. Lee |
| 1385-1390 | Formulation and Intestinal Absorption Enhancement Evaluation of Water-in-Oil Microemulsions Incorporating Medium-Chain Glycerides | Panayiotis P. Constantinides, Jean-Paul Scalart, Cindy Lancaster, Joseph Marcello and Gary Marks, et al. |
| 1391-1395 | Dependence of Dissolution Rate on Surface Area: Is a Simple Linear Relationship Valid for Co-Compressed Drug Mixtures? | Seshadri Neervannan, Marylee Z. Southard and Valentine J. Stella |
| 1396-1400 | Vehicle Effects on in Vitro Percutaneous Absorption Through Rat and Human Skin | Jennifer Hilton, Bruce H. Woollen, Robert C. Scott, Timothy R. Auton and Kathryn L. Trebilcock, et al. |
| 1401-1404 | Decanoic Acid Induced Enhancement of Rectal Absorption of Hydrophilic Compounds in Rats | Koji Takahashi, Teruo Murakami, Ryoko Yumoto, Tomomi Hattori and Yutaka Higashi, et al. |
| 1405-1413 | Mechanism and Kinetics of Transcellular Transport of a New β-Lactam Antibiotic Loracarbef Across an Intestinal Epithelial Membrane Model System (Caco-2) | Ming Hu, Jiyue Chen, Yanping Zhu, Anne H. Dantzig and Robert E. Stratford, Jr, et al. |
| 1414-1418 | Organization of Stratum Corneum Lipids in Relation to Permeability: Influence of Sodium Lauryl Sulfate and Preheating | Christèle Ribaud, Jean-Claude Garson, Jean Doucet and Jean-Luc Lévêque |
| 1419-1423 | Follicular (Pilosebaceous Unit) Deposition and Pharmacological Behavior of Cimetidine as a Function of Formulation | Linda Margaret Lieb, Gordon Flynn and Norman Weiner |
| 1424-1428 | Relationship Between Enoxacin and Ciprofloxacin Plasma Concentrations and Theophylline Disposition | John D. Davis, Leon Aarons and J. Brian Houston |
| 1429-1434 | Comparative Pharmacokinetic and Pharmacodynamic Analysis of Phthaloyl Glycine Derivatives with Potential Antiepileptic Activity | Omar Abu Salach, Salim Hadad, Abdullah Haj-Yehia, Sherbel Sussan and Meir Bialer |
| 1435-1442 | Pharmacokinetic and Pharmacodynamic Aspects of an Ophthalmic Pilocarpine Nanoparticle-Delivery-System | Andreas Zimmer, Ernst Mutschler, Günter Lambrecht, Dieter Mayer and Jörg Kreuter |
| 1443-1447 | Renin Inhibitor: Relationship Between Molecular Structure and Oral Absorption | Naofumi Hashimoto, Toshihiro Fujioka, Kunio Hayashi, Kunihiro Odaguchi and Tatsuo Toyoda, et al. |
| 1448-1451 | Renin Inhibitor: Transport Mechanism in Rat Small Intestinal Brush-Border Membrane Vesicles | Naofumi Hashimoto, Toshihiro Fujioka, Tatsuo Toyoda, Noriyuki Muranushi and Koichiro Hirano |
| 1452-1457 | Interaction of Benzothiadiazides with Human Serum Albumin Studied by Dialysis and Spectroscopic Methods | Norito Takamura, Mohamed Habibur Rahman, Keishi Yamasaki, Michio Tsuruoka and Masaki Otagiri |
| 1458-1461 | Cyclosporin Absorption Is Impaired by the Fat Substitutes, Sucrose Polyester and Tricarballylate Triester, in the Rat | Kamel Benmoussa, Alain Sabouraud, Jean-Michel Scherrmann and Jean-Marie Bourre |
| 1462-1466 | A Bayesian Approach to Arrhenius Prediction of Shelf-Life | Xiang-Yao Su, Alain Li Wan Po and Sumie Yoshioka |
| 1467-1473 | The Effect of Bulking Agent on the Solid-State Stability of Freeze-Dried Methylprednisolone Sodium Succinate | Beth D. Herman, Brent D. Sinclair, Nathaniel Milton and Steven L. Nail |
| 1474-1478 | Processing Considerations for an EC Latex Coating System: Influence of Curing Time and Temperature | Dawn Hutchings, Barbara Kuzmak and Adel Sakr |
| 1479-1484 | Polylactide Microparticles Prepared by Double Emulsion/Evaporation Technique. I. Effect of Primary Emulsion Stability | Nicole Nihant, Chantal Schugens, Christian Grandfils, Robert Jérôme and Philippe Teyssié |
| 1485-1491 | Gamma Sterilization of a Semi-Solid Poly(ortho ester) Designed for Controlled Drug Delivery—Validation and Radiation Effects | Alain Merkli, Jorge Heller, Cyrus Tabatabay and Robert Gurny |
| 1492-1495 | Selective Precipitation of Interleukin-4 Using Hydrophobic Ion Pairing: A Method for Improved Analysis of Proteins Formulated with Large Excesses of Human Serum Albumin | Jeffrey D. Meyer, James E. Matsuura, James A. Ruth, Eli Shefter and Suman T. Patel, et al. |
| 1496-1500 | Effects of Various Protease Inhibitors on the Intestinal Absorption and Degradation of Insulin in Rats | Akira Yamamoto, Toshio Taniguchi, Kaori Rikyuu, Tomoko Tsuji and Takuya Fujita, et al. |
| 1501-1504 | Intestinal Permeability Enhancement: Structure-Activity and Structure-Toxicity Relationships for Nonylphenoxypolyoxyethylene Surfactant Permeability Enhancers | E. Scott Swenson, William B. Milisen and William Curatolo |
| 1505-1508 | A Simple Method of Correlating Pharmacodynamic Equivalence with Absolute Bioavailability Following Noninvasive Delivery of Insulin | Yuping Li and Ashim K. Mitra |
| 1509 | BOOK REVIEWS |
| 1510 | EIGHTH ANNUAL PHARMACOKINETICS COURSE FOR PHARMACEUTICAL SCIENTISTS ONE-WEEK WORKSHOP ON ADVANCED METHODS IN PHARMACOKINETICS |
| 1511-1515 | Hepatic Blood Flow Measurements and Indocyanine Green Kinetics in a Chronic Dog Model | Andrej Skerjanec, Darryl W. O’Brien and Yun K. Tam |
| 1516-1518 | Carrier-Mediated Transport of H1-Antagonist at the Blood-Brain Barrier: A Common Transport System of H1-Antagonists and Lipophilic Basic Drugs | Masahiro Yamazaki, Tetsuya Terasaki, Kuniaki Yoshioka, Osamu Nagata and Hideo Kato, et al. |
| 1519-1523 | Effect of Renal or Hepatic Dysfunction on Neurotoxic Convulsion Induced by Ranitidine in Mice | Masafumi Shimokawa, Koujirou Yamamoto, Junichi Kawakami, Yasufumi Sawada and Tatsuji Iga |
| 1524-1529 | First-Pass Effect of cis-3,4-Dichloro-N-methyl-N-(2-(l-pyrrolidinyl)-cyclohexyl)-benzamide (U-54494) in Rats— A Model with Multiple Cannulas for Investigation of Gastrointestinal and Hepatic Metabolism | Wei-Zhu Zhong, Marta G. Williams, Kathleen J. Cook, Terri L. VandeGiessen and Brian W. Jones, et al. |
| 1530-1534 | Pharmacokinetics of Intranasally-Administered Dihydroergotamine in the Rat | David T.-W. Lau, Zhiling Yu, Renee L. Aun, Alan E. Hassell and Francis L. S. Tse |
| 1535-1539 | Identification of the Diastereomers of Pentobarbital N-Glucosides Excreted in Human Urine | William H. Soine, Phyllis J. Soine, Terry M. England, Ruth M. Graham and Gerald Capps |
| 1540-1544 | The Influence of Net Water Absorption on the Permeability of Antipyrine and Levodopa in the Human Jejunum | Dag Nilsson, Urban Fagerholm and Hans Lennernäs |
| 1545-1548 | Quantitative Analysis of a Drug in an Animal Feed Employing Sample Preparation by Supercritical Fluid Extraction | Dale C. Messer, Larry T. Taylor, William E. Weiser, John W. McRae and Christopher C. Cook |
| 1549-1556 | Effects of Configuration Around the Chiral Carbon Atoms on the Crystal Properties of Ephedrinium and Pseudoephedrinium Salicylates | Sarma P. Duddu and David J. W. Grant |
| 1557-1561 | The Measurement of Mixture Homogeneity and Dissolution to Predict the Degree of Drug Agglomerate Breakdown Achieved Through Powder Mixing | Melgardt M. Villiers and Jakkie G. Watt |
| 1562-1567 | Properties of Free Films Prepared from Aqueous Polymers by a Spraying Technique | Sakae Obara and James W. McGinity |
| 1568-1574 | Development and Characterization of Microencapsulated Microspheres | Achim Göpferich, Maria Jose Alonso and Robert Langer |
| 1575-1580 | Transepithelial Transport and Metabolism of Thyrotropin-Releasing Hormone (TRH) in Monolayers of a Human Intestinal Cell Line (Caco-2): Evidence for an Active Transport Component? | Elke Walter and Thomas Kissel |
| 1581-1587 | Aggregation Pathway of Recombinant Human Keratinocyte Growth Factor and Its Stabilization | Bao-lu Chen, Tsutomu Arakawa, Charles F. Morris, William C. Kenney and Christina M. Wells, et al. |
| 1588-1592 | Preparation of Sterically Stabilized Human Serum Albumin Nanospheres Using a Novel Dextranox-MPEG Crosslinking Agent | Wu Lin, Allan G. A. Coombes, Martin C. Garnett, Martyn C. Davies and Etienne Schacht, et al. |
| 1593-1598 | In Vitro Cutaneous and Percutaneous Delivery and in Vivo Efficacy of Tetracaine from Liposomal and Conventional Vehicles | Marianna Foldvari |
| 1599-1604 | Intestinal Uptake of Cimetidine and Ranitidine in Rats | Vanaja Mummaneni and Jennifer B. Dressman |
| 1605-1609 | A New Bioerodible Polymer Insert for the Controlled Release of Metronidazole | Kimberly A. Gates, Helen Grad, Peter Birek and Ping I. Lee |
| 1610-1616 | Subzero Thermal Analysis of Human Stratum Corneum | Hanafi Tanojo, Joke A. Bouwstra, Hans E. Junginger and Harry E. Boddé |
| 1617-1622 | Effects of Protease Inhibitors on Vasopressin Transport Across Rat Alveolar Epithelial Cell Monolayers | Hiroshi Yamahara, Kazuhiro Morimoto, Vincent H. L. Lee and Kwang-Jin Kim |
| 1623-1630 | Nasal Absorption in the Rat. III. Effect of Lysophospholipids on Insulin Absorption and Nasal Histology | Susan G. Chandler, Norman W. Thomas and Lisbeth Illum |
| 1631-1639 | Dermal Microdialysis Sampling in Vivo | Joseph M. Ault, Christopher M. Riley, Noel M. Meltzer and Craig E. Lunte |
| 1640-1645 | Colonic Absorption and Bioavailability of the Pentapeptide Metkephamid in the Rat | Peter Langguth, Gerhard Breves, Arthur Stökli, Hans P. Merkle and Siegfried Wolffram |
| 1646-1651 | Kinetic Analysis of the Drug Permeation Process Across the Intestinal Epithelium | Shinji Yamashita, Masako Yoshida, Yoko Taki, Toshiyasu Sakane and Tanekazu Nadai |
| 1652-1656 | Antiinflammatory Drug-Induced Small Intestinal Permeability: The Rat Is a Suitable Model | Neal M. Davies, Matthew R. Wright and Fakhreddin Jamali |
| 1657-1662 | Transdermal Delivery of Metoprolol by Electroporation | Rita Vanbever, Nathalie Lecouturier and Véronique Préat |
| 1663-1668 | In Vitro and in Vivo Evaluation in Dogs and Pigs of a Hydrophilic Matrix Containing Propylthiouracil | Louis Kabanda, Romain Adelin Lefebvre, Henri Jacques Bree and Jean Paul Remon |
| 1669-1672 | Pharmacokinetics of Two Enteric-Coated Ketoprofen Products in Humans with or Without Coadministration of Omeprazole and Comparison with Dissolution Findings | Saeed A. Qureshi, Gilles Caillé, Yves Lacasse and Iain J. McGilveray |
| 1673-1676 | In Vitro Plasma Metabolism of RMP-7 | Julie Ann Straub, Alan Akiyama and Parul Parmar |
| 1677-1679 | Entrapping Efficiency of an Oil-in-Water Emulsion Containing Isocarbacyclin Methyl Ester (TEI-9090) in Dog and Human Sera | Toshiya Minagawa, Yoshiro Kohno, Toshio Suwa and Akira Tsuji |
| 1680 | EIGHTH ANNUAL PHARMACOKINETICS COURSE FOR PHARMACEUTICAL SCIENTISTS ONE-WEEK WORKSHOP ON ADVANCED METHODS IN PHARMACOKINETICS |
| 1681-1688 | Insulin Fragments as a Carrier for Peptide Delivery Across the Blood–Brain Barrier | Makoto Fukuta, Hiroaki Okada, Satoshi Iinuma, Shigeo Yanai and Hajime Toguchi |
| 1689-1697 | Transsynovial Drug Distribution: Synovial Mean Transit Time of Diclofenac and Other Nonsteroidal Antiinflammatory Drugs | William F. Elmquist, Keith K. H. Chan and Ronald J. Sawchuk |
| 1698-1703 | The Effect of Cyclodextrins on the Stability of Peptides in Nasal Enzymic Systems | William J. Irwin, Anil K. Dwivedi, Paula A. Holbrook and Michael J. Dey |
| 1704-1706 | Mechanism of Optical Isomerization of(S)-N-[1-(2-Fluorophenyl)-3,4,6,7-tetrahydro-4-oxopyrrolo[3,2,1-jk] [l,4]-benzodiazepine-3-y1]-1H-indole-2-carboxamide (FK480) in Soft Capsules Containing Polyethylene Glycol 400 and Glycerol | Shinichi Fukuyama, Noriaki Kihara, Keiichi Nakashima, Noritsugu Morokoshi and Shigetaka Koda, et al. |
| 1707-1711 | Menthol-β-D-Glucuronide: A Potential Prodrug for Treatment of the Irritable Bowel Syndrome | Harold W. Nolen III and David R. Friend |
| 1712-1720 | Aqueous Stability of Human Epidermal Growth Factor 1-48 | Richard I. Senderoff, Scott C. Wootton, Amal M. Boctor, Tsun Ming Chen and Anne B. Giordani, et al. |
| 1721-1725 | Is Stability Prediction Possible for Protein Drugs? Denaturation Kinetics of β- Galactosidase in Solution | Sumie Yoshioka, Yukio Aso, Ken-ichi Izutsu and S. Kojima |
| 1726-1730 | Natriuretic Peptide-Potentiating Actions of Neutral Endopeptidase Inhibition in Rats with Experimental Heart Failure | Masato Yasuhara, Masayuki Yamaguchi, Hiromasa Shimizu, Yukiya Hashimoto and Norio Hama, et al. |
| 1731-1736 | Targeted Gene Delivery to Alveolar Macrophages via Fc Receptor-Mediated Endocytosis | Yongyut Rojanasakul, Li Ying Wang, Carl J. Malanga, Joseph K. H. Ma and Jiahorng Liaw |
| 1737-1741 | The Relation Between Swelling Properties and Enzymatic Degradation of Azo Polymers Designed for Colon-Specific Drug Delivery | Guy Van den Mooter, Celest Samyn and Renaat Kinget |
| 1742-1746 | Effect of Current Magnitude and Drug Concentration on lontophoretic Delivery of Octreotide Acetate (Sandostatin®) in the Rabbit | David T.-W. Lau, John W. Sharkey, Lew Petryk, Frank A. Mancuso and Zhiling Yu, et al. |
| 1747-1754 | Improving the Sensitivity of in Vitro Skin Penetration Experiments | Gerald B. Kasting, Thomas G. Filloon, William R. Francis and Michael P. Meredith |
| 1755-1760 | The Effects of Bile Salts and Lipids on the Physicochemical Behavior of Gemfibrozil | Paul E. Luner, Suresh R. Babu and Galen W. Radebaugh |
| 1761-1765 | Characteristics of Ceftibuten Uptake into Caco-2 Cells | Noriyuki Muranushi, Kazutoshi Horie, Kazuyoshi Masuda and Koichiro Hirano |
| 1766-1770 | Effect of 2-Hydroxypropyl-β-cyclodextrin on Crystallization and Polymorphic Transition of Nifedipine in Solid State | Fumitoshi Hirayama, Zheng Wang and Kaneto Uekama |
| 1771-1776 | Comparison of the Transport Characteristics of D- and L-Methionine in a Human Intestinal Epithelial Model (Caco-2) and in a Perfused Rat Intestinal Model | Lixing Zheng, Jiyue Chen, Yanping Zhu, Hua Yang and William Elmquist, et al. |
| 1777-1784 | Transport of β-Estradiol in Freshly Excised Human Skin in Vitro: Diffusion and Metabolism in Each Skin Layer | Puchun Liu, William I. Higuchi, Abdel-Halim Ghanem and William R. Good |
| 1785-1791 | The Role of Rheological Properties in Mucociliary Transport by Frog Palate Ciliated Model | Danny M. Yu, Gordon L. Amidon, Norman D. Weiner, David Fleisher and Arthur H. Goldberg |
| 1792-1799 | Formation and Characterization of Cisplatin-Loaded Poly(benzyl 1-glutamate) Microspheres for Chemoembolization | Chun Li, David J. Yang, Sarah Nikiforow, Wayne Tansey and Li-Ren Kuang, et al. |
| 1800-1808 | Surface Modification of Poly(lactide-co-glycolide) Nanospheres by Biodegradable Poly(lactide)-Poly(ethylene glycol) Copolymers | Snjezana Stolnik, Susan E. Dunn, Martin C. Garnett, Martyn C. Davies and Allan G. A. Coombes, et al. |
| 1809-1814 | Effect of Electroporation on Transdermal lontophoretic Delivery of Luteinizing Hormone Releasing Hormone (LHRH) in Vitro | D. Bommi Bommannan, Janet Tamada, Lewis Leung and Russell O. Potts |
| 1815-1819 | Enantioselective Kinetics of Verapamil and Norverapamil in Isolated Perfused Rat Livers | Reza Mehvar, James M. Reynolds, Megan A. Robinson and James A. Longstreth |
| 1820-1824 | Effect of Perfusate pH on Reduction of Quinidine Capillary Permeability by Albumin in Isolated Perfused Rat Heart | Denis J. Morgan and Cao Ling Xu |
| 1825-1828 | The Use of Multiple Doses and Pharmacodynamic System Analysis to Distinguish Between Dispositional Delays and Time-Variant Pharmacodynamics | Marc R. Gastonguay and Sorell L. Schwartz |
| 1829-1833 | Effect of Substituted Benzoylglycines (Hippurates) and Phenylacetylglycines on p-Aminohippurate Transport in Dog Renal Membrane Vesicles | Frans G. M. Russel and Wim G. Vermeulen |
| 1834-1837 | Rapid Temporal Control of Transdermal Drug Delivery by Electroporation | Mark R. Prausnitz, Uwe Pliquett, Robert Langer and James C. Weaver |
| 1838-1841 | Author Index to Volume 11 (1994) |
| 1842-1845 | Subject Index to Volume 11 (1994) |
| 1847 | ERRATUM |
| 1 | EDITORIAL |
| 2-11 | Stability of Protein Formulations: Investigation of Surfactant Effects by a Novel EPR Spectroscopic Technique | Narendra B. Bam, Theodore W. Randolph and Jeffrey L. Cleland |
| 12-17 | Hepatic Uptake of Octreotide, a Long-Acting Somatostatin Analogue, via a Bile Acid Transport System | Tetsuya Terasaki, Hiroko Mizuguchi, Chizuru Itoho, Ikumi Tamai and Michel Lemaire, et al. |
| 18-23 | Vitamin K Prodrugs: 1. Synthesis of Amino Acid Esters of Menahydroquinone-4 and Enzymatic Reconversion to an Active Form | Jiro Takata, Yoshiharu Karube, Mitsunobu Hanada, Kazuhisa Matsunaga and Yoshikazu Matsushima, et al. |
| 24-38 | Investigation of 3,5-Isoxazolidinediones as Hypolipidemic Agents in Rodents | Tyrone Woodard, Manik L. Debnath, Rupendra Simlot, Robert A. Izydore and Dwayne L. Daniels, et al. |
| 39-48 | Structures of Nanoparticles Prepared from Oil-in-Water Emulsions | Brita Sjöström, Alon Kaplun, Yeshayahu Talmon and Bernard Cabane |
| 49-52 | Rates of Systemic Degradation and Reticuloendothelial System Uptake of Calcein in the Dipalmitoylphosphatidylcholine Liposomes with Soybean-Derived Sterols in Mice | Xian-rong Qi, Yoshie Maitani and Tsuneji Nagai |
| 53-59 | Some Factors Associated with the Ultrasonic Nebulization of Proteins | Ralph W. Niven, Anna Y. Ip, S. Mittelman, S. J. Prestrelski and T. Arakawa |
| 60-68 | Reversible Adsorption of Soluble Hexameric Insulin onto the Surface of Insulin Crystals Cocrystallized with Protamine: An Electrostatic Interaction | Steven W. Dodd, Henry A. Havel, Paul M. Kovach, Chitra Lakshminarayan and Martin P. Redmon, et al. |
| 69-77 | Surface Denaturation at Solid-Void Interface—A Possible Pathway by Which Opalescent Participates Form During the Storage of Lyophilized Tissue-Type Plasminogen Activator at High Temperatures | Chung C. Hsu, Hoc M. Nguyen, Douglas A. Yeung, Dennis A. Brooks and Gary S. Koe, et al. |
| 78-84 | Differential Effects of Sulfate and Sulfobutyl Ether of β-Cyclodextrin on Erythrocyte Membranes in Vitro | Kazufumi Shiotani, Keiko Uehata, Tetsumi Irie, Kaneto Uekama and Diane O. Thompson, et al. |
| 85-87 | Acute Renal Toxicity of Doxorubicin (Adriamycin)-Loaded Cyanoacrylate Nanoparticles | Luc Manil, Philippe Mahieu and Patrick Couvreur |
| 88-95 | A New Method for Estimating Dermal Absorption from Chemical Exposure: 2. Effect of Molecular Weight and Octanol-Water Partitioning | Annette L. Bunge and Robert L. Cleek |
| 96-102 | Aerosol Deposition as a Function of Airway Disease: Cystic Fibrosis | Ted Martonen, Ira Katz and William Cress |
| 103-107 | Evaluation of Different Metrics as Indirect Measures of Rate of Drug Absorption from Extended Release Dosage Forms at Steady-State | Cristos Reppas, Larry F. Lacey, Oliver N. Keene, Panos Macheras and Alan Bye |
| 108-112 | Penetration Kinetics of 2′,3′-Dideoxyinosine in Dermis Is Described by the Distributed Model | Elora Gupta, M. Guillaume Wientjes and Jessie L.-S. Au |
| 113-116 | Pharmacokinetics of Antimony in Patients Treated with Sodium Stibogluconate for Cutaneous Leishmaniasis | May Al laser, Adnan El-Yazigi and Simon L. Croft |
| 117-123 | Assessment of Toxicokinetics and Toxicodynamics Following Intravenous Administration of Etoposide Phosphate in Beagle Dogs | Linus N. Igwemezie, Sanjeev Kaul and Rashmi H. Barbhaiya |
| 124-128 | Applying Bailer's Method for AUC Confidence Intervals to Sparse Sampling | Jerry R. Nedelman, Ekaterina Gibiansky and David T. W. Lau |
| 129-133 | The Use of Intracerebral Microdialysis to Determine Changes in Blood-Brain Barrier Transport Characteristics | Elizabeth C. M. de Lange, Mayke B. Hesselink, Meindert Danhof, Albertus G. de Boer and Douwe D. Breimer |
| 134-137 | Assessment of Glucocorticoid Lung Targeting by ex-Vivo Receptor Binding Studies in Rats | Guenther Hochhaus, Ricardo J. Gonzalez-Rothi, Anatoly Lukyanov, Hartmut Derendorf and Hans Schreier, et al. |
| 138-143 | Sumatriptan Absorption from Different Regions of the Human Gastrointestinal Tract | Patricia E. Warner, Kirn L. R. Brouwer, Elizabeth K. Hussey, George E. Dukes and Karl H. Donn, et al. |
| 144-148 | Comparison of Simulated and in-Vivo Plasma Levels of Cilastatin Following Intravenous in-Line Drug Administration | Joseph Wong, Wei-Youh Kuu, Ronald Burke, Robert Johnson and Ray W. Wood |
| 149-154 | Evaluation of the Intestinal Absorption of Erythromycin in Man: Absolute Bioavailability and Comparison with Enteric Coated Erythromycin | Andrew A. Somogyi, Felix Bochner, David Hetzel and Desmond B. Williams |
| 155-160 | Determination of Aliphatic Thiols by Fluorometric High-Performance Liquid Chromatography After Precolumn Derivatization with 2-(4-N-Maleimidophenyl)-6-Methylbenzothiazole | Abdullah I. Haj-Yehia and Leslie Z. Benet |
| 161-163 | Determination of Moisture in Intact Gelatin Capsules by Near-Infrared Spectrophotometry | Robert G. Buice, Jr, Thomas B. Gold, Robert A. Lodder and George A. Digenis |
| 164-167 | Metabolism of Acetylneurotensin(8–13) by Proteolytic Activities of Intestinal Enterocytes | Jane P. F. Bai and Li-Ling Chang |
| 168-170 | The Influence of the Shape of the Plasma Drug Concentration Profile upon the Pharmacological Effect | Mark Knowles and Stephen S. Hwang |
| 171-175 | Cultured Human Sweat Gland Epithelia: Isolation of Glands Using Neutral Red | David J. Brayden and Joan Fitzpatrick |
| 176 | BOOK REVIEWS |
| 177 | EDITORIAL |
| 179-186 | Transfollicular Drug Delivery | Andrea C. Lauer, Linda M. Lieb, C. Ramachandran, Gordon L. Flynn and Norman D. Weiner |
| 187-191 | Synthesis and Pharmacological Properties of 2-[S-Acetylthiorphan]-l,3-diacylaminopropan-2-ol Derivatives as Chimeric Lipid Drug Carriers Containing an Enkephalinase Inhibitor | Didier M. Lambert, Frank Mergen, Catherine F. Berens, Jacques H. Poupaert and Pierre Dumont |
| 192-195 | Physical Entrapment of Adriamycin in AB Block Copolymer Micelles | Glen S. Kwon, Mayumi Naito, Masayuki Yokoyama, Teruo Okano and Yasuhisa Sakurai, et al. |
| 196-200 | Construction of an Intermittent-Motion Capsule Filling Machine Simulator | Jeffrey R. Britten, Michael I. Barnett and N. Anthony Armstrong |
| 201-208 | Preparation and Physicochemical Characterization of Aqueous Dispersions of Coenzyme Q10 Nanoparticles | Britta Siekmann and Kirsten Westesen |
| 209-214 | Design for Cell-Specific Targeting of Proteins Utilizing Sugar-Recognition Mechanism: Effect of Molecular Weight of Proteins on Targeting Efficiency | Makiya Nishikawa, Hideki Hirabayashi, Yoshinobu Takakura and Mitsuru Hashida |
| 215-222 | Stabilization of Chimeric BR96-Doxorubicin Immunoconjugate | Nancy P. Barbour, Mehdi Paborji, Thomas C. Alexander, William P. Coppola and Joseph B. Bogardus |
| 223-230 | Efficacy Evaluation of a Novel Submicron Miconazole Emulsion in a Murine Cryptococcosis Model | Menashe Y. Levy, Itzhack Polacheck, Yechezkel Barenholz and Simon Benita |
| 231-236 | Comparison of Gamma Scintigraphy and a Pharmacokinetic Technique for Assessing Pulmonary Deposition of Terbutaline Sulphate Delivered by Pressurized Metered Dose Inhaler | Stephen Newman, Karen Steed, Gerard Hooper, Anders Källén and Lars Borgström |
| 237-243 | Estimation of Agitation Intensity in the GI Tract in Humans and Dogs Based on in Vitro/in Vivo Correlation | Noriko Katori, Nobuo Aoyagi and Tadao Terao |
| 244-247 | In Vivo Evaluation of a Colon-Specific Drug Delivery System: An Absorption Study of Theophylline from Capsules Coated with Azo Polymers in Rats | Guy Mooter, Celest Samyn and Renaat Kinget |
| 248-256 | Drug Transport Across Nylon 610 Films: Influence of Synthesis Variables | Kenneth Phares, Moo Cho, Keith Johnson and James Swarbrick |
| 257-262 | Effect of Norfloxacin on Theophylline Disposition: A Comparison with Other Fluoroquinolones | John D. Davis, Leon Aarons and J. Brian Houston |
| 263-269 | Incorporation of First-Order Uptake Rate Constants from Simple Mammillary Models into Blood-Flow Limited Physiological Pharmacokinetic Models via Extraction Efficiencies | William L. Roth, L. W. D. Weber and Karl K. Rozman |
| 270-274 | Pharmacokinetic Study of Zeolite A, Sodium Aluminosilicate, Magnesium Silicate, and Aluminum Hydroxide in Dogs | Eugenio A. Cefali, Joseph C. Nolan, William R. McConnell and Denise Lowe Walters |
| 275-283 | Comparative Tissue Distribution and Elimination of Amphotericin B Colloidal Dispersion (Amphocil®) and Fungizone® After Repeated Dosing in Rats | Laurence H. Wang, Robert M. Fielding, Philip C. Smith and Luke S. S. Guo |
| 284-290 | Age-Dependent Intestinal Absorption of Valproic Acid in the Rat | Allen Cato III, Gary M. Pollack and Kim L. R. Brouwer |
| 291-294 | Microdialysis Sampling to Determine the Pharmacokinetics of Unbound SDZ ICM 567 in Blood and Brain in Awake, Freely-Moving Rats | Maria J. Alonso, Armin Bruelisauer, Pierrette Misslin and Michel Lemaire |
| 295-298 | Estimation of Impurity Profiles of Drugs and Related Materials. 12. Isolation and Identification of an Isomeric Impurity in Danazol | Gábor Balogh, Éva Csizér, György G. Ferenczy, Zsuzsanna Halmos and Bulcsu Herényi, et al. |
| 299-304 | Changes in Solid-State Structure of Cyclophosphamide Monohydrate Induced by Mechanical Treatment and Storage | Jarkko Ketolainen, Antti Poso, Veijo Viitasaari, Jukka Gynther and Jukka Pirttimäki, et al. |
| 305-308 | Chemical Pathways of Degradation of the Bradykinin Analog, RMP-7 | Julie Ann Straub, Alan Akiyama, Parul Parmar and Gary F. Musso |
| 309-312 | Differential Expression of the Phenol Family of UDP-Glucuronosyltransferases in Hepatoma Cell Lines | Ah-Ng Tony Kong, Peiwen Fei and Bradley K. Wong |
| 313-316 | Pharmacokinetics of Caffeine and Its Demethylated Metabolites in Lactation: Predictions of Milk to Serum Concentration Ratios | Cheah Y. Oo, David E. Burgio, Robert C. Kuhn, Nirmala Desai and Patrick J. McNamara |
| 317-319 | Structural Requirements for Interaction with the Oligopeptide Transporter in Caco-2 Cells | Ismael J. Hidalgo, Pradip Bhatnagar, Chao-Pin Lee, Joanne Miller and Gregory Cucullino, et al. |
| 320-321 | Reviewers for Pharmaceutical Research (January 1, 1994 - November 30, 1994) |
| 322 | European Reviewers for Pharmaceutical Research (January 1, 1994 - November 23, 1994) |
| 323-328 | The Importance of Structural Factors on the Rate and the Extent of N,O-acyl Migration in Cyclic and Linear Peptides | Reza Oliyai, Teruna J. Siahaan and Valentine J. Stella |
| 329-336 | Soft Drugs. XX. Design, Synthesis, and Evaluation of Ultra-Short Acting Beta-Blockers | Hee-Sun Yang, Whei-Mei Wu and Nicholas Bodor |
| 337-341 | Crystal Structure of 2-Debenzoyl, 2-Acetoxy Paclitaxel (Taxol®): Conformation of the Paclitaxel Side-Chain | Qi Gao, Jian-Mei Wei and Shu-Hui Chen |
| 342-347 | Physicochemical Characterization of Parenteral Lipid Emulsion: Determination of Hamaker Constants and Activation Energy of Coalescence | Tetsuo Yamaguchi, Kaori Nishizaki, Shigeru Itai, Hidefumi Hayashi and Hiroyuki Ohshima |
| 348-355 | Chemical Pathways of Peptide Degradation. VIII. Oxidation of Methionine in Small Model Peptides by Prooxidant/Transition Metal Ion Systems: Influence of Selective Scavengers for Reactive Oxygen Intermediates | Shihong Li, Christian Schöneich and Ronald T. Borchardt |
| 356-359 | The Influence of Regional Deposition on the Pharmacokinetics of Pulmonary-Delivered Human Growth Hormone in Rabbits | Paul Colthorpe, Stephen J. Fair, Ian J. Smith, David Wyatt and Glyn Taylor |
| 360-365 | Transepithelial Transport Properties of Peptidomimetic Thrombin Inhibitors in Monolayers of a Human Intestinal Cell Line (Caco-2) and Their Correlation to in Vivo Data | Elke Walter, Thomas Kissel, Martin Reers, Gerhard Dickneite and Dieter Hoffmann, et al. |
| 366-369 | A Non-Ionic Vesicle Lipid Enhances Mastoparan-Stimulated GTPase Activity of Heterotrimeric G-Proteins | Bernd Nürnberg, Ralph Hoppe, Ulrich Rümenapp, Rainer Harhammer and Eberhard Nürnberg |
| 370-375 | Tumor Selective Effect of RS-1541 (Palmitoyl-Rhizoxin) in M5076 Sarcoma and Host Tissues in Vivo | Taro Tokui, Naoyuki Maeda, Chitose Kuroiwa, Kazuhiko Sasagawa and Takashi Inoue, et al. |
| 376-379 | The Description of the Gastrointestinal Transit of Pellets Assessed by Gamma Scintigraphy Using Statistical Moments | Fridrun Podczeck, John Michael Newton and Kay-Hay Yuen |
| 380-386 | The Application of Malononitriles as Microviscosity Probes in Pharmaceutical Systems | Sherry L. LaPorte, Abizer Harianawala and Robin H. Bogner |
| 387-392 | Drug Delivery Studies in Caco-2 Monolayers. Synthesis, Hydrolysis, and Transport of O-Cyclopropane Carboxylic Acid Ester Prodrugs of Various β-Blocking Agents | Lars Hovgaard, Helle Brøndsted, Anders Buur and Hans Bundgaard |
| 393-396 | The Effect of Different Concentrations of Mannitol in Solution on Small Intestinal Transit: Implications for Drug Absorption | Dawn A. Adkin, Stanley S. Davis, Robert A. Sparrow, Paul D. Huckle and Anthony J. Phillips, et al. |
| 397-405 | In Vitro and in Vivo Evaluation of Mucoadhesive Microspheres Prepared for the Gastrointestinal Tract Using Polyglycerol Esters of Fatty Acids and a Poly(acrylic acid) Derivative | Yohko Akiyama, Naoki Nagahara, Toshio Kashihara, Shinichiro Hirai and Hajime Toguchi |
| 406-412 | Neural Network Predicted Peak and Trough Gentamicin Concentrations | Michael E. Brier, Jacek M. Zurada and George R. Aronoff |
| 413-420 | A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability | Gordon L. Amidon, Hans Lennernäs, Vinod P. Shah and John R. Crison |
| 421-425 | Analysis of Tissue Distribution of Valproate in Guinea-Pigs: Evidence for Its Capacity-Limited Tissue Distribution | Hsiu-Ying Yu and Yu-Zen Shen |
| 426-432 | Regional Rectal Perfusion: A New in Vivo Approach to Study Rectal Drug Absorption in Man | Hans Lennernäs, Urban Fagerholm, Yngve. Raab, Bengt Gerdin and Roger Hällgren |
| 433-437 | A Compartmental Model for the Ocular Pharmacokinetics of Cyclosporine in Rabbits | Clifford Oh, Bradley A. Saville, Yu-Ling Cheng and David S. Rootman |
| 438-445 | Pharmacodynamic Analysis of Analgesic Clinical Trials Using Empirical Methods | Chui Yu Liu and Nancy C. Sambol |
| 446-450 | Second Derivative Infrared Spectroscopy as a Non-Destructive Tool to Assess the Purity and Structural Integrity of Proteins | D. Michael Byler, Rachel M. Wilson, Cynthia S. Randall and Theodore D. Sokoloski |
| 451-454 | Stabilization of Human Epidermal Growth Factor (hEGF) in Aqueous Formulation | Kyonghee Son and Changhyuk Kwon |
| 455-458 | Functional Evaluation of Anchored Skin Equivalent Cultured in Vitro: Percutaneous Absorption Studies and Lipid Analysis | Martine Michel, Lucie Germain, Pierre Maxime Bélanger and François A. Auger |
| 459-463 | Pharmacodynamic Modeling of Prednisolone Effects on Natural Killer Cell Trafficking | Zhi-Xin Xu, Mi-Jeong Lee, Robert A. Blum and William J. Jusko |
| 465-483 | Antigene, Ribozyme and Aptamer Nucleic Acid Drugs: Progress and Prospects | Robert A. Stull and Francis C. Szoka, Jr |
| 484-490 | Thermal Analysis of the Tertiary Butyl Alcohol-Water System and Its Implications on Freeze-Drying | Kasra Kasraian and Patrick P. DeLuca |
| 491-495 | The Effect of Tertiary Butyl Alcohol on the Resistance of the Dry Product Layer During Primary Drying | Kasra Kasraian and Patrick P. DeLuca |
| 496-507 | Physico-Mechanical Characterization of the Extrusion-Spheronization Process. Part II: Rheological Determinants for Successful Extrusion and Spheronization | Rajen D. Shah, Mohan Kabadi, David G. Pope and Larry L. Augsburger |
| 508-512 | Monosialoganglioside GMl Shortens the Blood Circulation Time of Liposomes in Rats | Dexi Liu, Feng Liu and Young K. Song |
| 513-517 | Insulin-Degrading Enzyme in a Human Colon Adenocarcinoma Cell Line (Caco-2) | Jane P. F. Bai, Matt J. P. Hsu and W. Thomas Shier |
| 518-522 | Is the Beneficial Effect of Calcium Channel Blockers Against Cyclosporine A Toxicity Related to a Restoration of ATP Synthesis? | Marie D. Salducci, Anne M. Chauvet-Monges, Bertrand M. Dussol, Yvon F. Berland and Aimé D. Crevat |
| 523-528 | Characterization of Drug Transport Through Tight-Junctional Pathway in Caco-2 Monolayer: Comparison with Isolated Rat Jejunum and Colon | Yoshihiro Tanaka, Yoko Taki, Toshiyasu Sakane, Tanekazu Nadai and Hitoshi Sezaki, et al. |
| 529-533 | Ocular Absorption and Irritation of Pilocarpine Prodrug Is Modified with Buffer, Polymer, and Cyclodextrin in the Eyedrop | Pekka Suhonen, Tomi Järvinen, Kari Lehmussaari, Timo Reunamäki and Arto Urtti |
| 534-540 | Evaluation of Poly(isobutylcyanoacrylate) Nanoparticles for Mucoadhesive Ocular Drug Delivery. I. Effect of Formulation Variables on Physicochemical Characteristics of Nanoparticles | Sudip K. Das, Ian G. Tucker, David J. T. Hill and Nandita Ganguly |
| 541-548 | Carrier-Mediated Transport Can Obey Fractal Kinetics | Panos Macheras |
| 549-555 | Measurement of Rapid Release Kinetics for Drug Delivery | Uwe Pliquett, Mark R. Prausnitz, Yuri A. Chizmadzhev and James C. Weaver |
| 556-559 | Effect of Humidity-Dependent Changes in Crystal Structure on the Solid-State Fluorescence Properties of a New HMG-CoA Reductase Inhibitor | Harry G. Brittain, Sunanda A. Ranadive and Abu T. M. Serajuddin |
| 560-564 | Effects of Inclusion Complexation on the Transepithelial Transport of a Lipophilic Substance in Vitro | M. J. Cho, F. J. Chen and Dennis L. Huczek |
| 565-571 | Development of a Human Nasal Epithelial Cell Culture Model and Its Suitability for Transport and Metabolism Studies Under in Vitro Conditions | Ute Werner and Thomas Kissel |
| 572-575 | Use of ATR-FTIR Spectroscopy to Study the Diffusion of Ethanol Through Glycerogelatin Films | A. Margarida L. Tralhão, Adam C. Watkinson, Keith R. Brain, Jonathan Hadgraft and N. Anthony Armstrong |
| 576-582 | In Vitro Evaluation of Polymerized Liposomes as an Oral Drug Delivery System | Jun'ichi Okada, Smadar Cohen and Robert Langer |
| 583-587 | QSAR Analysis of Skin Permeability of Various Drugs in Man as Compared to in Vivo and in Vitro Studies in Rodents | Eric J. Lien and Hua Gaot |
| 588-593 | The in Vitro Characterization and Biostability of 99mTc-Dextran and Its Accumulation Within the Inflamed Paws of Adjuvant-Induced Arthritic Rats | Ian W. Kellaway, Lisa Seale and Paul S. J. Spencer |
| 594-598 | Relationship Between the Phasic Period of Interdigestive Migrating Contraction and the Systemic Bioavailability of Acetaminophen in Dogs | Kazuyoshi Sagara, Hiroaki Mizuta, Minoru Ohshiko, Masahiro Shibata and Keiichiro Haga |
| 599-604 | Isothermal and Nonisothermal Decomposition of Famotidine in Aqueous Solution | Gunjan H. Junnarkar and Salomon Stavchansky |
| 605-608 | Transport Mechanism of Ceftibuten, a Dianionic Cephem, in Rat Renal Brush-Border Membrane | Imad Naasani, Mitsuru Sugawara, Michiya Kobayashi, Ken Iseki and Katsumi Miyazaki |
| 609-614 | Metabolism of Diltiazem in Hepatic and Extrahepatic Tissues of Rabbits: InVitro Studies | Walid Homsy, Marc Lefebvre, Gilles Caillé and Patrick du Souich |
| 615-620 | A Cellular Automata Model of the Hydrophobia Effect | Lemont B. Kier, Chao-Kun Cheng, Bernard Testa and Pierre-Alain Carrupt |
| 621-629 | A Solution Conformation Analysis of Forocidins I and Isoforocidins I Using NMR and Molecular Modeling | Kumar Ramu, Sachin Shringarpure and John S. Williamson |
| 630-633 | Amoebicidal in Vitro Activity Shown by Some Metronidazole Analogues: Biological Response-Reduction Potential Correlation | Ma. Elena Campos, Marco Meraz, Hugo Sánchez and Héctor Salgado-Zamora |
| 634-635 | Solution Properties of Two Fluoroquinolone Antibacterials | Richard J. Prankerd |
| 637-641 | The Effect of pH and Temperature on the Self-Association of Recombinant Human Interleukin-2 as Studied by Equilibrium Sedimentation | Siddharth J. Advant, Emory H. Braswell, C. Vijaya Kumar and Devendra S. Kalonia |
| 642-648 | Interdomain Interactions in the Chimeric Protein Toxin sCD4(178)-PE40: A Differential Scanning Calorimetry (DSC) Study | Stephen R. Davio, Kathryn M. Kienle and Brian E. Collins |
| 649-652 | Primary Interactions of Three Quaternary Ammonium Compounds with Blastospores of Candida albicans (MEN Strain) | Leo J. Schep, David S. Jones and Max G. Shepherd |
| 653-657 | Antitumor Effect of Arterial Administration of a Medium-Chain Triglyceride Solution of an Angiogenesis Inhibitor, TNP-470, in Rabbits Bearing VX-2 Carcinoma | Shigeo Yanai, Hiroaki Okada, Kazuhiro Saito, Yuji Kuge and Masafumi Misaki, et al. |
| 658-662 | Selective Inhibition of Bitter Taste of Various Drugs by Lipoprotein | Yoshihisa Katsuragi, Yoko Sugiura, Cao Lee, Kazuya Otsuji and Kenzo Kurihara |
| 663-668 | Prolonged Blood Circulation in Rats of Nanospheres Surface-Modified with Semitelechelic Poly[N-(2-Hydroxypropyl)methacrylamide] | Shigeru Kamei and Jindřich Kopeček |
| 669-675 | Modelling Mucoadhesion by Use of Surface Energy Terms Obtained from the Lewis Acid–Lewis Base Approach. II. Studies on Anionic, Cationic, and Unionisable Polymers | Maria Rillosi and Graham Buckton |
| 676-681 | Autoradiographic Imaging of the Distribution of 5-Fluorouracil Through Cervical Tissue Following in Vitro Surface Application of a Bioadhesive Cervical Patch | A. David Woolfson, Dermot F. McCafferty, Paul A. McCarron and John H. Price |
| 682-686 | Interaction Between Bile Salts and β-Adrenoceptor Antagonists | Martin P. Grosvenor and Jan-Erik Löfroth |
| 687-692 | Enhanced Transdermal Delivery of Diazepam by Submicron Emulsion (SME) Creams | Joseph S. Schwarz, Michael R. Weisspapir and Doron I. Friedman |
| 693-699 | Comparison of Intestinal Permeabilities Determined in Multiple in Vitro and inSitu Models: Relationship to Absorption in Humans | Barbra H. Stewart, O. Helen Chan, Rosalind H. Lu, Eric L. Reyner and Heidi L. Schmid, et al. |
| 700-708 | The Role of Metabolites in Bioequivalency Assessment. II. Drugs with Linear Pharmacokinetics and First-Pass Effect | Mei-Ling Chen and Andre J. Jackson |
| 709-714 | Monoclonal Digoxin-Specific Antibodies Induce Dose-and Affinity-Dependent Plasma Digoxin Redistribution in Rats | Nathalie J. Cano, Alain E. Sabouraud, Kamel Benmoussa, Francoise Roquet and Isabelle Navarro-Teulon, et al. |
| 715-719 | The Distribution of Oleic Acid Between Salbutamol Base Drug and Different Propellant Blends | Patrik M. Eriksson, Kenneth B. Sandström and Jarl B. Rosenholm |
| 720-728 | Pharmacokinetics of Oral Extended-Release Dosage Forms. I. Release Kinetics, Concentration, and Absorbed Fraction | Fang-Yu Liu, Nancy C. Sambol, Robert P. Giannini and Chui Yu Liu |
| 729-737 | Experimental Design and Efficient Parameter Estimation in Preclinical Pharmacokinetic Studies | Ene I. Ette, Catherine A. Howie, Andrew W. Kelman and Brian Whiting |
| 738-745 | Gradient High Performance Liquid Chromatographic Assay for Degradation Products of Adinazolam Mesylate in a Sustained Release Tablet Formulation | Nick L. Stemm, John W. Skoug and Russell H. Robins |
| 746-750 | Quantitative Microdialysis for Studying the in Vivo L-DOPA Kinetics in Blood and Skeletal Muscle of the Dog | Sophie Sarre, Dirk Deleu, Kristel Van Belle, Guy Ebinger and Yvette Michotte |
| 751-755 | The Electrophoretic Mobility of Tripeptides as a Function of pH and Ionic Strength: Comparison with lontophoretic Flux Data | Barbara VanOrman Huff, Gary G. Liversidge and Gregory L. McIntire |
| 756-762 | Analysis of Diclofenac and Four of Its Metabolites in Human Urine by HPLC | Ronald J. Sawchuk, Jill A. Maloney, Linda L. Cartier, Russell J. Rackley and Keith K. H. Chan, et al. |
| 763-767 | Prodrugs to Improve the Oral Bioavailability of a Diacidic Nonpeptide Angiotensin II Antagonist | Bruce J. Aungst, Judy A. Blake, Nancy J. Rogers, Hiroshi Saitoh and Munir A. Hussain, et al. |
| 768-772 | Electrolyte-Induced Changes in Glass Transition Temperatures of Freeze-Concentrated Solutes | Lih-Min Her, Michael Deras and Steven L. Nail |
| 773-779 | Process-Induced Crystallinity Changes in Albuterol Sulfate and Its Effect on Powder Physical Stability | Gary H. Ward and Robert K. Schultz |
| 780-786 | Gastric pH Influences the Appearance of Double Peaks in the Plasma Concentration-Time Profiles of Cimetidine After Oral Administration in Dogs | Vanaja Mummaneni, Gordon L. Amidon and Jennifer B. Dressman |
| 787-789 | Drug Release from Semisolids: Effect of Membrane Permeability on Sensitivity to Product Parameters | Joel L. Zatz |
| 790-795 | Model Features of a Cardiac lontophoretic Drug Delivery Implant | Steven P. Schwendeman, Vinod Labhasetwar and Robert J. Levy |
| 796-798 | Dose-Dependent Brain Delivery of Zidovudine Through the Use of a Zidovudine Chemical Delivery System | Marcus E. Brewster, Wesley R. Anderson, Danny O. Helton, Nicholas Bodor and Emil Pop |
| 799-806 | Molecular Mobility of Amorphous Pharmaceutical Solids Below Their Glass Transition Temperatures | Bruno C. Hancock, Sheri L. Shamblin and George Zografi |
| 807-816 | Human Insulin Receptor Monoclonal Antibody Undergoes High Affinity Binding to Human Brain Capillaries in Vitro and Rapid Transcytosis Through the Blood–Brain Barrier in Vivo in the Primate | William M. Pardridge, Young-Sook Kang, Jody L. Buciak and Jing Yang |
| 817-824 | Radiolabeling of Methylphosphonate and Phosphorothioate Oligonucleotides and Evaluation of Their Transport in Everted Rat Jejunum Sacs | Jeffrey A. Hughes, Anna V. Avrutskaya, Kim L. R. Brouwer, Eric Wickstrom and R. L. Juliano |
| 825-830 | The Fate of Plasmid DNA After Intravenous Injection in Mice: Involvement of Scavenger Receptors in Its Hepatic Uptake | Kenji Kawabata, Yoshinobu Takakura and Mitsuru Hashida |
| 831-837 | Development of an Efficient Single-Step Freeze-Drying Cycle for Protein Formulations | Byeong S. Chang and Norman L. Fischer |
| 838-843 | Increased Stabilizing Effects of Amphiphilic Excipients on Freeze-Drying of Lactate Dehydrogenase (LDH) by Dispersion into Sugar Matrices | Ken-ichi Izutsu, Sumie Yoshioka and Shigeo Kojima |
| 844-850 | Comprehensive Pharmacokinetics of Urinary Human Follicle Stimulating Hormone in Healthy Female Volunteers | J.-Y. le Cotonnec, H. C. Porchet, V. Beltrami, A. Khan and S. Toon, et al. |
| 851-856 | Gamma Irradiation Effects on Molecular Weight and in Vitro Degradation of Poly(D,L-Lactide-CO-Glycolide) Microparticles | Angela G. Hausberger, Richard A. Kenley and Patrick P. DeLuca |
| 857-863 | Controlled Release of a Contraceptive Steroid from Biodegradable and Injectable Gel Formulations: In Vitro Evaluation | Zhi-Hui Gao, Atul J. Shukla, James R. Johnson and William R. Crowley |
| 864-868 | Controlled Release of Contraceptive Steroids from Biodegradable and Injectable Gel Formulations: In Vivo Evaluation | Zhi-hui Gao, William R. Crowley, Atul J. Shukla, James R. Johnson and James F. Reger |
| 869-874 | Soft Drugs 18. Oral and Rectal Delivery of Loteprednol Etabonate, a Novel Soft Corticosteroid, in Rats—for Safer Treatment of Gastrointestinal Inflammation | Nicholas Bodor, Teruo Murakami and Whei-Mei Wu |
| 875-879 | Soft Drugs 19. Pharmacokinetics, Metabolism and Excretion of a Novel Soft Corticosteroid, Loteprednol Etabonate, in Rats | Nicholas Bodor, Whei-Mei Wu, Teruo Murakami and Steven Engel |
| 880-883 | Evaluation of Intestinal Absorption into the Portal System in Enterohepatic Circulation by Measuring the Difference in Portal–Venous Blood Concentrations of Diclofenac | Kenji Tabata, Kiyoshi Yamaoka, Takako Fukuyama and Terumichi Nakagawa |
| 884-888 | Regiospecific Intestinal Absorption of the HIV Protease Inhibitor L-735,524 in Beagle Dogs | Gloria Y. Kwei, Linda B. Novak, Lisa A. Hettrick, Elisabeth R. Reiss and Drazen Ostovic, et al. |
| 889-894 | Method to Estimate the Rate and Extent of Intestinal Absorption in Conscious Rats Using an Absorption Probe and Portal Blood Sampling | Daniel J. Hoffman, Terese Seifert, Anthony Borre and Hugh N. Nellans |
| 895-901 | Interspecies Scaling of Tebufelone Pharmacokinetic Data and Application to Preclinical Toxicology | Charles A. Cruze, Gary R. Kelm and Michael P. Meredith |
| 902-904 | Effect of Corticosteroid Binding Globulin on the Pharmacokinetics of Prednisolone in Rats | Hui C. Ko, Richard R. Almon and William J. Jusko |
| 905-910 | Pharmacokinetic Analysis and Antiepileptic Activity of N-Valproyl Derivatives of GABA and Glycine | Salim Hadad and Meir Bialer |
| 911-915 | Comparative Brain Exposure to (-)-Carbovir After (-)-Carbovir or (-)-6-Aminocarbovir Intravenous Infusion in Rats | Yan-Dong Wen, Rory P. Remmel, Phuong T. Pham, Robert Vince and Cheryl L. Zimmerman |
| 916-922 | Effect of Liposomal and Free Bisphosphonates on the IL-1β, IL-6 and TNFα Secretion from RAW 264 Cells in Vitro | Niina Pennanen, Seppo Lapinjoki, Arto Urtti and Jukka Mönkkönen |
| 923-929 | The Effect of Moisture on the Mechanical and Powder Flow Properties of Microcrystalline Cellulose | Gregory E. Amidon and Michael E. Houghton |
| 930-936 | 5-Bromomethyl Fluorescein (5-BMF) for Derivatization of Carboxyl Containing Analytes for Use with Laser-Induced Fluorescence Detection | Partha S. Mukherjee, Kapila H. DeSilva and H. Thomas Karnes |
| 937-942 | Without Extrapolation, Cmax/AUC is an Effective Metric in Investigations of Bioequivalence | Laszlo Tothfalusi and Laszlo Endrenyi |
| 943-944 | Patient-Oriented Pharmaceutical Research: Focus on the Individual | Gerhard Levy |
| 945-954 | Pharmaceutical Solids: A Strategic Approach to Regulatory Considerations | Stephen Byrn, Ralph Pfeiffer, Michael Ganey, Charles Hoiberg and Guirag Poochikian |
| 955-964 | Diffusion in HPMC Gels. I. Determination of Drug and Water Diffusivity by Pulsed-Field-Gradient Spin-Echo NMR | Ping Gao and Paul E. Fagerness |
| 965-971 | Diffusion in HPMC Gels. II. Prediction of Drug Release Rates from Hydrophilic Matrix Extended-Release Dosage Forms | Ping Gao, Phillip R. Nixon and John W. Skoug |
| 972-982 | A New Method for Estimating Dermal Absorption from Chemical Exposure. 3. Compared with Steady-State Methods for Prediction and Data Analysis | Annette L. Bunge, Robert L. Cleek and Brent E. Vecchia |
| 983-992 | Evaluation of Retinoid Lactones as Topical Therapeutic Agents in Dermatology | Anita H. Lewin, Sherry L. Black, Mary E. Bos, R. Richard Goehring and Xina Nair, et al. |
| 993-997 | In Vitro Percutaneous Absorption of Arildone, a Highly Lipophilic Drug, and the Apparent No-Effect of the Penetration Enhancer Azone in Excised Human Skin | E. J. Baker and J. Hadgraft |
| 998-1002 | Mechanisms Involved in lontophoretic Transport of Angiotensin | Martine Clemessy, Guy Couarraze, Bruno Bevan and Francis Puisieux |
| 1003-1010 | A New Large-Scale Process for Taxol and Related Taxanes from Taxusbrevifolia | Koppaka V. Rao, Jampani B. Hanuman, Claudio Alvarez, Mark Stoy and John Juchum, et al. |
| 1011-1018 | Characterization of Alkylating Versus Intercalating Anticancer Drug-Induced Effects on Cell Survival, Cell Cycle Kinetic and Morphonuclear Pattern of Three Neoplastic Cells Lines Growing in Vitro | Olivier Pauwels, Robert Kiss, Jean-Lambert Pasteels and Ghanem Atassi |
| 1019-1024 | Distribution, Metabolism and Tumoricidal Activity of Doxorubicin Administered in Sorbitan Monostearate (Span 60) Niosomes in the Mouse | Ijeoma F. Uchegbu, John A. Double, John A. Turton and Alexander T. Florence |
| 1025-1030 | Development of a Flow Microcalorimetry Method for the Assessment of Surface Properties of Powders | P. Louise Sheridan, Graham Buckton and David E. Storey |
| 1031-1039 | The Effect of Particle Fragmentation and Deformation on the Interparticulate Bond Formation Process During Powder Compaction | Maria Eriksson and Göran Alderborn |
| 1040-1044 | Improved Static Compression Behaviors and Tablettabilities of Spherically Agglomerated Crystals Produced by the Spherical Crystallization Technique with a Two-Solvent System | Yoshiaki Kawashima, Fude Cui, Hirofumi Takeuchi, Toshiyuki Niwa and Tomoaki Hino, et al. |
| 1045-1048 | Compressed Donut-Shaped Tablets with Zero-Order Release Kinetics | Cherng-ju Kim |
| 1049-1054 | Oral Solid Controlled Release Dosage Forms: Role of GI-Mechanical Destructive Forces and Colonic Release in Drug Absorption Under Fasted and Fed Conditions in Humans | Mohammed Shameem, Noriko Katori, Nobuo Aoyagi and Shigeo Kojima |
| 1055-1059 | Physicochemical, Pharmacokinetic and Pharmacodynamic Evaluation of Liposomal Tacrolimus (FK 506) in Rats | Mi-Jeong Lee, Robert M. Straubinger and William J. Jusko |
| 1060-1064 | Long-Circulating Emulsions (Oil-in-Water) as Carriers for Lipophilic Drugs | Feng Liu and Dexi Liu |
| 1065-1071 | Pharmacokinetics of lopromide Liposomes in Rabbits | Gabriele Schuhmann-Giampieri, Jens Leike, Andreas Sachse and Werner Krause |
| 1072-1076 | Adsorption of Salmon Calcitonin to PLGA Microspheres | Sema Calis, Ramasubbu Jeyanthi, Tsuimin Tsai, Rahul C. Mehta and Patrick P. DeLuca |
| 1077-1084 | Effects of Insulin Concentration and Self-Association on the Partitioning of Its A-21 Cyclic Anhydride Intermediate to Desamido Insulin and Covalent Dimer | Richard T. Darrington and Bradley D. Anderson |
| 1085-1091 | Effect of Aging on the Kinetics of Blood–Brain Barrier Uptake of Tryptophan in Rats | Jian-Ping Tang and Srikumaran Melethil |
| 1092-1095 | Uptake of Fractionated 3H-Heparin by Isolated Rat Kupffer Cells | Jim Watanabe, Masami Haba and Hiroaki Yuasa |
| 1096-1100 | Pharmacokinetic/Pharmacodynamic Evaluation of Deflazacort in Comparison to Methylprednisolone and Prednisolone | Helmut Möllmann, Günther Hochhaus, Shashank Rohatagi, Jürgen Barth and Hartmut Derendorf |
| 1101-1104 | pGlu-L-Dopa-Pro: A Tripeptide Prodrug Targeting the Intestinal Peptide Transporter for Absorption and Tissue Enzymes for Conversion | Jane P. F. Bai |
| 1105-1108 | Differential Induction of UDP-Glucuronosyltransferase Activity and Gene Expression in Rat Liver | Bradley K. Wong, Peiwen Fei and A.-N. Tony Kong |
| 1109-1114 | Hepatic Membrane Transport of Organic Cations Using Isolated Rat Hepatocyte Membrane Vesicles: Structure–Transport Relationships | Younggil Kwon and Marilyn E. Morris |
| 1115-1119 | Permeability of Peptides and Proteins in Human Cultured Alveolar A549 Cell Monolayer | Shinzo Kobayashi, Shuji Kondo and Kazuhiko Juni |
| 1120-1125 | Mechanisms of Transport of Quinapril in Caco-2 Cell Monolayers: Comparison with Cephalexin | Ming Hu, Lixing Zheng, Jiyue Chen, Lijuan Liu and Yanping Zhu, et al. |
| 1126-1133 | Enhanced Oral Bioavailability of DDI After Administration of 6-Cl-ddP, an Adenosine Deaminase-Activated Prodrug, to Chronically Catheterized Rats | Bradley D. Anderson, Michael E. Morgan and Dharmendra Singhal |
| 1134-1139 | Echo-Planar Magnetic Resonance Imaging to Assess Water Volume in the Distal Small Bowel | Dawn A. Adkin, Penny Gowland, Robin C. Spiller, Alan Freeman and Jonathon Hykin, et al. |
| 1140-1145 | Transport of Biologically Active Interferon-gamma Across Human Skin in Vitro | Sarah M. Short, Werner Rubas, Brian D. Paasch and Randall J. Mrsny |
| 1146-1150 | Different Effects of Absorption Promoters on Corneal and Conjunctival Penetration of Ophthalmic Beta-Blockers | Hitoshi Sasaki, Yoshiaki Igarashi, Toshiaki Nagano, Koyo Nishida and Junzo Nakamura |
| 1151-1157 | Effects of Absorption Enhancers on Rat Nasal Epithelium in Vivo: Release of Marker Compounds in the Nasal Cavity | Emmeline Marttin, J. Coos Verhoef, Stefan G. Romeijn and Frans W. H. M. Merkus |
| 1158-1164 | Species Dependent Esterase Activities for Hydrolysis of an Anti-HIV Prodrug Glycovir and Bioavailability of Active SC-48334 | Chyung S. Cook, Peter J. Karabatsos, Grant L. Schoenhard and Aziz Karim |
| 1165-1170 | Metabolism of Dynorphin A 1-13 in Human Blood and Plasma | Stefan Müller and Günther Hochhaus |
| 1171-1175 | Transepithelial Transport of Insulin: I. Insulin Degradation by Insulin-Degrading Enzyme in Small Intestinal Epithelium | Jane P. F. Bai and L. L. Chang |
| 1176-1183 | Preparation and Characterization of Dextran Magnetite-Incorporated Thermosensitive Liposomes: An on-line Flow System for Quantifying Magnetic Responsiveness | Ekapop Viroonchatapan, Masaharu Ueno, Hitoshi Sato, Isao Adachi and Hideo Nagae, et al. |
| 1184-1188 | Influence of Nonionic Liposomal Composition on Topical Delivery of Peptide Drugs into Pilosebaceous Units: An in Vivo Study Using the Hamster Ear Model | Susan M. Niemiec, Chandrasekharan Ramachandran and Norman Weiner |
| 1189-1198 | Liposomal Formulations of Cyclosporin A: Influence of Lipid Type and Dose on Pharmacokinetics | A. Fahr, M. Holz and G. Fricker |
| 1199-1204 | Quantitative Structure Activity Relationships of Catechol Derivatives on Nerve Growth Factor Secretion in L-M Cells | Angeliki Kourounakis and Nicholas Bodor |
| 1205-1210 | The Effect of Electrostatic Charge Interactions on Release Rates of Gentamicin from Collagen Matrices | Manish P. Singh, Joseph Stefko, Janice A. Lumpkin and Joel Rosenblatt |
| 1211-1217 | Polymeric Microspheres Prepared by Spraying into Compressed Carbon Dioxide | Roland Bodmeier, Hui Wang, David J. Dixon, Simon Mawson and Keith P. Johnston |
| 1218-1224 | Measurements of Size Distribution and Density of a Pharmaceutical Fat Emulsion, Using Field-Programmed Sedimentation Field-Flow Fractionation (SdFFF) | Shulamit Levin and Eytan Klausner |
| 1225-1230 | MicroPharm-K, a Microcomputer Interactive Program for the Analysis and Simulation of Pharmacokinetic Processes | Saïk Urien |
| 1231-1237 | Solubilisation of Drugs in Micellar Systems Studied by Eluent Gel Permeation Chromatography | Michael Draper, Matthew Savage, John H. Collett, David Attwood and Colin Price, et al. |
| 1238-1239 | Unbound Total (Plasma) Clearance Approach in Interspecies Pharmacokinetics Correlation: Theophylline-Cimetidine Interaction | Win L. Chiou and Young M. Choi |
| 1240-1243 | Synthesis and Pharmacological Evaluation of Spiro-Analogues of 5-Benzyl-5-ethyl Barbituric Acid | S. Bruce King, Eugene S. Stratford, Charles R. Craig and E. Kim Fifer |
| 1244 | ERRATUM |
| 1245-1246 | EDITORIAL |
| 1247 | The Many Faces of Pharmaceutical Research | Bernard Testa |
| 1248-1249 | Methodologies for Pharmaceutical Effectiveness and Pharmacoeconomics Research | Carol B. Gable |
| 1250-1259 | Optimization of Lyophilization Conditions for Recombinant Human Interleukin-2 by Dried-State Conformational Analysis Using Fourier-Transform Infrared Spectroscopy | Steven J. Prestrelski, Katherine A. Pikal and Tsutomu Arakawa |
| 1260-1263 | Vial Lyophilization: Calculations on Rate Limitation During Primary Drying | Hester Ybema, Lia Kolkman-Roodbeen, Marcel P. W. M. te Booy and Herman Vromans |
| 1264-1268 | Computer Simulation of Tablet Motion in Coating Drum | Kenji Yamane, Toshiharu Sato, Toshitsugu Tanaka and Yutaka Tsuji |
| 1269-1272 | Preparation of Controlled-Release Coevaporates of Dipyridamole by Loading Neutral Pellets in a Fluidized-Bed Coating System | Deniz B. Beten, Karim Amighi and André J. Moës |
| 1273-1278 | Physicochemical Characterization of Parenteral Lipid Emulsion: Influence of Cosurfactants on Flocculation and Coalescence | Tetsuo Yamaguchi, Kaori Nishizaki, Shigeru Itai, Hidefumi Hayashi and Hiroyuki Ohshima |
| 1279-1283 | Hydrophobic Contribution Constants of Amino Acid Residues to the Hydrophobicities of Oligopeptides | Hua Gao, Fengzhen Wang and Eric J. Lien |
| 1284-1288 | Precipitation of Insulinotropin in the Presence of Protamine: Effect of Phenol and Zinc on the Isophane Ratio and the Insulinotropin Concentration in the Supernatant | Yesook Kim and Carol A. Rose |
| 1289-1292 | Cholate-Induced Disruption of Calcitonin-Loaded Liposomes: Formation of Trypsin-Resistant Lipid-Calcitonin-Cholate Complexes | Albertina Ariën, Nelly Toulmé-Henry and Bernard Dupuy |
| 1293-1298 | Mucoadhesive Polymers in Peroral Peptide Drug Delivery. II. Carbomer and Polycarbophil Are Potent Inhibitors of the Intestinal Proteolytic Enzyme Trypsin | Henrik L. Lueßen, J. Coos Verhoef, Gerrit Borchard, Claus-M. Lehr and A. (Bert) G. de Boer, et al. |
| 1299-1303 | The Intestinal Transport Mechanism of Fluoroquinolones: Inhibitory Effect of Ciprofloxacin, an Enoxacin Derivative, on the Membrane Potential-Dependent Uptake of Enoxacin | Takeshi Hirano, Ken Iseki, Izumi Sato, Shozo Miyazaki and Masahiko Takada, et al. |
| 1304-1310 | Possible Involvement of Multiple P-Glycoprotein-Mediated Efflux Systems in the Transport of Verapamil and Other Organic Cations Across Rat Intestine | Hiroshi Saitoh and Bruce J. Aungst |
| 1311-1315 | Regional Gastrointestinal Absorption of Ranitidine in the Rat | Benjamin Suttle and Kim L. R. Brouwer |
| 1316-1322 | Gastrointestinal Transit and Distribution of Ranitidine in the Rat | A. Benjamin Suttle and Kim L. R. Brouwer |
| 1323-1327 | First-Pass Accumulation of Salicylic Acid in Gut Tissue After Absorption in Anesthetized Rat | Young M. Choi, Sang M. Chung and Win L. Chiou |
| 1328-1332 | Drug Delivery Studies in Caco-2 Monolayers. IV. Absorption Enhancer Effects of Cyclodextrins | Lars Hovgaard and Helle Brøndsted |
| 1333-1337 | New Evaluation Method for in Vitro/in Vivo Correlation of Enteric-Coated Multiple Unit Dosage Forms | Takashi Hayashi, Toshihiro Ogura and Yasushi Takagishi |
| 1338-1342 | Development and in Vitro-in Vivo Evaluation of a Multiparticulate Sustained Release Formulation of Diltiazem | Shun Por Li, Robert G. Felt, Louis C. Di Paolo, Mei-Ying Huang and Robert O. Williams III |
| 1343-1349 | The Pulmonary Absorption of Aerosolized and Intratracheally Instilled rhG-CSF and monoPEGylated rhG-CSF | Ralph W. Niven, K. Lane Whitcomb, Linda Shaner, Anna Y. Ip and Olaf B. Kinstler |
| 1350-1353 | Pharmacokinetics of 1 -(2-Deoxy-2-fluoro-β-L-arabino-furanosyl)-5-methyluracil (L-FMAU) in Rats | Jennifer D. Wright, Tianwei Ma, Chung K. Chu and F. Douglas Boudinot |
| 1354-1360 | Absorption of Sunscreens and Other Compounds Through Human Skin inVivo: Derivation of a Method to Predict Maximum Fluxes | Ursula Hagedorn-Leweke and Bernhard C. Lippold |
| 1361-1370 | Hydrolysis of the Prodrug, 2′, 3′, 5′ -Triacetyl-6-azauridine | C. M. Riley, M. A. Mummert, J. Zhou, R. L. Schowen and D. G. Vander Velde, et al. |
| 1371-1375 | Hydroxypropyl-β-Cyclodextrin Increases the Aqueous Solubility and Stability of Pilocarpine Prodrugs | Pekka Jarho, Arto Urtti and Tomi Järvinen |
| 1376-1379 | Measurement of the Diffusion of 2,2,2-trifluoroacetamide Within Thermoresponsive Hydrogels Using NMR Imaging | R. Dinarvand, B. Wood and A. D'Emanuele |
| 1380-1384 | Particle Size Distribution of Single and Multiple Sprays of Salbutamol Metered-Dose Inhalers (MDIs) | Susan J. Graham, Robert C. Lawrence, Eric D. Ormsby and Richard K. Pike |
| 1385-1387 | Influence of Surface Properties on the Inflammatory Response to Polymeric Nanoparticles | Rocío Fernández-Urrusuno, Elias Fattal, Dominique Porquet, Jeanne Féger and Patrick Couvreur |
| 1388-1390 | Evidence for the Lack of a Human Metabolic Isotope Effect of a Deuterium Analog of Fluphenazine | Salim Hadad, John W. Hubbard, Gordon McKay, Edward M. Hawes and Satishche Shrikhande, et al. |
| 1391-1392 | EDITORIAL |
| 1393-1394 | Quo Vadis, Pharmaceutical Sciences, and AAPS? | Wolfgang Sadée |
| 1395-1406 | Cerebrovascular Permeability to Peptides: Manipulations of Transport Systems at the Blood-Brain Barrier | Berislav V. Zlokovic |
| 1407-1416 | Thermosensitive Sterically Stabilized Liposomes: Formulation and in Vitro Studies on Mechanism of Doxorubicin Release by Bovine Serum and Human Plasma | Mohamed H. Gaber, Keelung Hong, Shi Kun Huang and Demetrios Papahadjopoulos |
| 1417-1422 | Application of a Membrane Fusion Assay for Rapid Drug Screening | Steven S. Vogel, Sven Beushausen and David S. Lester |
| 1423-1429 | An Improved Method for Determination of Acid Dissociation Constants of Peptides | Xiaojun Fang, Quintus Fernando, Sydney O. Ugwu and James Blanchard |
| 1430-1434 | Conformational Analysis of Methylphenidate and Its Structural Relationship to Other Dopamine Reuptake Blockers Such as CFT | Mark Froimowitz, Kennerly S. Patrick and Vivian Cody |
| 1435-1438 | Determination of the Surface Tension of Block Copolymer Micelles by Phagocytosis | Alain Rolland, Frank Paul, Katherine M. Stott and Cedric J. Olliff |
| 1439-1446 | Characterization of the MN gp120 HIV-1 Vaccine: Antigen Binding to Alum | Robert P. Weissburg, Phillip W. Berman, Jeffrey L. Cleland, Donna Eastman and Francis Farina, et al. |
| 1447-1452 | A New Strategy for Enhancing the Stability of Lyophilized Protein: The Effect of the Reconstitution Medium on Keratinocyte Growth Factor | Mei Z. Zhang, Jie Wen, Tsutomu Arakawa and Steven J. Prestrelski |
| 1453-1456 | Thermodynamic Study of Sulfanilamide Polymorphism: (I) Monotropy of the α-Variety | Siro Toscani, Sven Thorén, Viatcheslav Agafonov, René Céolin and Jérôme Dugué |
| 1457-1461 | Glycine Crystallization During Freezing: The Effects of Salt Form, pH, and Ionic Strength | Michael J. Akers, Nathaniel Milton, Stephen R. Byrn and Steven L. Nail |
| 1462-1465 | The Effect of Food on Pharmacokinetics of Zalcitabine in HIV-Positive Patients | L. A. Nazareno, A. A. Holazo, R. Limjuco, S. Passe and S. K. Twardy, et al. |
| 1466-1469 | Renal Clearance of a Recombinant Granulocyte Colony-Stimulating Factor, Nartograstim, in Rats | Takashi Kuwabara, You Ishikawa, Hiroyuki Kobayashi, Satoshi Kobayashi and Yuichi Sugiyama |
| 1470-1473 | Snake F(ab′)2 Antivenom from Hyperimmunized Horse: Pharmacokinetics Following Intravenous and Intramuscular Administrations in Rabbits | Stephanie Pepin, Charles Lutsch, Michel Grandgeorge and Jean-Michel Scherrmann |
| 1474-1477 | Pharmacokinetic Studies of Methotrexate in Plasma and Synovial Fluid Following IV Bolus and Topical Routes of Administration in Dogs | G. W. Lu, H. W. Jun, M. T. Dzimianski, H. C. Qiu and J. W. McCall |
| 1478-1482 | Enhanced Intestinal Absorption of Oxytocin Peptide Analogues in the Absence of Pancreatic Juice in Pigs | Pål D. P. Lundin, Stefan Lundin, Håkan Olsson, Börje W. Karlsson and Björn R. Weström, et al. |
| 1483-1487 | Transport Characteristics of Ceftibuten, a New Cephalosporin Antibiotic, via the Apical H+/Dipeptide Cotransport System in Human Intestinal Cell Line Caco-2: Regulation by Cell Growth | Shin-ichi Matsumoto, Hideyuki Saito and Ken-ichi Inui |
| 1488-1492 | Transport Characteristics of S-1090, A New Oral Cephem, in Rat Intestinal Brush-Border Membrane Vesicles | Noriyuki Muranushi, Naofumi Hashimoto and Koichiro Hirano |
| 1493-1498 | Microbial and Mammalian Metabolism Studies on the Semisynthetic Antimalarial, Deoxoartemisinin | Sherief I. Khalifa, John K. Baker, Mankil Jung, James D. McChesney and Charles D. Hufford |
| 1499-1505 | Development and Characterization of Rabbit Tracheal Epithelial Cell Monolayer Models for Drug Transport Studies | Neil R. Mathias, Kwang-Jin Kim, Timothy W. Robison and Vincent H. L. Lee |
| 1506-1512 | Role of Appendages in Skin Resistance and lontophoretic Peptide Flux: Human Versus Snake Skin | W. (Ine) H. M. Craane-van Hinsberg, J. Coos Verhoef, Leo. J. Bax, Hans E. Junginger and Harry E. Boddé |
| 1513-1520 | Controlled Release of Substituted Benzole and Naphthoic Acids Using Carbopol ® Gels: Measurement of Drug Concentration Profiles and Correlation to Release Rate Kinetics | Donna L. French, Bert O. Häglund, Kenneth J. Himmelstein and John W. Mauger |
| 1521-1525 | A Cellular Automata Model of Dissolution | Lemont B. Kier and Chao-Kun Cheng |
| 1526-1529 | A Solubility and Related Physicochemical Property Comparison of Buprenorphine and Its 3-Alkyl Esters | Audra L. Stinchcomb, Rajesh Dua, Anupam Paliwal, Ronald W. Woodard and Gordon L. Flynn |
| 1530-1534 | Age-Related Changes in Pharmacokinetic Parameters of Phenytoin After Liver Resection in Rats | Emi Nakashima, Ryo Matsushita, Yasunori Iida, Tohru Ohshima and Fujio Ichimura |
| 1535-1538 | Influence of Lipophilicity on the Protein Binding Affinity of Cephalosporins | Fabienne Demotes-Mainard Péhourcq, Ahmed Radouane, Laurence Labat and Bernard Bannwarth |
| 1539-1544 | Identification of Enzymatic Degradation Products of Luteinizing Hormone Releasing Hormone (LHRH)/[D-Ala6] LHRH in Rabbit Mucosal Homogenates | Kun Han, Jeong Sook Park, Youn Bok Chung, Mi Jeong Lee and Dong Cheul Moon, et al. |
| 1545-1547 | Poly(D,L-Lactide) Nanocapsules Containing Non-Steroidal Anti-Inflammatory Drugs: Gastrointestinal Tolerance Following Intravenous and Oral Administration | Silvia Stanisçuaski Guterres, Hatem Fessi, Gillian Barratt, Francis Puisieux and Jean-Philippe Devissaguet |
| 1548-1553 | Improved Cellular Delivery of Antisense Oligonucleotides Using Transferrin Receptor Antibody-Oligonucleotide Conjugates | Ian Walker, William J. Irwin and Saghir Akhtar |
| 1554-1555 | BOOK REVIEWS |
| 1557-1559 | EDITORIAL |
| 1560 | WHAT IS THE CURRENT NIGMS SCORING EXPERIMENT? HOW DOES IT WORK? WHAT IS IT ATTEMPTING TO ACCOMPLISH? | Rochelle M. Long |
| 1561-1572 | Lipid Microemulsions for Improving Drug Dissolution and Oral Absorption: Physical and Biopharmaceutical Aspects | Panayiotis P. Constantinides |
| 1573-1582 | Does Fluid Flow Across the Intestinal Mucosa Affect Quantitative Oral Drug Absorption? Is It Time for a Reevaluation? | Hans Lennernäs |
| 1583-1591 | Stabilization of the Hydrophilic Sphere of lobitridol, an lodinated Contrast Agent, as Revealed by Experimental and Computational Investigations | Dominique Meyer, Marie-Hélène Fouchet, Myriam Petta, Pierre-Alain Carrupt and Patrick Gaillard, et al. |
| 1592-1597 | Pharmacokinetics and Anticonvulsant Effect of a New Hypnotic, CL 284,846, in Rats | Jacques Gaudreault, France Varin and Gary M. Pollack |
| 1598-1604 | Human MCAF Gene Transfer Enhances the Metastatic Capacity of a Mouse Cachectic Adenocarcinoma Cell Line in Vivo | Emi Nakashima, Naofumi Mukaida, Yuri Kubota, Kouji Kuno and Kazuo Yasumoto, et al. |
| 1605-1613 | The Electrical Characteristics of Human Skin in Vivo | Yogeshvar N. Kalia and Richard H. Guy |
| 1614-1617 | Apparent pKa of the Fatty Acids Within Ordered Mixtures of Model Human Stratum Corneum Lipids | Renate Lieckfeldt, José Villalaín, Juan-Carlos Gómez-Fernández and Geoffrey Lee |
| 1618-1622 | Effect of PGML Excipient Mixture in a Transdermal System on the in Vitro Transport of Estradiol Across Skin | Gretchen D. Irion, Michael D. Garrison and William Abraham |
| 1623-1627 | Iontophoresis Enhances the Transport of Acyclovir Through Nude Mouse Skin by Electrorepulsion and Electroosmosis | Nadia Maria Volpato, Patrizia Santi and Paolo Colombo |
| 1628-1633 | A Predictive Algorithm for Skin Permeability: The Effects of Molecular Size and Hydrogen Bond Activity | Russell O. Potts and Richard H. Guy |
| 1634-1641 | Evaluation of Bioequivalence of Highly Variable Drugs Using Monte Carlo Simulations. I. Estimation of Rate of Absorption for Single and Multiple Dose Trials Using Cmax | Ahmed A. El-Tahtawy, André J. Jackson and Thomas M. Ludden |
| 1642-1646 | Effect of Omeprazole on Diazepam Disposition in the Rat: in Vitro and in Vivo Studies | K. Zomorodi and J. B. Houston |
| 1647-1651 | Effects of Gender, Pregnancy, and Anesthesia on the Pharmacokinetics of Zidovudine in Rats | Christine S.-H. Huang, F. Douglas Boudinot and Stuart Feldman |
| 1652-1657 | The Problem of Racemization in the Stereospecific Assay and Pharmacokinetic Evaluation of Ketorolac in Human and Rats | Majid Vakily, Brian Corrigan and Fakhreddin Jamali |
| 1658-1663 | Inhibition of Pulmonary Surfactant Biophysical Activity by Cationic Polyamino Acids | Paul M. Bummer, Shewan Aziz and Mark N. Gillespie |
| 1664-1670 | The Application of Crystal Soaking Technique to Study the Effect of Zinc and Cresol on Insulinotropin Crystals Grown from a Saline Solution | Yesook Kim and Anne M. Haren |
| 1671-1676 | Estimation of Recombinant Bovine Somatotropin Solubility by Excluded-Volume Interaction with Polyethylene Glycols | Cynthia L. Stevenson and Michael J. Hageman |
| 1677-1681 | Loading Effect on Particle Size Measurements by Inertial Sampling of Albuterol Metered Dose Inhalers | Moheb M. Nasr and James F. Allgire |
| 1682-1688 | Nebulization of Fluids of Different Physicochemical Properties with Air-Jet and Ultrasonic Nebulizers | Orla N. M. McCallion, Kevin M. G. Taylor, Marian Thomas and Anthony J. Taylor |
| 1689-1693 | A Microcalorimetric Investigation of the Interaction of Surfactants with Crystalline and Partially Crystalline Salbutamol Sulphate in a Model Inhalation Aerosol System | Peter M. Blackett and Graham Buckton |
| 1694-1700 | Structure of Disintegrating Pellets with Regard to Fractal Geometry | Martin Schröder and Peter Kleinebudde |
| 1701-1707 | Thermophysical Properties of Some Pharmaceutical Excipients Compressed in Tablets | Jarkko Ketolainen, L'udovit Kubičár, Vlastimil Boháč, Marián Markovič and Petteri Paronen |
| 1708-1715 | Photoinstability of Some Tyrphostin Drugs: Chemical Consequences of Crystallinity | Narendra Kumar, Vincent Windisch and Herman L. Ammon |
| 1716-1721 | Absorption and Presystemic Metabolism of Nefazodone Administered at Different Regions in the Gastrointestinal Tract of Humans | Punit H. Marathe, Daniel E. Salazar, Douglas S. Greene, John Brennan and Umesh A. Shukla, et al. |
| 1722-1726 | The Site of Absorption in the Small Intestine Determines Diltiazem Bioavailability in the Rabbit | Walid Homsy, Gilles Caillé and Patrick du Souich |
| 1727-1732 | Proton-Cotransport of Pravastatin Across Intestinal Brush-Border Membrane | Ikumi Tamai, Hitomi Takanaga, Hiroshi Maeda, Takuo Ogihara and Masaru Yoneda, et al. |
| 1733-1736 | Sucrose Urinary Excretion in the Rat Measured Using a Simple Assay: A Model of Gastroduodenal Permeability | Neal M. Davies, Brian W. Corrigan and Fakhreddin Jamali |
| 1737-1740 | Contribution of Parenchymal and Non-Parenchymal Liver Cells to the Clearance of Hepatocyte Growth Factor From the Circulation in Rats | Ke-Xin Liu, Yukio Kato, Tetsuya Terasaki, Shoichi Aoki and Kazuo Okumura, et al. |
| 1741-1745 | Evaluation of the Uptake of Pravastatin by Perfused Rat Liver and Primary Cultured Rat Hepatocytes | Michi Ishigami, Taro Tokui, Toru Komai, Kosyo Tsukahara and Masayo Yamazaki, et al. |
| 1746-1755 | Kinetic Analysis of Hepatobiliary Transport for Conjugated Metabolites in the Perfused Liver of Mutant Rats (EHBR) with Hereditary Conjugated Hyperbilirubinemia | Osamu Takenaka, Toru Horie, Kazuo Kobayashi, Hiroshi Suzuki and Yuichi Sugiyama |
| 1756-1760 | Hepatoprotective Activity of Xanthones and Xanthonolignoids Against tert-Butylhydroperoxide-Induced Toxicity in Isolated Rat Hepatocytes—Comparison with Silybin | Eduarda R. Fernandas, Félix D. Carvalho, Fernando G. Remião, Maria Lourdes Bastos and Madalena M. Pinto, et al. |
| 1761-1768 | Gamma-Irradiation of Non-Frozen, Frozen, and Freeze-Dried Liposomes | Nicolaas J. Zuidam, Stephen S. L. Lee and Daan J. A. Crommelin |
| 1769-1774 | Enhanced Therapeutic Effect of Cytidine-5′ -Diphosphate Choline when Associated with GM1 Containing Small Liposomes as Demonstrated in a Rat Ischemia Model | Massimo Fresta, Ernst Wehrli and Giovanni Puglisi |
| 1775-1780 | Antibody Dependent, Complement Mediated Liver Uptake of Liposomes Containing GM1 | Dexi Liu, Young K. Song and Feng Liu |
| 1781-1785 | Drug Release From Hydrocolloid Embeddings with High or Low Susceptibility to Hydrodynamic Stress | Wolfram D. Lindner and Bernhard C. Lippold |
| 1786-1790 | The Release of 5-Fluorouracil from a Swellable Matrix of a Triblock Copolymer of ε-Caprolactone and Ethylene Oxide | Luigi G. A. Martini, John H. Collett and David Attwood |
| 1791-1795 | Ocular Availability of Gentamicin in Small Animals After Topical Administration of a Conventional Eye Drop Solution and a Novel Long Acting Bioadhesive Ophthalmic Drug Insert | Florian Gurtler, Vassilios Kaltsatos, Bernard Boisramé, Jean Deleforge and Marianne Gex-Fabry, et al. |
| 1796-1800 | Biodegradable Delivery System for a Birth Control Vaccine: Immunogenicity Studies in Rats and Monkeys | Manmohan Singh, Om Singh and G. P. Talwar |
| 1801-1805 | Transport of Peptidomimetic Renin Inhibitors Across Monolayers of a Human Intestinal Cell Line (Caco-2): Evidence for Self-Enhancement of Paracellular Transport Route | Elke Walter, Thomas Kissel and Peter Raddatz |
| 1806-1809 | Reconversion of Fosphenytoin in the Presence of Intestinal Alkaline Phosphatase | Christopher N. TenHoor and Barbra H. Stewart |
| 1810-1812 | A Novel Isolation Method of a Stable Crystalline Salt of a Cyclic RGD Peptide Zwitterion | Michael B. Maurin and Munir A. Hussain |
| 1813-1816 | Ionic Strength Dependence of Dissolution for Eudragit S-100 Coated Pellets | Tugrul T. Kararli, Carol F. Kirchhoff and James E. Truelove |
| 1817-1819 | EDITORIAL |
| 1820 | WHAT INFORMATION ABOUT THE NIGMS IS PRESENTLY AVAILABLE ON THE WORLD WIDE WEB? WHAT IS COMING NEXT? | Rochelle M. Long |
| 1821-1822 | Imaging Can Be Much More Than Pretty Pictures | Walter Wolf |
| 1823-1837 | Biology of Membrane Transport Proteins | Wolfgang Sadée, Volkmar Drübbisch and Gordon L. Amidon |
| 1838-1844 | Study on Brain Interstitial Fluid Distribution and Blood-Brain Barrier Transport of Baclofen in Rats by Microdialysis | Yoshiharu Deguchi, Kazimori Inabe, Koichi Tomiyasu, Kenji Nozawa and Shizuo Yamada, et al. |
| 1845-1855 | Population Pharmacokinetic Modeling: The Importance of Informative Graphics | Ene I. Ette and Thomas M. Ludden |
| 1856-1864 | Sensitive and Specific Determination of the Equivalence of Absorption Rates | Laszlo Endrenyi and Passant Al-Shaikh |
| 1865-1868 | An Approach for Widening the Bioequivalence Acceptance Limits in the Case of Highly Variable Drugs | Alexander W. Boddy, Fred C. Snikeris, Robert O. Kringle, Greg C. G. Wei and James A. Oppermann, et al. |
| 1869-1873 | Reverse Iontophoresis: Noninvasive Glucose Monitoring in Vivo in Humans | G. Rao, R. H. Guy, P. Glikfeld, W. R. LaCourse and L. Leung, et al. |
| 1874-1877 | Dose-Dependent Pharmacokinetics of Warfarin in Healthy Volunteers | Shang-Ying P. King, Mark A. Joslin, Karen Raudibaugh, Henry J. Pieniaszek and Irma H. Benedek |
| 1878-1882 | Intra- and Inter-Subject Variabilities of CGP 33101 after Replicate Single Oral Doses of Two 200-mg Tablets and 400-mg Suspension | Wing K. Cheung, Farid Kianifard, Audrey Wong, Josette Mathieu and Terry Cook, et al. |
| 1883-1888 | Prolonged Circulation of Recombinant Human Granulocyte–Colony Stimulating Factor by Covalent Linkage to Albumin Through a Heterobifunctional Polyethylene Glycol | Aimee Guider Paige, K. Lane Whitcomb, Jennifer Liu and Olaf Kinstler |
| 1889-1895 | Systemic Absorption and Activity of Recombinant Consensus Interferons After Intratracheal Instillation and Aerosol Administration | Ralph W. Niven, K. Lane Whitcomb, Melissa Woodward, Jennifer Liu and Concesa Jornacion |
| 1896-1900 | The Effect of Cetylpyridinium Chloride (CPC) on the Cell Surface Hydrophobicity and Adherence of Candida albicansto Human Buccal Epithelial Cells in Vitro | David S. Jones, Leo J. Schep and Max G. Shepherd |
| 1901-1906 | Extensive Absorption of 2′,3′-Dideoxyinosine by Intratracheal Administration in Rats | Xiang Gao, M. Guillaume Wientjes and Jessie L.-S. Au |
| 1907-1916 | Diffusion of an Anti-Transferrin Receptor Antibody in Cultured Murine Melanoma Cell Layers | Venkatramani Vijaykumar and Elizabeth M. Topp |
| 1917-1923 | A Semisynthetic Quillaja Saponin as a Drug Delivery Agent for Aminoglycoside Antibiotics | Joanne Recchia, Maria H. A. Lurantos, Jennifer A. Amsden, James Storey and Charlotte R. Kensil |
| 1924-1931 | The Use of Intracerebral Microdialysis for the Determination of Pharmacokinetic Profiles of Anticancer Drugs in Tumor-Bearing Rat Brain | E. C. M. de Lange, J. D. de Vries, C. Zurcher, M. Danhof and A. G. de Boer, et al. |
| 1932-1936 | Transport of a Hydrophilic Compound into the Cerebrospinal Fluid During Experimental Allergic Encephalomyelitis and After Lipopolysaccharide Administration | Helga E. de Vries, Elaine F. Eppens, Martine Prins, Johan Kuiper and Theo J. C. van Berkel, et al. |
| 1937-1942 | A Novel Oligodeoxynucleotide Inhibitor of Thrombin. I. In VitroMetabolic Stability in Plasma and Serum | Jeng-Pyng Shaw, James A. Fishback, Kenneth C. Cundy and William A. Lee |
| 1943-1947 | A Novel Oligodeoxynucleotide Inhibitor of Thrombin. II. Pharmacokinetics in the Cynomolgus Monkey | William A. Lee, James A. Fishback, Jeng-Pyng Shaw, Louis C. Bock and Linda C. Griffin, et al. |
| 1948-1952 | Acceleration of Nitric Oxide (NO) Release from FK409, a Spontaneous NO Releaser, in the Presence of Sulfhydryl-bearing Compounds | Shinichi Fukuyama, Yoshimi Hirasawa, Dermot Cox, Shigetaka Koda and Yasuhiro Kita |
| 1953-1957 | Effect of Acute Renal Failure on Neurotoxicity of Cimetidine in Rats | Yu Nakada, Koujirou Yamamoto, Junichi Kawakami, Yasufumi Sawada and Tatsuji Iga |
| 1958-1963 | Renal Disposition and Drug Interaction Screening of (–)-2′-deoxy-3′-thiacytidine (3TC) in the Isolated Perfused Rat Kidney | Kevin R. Sweeney, Poe-Hirr Hsyu, Paul Statkevich and David R. Taft |
| 1964-1967 | Effect of Probenecid on the Enantioselective Pharmacokinetics of Oxprenolol and Its Glucuronides in the Rabbit | Martine E. Laethem, Frans M. Belpaire, Pascal Wijnant and Marc G. Bogaert |
| 1968-1972 | Characterization of LLC-PK1 Kidney Epithelial Cells as an in Vitro Model for Studying Renal Tubular Reabsorption of Protein Drugs | Yoshinobu Takakura, Takahiro Morita, Makoto Fujikawa, Mitsuko Hayashi and Hitoshi Sezaki, et al. |
| 1973-1979 | Vitamin K Prodrugs: 2. Water-Soluble Prodrugs of Menahydroquinone-4 for Systemic Site-Specific Delivery | Jiro Takata, Yoshiharu Karube, Mitsunobu Hanada, Kazuhisa Matsunaga and Yoshikazu Matsushima, et al. |
| 1980-1986 | Regional Drug Delivery I: Permeability Characteristics of the Rat 6-Day-Old Air Pouch Model of Inflammation | Steven W. Martin, Alexander J. Stevens, Beverley S. Brennan, Marina L. Reis and Lawrence A. Gifford, et al. |
| 1987-1996 | Regional Drug Delivery II: Relationship Between Drug Targeting Index and Pharmacokinetic Parameters for Three Non-Steroidal Anti-Inflammatory Drugs Using the Rat Air Pouch Model of Inflammation | Alexander J. Stevens, Steven W. Martin, Beverley S. Brennan, Andrew McLachlan and Lawrence A. Gifford, et al. |
| 1997-2002 | Controlled Release of Lidocaine from Injectable Gels and Efficacy in Rat Sciatic Nerve Block | Anne Paavola, Jouko Yliruusi, Yoji Kajimoto, Eija Kalso and Torsten Wahlström, et al. |
| 2003-2011 | Accurate Determination of Skin Flux from Flow-Through Diffusion Cell Data | Daniel J. Harrison and Kristine Knutson |
| 2012-2017 | Use of Drug Kinetics in Dermis to Predict in VivoBlood Concentration After Topical Application | Xiang Gao, M. Guillaume Wientjes and Jessie L.-S. Au |
| 2018-2023 | Radial Spread of Sodium Lauryl Sulfate After Topical Application | Sunita Patil, Parminder Singh and Howard Maibach |
| 2024-2029 | Absorption of an Oxytocin Antagonist (Antocin) and a Vasopressin Analogue (dDAVP) Through a Standardized Skin Erosion in Volunteers | Stefan Lundin, Pål Svedman, Peter Höglund, Karin Jönsson and Anja Breeders, et al. |
| 2030-2035 | Analysis of Drug Distribution in Hydrogels Using Fourier Transform Infrared Microscopy | Mary Tanya am Ende and Nikolaos A. Peppas |
| 2036-2040 | A Graphical Method for the Determination of the Mode of Hydrolysis of Biodegradable Polymers | Chung Shih |
| 2041-2048 | Calculation of Hydrolytic Rate Constants of Poly(ortho ester)s from Molecular Weights Determined by Gel Permeation Chromatography | Chung Shih |
| 2049-2052 | Oxidation of Recombinant Human Parathyroid Hormone: Effect of Oxidized Position on the Biological Activity | Yoshiaki Nabuchi, Eri Fujiwara, Kenjyu Ueno, Hitoshi Kuboniwa and Yoshinori Asoh, et al. |
| 2053-2056 | Regioselectivity and Enantioselectivity of Metoprolol Oxidation by Two Variants of cDNA-Expressed P4502D6 | Douglas S. Mautz, Danny D. Shen and Wendel L. Nelson |
| 2057-2059 | The Effects of Sub-Inhibitory Concentrations of Cationic, Non-Antibiotic, Antimicrobial Agents on the Morphogenesis of Candida albicans in Vitro | David S. Jones |
| 2060-2064 | Biodegradable Indium-111 Labeled Microspheres for in Vivo Evaluation of Distribution and Elimination | Bagavathikanun C. Thanoo, Walter J. Doll, Rahul C. Mehta, George A. Digenis and Patrick P. DeLuca |
| 2065-2070 | The Effect of Absorption Enhancers on the Oral Absorption of the GP IIB/IIIA Receptor Antagonist, DMP 728, in Rats and Dogs | Deborah L. Burcham, Bruce A. Aungst, Munir Hussain, Mary Ann Gorko and Check Y. Quon, et al. |
| 2071-2074 | Use of Parent Drug and Metabolite Data in Bioavailability Assessment of a Novel Diltiazem HC1 Once-Daily Product | Okponanabofa Eradiri and Kamal K. Midha |
| 2075-2078 | AAPS Workshop on Designing the Global Chemistry, Manufacturing, and Controls (CMC) Dossier | Christine Carrico |
| 2079-2081 | Reviewers for Pharmaceutical Research January through October 1995 |
| 2082-2086 | Author Index to Volume 12 (1995) |
| 2087-2095 | Subject Index to Volume 12 (1995) |
| 1-5 | Editorial |
| 6-9 | AAPS/USP Workshop on Dissolution Calibration and Testing | Christine K. Carrico |
| 10-11 | How Much Compliance Is Enough? | John Urquhart |
| 12-17 | Intravenous Microdialysis in the Mouse and the Rat: Development and Pharmacokinetic Application of a New Probe | Pierre A. Evrard, G. Deridder and Roger K. Verbeeck |
| 18-22 | Concentration-Dependent Plasma Protein Binding of Flurbiprofen in the Rat: An in Vivo Microdialysis Study | Pierre A. Evrard, Jean Cumps and Roger K. Verbeeck |
| 23-26 | An Integrated Method to Determine Epithelial Transport and Bioactivity of Oral Drug Candidates in Vitro | Werner Rubas, Mary E. M. Cromwell, Randall J. Mrsny, Gladys Ingle and Kathleen A. Elias |
| 27-31 | Targeting of Drug to the Hepatocytes by Fatty Acids. Influence of the Carrier (Albumin or Galactosylated Albumin) on the Fate of the Fatty Acids and Their Analogs | Vinciane Charbon, Isabella Latour, Didier M. Lambert, Pedro Buc-Calderon and Laurence Neuvens, et al. |
| 32-37 | Albumin Nanospheres as Carriers for Passive Drug Targeting: An Optimized Manufacturing Technique | Bernhard G. Müller, Hans Leuenberger and Thomas Kissel |
| 38-43 | Pharmacokinetics and Biodistribution of Oligonucleotide Adsorbed onto Poly(isobutylcyanoacrylate) Nanoparticles After Intravenous Administration in Mice | Yuichiro Nakada, Elias Fattal, Monique Foulquier and Patrick Couvreur |
| 44-51 | Physicochemical Characterization of Protein-Free Low Density Lipoprotein Models and Influence of Drug Loading | Astrid Gerke, Kirsten Westesen and Michel H. J. Koch |
| 52-56 | The Influence of Buffer Species and Strength on Diltiazem HC1 Release from Beads Coated with the Aqueous Cationic Polymer Dispersions, Eudragit RS, RL 30D | Roland Bodmeier, Xiaodi Guo, Rafael E. Sarabia and Paul F. Skultety |
| 57-61 | Enhanced Cellular Uptake of Oligonucleotides by EGF Receptor-Mediated Endocytosis in A549 Cells | Deepa Deshpande, David Toledo-Velasquez, Deepak Thakkar, WeiWen Liang and Yon Rojanasakul |
| 62-69 | Derivatives of Dexanabinol. I. Water-Soluble Salts of Glycinate Esters | Emil Pop, Zong Zheng Liu, Marcus E. Brewster, Yechezkel Barenholz and Veronica Korablyov, et al. |
| 70-75 | Acyloxymethyl as a Drug Protecting Group. Part 3. Tertiary O-Amidomethyl Esters of Penicillin G: Chemical Hydrolysis and Anti-Bacterial Activity | Rui Moreira, Teresa Calheiros, José Cabrita, Eduarda Mendes and Madalena Pimentel, et al. |
| 76-79 | Effects of Phospholipid Chain Length, Concentration, Charge, and Vesicle Size on Pulmonary Insulin Absorption | Yuping Li and Ashim K. Mitra |
| 80-83 | Pulmonary Delivery of Salmon Calcitonin Dry Powders Containing Absorption Enhancers in Rats | Shinzo Kobayashi, Shuji Kondo and Kazuhiko Juni |
| 84-90 | A Pharmacokinetic Approach for Evaluating Cytokine Binding Macromolecules as Antagonists | Murali Ramanathan |
| 91-96 | Pharmacokinetic-Pharmacodynamic Modeling of the Antibiotic Effect of Piperacillin in Vitro | Arno Nolting, Teresa Dalla Costa, Kenneth H. Rand and Hartmut Derendorf |
| 97-101 | Interspecies Scaling of Bosentan, A New Endothelin Receptor Antagonist and Integration of in Vitro Data into Allometric Scaling | Thierry Lave, Philippe Coassolo, Geneviève Ubeaud, Roger Brandt and Christophe Schmitt, et al. |
| 102-107 | Enteral Bioavailability of Human Granulocyte Colony Stimulating Factor Conjugated with Poly(ethylene glycol) | Kathleen E. Jensen-Pippo, K. Lane Whitcomb, Randolph B. DePrince, Lloyd Ralph and Alan D. Habberfield |
| 108-113 | Determining Intestinal Metabolism and Permeability for Several Compounds in Rats. Implications on Regional Bioavailability in Humans | Patrick J. Sinko and Peidi Hu |
| 114-119 | Intestinal Absorption Barriers and Transport Mechanisms, Including Secretory Transport, for a Cyclic Peptide, Fibrinogen Antagonist | Bruce J. Aungst and Hiroshi Saitoh |
| 120-123 | In Vitro Permeability Through Caco-2 Cells is not Quantitatively Predictive of in Vivo Absorption for Peptide-Like Drugs Absorbed via the Dipeptide Transporter System | Saeho Chong, Sandra A. Dando, Kathleen M. Soucek and Richard A. Morrison |
| 124-128 | First-Pass Metabolism of Diltiazem in Anesthetized Rabbits: Role of Extrahepatic Organs | Marc Lefebvre, Walid Homsy, Gilles Caillé and Patrick du Souich |
| 129-136 | Atom Level Electrotopological State Indexes in QSAR: Designing and Testing Antithyroid Agents | Rafiq R. A. Abou-Shaaban, Hamad A. Al-Khamees, Hisham S. Abou-Auda and Anthony. P. Simonelli |
| 137-140 | FK506 (Tacrolimus) and Its Immunoreactive Metabolites in Whole Blood of Liver Transplant Patients and Subjects with Mild Hepatic Dysfunction | Yuji Tokunaga and Ala M. Alak |
| 141-145 | Liposomal Methylprednisolone in Rats: Dose-Proportionality and Chronic-Dose Pharmacokinetics/Pharmacodynamics | Elena V. Mishina and William J. Jusko |
| 146-150 | Maltodextrins as Lyoprotectants in the Lyophilization of a Model Protein, LDH | Sam Corveleyn and Jean-Paul Remon |
| 151-154 | Polymorphism of Sulfanilamide: (II) Stability Hierarchy of α-, β- and γ- Forms from Energy Calculations by the Atom-Atom Potential Method and from the Construction of the p, T Phase Diagram | S. Toscani, A. Dzyabchenko, V. Agafonov, J. Dugué and R. Céolin |
| 155-162 | Effect of Change in Shape Factor of a Single Crystal on Its Dissolution Behavior | Mandar V. Dali and J. T. Carstensen |
| 163-167 | Estimation of the Increase in Solubility of Drugs as a Function of Bile Salt Concentration | Sabena D. Mithani, Vassiliki Bakatselou, Christopher N. TenHoor and Jennifer B. Dressman |
| 168-172 | Percutaneous Absorption of Ketoprofen from Different Anatomical Sites in Man | Ajit K. Shah, Greg Wei, Robert C. Lanman, Vijay O. Bhargava and Scott J. Weir |
| 173-178 | The Effect of Octanoic Acid on the Binding of the Enantiomers of Ibuprofen and Naproxen to Human Serum Albumin: A Chromatographic Implication | Vandana K. Cheruvallath, Christopher M. Riley, Sunanda R. Narayanan, Siegfried Lindenbaum and John H. Perrin |
| 179-182 | Triazolines 34. Structure and Stability Relationships of Novel Δ2-l,2,3-Triazoline Anticonvulsants | Albert H. L. Chow, Francis C. K. Chiu, L. A. Damani and Pankaja K. Kadaba |
| 183 | ERRATUM |
| 185 | WHAT ARE THE DIFFERENCES BETWEEN A REQUEST FOR APPLICATION (RFA) AND A PROGRAM ANNOUNCEMENT (PA)? WHAT ARE THE ADVANTAGES AND DISADVANTAGES OF EACH? | Rochelle M. Long |
| 186-195 | Erythrocytes and the Transport of Drugs and Endogenous Compounds | Martin S. Highley and Ernst A. De Bruijn |
| 196-201 | Temperature and pH-sensitive Polymers for Human Calcitonin Delivery | Anne Serres, Miroslav Baudyš and Sung Wan Kim |
| 202-209 | The Influence of Sodium Glycocholate and Other Additives on the in vivo Transfection of Plasmid DNA in the Lungs | Daniel J. Freeman and Ralph W. Niven |
| 210-215 | Water-in-Oil Microemulsions Containing Medium-chain Fatty Acids/Salts: Formulation and Intestinal Absorption Enhancement Evaluation | Panayiotis P. Constantinides, Gus Welzel, Harma Ellens, Philip L. Smith and Sandra Sturgis, et al. |
| 216-221 | Comparison of HT29-18-C1 and Caco-2 Cell Lines as Models for Studying Intestinal Paracellular Drug Absorption | Andrew Collett, Erika Sims, David Walker, Yan-Ling He and John Ayrton, et al. |
| 222-226 | Oral Delivery of Sodium Cromolyn: Preliminary Studies In Vivo and In Vitro | Andrea Leone-Bay, Harry Leipold, Donald Sarubbi, Bruce Variano and Theresa Rivera, et al. |
| 227-233 | Effects of Structural Modifications on the Intestinal Permeability of Angiotensin II Receptor Antagonists and the Correlation of In Vitro, In Situ, and In Vivo Absorption | Maria D. Ribadeneira, Bruce J. Aungst, Charles J. Eyermann and Shiew-Mei Huang |
| 234-237 | Near-Infrared Spectroscopic Monitoring of the Film Coating Process | John D. Kirsch and James K. Drennen |
| 238-242 | Aggregation of rhDNase Occurred During the Compression of KBr Pellets Used for FTIR Spectroscopy | Hak-Kim Chan, Boonsri Ongpipattanakul and Jacky Au-Yeung |
| 243-249 | Development of a Stable Freeze-dried Formulation of Recombinant Human Interleukin-1 Receptor Antagonist | Byeong S. Chang, Gail Reeder and John F Carpenter |
| 250-255 | Oxidative Degradation of Antiflammin 2 | Jennifer M. Ye and Janet L. Wolfe |
| 256-264 | The Interaction of Charged and Uncharged Drugs with Neutral (HP-β-CD) and Anionically Charged (SBE7-β-CD) β-Cyclodextrins | Kazuto Okimoto, Roger A. Rajewski, Kaneto Uekama, Janan A. Jona and Valentino J. Stella |
| 265-271 | Interaction Between Superoxide Dismutase and Dipalmitoylphosphotidylglycerol Bilayers: A Fourier Transform Infrared (FT-IR) Spectroscopic Study | Yu-Li Lo and Yueh-Erh Rahman |
| 272-278 | Formulation and Antitumor Activity Evaluation of Nanocrystalline Suspensions of Poorly Soluble Anticancer Drugs | E. Merisko-Liversidge, P. Sarpotdar, J. Bruno, S. Hajj and L. Wei, et al. |
| 279-283 | The Effects of Ageing on the Rheological, Dielectric and Mucoadhesive Properties of Poly(Acrylic Acid) Gel Systems | Slobodanka Tamburic and Duncan Q. M. Craig |
| 284-289 | Pharmacokinetic Analysis and Antiepileptic Activity of Tetra-Methylcyclopropane Analogues of Valpromide | Meir Bialer, Salim Hadad, Bashier Kadry, Ali Abdul-Hai and Abdulla Haj-Yehia, et al. |
| 290-295 | Transport of Dopamine at the Blood-Brain Barrier of the Guinea Pig: Inhibition by Psychotropic Drugs and Nicotine | Cynthia L. Martel, Jasmina B. Mackic, James D. Adams, J. Gordon McComb and Martin H. Weiss, et al. |
| 296-300 | Analgesic and Immunomodulatory Effects of Codeine and Codeine 6-glucuronide | Vinayak Srinivasan, Donna Wielbo, James Simpkins, Janet Karlix and Kenneth Sloan, et al. |
| 301-304 | Effect of Cimetidine on the Pharmacokinetics and Pharmacodynamics of Chlorpheniramine and Diphenhydramine in Rabbits | Keith J. Simons, Xueyu Chen, Terry G. Eraser and F. Estelle R. Simons |
| 305-310 | Enhanced Tumor Delivery and Antitumor Activity of Palmitoyl Rhizoxin Using Stable Lipid Emulsions in Mice | Atsushi Kurihara, Yoko Shibayama, Atsuko Mizota, Akiko Yasuno and Masaru Ikeda, et al. |
| 311-315 | Polyester Nanocapsules as New Topical Ocular Delivery Systems for Cyclosporin A | Pilar Calvo, Alejandro Sánchez, Jesús Martínez, María Isabel López and Margarita Calonge, et al. |
| 316-323 | Ion-Pairing Interactions between 99MTc-Based Myocardial Imaging Agents and Oleic Acid | Charles M. Heard and Jonathan Hadgraft |
| 324-328 | Tmax: An Unconfounded Metric for Rate of Absorption in Single Dose Bioequivalence Studies | Rodney P. Basson, Benito J. Cerimele, Karl A. DeSante and Daniel C. Howey |
| 329-333 | Kinetics of Swelling of Compressed Cellulose Matrices: A Mathematical Model | Tamotsu Koizumi, Suwannee P. Panomsuk, Tomomi Hatanaka and Kazunori Katayama |
| 335-343 | Lipophilicity in Molecular Modeling | Bernard Testa, Pierre-Alain Carrupt, Patrick Gaillard, Frédéric Billois and Peter Weber |
| 344-351 | Targeted Drug Delivery for Boron Neutron Capture Therapy | Samir C. Mehta and D. Robert Lu |
| 352-359 | Preparation and Characterization of Doxorubicin-Loaded Sterically Stabilized Immunoliposomes | Noam Emanuel, Eli Kedar, Elijah M. Bolotin, Nechama I. Smorodinsky and Yechezkel Barenholz |
| 360-367 | A Novel Method of Preparing PLGA Microcapsules Utilizing Methylethyl Ketone | Hongkee Sah, Melissa S. Smith and Rey T. Chern |
| 368-375 | Development of a Polymeric Surgical Paste Formulation for Taxol | Charles I. Winternitz, John K. Jackson, Ann Marie Oktaba and Helen M. Burt |
| 376-380 | Structure and Behavior in Hydrophilic Matrix Sustained Release Dosage Forms: 4. Studies of Water Mobility and Diffusion Coefficients in the Gel Layer of HPMC Tablets Using NMR Imaging | Ali R. Rajabi-Siahboomi, Richard W. Bowtell, Peter Mansfield, Martyn C. Davies and Colin D. Melia |
| 381-386 | Determination of Tablet Coating Distribution by Deconvolution of Uncoated and Coated Tablet Weight Distributions | Ji Zhou, Todd Williams, Herman Swopes and Thomas Hale |
| 387-390 | Relationship Between Drug Percolation Threshold and Particle Size in Matrix Tablets | Isidore Caraballo, Mónica Millan and Antonio María Rabasco |
| 391-397 | A Cascade Impactor Entry Port for MDI Sprays with Collection Characteristics Imitating a Physical Model of the Human Throat | Nicholas C. Miller and Annette M. Purrington |
| 398-403 | The Simultaneous Estimation of the Influx and Efflux Blood-Brain Barrier Permeabilities of Gabapentin Using a Microdialysis-Pharmacokinetic Approach | Yanfeng Wang and Devin R Welty |
| 404-410 | Evaluation of Adjuvants that Enhance the Effectiveness of Antisense Oligodeoxynucleotides | J. A. Hughes, A. I. Aronsohn, A. V. Avrutskaya and R. L. Juliano |
| 411-420 | Transdermal Drug Delivery Using Low-Frequency Sonophoresis | Samir Mitragotri, Daniel Blankschtein and Robert Langer |
| 421-426 | Non Steady-state Descriptions of Drug Permeation Through Stratum Corneum. I. The Biphasic Brick-and-Mortar Model | Michael Heisig, Renate Lieckfeldt, Gabriel Wittum, George Mazurkevich and Geoffrey Lee |
| 427-432 | Theoretical Design of Prodrug-Enhancer Combination Based on a Skin Diffusion Model: Prediction of Permeation of Acyclovir Prodrugs Treated with l-Geranylazacycloheptan-2-one | Hiroto Bando, Toshihide Takagi, Fumiyoshi Yamashita, Yoshinobu Takakura and Mitsuru Hashida |
| 433-439 | Effect of Nonionic Surfactant on Transport of Model Drugs in Emulsions | Kyung Ae Yoon and Diane J. Burgess |
| 440-444 | Effect of Food on the Bioavailability of SDZ DJN 608, an Oral Hypoglycemic Agent, from a Tablet and a Liquid-Filled Capsule in the Dog | Francis L. S. Tse, D. Labbadia, K. Habucky, A. Karara and S. Au |
| 445-448 | Pharmacokinetics, Bioavailability, and Safety of Montelukast Sodium (MK-0476) in Healthy Males and Females | Haiyung Cheng, Jonathan A. Leff, Raju Amin, Barry J. Gertz and Marina De Smet, et al. |
| 449-452 | The Effect of Probenecid on the Pharmacokinetics of Zalcitabine in HIV-Positive Patients | J. W. Massarella, L. A. Nazareno, S. Passe and B. Min |
| 453-456 | Absorption Rate Vs. Exposure: Which Is More Useful for Bioequivalence Testing? | Thomas N. Tozer, Frédéric Y. Bois, Walter W. Hauck, Mei-Ling Chen and Roger L. Williams |
| 457-461 | Nicanartine Improves in Vitro Resistance of Lipoproteins to Oxidation | Eric Dailly, Saïk Urien, Petra Wülfroth and Jean Paul Tillement |
| 462-468 | Differences in Lipoprotein Concentration and Composition Modify the Plasma Distribution of Free and Liposomal Annamycin | Kishor M. Wasan and Richard E. Morton |
| 469-475 | Derivatives of Dexanabinol. II. Salts of Amino Acid Esters Containing Tertiary and Quaternary Heterocyclic Nitrogen with Increased Water-Solubility | Emil Pop, Ferenc Soti, Marcus E. Brewster, Yechezkel Barenholz and Veronica Korablyov, et al. |
| 476-480 | Anti-Inflammatory and Antishock Water-Soluble Polyesters of Glucocorticoids with Low Level Systemic Toxicity | Serguei L. Timofeevski, Evgeny F. Panarin, Oleg L. Vinogradov and Michail V. Nezhentsev |
| 481-484 | Characterization of the Salts of a Cyclic RGB Peptide | Michael B. Maurin, Susan M. Rowe, Arlene Rockwell, C. M. Foris and Munir A. Hussain |
| 485-487 | pH-Sensitive Nanoparticles: An Effective Means to Improve the Oral Delivery of HIV-1 Protease Inhibitors in Dogs | Jean-Christophe Leroux, Robert M. Cozens, Johannes L. Roesel, Bruno Galli and Eric Doelker, et al. |
| 489-496 | Microtubule-based Motor Proteins: New Targets for Enhancing Drug Delivery? | Sarah F. Hamm-Alvarez |
| 497-513 | Recent Advances in Carrier-mediated Hepatic Uptake and Biliary Excretion of Xenobiotics | Masayo Yamazaki, Hiroshi Suzuki and Yuichi Sugiyama |
| 514-522 | Evidence for Intestinal Secretion as an Additional Clearance Pathway of Talinolol Enantiomers: Concentration- and Dose-dependent Absorption in Vitro and in Vivo | Ulrike Wetterich, Hildegard Spahn-Langguth, Ernst Mutschler, Bernd Terhaag and Wolfgang Rösch, et al. |
| 523-527 | Characterization of the Transport Properties of a Quinolone Antibiotic, Fleroxacin, in Rat Choroid Plexus | Tsuyoshi Ooie, Hiroshi Suzuki, Tetsuya Terasaki and Yuichi Sugiyama |
| 528-534 | The Use of Surfactants to Enhance the Permeability of Peptides Through Caco-2 Cells by Inhibition of an Apically Polarized Efflux System | Manoj M. Nerurkar, Philip S. Burton and Ronald T. Borchardt |
| 535-541 | Diffusivity of Bile Salt/Phospholipid Aggregates in Mucin | Ching-Yuan Li, Cheryl L. Zimmerman and Timothy S. Wiedmann |
| 542-546 | The Relative Effect of Azone® and Transcutol® on Permeant Diffusivity and Solubility in Human Stratum Corneum | Julian E. Harrison, Adam C. Watkinson, Darren M. Green, Jonathan Hadgraft and Keith Brain |
| 547-552 | Response Surface Method: A Novel Strategy to Optimize lontophoretic Transdermal Delivery of Thyrotropin-releasing Hormone | Yi-You Huang, Shian-Min Wu and Cheng-Yi Wang |
| 553-558 | Iontophoresis of Bases, Nucleosides, and Nucleotides | Ronald van der Geest, Frédérique Hueber, Francis C. Szoka and Richard H. Guy |
| 559-565 | Transdermal Delivery of Fentanyl by Electroporation I. Influence of Electrical Factors | Rita Vanbever, Eric Le Boulengé and Véronique Préat |
| 566-569 | Theoretical Considerations on Two Equations for Estimating the Extent of Absorption After Oral Administration of Drugs | Younggil Kwon and Philip B. Inskeep |
| 570-576 | Analysis of Intestinal Perfusion Data for Highly Permeable Drugs Using a Numerical Aqueous Resistance—Nonlinear Regression Method | P. J. Sinko, G. D. Leesman, A. P. Waclawski, H. Yu and J. H. Kou |
| 577-582 | Effects of Transfection with the Cu, Zn-Superoxide Dismutase Gene on Xanthine/Xanthine Oxidase-Induced Cytotoxicity in Fibroblasts from Rat Skin | Kohshi Nishiguchi, Kazue Ishida, Masanori Nakajima, Tetsuo Maeda and Fusao Komada, et al. |
| 583-587 | The Effect of Formulation on the Antimicrobial Activity of Cetylpyridinium Chloride in Candy Based Lozenges | R. Michael E. Richards, James Z. Xing and Lindsay F. C. Weir |
| 588-593 | Preparation and Characterization of Freeze-dried Chitosan-Poly(Ethylene Oxide) Hydrogels for Site-Specific Antibiotic Delivery in the Stomach | Vijay R. Patel and Mansoor M. Amiji |
| 594-598 | Relationship Between Gelation Rate of Controlled-release Acetaminophen Tablets Containing Polyethylene Oxide and Colonic Drug Release in Dogs | Kazuhiro Sako, Hiroshi Nakashima, Toyohiro Sawada and Muneo Fukui |
| 599-603 | Disposition Characteristics of Plasmid DNA in the Single-pass Rat Liver Perfusion System | Mitsunobu Yoshida, Ram I. Mahato, Kenji Kawabata, Yoshinobu Takakura and Mitsuru Hashida |
| 604-610 | Immunoliposomes as Enzyme-Carriers (Immuno-Enzymosomes) for Antibody-Directed Enzyme Prodrug Therapy (ADEPT): Optimization of Prodrug Activating Capacity | Monique H. Vingerhoeds, Hidde J. Haisma, Sheila O. Belliot, Roefke H. P. Smit and Daan J. A. Crommelin, et al. |
| 611-615 | Determination of R(+)- and S(–)-Lansoprazole Using Chiral Stationary-Phase Liquid Chromatography and Their Enantioselective Pharmacokinetics in Humans | Hisakazu Katsuki, Hatsumi Yagi, Kazuhiko Arimori, Chizuko Nakamura and Masahiro Nakano, et al. |
| 616-621 | Use of Near-Infrared Spectroscopy to Evaluate an Active in a Film Coated Tablet | Bruce R. Buchanan, Mark A. Baxter, T.-Show Chen, Xue-Zhi Qin and Priscilla A. Robinson |
| 622-627 | The Binding of Cyclosporin A to Human Plasma: An in Vitro Microdialysis Study | Hua Yang and William F. Elmquist |
| 628-632 | Pharmacokinetic Interaction Between Intravenous 2′,3′-Dideoxyinosine and Pentamidine in Rats | Teng-Kuang Yeh, Hyo-Jeong K. Kang, M. Guillaume Wientjes and Jessie L.-S. Au |
| 633-638 | Synergistic Effect of Electric Field and Ultrasound on Transdermal Transport | Joseph Kost, Uwe Pliquett, Samir Mitragotri, Aye Yamamoto and Robert Langer, et al. |
| 639-642 | Effects on the Pharmacokinetics and Pharmacodynamics in the Elderly of Coadministering Ramipril with Water, Apple Juice, and Applesauce | I-Der Lee, Thomas L. Hunt, Charles R. Bradley, Carol Copp and Lynne Griffiths, et al. |
| 643-646 | The Effect of the Reconstitution Medium on Aggregation of Lyophilized Recombinant Interleukin-2 and Ribonuclease A | Mei Z. Zhang, Katherine Pikal, Thai Nguyen, Tsutomu Arakawa and Steven J. Prestrelski |
| 647 | ERRATUM |
| 649-662 | Blood Radicals: Reactive Nitrogen Species, Reactive Oxygen Species, Transition Metal Ions, and the Vascular System | Victor Darley-Usmar and Barry Halliwell |
| 663-670 | A Fractal Approach to Heterogeneous Drug Distribution: Calcium Pharmacokinetics | Panos Macheras |
| 671-682 | Chemotherapeutic Drugs Released from Polymers: Distribution of 1,3-bis(2-chloroethyl)-l-nitrosourea in the Rat Brain | Lawrence K. Fung, Marian Shin, Betty Tyler, Henry Brem and W. Mark Saltzman |
| 683-691 | Morphological Characterization of Polyanhydride Biodegradable Implant Gliadel® During in Vitro and in Vivo Erosion Using Scanning Electron Microscopy | Wenbin Dang, Todd Daviau and Henry Brem |
| 692-700 | Deformation Kinetics Analysis of Polymeric Matrices | Susan K. Lum and Wendy C. Duncan-Hewitt |
| 701-709 | Polyvinyl Derivatives as Novel Interactive Polymers for Controlled Gene Delivery to Muscle | Russell J. Mumper, John G. Duguid, Khursheed Anwer, Melisa K. Barron and Hiroaki Nitta, et al. |
| 710-717 | Effects of Polyethyleneglycol Chain Length and Phospholipid Acyl Chain Composition on the Interaction of Polyethyleneglycol-phospholipid Conjugates with Phospholipid: Implications in Liposomal Drug Delivery | Frank K. Bedu-Addo, P. Tang, Y. Xu and Leaf Huang |
| 718-724 | Interaction of Polyethyleneglycol-Phospholipid Conjugates with Cholesterol-Phosphatidylcholine Mixtures: Sterically Stabilized Liposome Formulations | R K. Bedu-Addo, P. Tang, Y. Xu and L. Huang |
| 725-728 | Fat Emulsions Based on Structured Lipids (1,3-specific triglycerides): An Investigation of the in Vivo Fate | Marine Hedeman, Helle Brøndsted, Annette Müllertz and Sven Frokjaer |
| 729-733 | In Vivo ESR Studies on Pharmacokinetics and Metabolism of Parenteral Lipid Emulsion in Living Mice | Tetsuo Yamaguchi, Shigeru Itai, Hidefumi Hayashi, Seiji Soda and Akira Hamada, et al. |
| 734-738 | Delivery of Nasal Powders of β-Cyclodextrin by Insufflation | Alessia De Ascentiis, Ruggero Bettini, Giovanni Caponetti, Pier Luigi Catellani and Maria Teresa Peracchia, et al. |
| 739-743 | Enhancement of Nasal Salmon Calcitonin Absorption by Lauroylcarnitine Chloride in Rats | Seiya Kagatani, Tatsuki Shinoda, Muneo Fukui, Tadayoshi Ohmura and Shunji Hasumi, et al. |
| 744-748 | Pulmonary First-Pass and Steady-State Metabolism of Phenols | Paul A. Dickinson and Glyn Taylor |
| 749-755 | Methanol Inhalation: Site and Other Factors Influencing Absorption, and an Inhalation Toxicokinetic Model for the Rat | Robert A. Perkins, Keith W. Ward and Gary M. Pollack |
| 756-761 | Effects of Additives on Heat Denaturation of rhDNase in Solutions | Hak-Kim Chan, Kwok-Leung Au-Yeung and Igor Gonda |
| 762-769 | Isolation and Characterization of a Monomethioninesulfoxide Variant of Interferon α-2b | Gerry Gitlin, Anthony Tsarbopoulos, Suman T. Patel, Wasyl Sydor and Birendra N. Pramanik, et al. |
| 770-774 | Skin Penetration and Sun Protection Factor of Ultra-Violet Filters from Two Vehicles | P. Treffel and B. Gabard |
| 775-778 | Predicting Blood-Brain Transport of Drugs: A Computational Approach | Subhash C. Basak, Brian D. Gute and Lester R. Drewes |
| 779-783 | Vaginal Permeability and Enzymatic Activity Studies in Normal and Ovariectomized Rabbits | Füsun Acartürk and Joseph R. Robinson |
| 784-793 | Acute Gastrointestinal Toxic Effects of Suspensions of Unencapsulated and Encapsulated Ibuprofen in Rats | Christianah Moji Adeyeye, J. Douglas Bricker, Vinod D. Vilivalam and William I. Smith |
| 794-797 | Interspecies Pharmacokinetics of a Novel Hematoregulatory Peptide (SK&F 107647) in Rats, Dogs, and Oncologic Patients | Dion R. Brocks, Martin I. Freed, David E. Martin, Teresa S. Sellers and Nabeel Mehdi, et al. |
| 798-800 | Iontophoresis of Nafarelin Across Human Skin in Vitro | Amalia M. Rodríguez Bayón and Richard H. Guy |
| 801-803 | Evidence for the Existence of Insulin-Degrading Enzyme on the Brush-Border Membranes of Rat Enterocytes | Li-Ling Chang and Jane P. F. Bai |
| 804-808 | Hot Melt Extrusion of Acrylic Films | Carolyn Aitken-Nichol, Feng Zhang and James W. McGinity |
| 809-811 | Model for Moisture Transport into Inhalation Aerosols | James M. Reynolds and Daniel P. McNamara |
| 813-814 | WHAT ARE “REINVENTION ACTIVITIES”? HOW IS THE NIH PARTICIPATING? WHAT CHANGES CAN BE EXPECTED AT THE NIH? HOW CAN I GET CURRENT INFORMATION? | Rochelle M. Long Ph.D |
| 815-819 | Biomaterials Science at a Crossroads: Are Current Product Liability Laws in the United States Hampering Innovation and the Development of Safer Medical Implants? | Joachim Kohn |
| 820-831 | Macromolecular Carrier Systems for Targeted Drug Delivery: Pharmacokinetic Considerations on Biodistribution | Yoshinobu Takakura and Mitsuru Hashida |
| 832-838 | Population Pharmacokinetics of Terfenadine | Richard L. Lalonde, Denis Lessard and Jacques Gaudreault |
| 839-845 | Evaluation of Pharmacokinetic Studies: Is It Useful to Take into Account Concentrations Below the Limit of Quantification? | Henri Humbert, Marie Danièle Cabiac, José Barradas and Christophe Gerbeau |
| 846-850 | High Variability in Drug Pharmacokinetics Complicates Determination of Bioequivalence: Experience with Verapamil | Yu Chung Tsang, Radu Pop, Paul Gordon, John Hems and Michael Spino |
| 851-854 | lontophoretic Delivery of a Telomeric Oligonucleotide | Rhonda M. Brand and Patrick L. Iversen |
| 855-860 | Analysis of Simultaneous Transport and Metabolism of Ethyl Nicotinate in Hairless Rat Skin | Kenji Sugibayashi, Teruaki Hayashi, Tomio Hatanaka, Masahiko Ogihara and Yasunori Morimoto |
| 861-868 | Targeted Delivery of Doxorubicin via Sterically Stabilized Immunoliposomes: Pharmacokinetics and Biodistribution in Tumor-bearing Mice | Noam Emanuel, Eli Kedar, Elijah M. Bolotin, Nechama I. Smorodinsky and Yechezkel Barenholz |
| 869-874 | Erythrocytes as Carriers for Recombinant Human Erythropoietin | Marina-Inmaculada Garín, Rosa-María López, Silvia Sanz, Montserrat Pinilla and José Luque |
| 875-879 | Formulation of Polyiodinated Triglyceride Analogues in a Chylomicron Remnant-Like Liver-Selective Delivery Vehicle | Marc A. Longino, Douglas A. Bakan, Jamey P. Weichert and Raymond E. Counsell |
| 880-884 | Development and Pharmacokinetics of Galactosylated Poly-L-Glutamic Acid as a Biodegradable Carrier for Liver-Specific Drug Delivery | Hideki Hirabayashi, Makiya Nishikawa, Yoshinobu Takakura and Mitsuru Hashida |
| 885-890 | Age-dependent Expression of P-Glycoprotein gp17O in Caco-2 Cell Monolayers | Ken-ichi Hosoya, Kwang-Jin Kim and Vincent H. L. Lee |
| 891-895 | In Vivo Assessment of Intestinal, Hepatic, and Pulmonary First Pass Metabolism of Propofol in the Rat | Araz A. Raoof, Patrick R Augustijns and Roger K. Verbeeck |
| 896-901 | Enteral Absorption of Insulin in Rats from Mucoadhesive Chitosan-Coated Liposomes | Hirofumi Takeuchi, Hiromitsu Yamamoto, Toshiyuki Niwa, Tomoaki Hino and Yoshiaki Kawashima |
| 902-906 | Contribution of Lysosomes to the Subcellular Distribution of Basic Drugs in the Rat Liver | Junko Ishizaki, Koichi Yokogawa, Masako Hirano, Emi Nakashima and Yoshimichi Sai, et al. |
| 907-913 | Solubilization of Retinoids by Bile Salt/ Phospholipid Aggregates | Ching-Yuan Li, Cheryl L. Zimmerman and Timothy S. Wiedmann |
| 914-919 | Permeation Behavior of Salbutamol Sulfate Through Hydrophilic and Hydrophobic Membranes Embedded by Thermo-responsive Cholesteryl Oleyl Carbonate | Shan-Yang Lin, Yih-Yih Lin and Ko-Shao Chen |
| 920-925 | The Effect of Hydrophobic Character of Drugs and Helix-coil Transition of κ-Carrageenan on the Polyelectrolyte-drug Interaction | Ninus Caram-Lelham and Lars-Olof Sundelöf |
| 926-930 | Determination of Molecular Mobility of Lyophilized Bovine Serum Albumin and γ-Globulin by Solid-State 1H NMR and Relation to Aggregation-Susceptibility | Suraie Yoshioka, Yukio Aso and Shigeo Kojima |
| 931-938 | Effects of Polyaminocarboxylate Metal Chelators on Iron-thiolate Induced Oxidation of Methionine- and Histidine-Containing Peptides | Fang Zhao, Jian Yang and Christian Schöneich |
| 939-943 | Synthesis and Anti-proliferative Activity of 2-Hydroxy-l,2-dihydroacronycine Glycosides | Sofia Mitaku, Alexios-Léandros Skaltsounis, François Tillequin, Michel Koch and Yves Rolland, et al. |
| 944-949 | Investigations into the Relationship Between Drug Properties, Filling, and the Release of Drugs from Hard Gelatin Capsules Using Multivariate Statistical Analysis | James Hogan, Pei-Inn Shue, Fridrun Podczeck and J. Michael Newton |
| 950-951 | Effect of the Spermicide, Nonoxynol 9, on Vaginal Permeability in Normal and Ovariectomized Rabbits | Füsun Acatürk and Joseph R. Robinson |
| 952-956 | Primary Cell Culture of the Rabbit Choroid Plexus: An Experimental System to Investigate Membrane Transport | Vikram K. Ramanathan, Andrew C. Hui, Claire M. Brett and Kathleen M. Giacomini |
| 957-960 | The Effect of Iontophoresis on Skin Barrier Integrity: Non-invasive Evaluation by Impedance Spectroscopy and Transepidermal Water Loss | Yogeshvar N. Kalia, Lourdes B. Nonato and Richard H. Guy |
| 961 | ERRATUM |
| 963-977 | Carrier-Mediated Intestinal Transport of Drugs | Akira Tsuji and Ikumi Tamai |
| 978-988 | In-vitro Cell Culture Models of the Nasal Epithelium: A Comparative Histochemical Investigation of Their Suitability for Drug Transport Studies | Ute Werner and Thomas Kissel |
| 989-995 | Characterization of Glucose Dependent Gel-Sol Phase Transition of the Polymeric Glucose-Concanavalin A Hydrogel System | Aiman A. Obaidat and Kinam Park |
| 996-1002 | Characterization and Stability of N-terminally PEGylated rhG-CSF | Olaf B. Kinstler, David N. Brems, Scott L. Lauren, Amiee G. Paige and James B. Hamburger, et al. |
| 1003-1007 | Computer Simulation of Crystal-liquid Interface: Application to Wettability of Solids | Jamshed Anwar and Sohrab Khoshkhoo |
| 1008-1014 | Evidence for the Formation of Amphotericin B-phospholipid Complexes in Langmuir Monolayers | Martin R. Lance, Clive Washington and Stanley S. Davis |
| 1015-1019 | Mode of Interaction of Loop Diuretics with Human Serum Albumin and Characterization of Binding Site | Norito Takamura, Akihiko Haruta, Hirofumi Kodama, Michio Tsuruoka and Keishi Yamasaki, et al. |
| 1020-1027 | Percutaneous Absorption of Biologically-Active Interferon-gamma in a Human Skin Graft-Nude Mouse Model | Sarah M. Short, Brian D. Paasch, Jason H. Turner, Norman Weiner and Ann L. Daugherty, et al. |
| 1028-1037 | Interactions of Phosphodiester and Phosphorothioate Oligonucleotides with Intestinal Epithelial Caco-2 Cells | G. F. Beck, W. J. Irwin, P. L. Nicklin and S. Akhtar |
| 1038-1042 | Effect of Size and Serum Proteins on Transfection Efficiency of Poly ((2-dimethylamino)ethyl Methacrylate)-Plasmid Nanoparticles | Jong-Yuh Cherng, Petra van de Wetering, Herre Talsma, Daan J. A. Crommelin and Wim E. Hennink |
| 1043-1048 | Transcription Regulation of Rat Glutathione S-Transferase Ya Subunit Gene Expression by Chemopreventive Agents | Peiwen Fei, George A. Matwyshyn, Thomas H. Rushmore and Ah-Ng Tony Kong |
| 1049-1054 | Species Difference in the Disposition of Liposomes Among Mice, Rats, and Rabbits: Allometric Relationship and Species Dependent Hepatic Uptake Mechanism | H. Harashima, S. Komatsu, S. Kojima, C. Yanagi and Y. Morioka, et al. |
| 1055-1058 | The Role of Serum Complement on the Organ Distribution of Intravenously Administered Poly (methyl methacrylate) Nanoparticles: Effects of Pre-Coating with Plasma and with Serum Complement | Gerrit Borchard and Jörg Kreuter |
| 1059-1064 | In Vitro and in Vivo Evaluation in Rabbits of a Controlled Release 5-fluorouracil Subconjunctival Implant Based on Poly(D,L-lactide-co-glycolide) | Guangji Wang, Ian G. Tucker, Michael S. Roberts and Lawrence W. Hirst |
| 1065-1068 | Kinetics of Quinolone Antibiotics in Rats: Efflux from Cerebrospinal Fluid to the Circulation | Tsuyoshi Ooie, Hiroshi Suzuki, Tetsuya Terasaki and Yuichi Sugiyama |
| 1069-1072 | Modulation of Organic Cation Transport and Lipid Fluidity by Benzyl Alcohol in Rat Renal Brush-border Membranes | Tomohiro Nabekura, Mikihisa Takano, Michio Kimura, Masato Yasuhara and Ken-ichi Inui |
| 1073-1077 | Effect of Cyclosporin Analogues and FK506 on Transcellular Transport of Daunorubicin and Vinblastine via P-glycoprotein | Kumiko Tanaka, Midori Hirai, Yusuke Tanigawara, Masato Yasuhara and Ryohei Hori, et al. |
| 1078-1082 | Suitability of Enalapril as a Probe of the Dipeptide Transporter System: InVitro and In Vivo Studies | Richard A. Morrison, Saeho Chong, Anthony M. Marino, Martin A. Wasserman and Peter Timmins, et al. |
| 1083-1087 | Improved Oral Delivery of Desmopressin via a Novel Vehicle: Mucoadhesive Submicron Emulsion | Ehud Ilan, Shimon Amselem, Michael Weisspapir, Joseph Schwarz and Ayala Yogev, et al. |
| 1088-1094 | Development and Validation of Two Solid-Phase Enzyme Immunoassays (ELISA) for Quantitation of Human Epidermal Growth Factors (hEGFs) | Nywana Sizemore, Richard C. Dudeck, Charles M. Barksdale, Gerald D. Nordblom and Williams T. Mueller, et al. |
| 1095-1104 | Determination of the Composition of Delavirdine Mesylate Polymorph and Pseudopolymorph Mixtures Using 13C CP/MAS NMR | Ping Gao |
| 1105-1108 | Serial Versus Sparse Sampling in Toxicokinetic Studies | Francis L. S. Tse and Jerry R. Nedelman |
| 1109-1115 | Bioequivalence of a Highly Variable Drug: An Experience with Nadolol | Robert G. Buice, Veerappan S. Subramanian, Kenneth L. Duchin and Samuel Uko-Nne |
| 1116-1121 | Bioequivalence: Individual and Population Compartmental Modeling Compared to the Noncompartmental Approach | Helen S. Pentikis, James D. Henderson, Nhan L. Tran and Thomas M. Ludden |
| 1122-1126 | Demonstration of Sucralfate-mediated Preservation of Growth Factor Bioactivity in the Presence of Low pH with a Human Gastric Epithelial Cell Line (AGS) | Huaibao Sheng, Praful K. Shah and Kenneth L. Audus |
| 1127-1129 | Study of the Influence of Several Stabilizing Agents on the Entrapment and InVitro Release of pBC 264 from Poly(Lactide-Co-Glycolide) Microspheres Prepared by a W/O/W Solvent Evaporation Method | María J. Blanco-Príeto, Eliana Leo, Florence Delie, Annette Gulik and Patrick Couvreur, et al. |
| 1130-1131 | BOOK REVIEWS |
| 1133-1141 | Natural Products as a Resource for New Drugs | Alice M. Clark |
| 1142-1153 | Solid-State Stability of Human Insulin I. Mechanism and the Effect of Water on the Kinetics of Degradation in Lyophiles from pH 2–5 Solutions | Robert G. Strickley and Bradley D. Anderson |
| 1154-1161 | Zinc Uptake in Five Sectors of the Rat Gastrointestinal Tract: Kinetic Study in the Whole Colon | Sonia Luz Gisbert-González and Francisca Torres-Molina |
| 1162-1167 | Stratum Corneum Lipids of Human Epidermal Keratinocyte Air-Liquid Cultures: Implications for Barrier Function | Alane H. Kennedy, Guia M. Golden, Carol L. Gay, Richard H. Guy and Michael L. Francoeur, et al. |
| 1168-1173 | The Influence of an Electric Field on Ion and Water Accessibility to Stratum Corneum Lipid Lamellae | Louk A. R. M. Pechtold, William Abraham and Russell O. Potts |
| 1174-1180 | Characterization of Interactions Between Bile Salts and Drugs by Micellar Electrokinetic Capillary Chromatography. Part I. | Maria A. Schwarz, Reinhard H. H. Neubert and Gerhard Dongowski |
| 1181-1185 | Dielectric Analysis of Phosphorylcholine Head Group Mobility in Egg Lecithin Liposomes | Geoff Smith, Boris Yu. Shekunov, Jie Shen, Alistair P. Duffy and Jamshed Anwar, et al. |
| 1186-1190 | Insight into the Lipophilicity of the Aromatic N-Oxide Moiety | Giulia Caron, Pierre-Alain Carrupt, Bernard Testa, Giuseppe Ermondi and Alberto Gasco |
| 1191-1195 | Correlation of Physicochemical Parameters to the Hydrophobic Contribution Constants of Amino Acid Residues in Small Peptides | Darshana Palekar, Michael Shiue and Eric J. Lien |
| 1196-1200 | Immunostimulating Polysaccharides from Panax notoginseng | Hua Gao, Fengzhen Wang, Eric J. Lien and Melvin D. Trousdale |
| 1201-1204 | Local Absorption Kinetics of Levofloxacin from Intestinal Tract into Portal Vein in Conscious Rat Using Portal-Venous Concentration Difference | Yusuke Fujieda, Kiyoshi Yamaoka, Takashi Ito and Terumichi Nakagawa |
| 1205-1209 | The Effect of Size on Uptake of Orally Administered Latex Microparticles in the Small Intestine and Transport to Mesenteric Lymph Nodes | Katharine E. Carr, Rosemary A. Hazzard, Shane Reid and Giséle M. Hodges |
| 1210-1212 | Pectin/Ethylcellulose Film Coating Formulations for Colonic Drug Delivery | Z. Wakerly, J. T. Fell, D. Attwood and D. Parkins |
| 1213-1218 | Metabolism, Uptake, and Transepithelial Transport of the Diastereomers of Val-Val in the Human Intestinal Cell Line, Caco-2 | Kiyoshi Tamura, Pradip K. Bhatnagar, Joanne S. Takata, Chao-Pin Lee and Philip L. Smith, et al. |
| 1219-1227 | Effects of Permeation Enhancers on the Transport of a Peptidomimetic Thrombin Inhibitor (CRC 220) in a Human Intestinal Cell Line (Caco-2) | Ute Werner, Thomas Kissel and Martin Reers |
| 1228-1232 | Buccal Absorption of Testosterone and Its Esters Using a Bioadhesive Tablet in Dogs | Jody Voorspoels, Jean-Paul Remon, Willy Eechaute and Walter De Sy |
| 1233-1237 | In Vivo Buccal Delivery of the Peptide Drug Buserelin with Glycodeoxycholate as an Absorption Enhancer in Pigs | A. Janet Hoogstraate, J. Coos Verhoef, Anton Pijpers, Leo A. M. G. van Leengoed and Jos H. M. Verheijden, et al. |
| 1238-1242 | Nitric Oxide (NO)-releasing Pathway of FK409 in the Presence of Sulfhydryl-bearing Compounds | Shinichi Fukuyama, Toshio Azuma, Yoshimi Hirasawa, Noritugu Morokoshi and Toshihiro Akama, et al. |
| 1243-1246 | Glucuronidation Metabolic Kinetics of Valproate in Guinea Pigs: Nonlinear at Clinical Concentration Levels | Hsiu-Ying Yu and Yu-Zen Shen |
| 1247-1251 | Transport of Drugs Across the Xenopus Pulmonary Membrane and Their Absorption Enhancement by Various Absorption Enhancers | Shigeki Okumura, Yoshimi Fukuda, Kanae Takahashi, Takuya Fujita and Akira Yamamoto, et al. |
| 1252-1257 | Oxidation of Human Insulin-like Growth Factor I in Formulation Studies: Kinetics of Methionine Oxidation in Aqueous Solution and in Solid State | Jonas Fransson, Ebba FIorin-Robertsson, Kent Axelsson and Christina Nyhlén |
| 1258-1264 | Excipient Interaction with Cetylpyridinium Chloride Activity in Tablet Based Lozenges | R. Michael E. Richards, James Z. Xing and Kirsty M. B. Mackay |
| 1265-1271 | The in Vitro Release of Some Antimuscarinic Drugs from Monoolein/ Water Lyotropic Liquid Crystalline Gels | Pauline B. Geraghty, David Attwood, John H. Collett and Yogesh Dandiker |
| 1272-1275 | High-Performance Liquid Chromatographic Analysis of Dipyrone Metabolites to Study Their Formation in Human Liver Microsomes | Gerd Geisslinger, Ronald Böcker and Micha Levy |
| 1276-1278 | Mechanisms of 5-Fluorouracil (5-FU) Transport in Isolated Rabbit Choroid Plexus Tissue Slices | Carla B. Washington and Kathleen M. Giacomini |
| 1279 | WHAT ARE THE SMALL BUSINESS INNOVATION RESEARCH (SBIR) AND SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAMS? WHAT KINDS OF AWARDS ARE AVAILABLE? WHO CAN PARTICIPATE? HOW CAN I GET CURRENT INFORMATION AND AN APPLICATION? | Rochelle M. Long |
| 1280-1282 | Performance of Bailer's Method for AUC Confidence Intervals from Sparse Non-Normally Distributed Drug Concentrations in Toxicokinetic Studies | Sudhakar M. Pai, Jerry R. Nedelman, Gerald Hajian, Ekaterina Gibiansky and Vijay K. Batra |
| 1283-1290 | Characterization of AUCs from Sparsely Sampled Populations in Toxicology Studies | Sudhakar M. Pai, Scott H. Fettner, Gerald Hajian, Mitchell N. Cayen and Vijay K. Batra |
| 1291-1298 | A Reasoned Action Approach to Physicians' Utilization of Drug Information Sources | Caroline A. Gaither, Richard P. Bagozzi, Frank J. Ascione and Duane M. Kirking |
| 1299-1304 | Increasing Clients' Knowledge of Community Pharmacists' Roles | Betty Chewning and Jon C. Schommer |
| 1305-1312 | Differential Effect of Taxol in Rat Primary and Metastatic Prostate Tumors: Site-Dependent Pharmacodynamics | Wan-Ching Yen, M. Guillaume Wientjes and Jessie L.-S. Au |
| 1313-1316 | Steady-State Kinetics of Imipramine in Transgenic Mice with Elevated Serum AAG Levels | John W. Holladay, Michael J. Dewey and Sun D. Yoo |
| 1317-1321 | Covalent Binding Between Bucillamine Derivatives and Human Serum Albumin | Ryuichi Narazaki, Mizuho Hamada, Kumiko Harada and Masaki Otagiri |
| 1322-1326 | PC-2, Linear Homoglucan with α-linkages, Peripherally Enhances the Hippocampal Long-Term Potentiation | Miroslav Smriga, Hiroshi Saito, Shoji Shibata, Takao Narui and Toru Okuyama, et al. |
| 1327-1330 | Purification and Partial Characterization of an Indomethacin Hydrolyzing Enzyme from Pig Liver | Keisuke Terashima, Satomi Takai, Yoshiko Usami, Tetsuo Adachi and Tadashi Sugiyama, et al. |
| 1331-1335 | Horseradish Peroxidase Transport Across Rat Alveolar Epithelial Cell Monolayers | Yasuhisa Matsukawa, Hiroshi Yamahara, Vincent H. L. Lee, Edward D. Crandall and Kwang-Jin Kim |
| 1336-1342 | Comparison Between Permeability Coefficients in Rat and Human Jejunum | Urban Fagerholm, Monica Johansson and Hans Lennernäs |
| 1343-1347 | Transport of Alpha-Tocopherol and Its Derivatives Through Erythrocyte Membranes | Francesco Bonina, Maria Lanza, Lucia Montenegro, Loredana Salerno and Patrizia Smeriglio, et al. |
| 1348-1353 | Transdermal Permeation of Alniditan by Iontophoresis: In Vitro Optimization and Human Pharmacokinetic Data | Anne Jadoul, Jean Mesens, Wim Caers, Frank de Beukelaar and R. Crabbé, et al. |
| 1354-1359 | Passive Drug Diffusion via Standardized Skin Mini-erosion; Methodological Aspects and Clinical Findings with New Device | Paul Svedman, Stefan Lundin, Peter Höglund, Christer Hammarlund and Christer Malmros, et al. |
| 1360-1366 | Transdermal Delivery of Fentanyl by Electroporation II. Mechanisms Involved in Drug Transport | Rita Vanbever, Nathalie De Morre and Véronique Préat |
| 1367-1372 | Intracellular Distribution and Mechanism of Delivery of Oligonucleotides Mediated by Cationic Lipids | Olivier Zelphati and Francis C. Szoka |
| 1373-1377 | Comparison of Pharmacokinetic Parameters of a Polypeptide, the Bowman-Birk Protease Inhibitor (BBI), and Its Palmitic Acid Conjugate | Laura Honeycutt, Jeff Wang, Hossein Ekrami and Wei-Chiang Shen |
| 1378-1383 | Lectin-bearing Polymerized Liposomes as Potential Oral Vaccine Carriers | Hongming Chen, Vladimir Torchilin and Robert Langer |
| 1384-1388 | In Vitro-In Vivo Myotoxicity of Intramuscular Liposomal Formulations | Saleh A. Al-Suwayeh, Ian R. Tebbett, Donna Wielbo and Gayle A. Brazeau |
| 1389-1392 | Liposomal Induction of a Heat-stable Macrophage Priming Factor to Induce Nitric Oxide in Response to LPS | Yukihiko Aramaki, Hidetoshi Arima, Toshifumi Hara and Seishi Tsuchiya |
| 1393-1400 | Effects of Sugars and Polymers on Crystallization of Poly(ethylene glycol) in Frozen Solutions: Phase Separation Between Incompatible Polymers | Ken-ichi Izutsu, Sumie Yoshioka, Shigeo Kojima, Theodore W. Randolph and John F. Carpenter |
| 1401-1405 | Solubility Behavior, Phase Transition, and Structure-Based Nucleation Inhibition of Etanidazole in Aqueous Solutions | Michael B. Maurin, Susan M. Rowe, Kenneth S. Field, Robert C. Swintosky and Munir A. Hussain |
| 1406-1410 | Evidence for Phospholipid Bilayer Formation in Solid Lipid Nanoparticles Formulated with Phospholipid and Triglyceride | Hashem Heiati, Nigel C. Phillips and Rashad Tawashi |
| 1411-1416 | Atomic Force Microscopy Studies of Solid Lipid Nanoparticles | A. zur Mühlen, E. zur Mühlen, H. Niehus and W. Mehnert |
| 1417-1418 | Lack of Effect of Catheterization on the Pharmacokinetics of (-)-Carbovir in Rats | Cheryl L. Zimmerman, Kit J. Ha and Shu-hui Huang |
| 1419-1422 | A Cellular Automata Model of Micelle Formation | Lemont B. Kier, Chao-Kung Cheng, Bernard Testa and Pierre-Alain Carrupt |
| 1423 | ERRATUM |
| 1425-1426 | WHAT PROGRAM ANNOUNCEMENTS ARE CURRENTLY OPEN AT THE NIGMS? WHO ARE THE CONTACT PEOPLE? HOW CAN I GET MORE INFORMATION? | Rochelle M. Long |
| 1427-1437 | Design of Biological Equivalence Programs for Therapeutic Biotechnology Products in Clinical Development: A Perspective | Joyce Mordenti, Joy A. Cavagnaro and James D. Green |
| 1438-1444 | Pharmacokinetic Analysis of Drug Disposition After Intratumoral Injection in a Tissue-Isolated Tumor Perfusion System | Akira Saikawa, Takehiko Nomura, Fumiyoshi Yamashita, Yoshinobu Takakura and Hitoshi Sezaki, et al. |
| 1445-1452 | Design and Results of a Group Counter-detailing DUR Educational Program | Karen B. Farris, Duane M. Kirking, Leslie A. Shimp and Ruth Ann C. Opdycke |
| 1453-1459 | Intrinsic Solubility Estimation and pH-Solubility Behavior of Cosalane (NSC 658586), an Extremely Hydrophobic Diprotic Acid | Srinivasan Venkatesh, Jianmin Li, Yuehong Xu, Rao Vishnuvajjala and Bradley D. Anderson |
| 1460-1463 | Hydrotropic Solubilization— Mechanistic Studies | Renée E. Coffman and Dane O. Kildsig |
| 1464-1475 | Stable Formulations of Recombinant Human Growth Hormone and Interferon-γ for Microencapsulation in Biodegradable Mircospheres | Jeffrey L. Cleland and Andrew J. S. Jones |
| 1476-1481 | Oxidation of Human Insulin-Like Growth Factor I in Formulation Studies, II. Effects of Oxygen, Visible Light, and Phosphate on Methionine Oxidation in Aqueous Solution and Evaluation of Possible Mechanisms | Jonas Fransson and Anders Hagman |
| 1482-1487 | Synthesis, Antiinflammatory, and Cytotoxic Activities of 2-Alkyl and 2-Benzyl-2-Dimethylaminomethyl-5-(E)-Arylidene Cyclopentanone Hydrochlorides | Haitao Chen, Zhizhong Ji, Lan K. Wong, Jerome F. Siuda and Ven L. Narayanan |
| 1488-1494 | In Vitro and In Vivo Activity of 16,17-dehydro-epipregnanolones: 17,20-Bond Torsional Energy Analysis and D-ring Conformation | Michael B. Bolger, Scott Wieland, Jon E. Hawkinson, Haiji Xia and Ravindra Upasani, et al. |
| 1495-1500 | Structure-Activity Relationships for Substrates and Inhibitors of Mammalian Liver Microsomal Carboxylesterases | Tien L. Huang, Takahiro Shiotsuki, Tamon Uematsu, Babak Borhan and Qing X. Li, et al. |
| 1501-1506 | In Vitro-In Vivo Relationship of Oral Extended-Release Dosage Forms | Fang-Yu Liu, Nancy C. Sambol, Robert P. Giannini and Chui Yu Liu |
| 1507-1513 | Predicting Injection Site Muscle Damage I: Evaluation of Immediate Release Parenteral Formulations in Animal Models | Steven C. Sutton, Loreen A. F. Evans, Michelle T. S. Rinaldi and Kathy A. Norton |
| 1514-1518 | Predicting Injection Site Muscle Damage II: Evaluation of Extended Release Parenteral Formulations in Animal Models | Steven C. Sutton, Loreen A. F. Evans, Michelle T. S. Rinaldi and Kathy A. Norton |
| 1519-1523 | Permeation of Buprenorphine and Its 3-Alkyl-Ester Prodrugs Through Human Skin | Audra L. Stinchcomb, Anupam Paliwal, Rajesh Dua, Hirofumi Imoto and Ronald W. Woodard, et al. |
| 1524-1529 | Evaluation of Stereoselective Transdermal Transport and Concurrent Cutaneous Hydrolysis of Several Ester Prodrugs of Propranolol: Mechanism of Stereoselective Permeation | Shamim Ahmed, Teruko Imai and Masaki Otagiri |
| 1530-1534 | Influence of Vehicle, Distant Topical Delivery, and Biotransformation on the Chemopreventive Activity of Apigenin, a Plant Flavonoid, in Mouse Skin | Boyong Li, Heather Pinch and Diane R Birt |
| 1535-1540 | Absorption and Presystemic Metabolism of Selegiline Hydrochloride at Different Regions in the Gastrointestinal Tract in Healthy Males | Jeffrey S. Barrett, Peter Szego, Shashank Rohatagi, Richard J. Morales and Kimberly E. DeWitt, et al. |
| 1541-1546 | Effect of Destruction Force on Drug Release from Multiple Unit Controlled Release Dosage Forms in Humans | Noriko Katori, Wen-Shi Ma, Nobuo Aoyagi and Shigeo Kojima |
| 1547-1553 | A Novel Extravascular Input Function for the Assessment of Drug Absorption in Bioavailability Studies | Michael Weiss |
| 1554-1558 | The Relationship Between Rat Intestinal Permeability and Hydrophilic Probe Size | Majella E. Lane, Caitriona M. O'Driscoll and Owen I. Corrigan |
| 1559-1564 | Uptake Is the Rate-limiting Step in the Overall Hepatic Elimination of Pravastatin at Steady-state in Rats | Masayo Yamazaki, Sayoko Akiyama, Ryuichiro Nishigaki and Yuichi Sugiyama |
| 1565-1569 | Microdialysis Assessment of Microfibrous Collagen Containing a P-Glycoprotein-Mediated Transport Inhibitor, Cyclosporine A, for Local Delivery of Etoposide | Hitoshi Sato, Hidenori Kitazawa, Isao Adachi and Isamu Horikoshi |
| 1570-1575 | Fluconazole Distribution to the Brain: A Crossover Study in Freely-moving Rats Using In Vivo Microdialysis | Hua Yang, Qin Wang and William R Elmquist |
| 1576-1580 | Controlled Systemic Absorption and Increased Anesthetic Effect of Bupivacaine Following Epidural Administration of Bupivacaine-Hydroxypropyl-β-Cyclodextrin Complex | Jean Christophe Fréville, Gilles Dollo, Pascal Le Corre, François Chevanne and Roger Le Verge |
| 1581-1584 | Effect of Iontophoresis in Combination with Ionic Enhancers on the Lipid Structure of the Stratum Corneum: An X-ray Diffraction Study | Sophie Chesnoy, Jean Doucet, Dominique Durand and Guy Couarraze |
| 1585-1587 | Predicting Injection Site Muscle Damage III: Evaluation of Intramuscular Formulations in the L6 Cell Model | Loreen A. F. Evans, Paul E. Genereux, E. Michael Gibbs and Steven C. Sutton |
| 1589 | WHAT RESEARCH TRAINING OPPORTUNITIES ARE SPONSORED BY NIGMS AT THE NIH? HOW CAN I GET INFORMATION ABOUT THIS AND OTHER POSTDOCTORAL PROGRAMS AT THE NIH? | Rochelle M. Long |
| 1590-1594 | Evaluation of Orally Administered Highly Variable Drugs and Drug Formulations | Vinod P. Shah, Avraham Yacobi, William H. Barr, Leslie Z. Benet and Douwe Breimer, et al. |
| 1595-1614 | Pharmaceutical Approach to Somatic Gene Therapy | Fred D. Ledley |
| 1615-1623 | Esterase-Sensitive Cyclic Prodrugs of Peptides: Evaluation of an Acyloxyalkoxy Promoiety in a Model Hexapeptide | Giovanni M. Pauletti, Sanjeev Gangwar, Franklin W. Okumu, Teruna J. Siahaan and Valentine J. Stella, et al. |
| 1624-1630 | Structure-based Search for Peptide Ligands that Cross-react with Melanocortin Receptors | J. Mark Quillan and Wolfgang Sadée |
| 1631-1634 | Human Dipeptide Transporter, hPEPTl, Stably Transfected into Chinese Hamster Ovary Cells | Kuang-Ming Y. Covitz, Gordon L. Amidon and Wolfgang Sadée |
| 1635-1641 | Development of Caco-2 Cells Expressing High Levels of cDNA-Derived Cytochrome P4503A4 | Charles L. Crespi, Bruce W. Penman and Ming Hu |
| 1642-1646 | Effect of Non-Ionic Surfactants on the Formation of DNA/Emulsion Complexes and Emulsion-Mediated Gene Transfer | Feng Liu, Jingping Yang, Leaf Huang and Dexi Liu |
| 1647-1656 | Paclitaxel and Nocodazole Differentially Alter Endocytosis in Cultured Cells | Sarah F Hamm-Alvarez, Manisha Sonee, Kathleen Loran-Goss and Wei-Chiang Shen |
| 1657-1662 | The Effect of Conformation on Membrane Permeability of an Acyloxyalkoxy-linked Cyclic Prodrug of a Model Hexapeptide | Sanjeev Gangwar, Seetharama D. S. Jois, Teruna J. Siahaan, David G. Vander Velde and Valentine J. Stella, et al. |
| 1663-1667 | Metabolism, Uptake, and Transepithelial Transport of the Stereoisomers of Val-Val-Val in the Human Intestinal Cell Line, Caco-2 | Kiyoshi Tamura, Chao-Pin Lee, Philip L. Smith and Ronald T. Borchardt |
| 1668-1672 | Mucoadhesive Polymers in Peroral Peptide Drug Delivery. VI. Carbomer and Chitosan Improve the Intestinal Absorption of the Peptide Drug Buserelin In Vivo | Henrik. L. Lueßen, Bas. J. de Leeuw, Mariska W. E. Langemeÿer, A.(Bert) G. de Boer and J. Coos. Verhoef, et al. |
| 1673-1678 | Oral Absorption of D-Oligopeptides in Rats via the Paracellular Route | Yan-Ling He, Susan Murby, Larry Gifford, Andrew Collett and Geoff Warhurst, et al. |
| 1679-1685 | Proteolysis of Human Calcitonin in Excised Bovine Nasal Mucosa: Elucidation of the Metabolic Pathway by Liquid Secondary lonization Mass Spectrometry (LSIMS) and Matrix Assisted Laser Desorption lonization Mass Spectrometry (MALDI) | Steffen R. Lang, Werner Staudenmann, Peter James, Hans-Jörg Manz and Rudolf Kessler, et al. |
| 1686-1692 | Chitosans as Absorption Enhancers for Poorly Absorbable Drugs. 1: Influence of Molecular Weight and Degree of Acetylation on Drug Transport Across Human Intestinal Epithelial (Caco-2) Cells | Nicolaas G. M. Schipper, Kjell M. Vårum and Per Artursson |
| 1693-1698 | Improving Protein Delivery from Microparticles Using Blends of Poly(DL lactide co-glycolide) and Poly(ethylene oxide)-poly(propylene oxide) Copolymers | Ming-Kung Yeh, Stanley S. Davis and Allan G. A. Coombes |
| 1699-1703 | Pulmonary Targeting of Liposomal Triamcinolone Acetonide Phosphate | Ricardo J. Gonzalez-Rothi, Sandra Suarez, Guenther Hochhaus, Hans Schreier and Anatoly Lukyanov, et al. |
| 1704-1709 | Synergistic Effect Between Size and Cholesterol Content in the Enhanced Hepatic Uptake Clearance of Liposomes Through Complement Activation in Rats | H. Harashima, T. M. Huong, T. Ishida, Y. Manabe and H. Matsuo, et al. |
| 1710-1715 | In Vivo and In Vitro Percutaneous Absorption of Cancer Preventive Flavonoid Apigenin in Different Vehicles in Mouse Skin | Boyong Li and Diane F. Birt |
| 1716-1719 | Bioadhesion of Lectin-Latex Conjugates to Rat Intestinal Mucosa | Juan M. Irache, Carlo Durrer, Dominique Duchêne and Gilles Ponchel |
| 1720-1724 | Applications and Simulations of a Discontinuous Oral Absorption Pharmacokinetic Model | Jennifer Wright Witcher and F. Douglas Boudinot |
| 1725-1729 | The Influence of Water on Electrostatic Charge Retention and Dissipation in Pharmaceutical Compacts for Powder Coating | M. P. Grosvenor and J. N. Staniforth |
| 1730-1733 | The Effect of Temperature on the Surface Nature of an Adsorbed Layer of Poly(oxyethylene)-poly(oxypropylene)-poly(oxyethylene) Block Copolymers | David L Carthew, Graham Buckton, Gary E. Parsons and Stephen Poole |
| 1734-1738 | Development and Mechanical Characterization of Bioadhesive Semi-Solid, Polymeric Systems Containing Tetracycline for the Treatment of Periodontal Diseases | David S. Jones, A. David Woolfson, Jasmina Djokic and W. A. Coulter |
| 1739-1745 | A Comparison of Elastic Moduli Derived from Theory, Microindentation, and Ultrasonic Testing | Susan K. Lum and Wendy C. Duncan-Hewitt |
| 1746-1751 | Influence of Surface Free Energies and Cohesion Parameters on Pharmaceutical Material Interaction Parameters–Theoretical Simulations | Jérôme Barra, François Lescure and Eric Doelker |
| 1752-1754 | Effect of Charge on Oligopeptide Transporter-Mediated Permeation of Cyclic Dipeptides Across Caco-2 Cell Monolayers | Kiyoshi Tamura, Chao-Pin Lee, Philip L. Smith and Ronald T. Borchardtu |
| 1755-1758 | An Improved Intercept Method for the Assessment of Absorption Rate in Bioequivalence Studies | Panos Macheras, Mira Symillides and Christos Reppas |
| 1759 | Controlled Release Technologies: Current Status and Future Prospects | Richard Guy, Michael Powell, Joseph Fix and Kinam Park |
| 1760-1764 | Oral Controlled Release Technology for Peptides: Status and Future Prospects | Joseph A. Fix |
| 1765-1769 | Current Status and Future Prospects of Transdermal Drug Delivery | Richard H. Guy |
| 1770-1776 | Biocompatibility Issues of Implantable Drug Delivery Systems | Haesun Park and Kinam Park |
| 1777-1785 | Drug Delivery Issues in Vaccine Development | Michael R Powell |
| 1786-1794 | Characterization of Lipid Membrane Dynamics by Simulation: 3. Probing Molecular Transport Across the Phospholipid Bilayer | B. Jin and J. Hopfinger |
| 1795-1798 | Guidance in the Setting of Drug Particle Size Specifications to Minimize Variability in Absorption | Kevin C. Johnson and Archie C. Swindell |
| 1799-1803 | In-Vitro Dissolution Profile Comparison: Statistics and Analysis, Model Dependent Approach | Pradeep M. Sathe, Yi Tsong and Vinod P. Shah |
| 1804-1810 | Feasibility of Effect-Controlled Clinical Trials of Drugs with Pharmacodynamic Hysteresis Using Sparse Data | William E Ehling, Yoshiaki Matsumoto and Gerhard Levy |
| 1811-1814 | Characterization of a Solid State Reaction Product from a Lyophilized Formulation of a Cyclic Heptapeptide. A Novel Example of an Excipient-Induced Oxidation | David C. Dubost, Michael J. Kaufman, Jeffrey A. Zimmerman, Michael J. Bogusky and Arthur B. Coddington, et al. |
| 1815-1820 | Degradation Kinetics of BMP 777, an Elastase Inhibitor | Krishnaswamy S. Raghavan, David B. Gray, Thomas H. Scholz, Gregory A. Nemeth and Munir A. Hussain |
| 1821-1827 | Chemical and Swelling Evaluations of Amino Group Crosslinking in Gelatin and Modified Gelatin Matrices | Clyde M. Ofner, III and William A. Bubnis |
| 1828-1832 | Stereoselective and Carrier-Mediated Transport of Monocarboxylic Acids Across Caco-2 Cells | Takuo Ogihara, Ikumi Tamai, Hitomi Takanaga, Yoshimichi Sai and Akira Tsuji |
| 1833-1837 | Biliary Excretion of Glycyrrhizin in Rats: Kinetic Basis for Multiplicity in Bile Canalicular Transport of Organic Anions | Hisafumi Shimamura, Hiroshi Suzuki, Osamu Tagaya, Tohru Horie and Yuichi Sugiyama |
| 1838-1845 | Gastrointestinal Uptake of Biodegradable Microparticles: Effect of Particle Size | Manisha P. Desai, Vinod Labhasetwar, Gordon L. Amidon and Robert J. Levy |
| 1846-1850 | Liver Targeting of Interferon Through Pullulan Conjugation | Keli Xi, Yasuhiko Tabata, Kazuko Uno, Miwa Yoshimoto and Tsunataro Kishida, et al. |
| 1851-1855 | The pH-Dependence in the Partitioning Behaviour of (RS)-[3H]Propranolol Between MDCK Cell Lipid Vesicles and Buffer | Stefanie D. Krämer and Heidi Wunderli-Allenspach |
| 1856-1860 | New Cationic Lipid Formulations for Gene Transfer | Feng Liu, Jingping Yang, Leaf Huang and Dexi Liu |
| 1861-1864 | Riboflavin-Enhanced Transport of Serum Albumin Across the Distal Pulmonary Epithelium | O. Douglas Wangensteen, Marilyn M. Bartlett, Jonathan K. James, Zhen-fan Yang and Philip S. Low |
| 1865-1870 | Anionic Gels as Vehicles for Electrically-Modulated Drug Delivery. I. Solvent and Drug Transport Phenomena | Chang-Shan Hsu and Lawrence H. Block |
| 1871-1874 | A New Method for Diffusion Measurement in Polymeric Films Based on a Stacked Sheet Concept | Hans Sjöberg, Rolf Bergman and Lars-Olof Sundelöf |
| 1875-1880 | Deacetylation of Diltiazem by Several Rabbit Tissues | Lorenzo J. Fraile, José J. Aramayona, Miguel A. Bregante, María A. García and Ana R. Abadía |
| 1881-1886 | Localization of Purine Metabolizing Enzymes in Bovine Brain Microvessel Endothelial Cells: An Enzymatic Blood-Brain Barrier for Dideoxynucleosides? | Mark D. Johnson and Bradley D. Anderson |
| 1887-1891 | Different pH Dependency of Mitomycin C Activity in Monolayer and Three-Dimensional Cultures | Wan-Ching Yen, Thomas Schmittgen and Jessie L.-S. Au |
| 1892-1895 | Application of the Electrotopological State Index to QSAR Analysis of Flavone Derivatives as HIV-1 Integrase Inhibitors | John K. Buolamwini, Krishnamchari Raghavan, Mark R. Fesen, Yves Pommier and Kurt W. Kohn, et al. |
| 1896-1901 | A Candidate for Cancer Gene Therapy: MIP-lα Gene Transfer to an Adenocarcinoma Cell Line Reduced T\imorigenicity and Induced Protective Immunity in Immunocompetent Mice | Emi Nakashima, Akiko Oya, Yuri Kubota, Naomi Kanada and Ryo Matsushita, et al. |
| 1902-1904 | BOOK REVIEWS |
| 1905-1906 | Reviewers for Pharmaceutical Research November 1995 Through October 1996 |
| 1907-1910 | Author Index to Volume 13 (1996) |
| 1911-1915 | Subject Index to Volume 13 (1996) |